Rudolf Winklbauer

Research

Boundary Formation Cell Adhesion Embryo Eph Receptor Ephrin Protocadherin Tissue Mechanics Tissue Separation

Latest papers

Adhesion strength, cell packing density and cell surface buckling in pericellular matrix-mediated tissue cohesion.
Development (Cambridge, England) · 2025 · first author
Cell contacts and pericellular matrix in the Xenopus gastrula chordamesoderm.
PloS one · 2024 · senior author
Two-phase kinetics and cell cortex elastic behavior in Xenopus gastrula cell-cell adhesion.
Developmental cell · 2024 · senior author

All 41 publications

Latest funding

Cellular mechanisms and the mechanics of a cleft-like tissue boundary
CIHR · 2017 · Nominated PI
$535,500
A conserved control module for cleft-like tissue boundary formation in the vertebrate embryo
NSERC · 2017 · Principal investigator
$469,000
Control of mesoderm involution during gastrulation
NSERC · 2012 · Principal investigator
$26,000

All 14 grants and awards

41 publications.

01

Adhesion strength, cell packing density and cell surface buckling in pericellular matrix-mediated tissue cohesion.

Winklbauer R, Luu O, Barua D, Nagel M, Huang Y

Development (Cambridge, England)2025First author

DOI: 10.1242/dev.204663 PMID: 40772725

02

Cell contacts and pericellular matrix in the Xenopus gastrula chordamesoderm.

Luu O, Barua D, Winklbauer R

PloS one2024Senior author

DOI: 10.1371/journal.pone.0297420 PMID: 38346069

03

Two-phase kinetics and cell cortex elastic behavior in Xenopus gastrula cell-cell adhesion.

Parent SE, Luu O, Bruce AEE, Winklbauer R

Developmental cell2024Senior author

DOI: 10.1016/j.devcel.2023.11.014 PMID: 38091998

04

Polarized contact behavior in directionally migrating Xenopus gastrula mesendoderm.

Nagel M, Winklbauer R

The International journal of developmental biology2023Senior author

DOI: 10.1387/ijdb.230123rw PMID: 37732810

05

Eph/ephrin signaling controls cell contacts and formation of a structurally asymmetrical tissue boundary in the Xenopus gastrula.

Barua D, Winklbauer R

Developmental biology2022Senior author

DOI: 10.1016/j.ydbio.2022.07.007 PMID: 35868403

06

Cell cortex regulation by the planar cell polarity protein Prickle1.

Huang Y, Winklbauer R

The Journal of cell biology2022Senior author

DOI: 10.1083/jcb.202008116 PMID: 35512799

07

Characterization of convergent thickening, a major convergence force producing morphogenic movement in amphibians.

Shook DR, Wen JWH, Rolo A, O'Hanlon M, Francica B, Dobbins D, Skoglund P, DeSimone DW, Winklbauer R, Keller RE

eLife2022

DOI: 10.7554/elife.57642 PMID: 35404236

08

Cell-cell contact landscapes in Xenopus gastrula tissues.

Barua D, Nagel M, Winklbauer R

Proceedings of the National Academy of Sciences of the United States of America2021Senior author

DOI: 10.1073/pnas.2107953118 PMID: 34544871

09

Capillarity and active cell movement at mesendoderm translocation in the Xenopus gastrula.

Nagel M, Barua D, Damm EW, Kashef J, Hofmann R, Ershov A, Cecilia A, Moosmann J, Baumbach T, Winklbauer R

Development (Cambridge, England)2021Senior author

DOI: 10.1242/dev.198960 PMID: 33674259

10

Editorial for special issue "Gastrulation: from transcriptional patterning to morphogenetic movement".

Müller HJ, Winklbauer R

Mechanisms of development2020Senior author

DOI: 10.1016/j.mod.2020.103643 PMID: 32898656

Cellular mechanisms and the mechanics of a cleft-like tissue boundary

Nominated PICIHR2017Project Grant

Principal investigators: Winklbauer, Rudolf

Keywords: Boundary Formation; Cell Adhesion; Embryo; Eph Receptor; Ephrin; Protocadherin; Tissue Mechanics; Tissue Separation; Tissue Surface Tension; Xenopus

$535,500

A conserved control module for cleft-like tissue boundary formation in the vertebrate embryo

Principal investigatorNSERC2017Discovery Grants Program - Individual

Principal investigators: Winklbauer, Rudolf

$469,000

Control of mesoderm involution during gastrulation

Principal investigatorNSERC2012Discovery Grants Program - Individual

Principal investigators: Winklbauer, Rudolf

$26,000

Cell adhesion and migration in the vertebrate gastrula

Nominated PICIHR2011Operating Grant

Principal investigators: Winklbauer, Rudolf

Keywords: Cadherin; Cell Adhesion; Cell Migration; Ephrin; Planar Cell Polarity; Tissue Cohesion; Tissue Separation

$869,780

Spectrophotometers for multi-user molecular core facility: Quantification of DNA, RNA and protein

Co-investigatorNSERC2007Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Godt, Dorothea

$23,787

Multi-user imaging facility: upgrades for transmision electron microsopy

Co-investigatorNSERC2007Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Tepass, Ulrich

$98,392

Analysis of gastrulation processes in vertebrates

Principal investigatorNSERC2007Discovery Grants Program - Individual

Principal investigators: Winklbauer, Rudolf

$25,000

Ultramicrotome for multi-user microscopy facility

Co-investigatorNSERC2006Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Tepass, Ulrich

$58,583

Upgrades for multi-user confocal microscopy facility

Co-investigatorNSERC2005Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Tepass, Ulrich

$57,206

Molecular core facility real-time PCR

Co-investigatorNSERC2004Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Romans, Patricia

$53,803

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Cell and Systems Biology
Samuel Lunenfeld Research Institute
Lunenfeld-Tanenbaum Research Institute

Co-authors at University of Toronto, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Laurence Pelletier

Lunenfeld-Tanenbaum Research Institute

1 shared papers, latest 2015

Helen McNeill

Samuel Lunenfeld Research Institute

1 shared papers, latest 2012

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Subject: Prospective PhD student: Boundary Formation Dear Professor Winklbauer, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Adhesion strength, cell packing density and cell surface buckling in pericellular matrix-mediated tissue cohesion." (2025), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]