Faculty profile

Mei Zhen

ResearcherSamuel Lunenfeld Research InstituteUniversity of Toronto

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Toronto directory, so their courses and email address may be missing. Find their university profile.

Mei Zhen

Researcher

Samuel Lunenfeld Research Institute

Health Sciences

University of Toronto

Toronto, Ontario, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
20 publications in the last five years, latest in 2026.
Senior (last) author on 6 recent papers, a sign of leading a research group.
Principal investigator on 15 research grants (10 CIHR, 5 NSERC), most recently in 2024.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

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Grants

Publications by year

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Signals and details

Research

C. Elegans Optogenetics Electron Microscopy Genetics Imaging Dauer Developmental Connectomics High-Throughput Electron Microscopy

Latest papers

Three muscle-specific DAF-16/FOXO transcriptional targets activated by reduced insulin/IGF-1 signaling.
G3 (Bethesda, Md.) · 2026 · senior author
Author Correction: Towards a reference cell atlas of liver diversity over the human lifespan.
Nature reviews. Gastroenterology & hepatology · 2026 · senior author
Towards a reference cell atlas of liver diversity over the human lifespan.
Nature reviews. Gastroenterology & hepatology · 2026 · senior author

All 82 publications

Latest funding

Canada Research Chair - Tier 1
CIHR · 2024 · Nominated PI
$1,400,000
A Circuit Investigation of the C. elegans Behavioral States
NSERC · 2024 · Principal investigator
$63,000
Genetic- and experience-dependent wiring decisions
CIHR · 2024 · Nominated PI
$1,422,900

All 15 grants and awards

82 publications.

Three muscle-specific DAF-16/FOXO transcriptional targets activated by reduced insulin/IGF-1 signaling.

Wu S, Gao J, Li Y, Roy C, Wang Y, Mulcahy B, Li W, Ravivarma S, Calarco J, Hung W, Zhen M

G3 (Bethesda, Md.)2026Senior author

DOI: 10.1093/g3journal/jkag030 PMID: 41773048

Author Correction: Towards a reference cell atlas of liver diversity over the human lifespan.

Taylor SA, Bader GD, MacParland S, Mullen AC, Andrews T, Cuenca AG, DasGupta R, Gehring AJ, Grün D, Guilliams M, Gulamhusein A, Henderson NC, Hirschfield G, Huppert SS, Itzkovitz S, Jiang ZG, Lauer GM, McGilvray I, Mysore KR, Pirola CJ, Quon G, Rahbari M, Regev A, Ricciuto A, Scott CL, Sharma A, Sookoian S, Tana MM, Teichmann SA, Vallier L, Vlachos IS, Wang B, Zhen M

Nature reviews. Gastroenterology & hepatology2026Senior author

DOI: 10.1038/s41575-025-01145-w PMID: 41131357

Towards a reference cell atlas of liver diversity over the human lifespan.

Nature reviews. Gastroenterology & hepatology2026Senior author

DOI: 10.1038/s41575-025-01114-3 PMID: 41083606

Transfer learning improves performance in volumetric electron microscopy organelle segmentation across tissues.

Xie R, Mulcahy B, Darbandi A, Marwah S, Ali F, Lee Y, Parlakgul G, Hotamisligil GS, Wang B, MacParland S, Zhen M, Bader GD

Bioinformatics advances2025

DOI: 10.1093/bioadv/vbaf021 PMID: 40196751

UBR-1 deficiency leads to ivermectin resistance in Caenorhabditis elegans.

Li Y, Gong L, Wu J, Hung W, Zhen M, Gao S

eLife2025

DOI: 10.7554/elife.103718 PMID: 40167441

3D electron microscopy for analyzing nanoparticles in the tumor endothelium.

Mladjenovic SM, Chandok IS, Darbandi A, Nguyen LNM, Stordy B, Zhen M, Chan WCW

Proceedings of the National Academy of Sciences of the United States of America2024

DOI: 10.1073/pnas.2406331121 PMID: 39665759

Robotic microinjection enables large-scale transgenic studies of Caenorhabditis elegans.

Pan P, Zoberman M, Zhang P, Premachandran S, Bhatnagar S, Pilaka-Akella PP, Sun W, Li C, Martin C, Xu P, Zhang Z, Li R, Hung W, Tang H, MacGillivray K, Yu B, Zuo R, Pe K, Qin Z, Wang S, Li A, Derry WB, Zhen M, Saltzman AL, Calarco JA, Liu X

Nature communications2024

DOI: 10.1038/s41467-024-53108-5 PMID: 39397017

C. elegans touch receptor neurons direct mechanosensory complex organization via repurposing conserved basal lamina proteins.

Das A, Franco JA, Mulcahy B, Wang L, Chapman D, Jaisinghani C, Pruitt BL, Zhen M, Goodman MB

Current biology : CB2024

DOI: 10.1016/j.cub.2024.06.013 PMID: 38964319

A leak K+ channel TWK-40 sustains the rhythmic motor program.

Yue Z, Li Y, Yu B, Xu Y, Chen L, Chitturi J, Meng J, Wang Y, Tian Y, Mouridi SE, Zhang C, Zhen M, Boulin T, Gao S

PNAS nexus2024

DOI: 10.1093/pnasnexus/pgae234 PMID: 38957449

A tonically active master neuron modulates mutually exclusive motor states at two timescales.

Meng J, Ahamed T, Yu B, Hung W, Ei Mouridi S, Wang Z, Zhang Y, Wen Q, Boulin T, Gao S, Zhen M

Science advances2024Senior author

DOI: 10.1126/sciadv.adk0002 PMID: 38598630