This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Toronto directory, so their courses may be missing. Find their university profile.
Research
Latest papers
The functional landscape of coding variation in the familial hypercholesterolemia gene LDLR.
Science (New York, N.Y.) · 2026
Systematically testing human HMBS missense variants to reveal mechanism and pathogenic variation.
American journal of human genetics · 2023
Systematically testing human HMBS missense variants to reveal mechanism and pathogenic variation.
bioRxiv : the preprint server for biology · 2023
Latest funding
- $1,690,650
A strategy for using machine intelligence to design high-capacity viral vectors that evade pre-existing immunity and enable gene therapies for diseases involving defects in large genes.
CIHR · 2025 · Nominated PI
- $500,000
Canada Research Chair - Tier 2
CIHR · 2023 · Nominated PI
- $450,000
Training Program in Engineering Approaches to Preserve and Rejuvenate Organs (TENPRO)
NSERC · 2023 · Co-investigator
14 publications.
The functional landscape of coding variation in the familial hypercholesterolemia gene LDLR.
Tabet DR, Coté AG, Lancaster MC, Weile J, Rayhan A, Fotiadou I, Kishore N, Li R, Kuang D, Knapp JJ, Carrero CS, Taverniti O, Axakova A, Castelli JMP, Islam MM, Sowlati-Hashjin S, Gandhi A, Maaieh R, Garton M, Matreyek K, Fowler DM, Bourbon M, Pfisterer SG, Glazer AM, Kroncke BM, Parikh VN, Ashley EA, Knowles JW, Claussnitzer M, Cirulli ET, Hegele RA, Roden DM, MacRae CA, Roth FP
Systematically testing human HMBS missense variants to reveal mechanism and pathogenic variation.
van Loggerenberg W, Sowlati-Hashjin S, Weile J, Hamilton R, Chawla A, Sheykhkarimli D, Gebbia M, Kishore N, Frésard L, Mustajoki S, Pischik E, Di Pierro E, Barbaro M, Floderus Y, Schmitt C, Gouya L, Colavin A, Nussbaum R, Friesema ECH, Kauppinen R, To-Figueras J, Aarsand AK, Desnick RJ, Garton M, Roth FP
Systematically testing human HMBS missense variants to reveal mechanism and pathogenic variation.
van Loggerenberg W, Sowlati-Hashjin S, Weile J, Hamilton R, Chawla A, Gebbia M, Kishore N, Frésard L, Mustajoki S, Pischik E, Di Pierro E, Barbaro M, Floderus Y, Schmitt C, Gouya L, Colavin A, Nussbaum R, Friesema ECH, Kauppinen R, To-Figueras J, Aarsand AK, Desnick RJ, Garton M, Roth FP
Dawn of a New Era for Membrane Protein Design.
Sowlati-Hashjin S, Gandhi A, Garton M
Shifting landscapes of human MTHFR missense-variant effects.
Weile J, Kishore N, Sun S, Maaieh R, Verby M, Li R, Fotiadou I, Kitaygorodsky J, Wu Y, Holenstein A, Bürer C, Blomgren L, Yang S, Nussbaum R, Rozen R, Watkins D, Gebbia M, Kozich V, Garton M, Froese DS, Roth FP
The geometric influence on the Cys2His2 zinc finger domain and functional plasticity.
Mueller AL, Corbi-Verge C, Giganti DO, Ichikawa DM, Spencer JM, MacRae M, Garton M, Kim PM, Noyes MB
Rapid and accurate structure-based therapeutic peptide design using GPU accelerated thermodynamic integration.
Garton M, Corbi-Verge C, Hu Y, Nim S, Tarasova N, Sherborne B, Kim PM
Interplay of self-association and conformational flexibility in regulating protein function.
Garton M, MacKinnon SS, Malevanets A, Wodak SJ
Method to generate highly stable D-amino acid analogs of bioactive helical peptides using a mirror image of the entire PDB.
Garton M, Nim S, Stone TA, Wang KE, Deber CM, Kim PM
A computational approach for designing D-proteins with non-canonical amino acid optimised binding affinity.
Garton M, Sayadi M, Kim PM
A strategy for using machine intelligence to design high-capacity viral vectors that evade pre-existing immunity and enable gene therapies for diseases involving defects in large genes.
Principal investigators: Garton, Michael J
Keywords: Viral Vector Design
Canada Research Chair - Tier 2
Principal investigators: Garton, Michael J
Keywords: Crc
Training Program in Engineering Approaches to Preserve and Rejuvenate Organs (TENPRO)
Principal investigators: Sefton, Michael MV
Keywords: bioengineering; biomedical devices; biotechnology; cell therapy; commercialization; gene editing; manufacturing; regeneration; tissue repair; translation
A generative AI strategy to reducing immunogenicity of synthetic and autoantigen proteins
Principal investigators: Garton, Michael
Keywords: Synthetic biology; Protein design; Generative AI; Autoimmunity; Human leucocyte antigen display
Enabling novel cardiac therapies with pluripotent stem cells
Principal investigators: Laflamme, Michael
Keywords: Cardiac regeneration; Pluripotent stem cells; Cell manufacturing; Heart failure; Synthetic biology; Tissue engineering; Biomedical imaging; 3D bioprinting; Mathematical modeling; Health technology assessment; Bioethics
Expanding the world of protein secondary structure beyond boundaries of evolution
Principal investigators: Garton, Michael
A strategy for expanding cell capabilities to sense their environment
Principal investigators: Garton, Michael J
Keywords: Cell-Based Therapy; Protein Design; Receptor Design; Synthetic Biology
Expanding the world of protein secondary structure beyond boundaries of evolution
Principal investigators: Garton, Michael
An integrated strategy for the development of next generation peptide therapeutics
Principal investigators: Kim, Philip M; Garton, Michael J
Keywords: Biologics; Computational Modeling; D-Amino Acid; Gpcr; Hormone; Molecular Dynamics; Peptide Therapeutic
Canada Research Chair - Tier 2
Principal investigators: Garton, Michael J
Keywords: Crc
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
Frequent collaborators
- Biomedical Engineering
- Donnelly Centre
- Pediatrics/Human Genetics
Co-authors at University of Toronto, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.
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