Radhakrishnan Mahadevan, University of Toronto

Research

Crohn'S Disease Intestinal Inflammation Metabolic Syndrome Mouse Models Probiotics Synthetic Biology

Latest papers

Method for assessing inter-individual variability in the carbohydrate utilization potential of gut microbiota ex vivo.
MethodsX · 2026
Membrane and proteome allocation constraints in Escherichia coli models during overflow metabolism.
Biophysical journal · 2026 · senior author
Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy.
FEBS letters · 2026

All 116 publications

Latest funding

In situ monitoring of intestinal mucus barrier regulation in colorectal cancer
SSHRC · 2024 · Co-investigator
$125,000
Electro-Biocatalytic Conversion of CO2 into Valuable Aromatics
NSERC · 2024 · Principal investigator
$300,000
Novel Computational and Experimental Tools for Production of Zero Emissions Fuels and Chemicals
NSERC · 2023 · Principal investigator
$138,000

All 35 grants and awards

116 publications.

01

Method for assessing inter-individual variability in the carbohydrate utilization potential of gut microbiota ex vivo.

Asbury RE, Hoffman TA, Chu C, Mahadevan R, Saville BA

MethodsX2026

DOI: 10.1016/j.mex.2026.104154 PMID: 42787584

02

Membrane and proteome allocation constraints in Escherichia coli models during overflow metabolism.

Garcia-Benitez M, Scott M, Carlson R, Mahadevan R

Biophysical journal2026Senior author

DOI: 10.1016/j.bpj.2026.01.028 PMID: 41580894

03

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy.

Carlson RP, Gedeon T, Benitez MG, Putnam C, Harcombe WR, Mahadevan R, Beck AE

FEBS letters2026

DOI: 10.1002/1873-3468.70380 PMID: 42339668

04

Patient-specific modeling identifies metabolic interventions for reversing glucose use reprogramming in alcohol-associated hepatitis.

Manchel A, Mahadevan R, Hoek JB, Bataller R, Vadigepalli R

Communications biology2026

DOI: 10.1038/s42003-026-10407-5 PMID: 42243508

05

Enabling Plasmid-Based Expression in Clostridium kluyveri Using a Biparental Methylation-Conjugation System.

Agena EM, Badani AA, Lindner BG, Gois IM, Dempster AW, Minton NP, Mahadevan R, Lawson CE

ACS synthetic biology2026

DOI: 10.1021/acssynbio.5c00788 PMID: 41848340

06

Multicriteria evaluation of ethylene glycol assimilation pathways.

Feigis M, Mahadevan R

Journal of industrial microbiology & biotechnology2026Senior author

DOI: 10.1093/jimb/kuag007 PMID: 41697148

07

Improving a photosynthetic bioprocess with a ubiquitous additive: Using clay powder in the cultivation of Rhodopseudomonas palustris.

Stephens S, Abo-Hashesh M, Mahadevan R, Allen DG

Biotechnology reports (Amsterdam, Netherlands)2025

DOI: 10.1016/j.btre.2025.e00930 PMID: 41141383

08

Establishing a quantitative link between crystal violet absorbance and biomass in biofilms.

Stephens S, Mahadevan R, Allen DG

MethodsX2025

DOI: 10.1016/j.mex.2025.103630 PMID: 41031184

09

Modeling reveals a metabolic basis of competition among Dehalobacter strains during tandem chloroform and dichloromethane metabolism.

Bulka O, Edwards EA, Mahadevan R

mSystems2025Senior author

DOI: 10.1128/msystems.00847-25 PMID: 40910777

10

Model-Based Optimization of a qCRISPRi Circuit for Dynamic Control of Metabolic Pathways.

Golla SA, Abo-Hashesh M, Gupta D, Liu Y, Mahadevan R

ACS synthetic biology2025Senior author

DOI: 10.1021/acssynbio.5c00095 PMID: 41021780

In situ monitoring of intestinal mucus barrier regulation in colorectal cancer

Co-investigatorSSHRC2024New Frontiers in Research Fund - Exploration

Principal investigators: Girardin, Stephen

$125,000

Electro-Biocatalytic Conversion of CO2 into Valuable Aromatics

Principal investigatorNSERC2024International - Collaboration

Principal investigators: Mahadevan, Radhakrishnan

Keywords: Industrial chemicals (solvents, resins); Engineering

$300,000

Novel Computational and Experimental Tools for Production of Zero Emissions Fuels and Chemicals

Principal investigatorNSERC2023Discovery Grants Program - Individual

Principal investigators: Mahadevan, Radhakrishnan

Keywords: Bacterial Micro-compartments; Biochemical Engineering; Biofoundries; Genome-scale Metabolic Modeling; Machine Learning; Metabolic Engineering; Metabolic Pathways; Negative Emissions Biochemicals; Synthetic Biology; Zero Emissions Fuels

$138,000

Critical Resource Extraction using Sustainable Techniques (CREST)

Co-investigatorNSERC2023Alliance Grants

Principal investigators: Gu, Frank FX

Keywords: bioremediation; circular economy; critical minerals; metal recovery; microbes; mine tailings valorization; photocatalysis; tailings

$500,000

Leveraging probiotic-derived membrane vesicles as a postbiotic therapeutic for Crohn's disease

SupervisorCIHR2022Doctoral Research Award: Canada Graduate Scholarships

Principal investigators: Baerg, Lauren

Keywords: Bacterial Membrane Vesciles; Crohn'S Disease; Drug Delivery; Intestinal Repair; Metabolic Engineering; Nod2 Receptor; Organoid Models; Postbiotics

$105,000

Expanding the product spectrum of anaerobic digestion for a circular economy

Co-investigatorNSERC2022Alliance Grants

Principal investigators: Lawson, Christopher CEL

Keywords: Anaerobic Biotechnology; Bioengineering; Circular Economy; Membrane Separations; Microbial Ecology; Resource Recovery; Synthetic Biology

$181,437

Engineering Acidophilic Yeasts for Sustainable Chemical Production

Principal investigatorNSERC2021Alliance Grants

Principal investigators: Mahadevan, Radhakrishnan R

$103,514

Design of probiotic bacteria to promote digestive and metabolic health

Co-investigatorNSERC2020Collaborative Health Research Projects

Principal investigators: Philpott, Dana

$450,330

BioZone: An Open Bioscience and Bioengineering Research and Training Environment

Co-investigatorNSERC2019Collaborative Research and Training Experience

Principal investigators: Master, Emma

$1,650,000

Metabolic Systems Engineering

Principal investigatorNSERC2019Canada Research Chairs

Principal investigators: Mahadevan, Radhakrishnan

$800,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Chemical Engineering and Applied Chemistry
Immunology
Microbiology and Infectious Diseases
Cellular and Molecular Medicine

Co-authors at University of Toronto, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Alexei Savchenko

Chemical Engineering and Applied Chemistry

10 shared papers, latest 2024

Alexei Savchenko

Microbiology and Infectious Diseases

7 shared papers, latest 2024

Mads Kaern

Cellular and Molecular Medicine

1 shared papers, latest 2021

Alison McGuigan

Chemical Engineering and Applied Chemistry

1 shared papers, latest 2012

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their NSERC grant from 2024

Subject: Prospective PhD student: Crohn'S Disease Dear Professor Mahadevan, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Method for assessing inter-individual variability in the carbohydrate utilization potential of gut microbiota ex vivo." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your NSERC-funded project "Electro-Biocatalytic Conversion of CO2 into Valuable Aromatics" (2024), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]