Faculty profile

Jack Greenblatt

ResearcherDonnelly CentreUniversity of Toronto

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Toronto directory, so their courses may be missing. Find their university profile.

Jack Greenblatt

Researcher

Donnelly Centre

Health Sciences

University of Toronto

Toronto, Ontario, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
4 publications in the last five years, latest in 2023.
Principal investigator on 5 research grants (5 CIHR), most recently in 2016.
Supervisor on 1 trainee award (1 CIHR), most recently in 2009.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

152

Citations

Collaborators

Grants

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

Profiles and links

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Signals and details

Research

Transcription Rna Polymerase Ii Chip-Sequencing Mass Spectrometry Protein-Protein Interactions Splicing Transcription Termination C2h2 Zinc Finger Proteins

Latest papers

Survival-based CRISPR genetic screens across a panel of permissive cell lines identify common and cell-specific SARS-CoV-2 host factors
Trials in Vaccinology · 2023
RNA-binding proteins that lack canonical RNA-binding domains are rarely sequence-specific.
Scientific reports · 2023
A central chaperone-like role for 14-3-3 proteins in human cells.
Molecular cell · 2023

All 42 publications

Latest funding

Using Herpesvirus Proteomics to Identify Mechanisms of Cellular Regulation
CIHR · 2016 · Co-investigator
$1,201,050
Characterization of a gene regulatory pathway involving proteins mutated in SMA, ALS, and FTD
CIHR · 2016 · Nominated PI
$764,500
Human gene expression regulatory mechanisms
CIHR · 2016 · Nominated PI
$6,135,843

All 10 grants and awards

42 publications.

Survival-based CRISPR genetic screens across a panel of permissive cell lines identify common and cell-specific SARS-CoV-2 host factors

Chan K, Farias AG, Lee H, Guvenc F, Mero P, Brown KR, Ward H, Billmann M, Aulakh K, Astori A

Trials in Vaccinology202330 citations

DOI: 10.1016/j.heliyon.2022.e12744

RNA-binding proteins that lack canonical RNA-binding domains are rarely sequence-specific.

Ray D, Laverty KU, Jolma A, Nie K, Samson R, Pour SE, Tam CL, von Krosigk N, Nabeel-Shah S, Albu M, Zheng H, Perron G, Lee H, Najafabadi H, Blencowe B, Greenblatt J, Morris Q, Hughes TR

Scientific reports2023

DOI: 10.1038/s41598-023-32245-9 PMID: 37002329

A central chaperone-like role for 14-3-3 proteins in human cells.

Segal D, Maier S, Mastromarco GJ, Qian WW, Nabeel-Shah S, Lee H, Moore G, Lacoste J, Larsen B, Lin ZY, Selvabaskaran A, Liu K, Smibert C, Zhang Z, Greenblatt J, Peng J, Lee HO, Gingras AC, Taipale M

Molecular cell2023

DOI: 10.1016/j.molcel.2023.02.018 PMID: 36931259

Epstein-Barr Virus BGLF2 commandeers RISC to interfere with cellular miRNA function.

Campbell AM, De La Cruz-Herrera CF, Marcon E, Greenblatt J, Frappier L

PLoS pathogens2022

DOI: 10.1371/journal.ppat.1010235 PMID: 35007297

Characterization of a cancer-associated Epstein-Barr virus EBNA1 variant reveals a novel interaction with PLOD1 and PLOD3.

Shire K, Marcon E, Greenblatt J, Frappier L

Virology2021

DOI: 10.1016/j.virol.2021.07.009 PMID: 34304093

USP7 Regulates Cytokinesis through FBXO38 and KIF20B.

Georges A, Coyaud E, Marcon E, Greenblatt J, Raught B, Frappier L

Scientific reports2019

DOI: 10.1038/s41598-019-39368-y PMID: 30804394

Direct interaction between the PRDM3 and PRDM16 tumor suppressors and the NuRD chromatin remodeling complex.

Ivanochko D, Halabelian L, Henderson E, Savitsky P, Jain H, Marcon E, Duan S, Hutchinson A, Seitova A, Barsyte-Lovejoy D, Filippakopoulos P, Greenblatt J, Lima-Fernandes E, Arrowsmith CH

Nucleic acids research2019

DOI: 10.1093/nar/gky1192 PMID: 30462309

Epstein-Barr virus BORF2 inhibits cellular APOBEC3B to preserve viral genome integrity.

Cheng AZ, Yockteng-Melgar J, Jarvis MC, Malik-Soni N, Borozan I, Carpenter MA, McCann JL, Ebrahimi D, Shaban NM, Marcon E, Greenblatt J, Brown WL, Frappier L, Harris RS

Nature microbiology2019

DOI: 10.1038/s41564-018-0284-6 PMID: 30420783

Crosstalk between RNA Pol II C-Terminal Domain Acetylation and Phosphorylation via RPRD Proteins.

Ali I, Ruiz DG, Ni Z, Johnson JR, Zhang H, Li PC, Khalid MM, Conrad RJ, Guo X, Min J, Greenblatt J, Jacobson M, Krogan NJ, Ott M

Molecular cell2019

DOI: 10.1016/j.molcel.2019.04.008 PMID: 31054975

The Epstein-Barr Virus BMRF1 Protein Activates Transcription and Inhibits the DNA Damage Response by Binding NuRD.

Salamun SG, Sitz J, De La Cruz-Herrera CF, Yockteng-Melgar J, Marcon E, Greenblatt J, Fradet-Turcotte A, Frappier L

Journal of virology2019

DOI: 10.1128/jvi.01070-19 PMID: 31462557

Using Herpesvirus Proteomics to Identify Mechanisms of Cellular Regulation

Co-investigatorCIHR2016Project Grant

Principal investigators: Frappier, Lori D

Keywords: Affinity Purification-Mass Spectroscopy; Cytomegalovirus; Epstein-Barr Virus; Herpes Simplex Virus; Protein Interactions

$1,201,050

Characterization of a gene regulatory pathway involving proteins mutated in SMA, ALS, and FTD

Nominated PICIHR2016Project Grant

Principal investigators: Greenblatt, Jack F

Keywords: Amyotrophic Lateral Sclerosis (Als); Dna Damage; Fronto-Temporal Dementia (Ftd); R-Loops; Rna Polymerase Ii; Rna-Seq; Spinal Muscular Atrophy (Sma); Splicing; Transcription; Transcription Termination

$764,500

Human gene expression regulatory mechanisms

Nominated PICIHR2016Foundation Grant

Principal investigators: Greenblatt, Jack F

Keywords: Amyotrophic Lateral Sclerosis; Cancer; Chip Sequencing; Iclip Sequencing; Mass Spectrometry; Neurodegeneration; Rna Polymerase Ii; Splicing; Transcription; Transcription Termination

$6,135,843

Mechanisms of gene regulation by the human C2H2 zinc finger proteins and interacting RNAs

Nominated PICIHR2016Project Grant

Principal investigators: Greenblatt, Jack F; Taipale, Mikko

Keywords: C2h2 Zinc Finger Proteins; Chia-Pet; Chip-Sequencing; Clip-Sequencing; Dna Looping; Lumier; Net-Sequencing; Protein-Protein Interactions; Protein-Rna Interactions; Rna Polymerase Ii

$1,058,835

Elucidation of protein interaction networks for the human transcription factors

Nominated PICIHR2012Operating Grant

Principal investigators: Greenblatt, Jack F

Keywords: Bioinformatics; Chip-Sequencing; Chromatin Immunoprecipitation; Mass Spectrometry; Protein-Protein Interactions; Proteomics; Rna Interference; Transcription; Transcription Factors

$1,544,245

Roles of human RNA polymerase II CTD-interacting proteins in the regulation of gene expression

Nominated PICIHR2011Operating Grant

Principal investigators: Greenblatt, Jack F

Keywords: Chip-Sequencing; Chromatin Immunoprecipitation; Ctd; Human Tissue Culture Cells; Mass Spectrometry; Phosphorylation; Rna Polymerase Ii; Rprd Proteins; Transcription

$763,865

The E. coli Cell Envelope Interactome: Identifying Protein Complexes Critical for Bacterial Cell Growth and Pathogenesis

Co-investigatorCIHR2010Operating Grant

Principal investigators: Emili, Andrew N

Keywords: Affinity Purification; Bacteria; Genomics; Informatics; Mass Spectrometry; Membrane Protein Complex

$959,064

Charting Bacterial Pathways and Functional Interaction Networks Using E. coli Synthetic Genetic Arrays

Co-investigatorCIHR2009Operating Grant

Principal investigators: Emili, Andrew N

Keywords: E.Coli; Functional Genomics; Functional Modules And Networks; Genetic (Gene-Gene) Interactions; Synthetic Genetic Arrays; Synthetic Lethality

$916,972

Cell type-specific features of the RNA polymerase II transcriptional apparatus in mammalian cells

SupervisorCIHR2009CIHR Fellowship

Principal investigators: Ni, Zuyao

Keywords: Cancer; Cellular Signaling; Chromatin Remodeling; Functional Genomics; Gene Regulation/Transcription; Genetics; Mass Spectrometry; Proteomics; Recombineering

$135,000

Elucidating the Bacterial Cell Envelope 'Interactome' using E. coli as a Model

Co-investigatorCIHR2008Operating Grant - PA: Institute of Genetics (Bridge Funding)

Principal investigators: Emili, Andrew N

Keywords: Affinity Purification; Bacteria; Genomics; Informatics; Mass Spectrometry; Membrane Protein Complex

$100,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Jack Greenblatt

Research

Latest papers

Latest funding

Survival-based CRISPR genetic screens across a panel of permissive cell lines identify common and cell-specific SARS-CoV-2 host factors

RNA-binding proteins that lack canonical RNA-binding domains are rarely sequence-specific.

A central chaperone-like role for 14-3-3 proteins in human cells.

Epstein-Barr Virus BGLF2 commandeers RISC to interfere with cellular miRNA function.

Characterization of a cancer-associated Epstein-Barr virus EBNA1 variant reveals a novel interaction with PLOD1 and PLOD3.

USP7 Regulates Cytokinesis through FBXO38 and KIF20B.

Direct interaction between the PRDM3 and PRDM16 tumor suppressors and the NuRD chromatin remodeling complex.

Epstein-Barr virus BORF2 inhibits cellular APOBEC3B to preserve viral genome integrity.

Crosstalk between RNA Pol II C-Terminal Domain Acetylation and Phosphorylation via RPRD Proteins.

The Epstein-Barr Virus BMRF1 Protein Activates Transcription and Inhibits the DNA Damage Response by Binding NuRD.

Frequent collaborators

Andrew Emili

Lori Frappier

John Parkinson

Zhaolei Zhang

Mohan Babu

Amélie Fradet-Turcotte

Brian Raught

Anne-Claude Gingras

Mikko Taipale

Jason Moffat

Alexei Savchenko

Craig Smibert

Michael Garton

Jean-Philippe Lambert

Finlay Maguire

Arinjay Banerjee

Dalia Barsyte-Lovejoy

Benjamin Blencowe

Charles Boone

Timothy Hughes

Eric Brown

Karen Mossman