Faculty profile

Alexei Savchenko

ResearcherMicrobiology and Infectious DiseasesUniversity of Calgary

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Calgary directory, so their courses may be missing. Find their university profile.

Alexei Savchenko

Researcher

Microbiology and Infectious Diseases

Health Sciences

University of Calgary

Calgary, Alberta, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
48 publications in the last five years, latest in 2026.
Senior (last) author on 16 recent papers, a sign of leading a research group.
Principal investigator on 4 research grants (3 NSERC, 1 CIHR), most recently in 2024.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

565

Citations

h-index

Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

Profiles and links

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Signals and details

Research

Candida Albicans Enzymatic Activity Protein Structure Shikimate Pathway Small Molecule Inhibitors

Latest papers

Structural Analysis of 23S rRNA Methylating Enzyme Cfr Reveals RNA-Binding Determinants for Methylation Regiospecificity and Antibiotic Resistance.
ACS infectious diseases · 2026
Polycationic nanopeptide-fused endolysins for the control of Mannheimia haemolytica.
Applied microbiology and biotechnology · 2026
A Bifunctional T3SS-Effector Simultaneously Cleaves Host MAP Kinase and Inhibits PPM1A Phosphatase.
Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026

All 75 publications

Latest funding

The structure and function(s) of Borrelia telomere resolvase, ResT
CIHR · 2026 · Co-investigator
$100,000
Harnessing Bacterial Effector Proteins for Eukaryotic Synthetic Biology: Unlocking Functional Insights
NSERC · 2024 · Principal investigator
$47,000
Body heat-sensing proteins that control bacterial biofilm growth and immunopathogenesis
CIHR · 2022 · Co-investigator
$914,176

All 9 grants and awards

75 publications.

Structural Analysis of 23S rRNA Methylating Enzyme Cfr Reveals RNA-Binding Determinants for Methylation Regiospecificity and Antibiotic Resistance.

Fruci M, Rodríguez Hernández A, Skarina T, Verellen LA, Tsai K, Virta JM, Fujimori DG, Savchenko A, Stogios PJ

ACS infectious diseases2026

DOI: 10.1021/acsinfecdis.5c00828 PMID: 41615325

Polycationic nanopeptide-fused endolysins for the control of Mannheimia haemolytica.

Moqaddes S, Du H, Lin J, Hyun JE, Gohar M, Savchenko A, Stanford K, Ralston B, McAllister TA, Niu YD

Applied microbiology and biotechnology2026

DOI: 10.1007/s00253-026-13835-9 PMID: 42104005

A Bifunctional T3SS-Effector Simultaneously Cleaves Host MAP Kinase and Inhibits PPM1A Phosphatase.

Socol Y, Gur-Arie L, Tzarum N, Wellins T, Katsowich N, Ravins M, Bejerano-Sagie M, Cohen K, Livnah O, Adkins JN, Nakayasu E, Savchenko A, Choong YK, Tulsian NK, Machida S, Ben-Yehuda S, Litvak Y, Sivaraman J, Rosenshine I

Advanced science (Weinheim, Baden-Wurttemberg, Germany)2026

DOI: 10.1002/advs.202509702 PMID: 41902461

Crystal structure and biochemical analysis of the polyester-degrading carboxylesterase SM0281 from the symbiotic legume-associated rhizobacterium Sinorhizobium (Ensifer) meliloti.

Lemak S, Khusnutdinova AN, Stogios PJ, Evdokimova E, Savchenko A, Golyshin PN, Edwards EA, Yakunin AF

The FEBS journal2026

DOI: 10.1111/febs.70734 PMID: 42770702

Structural genomics of bacterial drug targets: Application of a high-throughput pipeline to solve 58 protein structures from pathogenic and related bacteria.

Inniss NL, Minasov G, Chang C, Tan K, Kim Y, Maltseva N, Stogios P, Filippova E, Michalska K, Osipiuk J, Jaroszewki L, Godzik A, Savchenko A, Joachimiak A, Anderson WF, Satchell KJF, Center for Structural Biology of Infectious Diseases Team members

Microbiology resource announcements2025

DOI: 10.1128/mra.00200-25 PMID: 40391899

Structural and Biochemical Insights into Lignin-Oxidizing Activity of Bacterial Peroxidases against Soluble Substrates and Kraft Lignin.

Choolaei Z, Khusnutdinova AN, Skarina T, Stogios P, Diep P, Lemak S, Edwards EA, Savchenko A, Yakunin AF

ACS chemical biology2025

DOI: 10.1021/acschembio.4c00788 PMID: 40145573

Structural architecture of TolQ-TolR inner membrane protein complex from opportunistic pathogen Acinetobacter baumannii.

Karimullina E, Guo Y, Khan HM, Emde T, Quade B, Di Leo R, Otwinowski Z, Tieleman DP, Borek D, Savchenko A

Science advances2025Senior author

DOI: 10.1126/sciadv.adq9845 PMID: 40184442

Structure-guided optimization of small molecules targeting Yck2 as a strategy to combat Candida albicans.

Puumala E, Nandakumar M, Yiu B, Stogios PJ, Strickland BG, Zarnowski R, Wang X, Williams NS, Savchenko A, Andes DR, Robbins N, Whitesell L, Willson TM, Cowen LE

Nature communications2025

DOI: 10.1038/s41467-025-57346-z PMID: 40038303

Torsional twist of the SARS-CoV and SARS-CoV-2 SUD-N and SUD-M domains.

Rosas-Lemus M, Minasov G, Brunzelle JS, Taha TY, Lemak S, Yin S, Shuvalova L, Rosecrans J, Khanna K, Seifert HS, Savchenko A, Stogios PJ, Ott M, Satchell KJF

Protein science : a publication of the Protein Society2025

DOI: 10.1002/pro.70050 PMID: 39969084

The Crystal Structure of the Domain of Unknown Function 1480 (DUF1480) From Klebsiella pneumoniae.

Patel DH, Watanabe N, Savchenko A, Semper C

Proteins2025

DOI: 10.1002/prot.26752 PMID: 39324284

The structure and function(s) of Borrelia telomere resolvase, ResT

Co-investigatorCIHR2026Project Grant - Priority Announcement: Infection and Immunity

Principal investigators: Semper, Cameron

Keywords: Bacterial Pathogenesis; Dna Maintenance; Lyme Disease; Proteomics; Telomere Resolution

$100,000

Harnessing Bacterial Effector Proteins for Eukaryotic Synthetic Biology: Unlocking Functional Insights

Principal investigatorNSERC2024Discovery Grants Program - Individual

Principal investigators: Savchenko, Alexei

Keywords: bacterial secreted effectors; molecular structure; biochemical function; conserved eukaryotic signalling pathways; yeast model system; human cell lines; post translational modifications; protein-protein interactions; x-ray crystallography; single particle cryo-em analysis

$47,000

Body heat-sensing proteins that control bacterial biofilm growth and immunopathogenesis

Co-investigatorCIHR2022Project Grant

Principal investigators: Harrison, Joe J

Keywords: Bacterial Pathogenesis; Biofilms; Intravital Imaging; Microbial Genetics; Microbiology; Molecular Simulation; Protein Chemistry; Protein Engineering; Signal Transduction; Structural Biology

$914,176

Discovery and development of inhibitors for shikimate pathway Aro1 multienzyme in the opportunistic fungal pathogen Candida albicans

Nominated PICIHR2022Project Grant - PA: Antimicrobial Resistance (Bridge Grant)

Principal investigators: Savchenko, Alexei

Keywords: Candida Albicans; Enzymatic Activity; Protein Structure; Shikimate Pathway; Small Molecule Inhibitors

$100,000

BioZone: An Open Bioscience and Bioengineering Research and Training Environment

Co-investigatorNSERC2019Collaborative Research and Training Experience

Principal investigators: Master, Emma

$1,650,000

Engineering of Transferase Enzymes for DNA Synthesis**

Principal investigatorNSERC2018Engage Grants Program

Principal investigators: Savchenko, Alexei

$25,000

Mining the Legionella core ?effectome? for molecular modulators of conserved eukaryotic cell signaling

Principal investigatorNSERC2017Discovery Grants Program - Individual

Principal investigators: Savchenko, Alexei

$168,000

Operations and Maintenance Support for the BioZone MS Facility

Co-investigatorNSERC2017Research Tools and Instruments

Principal investigators: Yakunin, Alexander

$150,000

Engineering a broadly cross-protective vaccine that confers sterilizing immunity against Haemophilus influenzae.

Co-investigatorCIHR2016Project Grant

Principal investigators: Schryvers, Anthony B

Keywords: Bacteriology; Immunoassays; Infectious Disease; Mouse Models; Protein Engineering; Structural Biology; Vaccines

$814,195

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Alexei Savchenko

Research

Latest papers

Latest funding

Structural Analysis of 23S rRNA Methylating Enzyme Cfr Reveals RNA-Binding Determinants for Methylation Regiospecificity and Antibiotic Resistance.

Polycationic nanopeptide-fused endolysins for the control of Mannheimia haemolytica.

A Bifunctional T3SS-Effector Simultaneously Cleaves Host MAP Kinase and Inhibits PPM1A Phosphatase.

Crystal structure and biochemical analysis of the polyester-degrading carboxylesterase SM0281 from the symbiotic legume-associated rhizobacterium Sinorhizobium (Ensifer) meliloti.

Structural genomics of bacterial drug targets: Application of a high-throughput pipeline to solve 58 protein structures from pathogenic and related bacteria.

Structural and Biochemical Insights into Lignin-Oxidizing Activity of Bacterial Peroxidases against Soluble Substrates and Kraft Lignin.

Structural architecture of TolQ-TolR inner membrane protein complex from opportunistic pathogen Acinetobacter baumannii.

Structure-guided optimization of small molecules targeting Yck2 as a strategy to combat Candida albicans.

Torsional twist of the SARS-CoV and SARS-CoV-2 SUD-N and SUD-M domains.

The Crystal Structure of the Domain of Unknown Function&#xa0;1480 (DUF1480) From Klebsiella pneumoniae.

The structure and function(s) of Borrelia telomere resolvase, ResT

Harnessing Bacterial Effector Proteins for Eukaryotic Synthetic Biology: Unlocking Functional Insights

Body heat-sensing proteins that control bacterial biofilm growth and immunopathogenesis

Discovery and development of inhibitors for shikimate pathway Aro1 multienzyme in the opportunistic fungal pathogen Candida albicans

BioZone: An Open Bioscience and Bioengineering Research and Training Environment

Engineering of Transferase Enzymes for DNA Synthesis**

Mining the Legionella core ?effectome? for molecular modulators of conserved eukaryotic cell signaling

Operations and Maintenance Support for the BioZone MS Facility

Engineering a broadly cross-protective vaccine that confers sterilizing immunity against Haemophilus influenzae.

Frequent collaborators

Alexei Savchenko

Cameron Semper

Radhakrishnan Mahadevan

Gerard Wright

Brian Coombes

Justin Nodwell

Harry Brumer

Alind Gupta

Cheryl Arrowsmith

Anne-Claude Gingras

Bebhinn Treanor

Gerd Prehna

John Whitney

George Chaconas

Edward Topp

Andrew McArthur

Charles Boone

The Crystal Structure of the Domain of Unknown Function 1480 (DUF1480) From Klebsiella pneumoniae.