Helen McNeill, University of Toronto

Research

Cystic Kidney Disease Mesenchymal-Epithelial Transition (Met)Planar Cell Polarity Crc Dysplastic Kidney Disease Kidney Development Mesenchymal-Epithelial Transitions Mitochondrial Function

Latest papers

Expanded directly binds conserved regions of Fat to restrain growth via the Hippo pathway.
The Journal of cell biology · 2023 · senior author
Transgenic force sensors and software to measure force transmission across the mammalian nuclear envelope in vivo.
Biology open · 2022
The NEMP family supports metazoan fertility and nuclear envelope stiffness.
Science advances · 2020 · senior author

All 57 publications

Latest funding

Canada Research Chair Tier 1
CIHR · 2015 · Nominated PI
$1,400,000
Analysis of planar cell polarity and growth in a simple metazon, Hydra
NSERC · 2015 · Principal investigator
$180,000
Coordinating tissue growth and tissue organization: Fat cadherins and the Hippo kinase pathway
CIHR · 2014 · Nominated PI
$3,233,905

All 11 grants and awards

57 publications.

01

Expanded directly binds conserved regions of Fat to restrain growth via the Hippo pathway.

Fulford AD, Enderle L, Rusch J, Hodzic D, Holder MV, Earl A, Oh RH, Tapon N, McNeill H

The Journal of cell biology2023Senior author

DOI: 10.1083/jcb.202204059 PMID: 37071483

02

Transgenic force sensors and software to measure force transmission across the mammalian nuclear envelope in vivo.

Fenelon KD, Thomas E, Samani M, Zhu M, Tao H, Sun Y, McNeill H, Hopyan S

Biology open2022

DOI: 10.1242/bio.059656 PMID: 36350289

03

The NEMP family supports metazoan fertility and nuclear envelope stiffness.

Tsatskis Y, Rosenfeld R, Pearson JD, Boswell C, Qu Y, Kim K, Fabian L, Mohammad A, Wang X, Robson MI, Krchma K, Wu J, Gonçalves J, Hodzic D, Wu S, Potter D, Pelletier L, Dunham WH, Gingras AC, Sun Y, Meng J, Godt D, Schedl T, Ciruna B, Choi K, Perry JRB, Bremner R, Schirmer EC, Brill JA, Jurisicova A, McNeill H

Science advances2020Senior author

DOI: 10.1126/sciadv.abb4591 PMID: 32923640

04

Ancestral roles of atypical cadherins in planar cell polarity.

Brooun M, Klimovich A, Bashkurov M, Pearson BJ, Steele RE, McNeill H

Proceedings of the National Academy of Sciences of the United States of America2020Senior author

DOI: 10.1073/pnas.1917570117 PMID: 32727892

05

Atypical cadherin FAT4 orchestrates lymphatic endothelial cell polarity in response to flow.

Betterman KL, Sutton DL, Secker GA, Kazenwadel J, Oszmiana A, Lim L, Miura N, Sorokin L, Hogan BM, Kahn ML, McNeill H, Harvey NL

The Journal of clinical investigation2020

DOI: 10.1172/jci99027 PMID: 32182215

06

Localization of YAP activity in developing skeletal rudiments is responsive to mechanical stimulation.

Shea CA, Rolfe RA, McNeill H, Murphy P

Developmental dynamics : an official publication of the American Association of Anatomists2020

DOI: 10.1002/dvdy.137 PMID: 31747096

07

Hedgehog-Activated Fat4 and PCP Pathways Mediate Mesenchymal Cell Clustering and Villus Formation in Gut Development.

Rao-Bhatia A, Zhu M, Yin WC, Coquenlorge S, Zhang X, Woo J, Sun Y, Dean CH, Liu A, Hui CC, Shivdasani RA, McNeill H, Hopyan S, Kim TH

Developmental cell2020

DOI: 10.1016/j.devcel.2020.02.003 PMID: 32155439

08

Fat/Dachsous family cadherins in cell and tissue organisation.

Fulford AD, McNeill H

Current opinion in cell biology2020Senior author

DOI: 10.1016/j.ceb.2019.10.006 PMID: 31739265

09

Four-jointed knock-out delays renal failure in an ADPKD model with kidney injury.

Formica C, Happé H, Veraar KA, Vortkamp A, Scharpfenecker M, McNeill H, Peters DJ

The Journal of pathology2019

DOI: 10.1002/path.5286 PMID: 31038742

10

Fat regulates expression of four-jointed reporters in vivo through a 20 bp element independently of the Hippo pathway.

Arbouzova NI, Fulford AD, Zhang H, McNeill H

Developmental biology2019Senior author

DOI: 10.1016/j.ydbio.2019.03.004 PMID: 30858024

Canada Research Chair Tier 1

Nominated PICIHR2015Canada Research Chairs - CIHR Funded - Tier 1

Principal investigators: McNeill, Helen

Keywords: Crc

$1,400,000

Analysis of planar cell polarity and growth in a simple metazon, Hydra

Principal investigatorNSERC2015Discovery Grants Program - Individual

Principal investigators: McNeill, Helen

$180,000

Coordinating tissue growth and tissue organization: Fat cadherins and the Hippo kinase pathway

Nominated PICIHR2014Foundation Grant

Principal investigators: McNeill, Helen

Keywords: Cell Adhesion; Cystic Kidney Disease; Drosophila; Fat And Dachsous Cadherins; Genetics; Hippo Pathway; Mesenchymal-Epithelial Transition (Met); Mitochondria; Mouse Models; Planar Cell Polarity

$3,233,905

Analysis of planar cell polarity in a simple metazoan, Hydra

Principal investigatorNSERC2014Discovery Grants Program - Individual

Principal investigators: McNeill, Helen

$41,000

Analysis of Fat4 function in mesenchymal-epithelial transitions and kidney development

Nominated PICIHR2014Operating Grant

Principal investigators: McNeill, Helen

Keywords: Cystic Kidney Disease; Dysplastic Kidney Disease; Kidney Development; Mesenchymal-Epithelial Transition (Met); Mesenchymal-Epithelial Transitions; Mitochondrial Function; Mouse Development; Planar Cell Polarity; Proliferation Control

$821,394

Characterizing the role and regulation of the mammalian tumour suppressor gene Fat4 on metabolism, mitochondrial complex activity and stability

SupervisorCIHR2014Doctoral Award - Frederick Banting and Charles Best Canada Graduate Scholarships

Principal investigators: Yau, Norman

Keywords: Cell Growth And Proliferation; Cell Signalling And Cancer; Drosophila Melanogaster Genetics; Fat Cadherins; Mammalian Cell Culture Models; Metabolism; Mitochondria; Molecular And Cell Biology; Planar Cell Polarity

$105,000

CANFLY XI - Eleventh Canadian Drosophila Research Conference

Co-investigatorCIHR2010Meetings, Planning and Dissemination Grant: Genetics

Principal investigators: Lipshitz, Howard D

Keywords: Behavioural Biology; Developmental Biology; Drosophila; Genetics; Molecular Biology

$5,000

Dissection of growth control by the atypical cadherin Fat in Drosophila melanogaster

Nominated PICIHR2009Operating Grant

Principal investigators: McNeill, Helen

Keywords: Cancer; Drosophila; Hippo Pathway; Kinases; Proliferation

$803,692

Using Drosophila to investigate mechanisms underlying planar cell polarity

Nominated PICIHR2009Operating Grant

Principal investigators: McNeill, Helen

Keywords: Atrophin; Development; Drosophila Melanogaster; Fat; Genetics; Planar Cell Polarity

$750,680

Mammalian kidney development: insight from different planar cell polarity genetic models.

SupervisorCIHR2009Master's Award: Frederick Banting and Charles Best Canada Graduate Scholarships

Principal investigators: Bagherie-Lachidan, Mazdak

Keywords: Fat; Gdnf; Kidney Development; Mouse; Ret; Sprouty

$17,500

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Lunenfeld-Tanenbaum Research Institute

1 shared papers, latest 2020

Anne-Claude Gingras

Department of Molecular Genetics

1 shared papers, latest 2020

Tak Mak

Medical Biophysics & Immunology

1 shared papers, latest 2016

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Subject: Prospective PhD student: Cystic Kidney Disease Dear Professor McNeill, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Expanded directly binds conserved regions of Fat to restrain growth via the Hippo pathway." (2023), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]