Faculty profile

Molly Shoichet

ResearcherChemical Engineering and Applied ChemistryUniversity of Toronto

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Toronto directory, so their courses may be missing. Find their university profile.

Molly Shoichet

Researcher

Chemical Engineering and Applied Chemistry

Health Sciences

University of Toronto

Toronto, Ontario, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
2 publications in the last five years, latest in 2026.
Senior (last) author on 1 recent paper, a sign of leading a research group.
Principal investigator on 56 research grants (40 NSERC, 16 CIHR), most recently in 2025.
Supervised 3 trainees who won CIHR awards, most recently in 2024.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

Citations

h-index

Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

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Signals and details

Research

Hydrogels Spinal Cord Injury Local Delivery Breast Cancer Drug Delivery Affinity Release Vision Repair Blindness

Latest papers

Novel Vitreous Substitutes in Animal and Human Models: A Systematic Review.
BioMed research international · 2026
Computationally identified peptides immobilized to hydrogel delivery vehicles enable affinity-controlled release of proteins.
Acta biomaterialia · 2026 · senior author
Nanoparticle delivery of a pH-sensitive prodrug of doxorubicin and a mitochondrial targeting VES-H8R8 synergistically kill multi-drug resistant breast cancer cells.
Scientific reports · 2020 · senior author

All 14 publications

Latest funding

Neuroprotection of the Retina
CIHR · 2025 · Nominated PI
$983,024
Replacement and Upgrade of a Nanoparticle Formulation System
NSERC · 2025 · Co-investigator
$131,827
Chase Biotherapeutics: local delivery, global benefits in the central nervous system
CIHR · 2025 · Nominated PI
$948,600

All 80 grants and awards

14 publications.

Novel Vitreous Substitutes in Animal and Human Models: A Systematic Review.

Solish D, Huo L, Jin TS, Hall B, You EL, Popovic MM, Forman A, Shoichet M, Devenyi R, Ballios BG, Yan P

BioMed research international2026

DOI: 10.1155/bmri/8731510 PMID: 42334066

Computationally identified peptides immobilized to hydrogel delivery vehicles enable affinity-controlled release of proteins.

Yao Y, Hong C, Teal CJ, Bahsoun NE, Lu SP, Fernandes I, Keller G, Shoichet M

Acta biomaterialia2026Senior author

DOI: 10.1016/j.actbio.2025.12.034 PMID: 41412290

Nanoparticle delivery of a pH-sensitive prodrug of doxorubicin and a mitochondrial targeting VES-H8R8 synergistically kill multi-drug resistant breast cancer cells.

Czupiel P, Delplace V, Shoichet M

Scientific reports2020Senior author

DOI: 10.1038/s41598-020-65450-x PMID: 32457422

A 3D culture model of innervated human skeletal muscle enables studies of the adult neuromuscular junction.

Afshar Bakooshli M, Lippmann ES, Mulcahy B, Iyer N, Nguyen CT, Tung K, Stewart BA, van den Dorpel H, Fuehrmann T, Shoichet M, Bigot A, Pegoraro E, Ahn H, Ginsberg H, Zhen M, Ashton RS, Gilbert PM

eLife2019

DOI: 10.7554/elife.44530 PMID: 31084710

Effect of hyaluronic acid hydrogels containing astrocyte-derived extracellular matrix and/or V2a interneurons on histologic outcomes following spinal cord injury.

Thompson RE, Pardieck J, Smith L, Kenny P, Crawford L, Shoichet M, Sakiyama-Elbert S

Biomaterials2018

DOI: 10.1016/j.biomaterials.2018.02.013 PMID: 29459311

Cyclosporine-immunosuppression does not affect survival of transplanted skin-derived precursor Schwann cells in the injured rat spinal cord.

May Z, Torres-Espín A, Lucas-Osma AM, Batty NJ, Raposo P, Fenrich KK, Stykel MG, Führmann T, Shoichet M, Biernaskie J, Fouad K

Neuroscience letters2017

DOI: 10.1016/j.neulet.2017.08.045 PMID: 28843345

Engineered polymeric nanoparticles to guide the cellular internalization and trafficking of small interfering ribonucleic acids.

Arnold AE, Czupiel P, Shoichet M

Journal of controlled release : official journal of the Controlled Release Society2017Senior author

DOI: 10.1016/j.jconrel.2017.02.019 PMID: 28232223

Delivery strategies for treatment of age-related ocular diseases: From a biological understanding to biomaterial solutions.

Delplace V, Payne S, Shoichet M

Journal of controlled release : official journal of the Controlled Release Society2015Senior author

DOI: 10.1016/j.jconrel.2015.09.065 PMID: 26435454

Endothelial cells guided by immobilized gradients of vascular endothelial growth factor on porous collagen scaffolds.

Odedra D, Chiu LL, Shoichet M, Radisic M

Acta biomaterialia2011

DOI: 10.1016/j.actbio.2011.05.002 PMID: 21601017

Experimental assessment of pro-lymphangiogenic growth factors in the treatment of post-surgical lymphedema following lymphadenectomy.

Baker A, Kim H, Semple JL, Dumont D, Shoichet M, Tobbia D, Johnston M

Breast cancer research : BCR2010

DOI: 10.1186/bcr2638 PMID: 20825671

Neuroprotection of the Retina

Nominated PICIHR2025Project Grant

Principal investigators: Shoichet, Molly S

Keywords: Affinity Release; Computational Modeling; Hydrogels; Molecular Dynamics Simulations; Protein Stability; Therapeutic Delivery; Vision

$983,024

Replacement and Upgrade of a Nanoparticle Formulation System

Co-investigatorNSERC2025Research Tools and Instruments

Principal investigators: Walker, Gilbert

Keywords: nanoparticles; lipid nanoparticles; biomaterials engineering; formulation science

$131,827

Chase Biotherapeutics: local delivery, global benefits in the central nervous system

Nominated PICIHR2025Project Grant

Principal investigators: Shoichet, Molly S; Fouad, Karim; Kwon, Brian K

Keywords: Affinity Release; Chondroitinase Abc; Glial Scar; Injectable Hydrogel; Local Delivery; Oxime Crosslinking; Spinal Cord Injury; Stroke

$948,600

Hodgkin Lymphoma Treatment Revolution: Advanced Drug Screening in a 3D-Biomimetic Tumour-Associated Macrophage-Integrated Model

SupervisorCIHR2024Doctoral Research Award: Canada Graduate Scholarships

Principal investigators: Chin, Allysia A

Keywords: 3d Biomimetic Cancer-Immune Cell Co-Culture Hydrogel Model; 3d High-Throughput Drug Screening In Hodgkin Lymphoma; Dose-Response Curves/Drug Potency And Efficacy; Gene Set Enrichment Analysis For Mechanism Elucidation; Hodgkin Lymphoma Tumour Microenvironment; Hyaluronan And Gelatin-Based Biomaterials; Single Cell Rna Sequencing/Flow Cytometry/Viability Assays; Synthesis And Characterization Of Tunable 3d Hydrogels; Targeting Tumor-Associated Macrophages In Hodgkin Lymphoma; Translational Medicine In Cancer Immunology

$120,000

Antibody Affinity Release: Market Assessment

Principal investigatorNSERC2023Idea to Innovation

Principal investigators: Shoichet, Molly S

Keywords: affinity; antibodies; binding peptides; controlled release; hydrogels; local delivery; market assessment; polymers

$15,000

Peptide Synthesizer & Cell Culture

Principal investigatorNSERC2023Research Tools and Instruments

Principal investigators: Shoichet, Molly

$89,043

Manipulating the cellular microenvironment to bioengineer bile ducts

Co-investigatorCIHR2023Project Grant

Principal investigators: Mcgilvray, Ian D

Keywords: Bile Duct; Bioengineering; Fibrosis; Immunology; Liver; Macrophage Phenotype; Microsurgery; Single Cell Transcriptomics; Single Nucleus Transcriptomics; Transplantation

$1,067,175

Enabling novel cardiac therapies with pluripotent stem cells

Co-investigatorSSHRC2022New Frontiers in Research Fund - Transformation

Principal investigators: Laflamme, Michael

Keywords: Cardiac regeneration; Pluripotent stem cells; Cell manufacturing; Heart failure; Synthetic biology; Tissue engineering; Biomedical imaging; 3D bioprinting; Mathematical modeling; Health technology assessment; Bioethics

$7,908,900

Overcoming ER+ Breast Cancer with Fulvestrant-siRNA co-delivery

Nominated PICIHR2022Project Grant

Principal investigators: Shoichet, Molly S

Keywords: Breast Cancer; Colloidal Drug Aggregates; Combination Drug Formulations; Endosomal Escape; Fulvestrant Analogues; Lipid Nanoparticles; Sirna Delivery

$665,552

Vision Rescue: Transforming Therapeutics with Hydrogel Delivery

Nominated PICIHR2021Project Grant

Principal investigators: Shoichet, Molly S

Keywords: Afffinity Release; Hydrogels; Neuroprotection; Photoreceptors; Proteins; Vision Repair

$573,752

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Molly Shoichet

Research

Latest papers

Latest funding

Novel Vitreous Substitutes in Animal and Human Models: A Systematic Review.

Computationally identified peptides immobilized to hydrogel delivery vehicles enable affinity-controlled release of proteins.

Nanoparticle delivery of a pH-sensitive prodrug of doxorubicin and a mitochondrial targeting VES-H8R8 synergistically kill multi-drug resistant breast cancer cells.

A 3D culture model of innervated human skeletal muscle enables studies of the adult neuromuscular junction.

Effect of hyaluronic acid hydrogels containing astrocyte-derived extracellular matrix and/or V2a interneurons on histologic outcomes following spinal cord injury.

Cyclosporine-immunosuppression does not affect survival of transplanted skin-derived precursor Schwann cells in the injured rat spinal cord.

Engineered polymeric nanoparticles to guide the cellular internalization and trafficking of small interfering ribonucleic acids.

Delivery strategies for treatment of age-related ocular diseases: From a biological understanding to biomaterial solutions.

Endothelial cells guided by immobilized gradients of vascular endothelial growth factor on porous collagen scaffolds.

Experimental assessment of pro-lymphangiogenic growth factors in the treatment of post-surgical lymphedema following lymphadenectomy.

Neuroprotection of the Retina

Replacement and Upgrade of a Nanoparticle Formulation System

Chase Biotherapeutics: local delivery, global benefits in the central nervous system

Hodgkin Lymphoma Treatment Revolution: Advanced Drug Screening in a 3D-Biomimetic Tumour-Associated Macrophage-Integrated Model

Antibody Affinity Release: Market Assessment

Peptide Synthesizer & Cell Culture

Manipulating the cellular microenvironment to bioengineer bile ducts

Enabling novel cardiac therapies with pluripotent stem cells

Overcoming ER+ Breast Cancer with Fulvestrant-siRNA co-delivery

Vision Rescue: Transforming Therapeutics with Hydrogel Delivery

Frequent collaborators

Mei Zhen

Gordon Keller

Cindi Morshead

Milica Radisic

Karim Fouad

Ryan Wylie