Faculty profile

Laurence Pelletier

ResearcherLunenfeld-Tanenbaum Research InstituteUniversity of Toronto

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Toronto directory, so their courses and email address may be missing. Find their university profile.

Laurence Pelletier

Researcher

Lunenfeld-Tanenbaum Research Institute

Health Sciences

University of Toronto

Toronto, Ontario, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
14 publications in the last five years, latest in 2026.
Senior (last) author on 7 recent papers, a sign of leading a research group.
Principal investigator on 12 research grants (9 CIHR, 3 NSERC), most recently in 2025.
Supervisor on 7 trainee awards (7 CIHR), most recently in 2025.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

Citations

Collaborators

Grants

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

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Signals and details

Research

Cytoskeleton Mitosis Cell Cycle Microscopy Microtubules Centrosome Proteomics Cancer

Latest papers

Multimodal holotomography for volumetric monitoring of host-pathogen interactions.
Biomedical engineering online · 2026
The molecular glue CLEO4-88 inhibits the ACAA1 thiolase by induced binding to GID4.
Nature chemical biology · 2026
Intracellular IL-23R is necessary for mitotic spindle formation and viability in AML.
Leukemia · 2026

All 67 publications

Latest funding

The Protein Interaction Landscape of Autosomal Recessive Primary Microcephaly (MCPH)
CIHR · 2025 · Nominated PI
$1,040,400
Deciphering the mechanisms underpinning breast cancer cell intravasation and extravasation using a novel in vitro vascularized tissue system.
CIHR · 2025 · Supervisor
$120,000
Investigating the proteostatic roles of PCNT-HSP70-PCM1 axis in centrosome-amplified breast cancer cells
CIHR · 2024 · Supervisor
$210,000

All 22 grants and awards

67 publications.

Multimodal holotomography for volumetric monitoring of host-pathogen interactions.

Yu Z, Jin L, Liang M, Au A, Kannen TL, Serles P, Filleter T, Pelletier L, Gray-Owen SD, Yip CM

Biomedical engineering online2026

DOI: 10.1186/s12938-026-01577-8 PMID: 42098809

The molecular glue CLEO4-88 inhibits the ACAA1 thiolase by induced binding to GID4.

Chana CK, Ben Makhlouf I, Kim J, Yu AJY, Moatti N, Orlicky S, Wong CJ, Baronijan L, Tang X, Mao D, Larsen B, McGary L, Seale B, Mader P, Ceccarelli DF, Barbulescu P, Martin A, Durocher D, Pelletier L, Gingras AC, Sicheri F

Nature chemical biology2026

DOI: 10.1038/s41589-026-02183-4 PMID: 41957281

Intracellular IL-23R is necessary for mitotic spindle formation and viability in AML.

Duong N, Khan DH, Thomas GE, Feng Y, Hurren R, Lee JB, St-Germain J, Drimmer L, Yan Y, Zhang LX, Fang KK, Ling D, Ma ML, MacLean N, Gronda M, Rondeau V, Brown BD, Matellán L, Jones CL, Chang H, Arruda A, Xie S, Pelletier L, Minden MD, Zhang L, Kornblau SM, Raught B, Jacobs K, Jacobs MG, Goede D, Spadavecchio V, Schimmer AD

Leukemia2026

DOI: 10.1038/s41375-026-02949-8 PMID: 41998300

Author Correction: Atypical function of a centrosomal module in WNT signalling drives contextual cancer cell motility.

Luo Y, Barrios-Rodiles M, Gupta GD, Zhang YY, Ogunjimi AA, Bashkurov M, Tkach JM, Underhill AQ, Zhang L, Bourmoum M, Wrana JL, Pelletier L

Nature communications2025Senior author

DOI: 10.1038/s41467-025-57127-8 PMID: 40011433

qTAG: an adaptable plasmid scaffold for CRISPR-based endogenous tagging.

Philip R, Sharma A, Matellan L, Erpf AC, Hsu WH, Tkach JM, Wyatt HDM, Pelletier L

The EMBO journal2025Senior author

DOI: 10.1038/s44318-024-00337-5 PMID: 39668248

Centriolar satellites: KIF9 protects centrosome maturation.

Fang CT, Pelletier L

Current biology : CB2025Senior author

DOI: 10.1016/j.cub.2025.09.055 PMID: 41187716

Systematic surveillance of SARS-CoV-2 reveals dynamics of variant mutagenesis and transmission in a large urban population.

Aynaud MM, Caldwell L, Al-Zahrani KN, Barutcu S, Chan K, Obersterescu A, Ogunjimi AA, Jin M, Zakoor KR, Patel S, Padilla R, Jen MCC, Veniegas PM, Dewsi N, Yonathan F, Zhang L, Ayson-Fortunato A, Aquino A, Krzyzanowski P, Simpson J, Bartlett J, Lungu I, Wouters BG, Rini JM, Gekas M, Poutanen S, Pelletier L, Mazzulli T, Wrana JL

Nature communications2024

DOI: 10.1038/s41467-024-55031-1 PMID: 39738001

β-catenin mediates growth defects induced by centrosome loss in a subset of APC mutant colorectal cancer independently of p53.

Bourmoum M, Radulovich N, Sharma A, Tkach JM, Tsao MS, Pelletier L

PloS one2024Senior author

DOI: 10.1371/journal.pone.0295030 PMID: 38324534

Centriolar satellites expedite mother centriole remodeling to promote ciliogenesis.

Hall EA, Kumar D, Prosser SL, Yeyati PL, Herranz-Pérez V, García-Verdugo JM, Rose L, McKie L, Dodd DO, Tennant PA, Megaw R, Murphy LC, Ferreira MF, Grimes G, Williams L, Quidwai T, Pelletier L, Reiter JF, Mill P

eLife2023

DOI: 10.7554/elife.79299 PMID: 36790165

A fast blind zero-shot denoiser.

Lequyer J, Philip R, Sharma A, Hsu WH, Pelletier L

Nature machine intelligence2022Senior author

DOI: 10.1038/s42256-022-00547-8 PMID: 36415333

The Protein Interaction Landscape of Autosomal Recessive Primary Microcephaly (MCPH)

Nominated PICIHR2025Project Grant

Principal investigators: Pelletier, Laurence P

Keywords: Centrioles; Centrosomes; Cerebral Organoids; Cytoskeleton; Microcephaly; Microscopy; Microtubules; Mitosis; Mitotic Cell Division; Proteomics

$1,040,400

Deciphering the mechanisms underpinning breast cancer cell intravasation and extravasation using a novel in vitro vascularized tissue system.

SupervisorCIHR2025DRA : Canada Graduate Research Scholarship - Doctoral Program (CGRS D)

Principal investigators: Guo, Yaxin

Keywords: Cancer; Metastasis

$120,000

Investigating the proteostatic roles of PCNT-HSP70-PCM1 axis in centrosome-amplified breast cancer cells

SupervisorCIHR2024CIHR Fellowship

Principal investigators: Fang, Chieh-Ting

Keywords: Aggresome; Breast Cancer; Centrosome; Crispr-Based Genome Editing; Hsp70; Pcm1; Pcnt; Proteostasis; Super-Resolution Microscopy; Vascularized Spheroid Culture

$210,000

Canada Research Chair - Tier 1

Nominated PICIHR2024Canada Research Chairs - CIHR Funded - Tier 1

Principal investigators: Pelletier, Laurence P

Keywords: Crc

$1,400,000

Deciphering the role of the Formin / Wnt-PCP axis in breast cancer cell motility and Metastasis.

SupervisorCIHR2022CIHR Fellowship

Principal investigators: Sharma, Amit

Keywords: Breast Cancer; Cell Cycle; Cell Motility; Cell Signalling And Cancer; Crispr/Cas9 Screening; Dynamic Remodeling; Ecm Degradadation; Mass Spectrometry; Molecular Biology; Super-Resolution Microscopy

$135,000

Mapping the Emergence and Functional Impact of Novel SARS-CoV-2 Variants

Co-investigatorCIHR2021Operating Grant: Emerging COVID-19 Research Gaps and Priorities - Variants

Principal investigators: Wrana, Jeffrey L

Keywords: Functional Mapping; Sars-Cov-2 Variants; Variant Identification

Identifying new factors implicated in pericentriolar material formation and integrity using a photo-conversion based high-throughput phenotypic CRISPR screening platform

SupervisorCIHR2021CIHR Fellowship

Principal investigators: Erpf, Anna C

Keywords: Bioid; Cancer; Cell Cycle; Crispr/Cas9 Screen; High-Throughput Screening; Pericentriolar Material; Phenotypic Screening Platform; Super-Resolution Microscopy

$135,000

A vascularized human organoid platform for disease modelling and preclinical testing

Co-investigatorCIHR2019Collaborative Health Research Projects (NSERC partnered)

Principal investigators: Attisano, Liliana; Louis, Sharon A; Yip, Christopher M

Keywords: Cerebral Organoids; Drug Development; High-Resolution Imaging; Human Disease Modelling; Human Organoids; Intestinal Organoids; Preclinical Model; Tissue Engineering; Vascularization

A low- to super-resolution imaging pipeline to dissect the molecular mechanisms underpinning mitotic spindle assembly

Principal investigatorNSERC2019Discovery Grants Program - Individual

Principal investigators: Pelletier, Laurence

$42,000

Mechanisms of centrosome number control.

Nominated PICIHR2019Project Grant

Principal investigators: Pelletier, Laurence P

Keywords: Cell Cycle; Cell Division; Centriole; Centrosomes; Chromsome Segregation; Crispr; Cytoskeleton; Mitosis; Proteomics

$100,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Laurence Pelletier

Research

Latest papers

Latest funding

Multimodal holotomography for volumetric monitoring of host-pathogen interactions.

The molecular glue CLEO4-88 inhibits the ACAA1 thiolase by induced binding to GID4.

Intracellular IL-23R is necessary for mitotic spindle formation and viability in AML.

Author Correction: Atypical function of a centrosomal module in WNT signalling drives contextual cancer cell motility.

qTAG: an adaptable plasmid scaffold for CRISPR-based endogenous tagging.

Centriolar satellites: KIF9 protects centrosome maturation.

Systematic surveillance of SARS-CoV-2 reveals dynamics of variant mutagenesis and transmission in a large urban population.

&#x3b2;-catenin mediates growth defects induced by centrosome loss in a subset of APC mutant colorectal cancer independently of p53.

Centriolar satellites expedite mother centriole remodeling to promote ciliogenesis.

A fast blind zero-shot denoiser.

A low- to super-resolution imaging pipeline to dissect the molecular mechanisms underpinning mitotic spindle assembly

Frequent collaborators

Anne-Claude Gingras

Brian Raught

Daniel Durocher

Jason Moffat

Rod Bremner

Tony Mazzulli

Frank Sicheri

Ji-Young Youn

Jean-Philippe Lambert

Susan Poutanen

Liliana Attisano

Helen McNeill

Ming-Sound Tsao

Yu Sun

Brian Ciruna

Li Zhang

Rudolf Winklbauer

David Safronetz

Stephanie Xie

Robert Rottapel

Brenda Andrews

Hong Han

β-catenin mediates growth defects induced by centrosome loss in a subset of APC mutant colorectal cancer independently of p53.