Faculty profile

Alexei Savchenko

ResearcherChemical Engineering and Applied ChemistryUniversity of Toronto

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Toronto directory, so their courses may be missing. Find their university profile.

Alexei Savchenko

Researcher

Chemical Engineering and Applied Chemistry

Health Sciences

University of Toronto

Toronto, Ontario, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
34 publications in the last five years, latest in 2026.
Senior (last) author on 12 recent papers, a sign of leading a research group.
Principal investigator on 1 research grant (1 CIHR), most recently in 2015.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

124

Publications

804

Citations

Collaborators

Grants

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

Profiles and links

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Signals and details

Research

E3 Ubiquitin Ligases Pathogenic E. Coli Secreted Pathogenic Factors Type 3 Secretion System Ubiquitination

Latest papers

Structural Analysis of 23S rRNA Methylating Enzyme Cfr Reveals RNA-Binding Determinants for Methylation Regiospecificity and Antibiotic Resistance.
ACS infectious diseases · 2026
Crystal structure and biochemical analysis of the polyester-degrading carboxylesterase SM0281 from the symbiotic legume-associated rhizobacterium Sinorhizobium (Ensifer) meliloti.
The FEBS journal · 2026
Structural analysis of 23S rRNA methylating enzyme Cfr reveals RNA binding determinants for methylation regiospecificity and antibiotic resistance.
bioRxiv : the preprint server for biology · 2025

All 124 publications

Latest funding

Interrogating effector interactions to uncover fundamental mechanisms of molecular pathogenesis.
CIHR · 2025 · Co-investigator
$1,220,175
Using a novel class of effectors to probe fundamental mechanisms of intracellular disease.
CIHR · 2018 · Co-investigator
$956,250
Exploitation of host ubiquitination pathways by pathogenic E. coli
CIHR · 2015 · Nominated PI
$656,298

All 10 grants and awards

124 publications.

Structural Analysis of 23S rRNA Methylating Enzyme Cfr Reveals RNA-Binding Determinants for Methylation Regiospecificity and Antibiotic Resistance.

Fruci M, Rodríguez Hernández A, Skarina T, Verellen LA, Tsai K, Virta JM, Fujimori DG, Savchenko A, Stogios PJ

ACS infectious diseases2026

DOI: 10.1021/acsinfecdis.5c00828 PMID: 41615325

Crystal structure and biochemical analysis of the polyester-degrading carboxylesterase SM0281 from the symbiotic legume-associated rhizobacterium Sinorhizobium (Ensifer) meliloti.

Lemak S, Khusnutdinova AN, Stogios PJ, Evdokimova E, Savchenko A, Golyshin PN, Edwards EA, Yakunin AF

The FEBS journal2026

DOI: 10.1111/febs.70734 PMID: 42770702

Structural analysis of 23S rRNA methylating enzyme Cfr reveals RNA binding determinants for methylation regiospecificity and antibiotic resistance.

Fruci M, Rodríguez Hernández A, Skarina T, Verellen LA, Tsai K, Virta JM, Fujimori DG, Savchenko A, Stogios PJ

bioRxiv : the preprint server for biology2025

DOI: 10.1101/2025.09.18.677109 PMID: 41000619

Structure-guided optimization of small molecules targeting Yck2 as a strategy to combat Candida albicans.

Puumala E, Nandakumar M, Yiu B, Stogios PJ, Strickland BG, Zarnowski R, Wang X, Williams NS, Savchenko A, Andes DR, Robbins N, Whitesell L, Willson TM, Cowen LE

Nature communications2025

DOI: 10.1038/s41467-025-57346-z PMID: 40038303

Structural analysis of extracellular ATP-independent chaperones of streptococcal species and protein substrate interactions.

Agbavor C, Torres M, Inniss NL, Latimer S, Minasov G, Shuvalova L, Wawrzak Z, Borek D, Otwinowski Z, Stogios PJ, Savchenko A, Anderson WF, Satchell KJF, Cahoon LA

mSphere2025

DOI: 10.1128/msphere.01078-24 PMID: 39878509

Global atlas of predicted functional domains in Legionella pneumophila Dot/Icm translocated effectors.

Patel DT, Stogios PJ, Jaroszewski L, Urbanus ML, Sedova M, Semper C, Le C, Takkouche A, Ichii K, Innabi J, Patel DH, Ensminger AW, Godzik A, Savchenko A

Molecular systems biology2025Senior author

DOI: 10.1038/s44320-024-00076-z PMID: 39562741

Structural and functional analyses of SARS-CoV-2 Nsp3 and its specific interactions with the 5' UTR of the viral genome.

Lemak S, Skarina T, Patel DT, Stogios PJ, Savchenko A

Microbiology spectrum2025Senior author

DOI: 10.1128/spectrum.02871-24 PMID: 40621910

Mechanistic plasticity in ApmA enables aminoglycoside promiscuity for resistance

Bordeleau E, Stogios PJ, Evdokimova E, Koteva K, Savchenko A, Wright GD

Nature Chemical Biology202411 citations

DOI: 10.1038/s41589-023-01483-3

A random mutagenesis screen enriched for missense mutations in bacterial effector proteins.

Urbanus ML, Zheng TM, Khusnutdinova AN, Banh D, O'Connor Mount H, Gupta A, Stogios PJ, Savchenko A, Isberg RR, Yakunin AF, Ensminger AW

G3 (Bethesda, Md.)2024

DOI: 10.1093/g3journal/jkae158 PMID: 39028840

Structure analysis of the telomere resolvase from the Lyme disease spirochete Borrelia garinii reveals functional divergence of its C-terminal domain.

Semper C, Watanabe N, Karimullina E, Patel DT, Di Leo R, Castellanos M, Patel DH, Chaconas G, Savchenko A

Nucleic acids research2024Senior author

DOI: 10.1093/nar/gkae580 PMID: 38979576

Interrogating effector interactions to uncover fundamental mechanisms of molecular pathogenesis.

Co-investigatorCIHR2025Project Grant

Principal investigators: Ensminger, Alexander W

Keywords: Bacterial Pathogenesis; Chlamydia; Effectors; Legionella; Metaeffectors; Molecular Microbiology; Protein Structure; Yeast

$1,220,175

Using a novel class of effectors to probe fundamental mechanisms of intracellular disease.

Co-investigatorCIHR2018Project Grant

Principal investigators: Ensminger, Alexander W

Keywords: Bacterial Pathogenesis; Fundamental Mechanisms Of Microbial Disease; Host-Pathogen Interactions; Legionella; Metaeffectors; Microbial Systems Biology; Molecular Microbiology; Structure-Function Studies; Translocated Effectors; Ubiquitination

$956,250

Exploitation of host ubiquitination pathways by pathogenic E. coli

Nominated PICIHR2015Operating Grant

Principal investigators: Savchenko, Alexei

Keywords: E3 Ubiquitin Ligases; Pathogenic E. Coli; Secreted Pathogenic Factors; Type 3 Secretion System; Ubiquitination

$656,298

Core facility infrastructure for optimizing conditions for lipidic cubic phase-based membrane protein crystallization

Co-investigatorNSERC2015Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Lee, Jeffrey

$150,000

Examining Biomolecular Interactions using Microscale Thermophoresis

Co-investigatorNSERC2014Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Moraes, Trevor

$150,000

NSERC Industrial Biocatalysis Network

Co-investigatorNSERC2013Research Networks

Principal investigators: Edwards, Elizabeth

$5,150,000

Overcoming antibiotic resistance through the inhibition of aminoglycoside phosphotransferases (APH).

Co-investigatorNSERC2013Collaborative Health Research Projects

Principal investigators: Capretta, Alfredo

$169,101

High throughput culturing system for evolutionary engineering

Co-investigatorNSERC2011Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Mahadevan, Radhakrishnan

$126,760

Molecular mechanisms of the CRISPR-based microbial defense system

Co-investigatorNSERC2010Discovery Grants Program - Group

Principal investigators: Yakunin, Alexander

$165,000

Applied structural and functional proteomics of microbial dehalogenases

Co-investigatorNSERC2004Strategic Projects - Group

Principal investigators: Edwards, Elizabeth

$342,500

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Alexei Savchenko

Research

Latest papers

Latest funding

Structural Analysis of 23S rRNA Methylating Enzyme Cfr Reveals RNA-Binding Determinants for Methylation Regiospecificity and Antibiotic Resistance.

Crystal structure and biochemical analysis of the polyester-degrading carboxylesterase SM0281 from the symbiotic legume-associated rhizobacterium Sinorhizobium (Ensifer) meliloti.

Structural analysis of 23S rRNA methylating enzyme Cfr reveals RNA binding determinants for methylation regiospecificity and antibiotic resistance.

Structure-guided optimization of small molecules targeting Yck2 as a strategy to combat Candida albicans.

Structural analysis of extracellular ATP-independent chaperones of streptococcal species and protein substrate interactions.

Global atlas of predicted functional domains in Legionella pneumophila Dot/Icm translocated effectors.

Structural and functional analyses of SARS-CoV-2 Nsp3 and its specific interactions with the 5' UTR of the viral genome.

Mechanistic plasticity in ApmA enables aminoglycoside promiscuity for resistance

A random mutagenesis screen enriched for missense mutations in bacterial effector proteins.

Structure analysis of the telomere resolvase from the Lyme disease spirochete Borrelia garinii reveals functional divergence of its C-terminal domain.

Interrogating effector interactions to uncover fundamental mechanisms of molecular pathogenesis.

Using a novel class of effectors to probe fundamental mechanisms of intracellular disease.

Exploitation of host ubiquitination pathways by pathogenic E. coli

Core facility infrastructure for optimizing conditions for lipidic cubic phase-based membrane protein crystallization

Examining Biomolecular Interactions using Microscale Thermophoresis

NSERC Industrial Biocatalysis Network

Overcoming antibiotic resistance through the inhibition of aminoglycoside phosphotransferases (APH).

High throughput culturing system for evolutionary engineering

Molecular mechanisms of the CRISPR-based microbial defense system

Applied structural and functional proteomics of microbial dehalogenases

Frequent collaborators

Alexei Savchenko

Radhakrishnan Mahadevan

Gerard Wright

Cameron Semper

Alexander Singer

Harry Brumer

Brian Coombes

Jack Greenblatt

Justin Nodwell

Cheryl Arrowsmith

Alind Gupta

Edward Topp

Sarah Shalhoub

George Chaconas

Mohan Babu

Timothy Hughes

Brian Raught

John Parkinson

Andrew Emili

Bebhinn Treanor

Alfredo Capretta

Mikko Taipale

Turlough Mary Finan

Andrew McArthur

John Whitney

Anne-Claude Gingras

Charles Boone