Simon Sharpe, University of Toronto

Research

Biophysical Techniques Elastic Recoil Elastin Mechanical Properties Molecular Dynamics Simulations Protein Phase Separation Self-Assembled Elastomeric Proteins Solid State And Solution Nmr

Latest papers

Conformation and Dynamics of Monomeric, Phase-Separated, and Cross-Linked Resilin Biomaterials.
Journal of the American Chemical Society · 2025 · senior author
Initiation of Medial Calcification: Revisiting Calcium Ion Binding to Elastin.
The journal of physical chemistry. B · 2024
Structural studies of a serum amyloid A octamer that is primed to scaffold lipid nanodiscs.
Protein science : a publication of the Protein Society · 2024 · senior author

All 33 publications

Latest funding

Proposed Helium Recovery System for the UofT/Sick Kids Biomolecular NMR Facility
NSERC · 2023 · Co-investigator
$150,000
Understanding the mechanism of vascular elastocalcinosis and its prevention by MGP
CIHR · 2019 · Co-investigator
$925,650
Uncovering the structural basis for the mechanical properties of elastin
CIHR · 2018 · Principal investigator
$895,050

All 11 grants and awards

33 publications.

01

Conformation and Dynamics of Monomeric, Phase-Separated, and Cross-Linked Resilin Biomaterials.

Otis JB, Reichenwallner J, Reichheld SE, Au A, Yip CM, Ernst OP, Sharpe S

Journal of the American Chemical Society2025Senior author

DOI: 10.1021/jacs.5c12305 PMID: 41001791

02

Initiation of Medial Calcification: Revisiting Calcium Ion Binding to Elastin.

Lau K, Sharpe S, Cerruti M

The journal of physical chemistry. B2024

DOI: 10.1021/acs.jpcb.4c04464 PMID: 39324564

03

Structural studies of a serum amyloid A octamer that is primed to scaffold lipid nanodiscs.

Nady A, Reichheld SE, Sharpe S

Protein science : a publication of the Protein Society2024Senior author

DOI: 10.1002/pro.4983 PMID: 38659173

04

A secreted bacterial protein protects bacteria from cationic antimicrobial peptides by entrapment in phase-separated droplets.

Ostan NKH, Cole GB, Wang FZ, Reichheld SE, Moore G, Pan C, Yu R, Lai CC, Sharpe S, Lee HO, Schryvers AB, Moraes TF

PNAS nexus2024

DOI: 10.1093/pnasnexus/pgae139 PMID: 38633880

05

The RavA-ViaA chaperone complex modulates bacterial persistence through its association with the fumarate reductase enzyme.

Bhandari V, Reichheld SE, Houliston S, Lemak A, Arrowsmith CH, Sharpe S, Houry WA

The Journal of biological chemistry2023

DOI: 10.1016/j.jbc.2023.105199 PMID: 37660904

06

Sequence Context and Complex Hofmeister Salt Interactions Dictate Phase Separation Propensity of Resilin-like Polypeptides.

Otis JB, Sharpe S

Biomacromolecules2022Senior author

DOI: 10.1021/acs.biomac.2c01027 PMID: 36378745

07

Phosphorylation of the DNA repair scaffold SLX4 drives folding of the SAP domain and activation of the MUS81-EME1 endonuclease.

Payliss BJ, Tse YWE, Reichheld SE, Lemak A, Yun HY, Houliston S, Patel A, Arrowsmith CH, Sharpe S, Wyatt HDM

Cell reports2022

DOI: 10.1016/j.celrep.2022.111537 PMID: 36288699

08

Globule and fiber formation with elastin-like polypeptides: a balance of coacervation and crosslinking.

Lau K, Reichheld S, Sharpe S, Cerruti M

Soft matter2022

DOI: 10.1039/d2sm00049k PMID: 35404375

09

Elastin calcification in in vitro models and its prevention by MGP's N-terminal peptide.

Parashar A, Gourgas O, Lau K, Li J, Muiznieks L, Sharpe S, Davis E, Cerruti M, Murshed M

Journal of structural biology2021

DOI: 10.1016/j.jsb.2020.107637 PMID: 33059036

10

The evolutionary background and functional consequences of the rs2071307 polymorphism in human tropoelastin.

Reichheld SE, Muiznieks LD, Huynh Q, Wang N, Ing C, Miao M, Sitarz EE, Pomès R, Sharpe S, Keeley FW

Biopolymers2021

DOI: 10.1002/bip.23414 PMID: 33351193

Proposed Helium Recovery System for the UofT/Sick Kids Biomolecular NMR Facility

Co-investigatorNSERC2023Research Tools and Instruments

Principal investigators: Kay, Lewis

$150,000

Understanding the mechanism of vascular elastocalcinosis and its prevention by MGP

Co-investigatorCIHR2019Project Grant

Principal investigators: Murshed, Monzur

Keywords: Elastocalcinosis; Inhibitors Of Vascular Calcification; Vascular Calcification

$925,650

Uncovering the structural basis for the mechanical properties of elastin

Principal investigatorCIHR2018Project Grant

Principal investigators: Pomes, Régis; Sharpe, Simon J

Keywords: Biophysical Techniques; Elastic Recoil; Elastin; Mechanical Properties; Molecular Dynamics Simulations; Protein Phase Separation; Self-Assembled Elastomeric Proteins; Solid State And Solution Nmr; Structural Biology; Structure-Function Studies

$895,050

Molecular underpinnings of elasticity and adhesion in self-assembling protein biopolymers

Principal investigatorNSERC2018Discovery Grants Program - Individual

Principal investigators: Sharpe, Simon

$216,000

An Enhanced Combinatorial Super-Resolution Microscopy Platform

Co-investigatorNSERC2016Research Tools and Instruments

Principal investigators: Yip, Christopher

$150,000

Structure, assembly, and biological activity of amyloid peptides and proteins.

Principal investigatorNSERC2013Discovery Grants Program - Individual

Principal investigators: Sharpe, Simon

$215,000

CANADA RESEARCH CHAIRHOLDER / TITULAIRE DE CHAIRE DE RECHERCHE DU CANADA

Nominated PICIHR2011Canada Research Chairs - CIHR Funded - Tier 2

Principal investigators: Sharpe, Simon J

Keywords: Chairs

$500,000

A protein on the edge: balancing structural order and disorder in the assembly of elastin. Implications for vascular pathology.

Co-investigatorCIHR2010Operating Grant

Principal investigators: Keeley, Fred W

Keywords: Amyloid; Aorta; Assembly; Elastin; Structure; Vascular

$350,622

Structure-Toxicity Relation of Fibrillogenic Fragments in Human Prion Protein and Implications on Neuronal Cells

SupervisorCIHR2010Master's Award: Canada Graduate Scholarships

Principal investigators: Yau, Jason H

Keywords: Amyloid Fibril; Cell Toxicity; Neurodegenerative Disease; Protein Structure; Solid State Nuclear Magnetic Resonance

$17,500

National ultrahigh-field NMR facility for solids

Co-investigatorNSERC2009Major Resources Support Program - Infrastructure

Principal investigators: Bryce, David

$443,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Stomatology
Department of Medical Biophysics
Tanz Centre for Research in Neurodegenerative Diseases
Biochemistry
Medicine
Other

Co-authors at University of Toronto, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Monzur Murshed

Medicine

1 shared papers, latest 2021

Gerold Schmitt-Ulms

Tanz Centre for Research in Neurodegenerative Diseases

1 shared papers, latest 2017

Holger Wille

Biochemistry

1 shared papers, latest 2017

Antonio Nanci

Stomatology

1 shared papers, latest 2019

Arash Zarrine-Afsar

Department of Medical Biophysics

1 shared papers, latest 2012

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Subject: Prospective PhD student: Biophysical Techniques Dear Professor Sharpe, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Conformation and Dynamics of Monomeric, Phase-Separated, and Cross-Linked Resilin Biomaterials." (2025), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]