Faculty profile
Stephen Lye
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Research
Latest papers
Independent effects of depression and elevated body mass index on maternal CRP levels in pregnancy.
Journal of affective disorders · 2026
Somatostatin and its type 2 receptor expression in the pregnant and labouring myometrium.
American journal of physiology. Cell physiology · 2026 · senior author
Seasonal moderators of maternal CRP levels during pregnancy.
Brain, behavior, & immunity - health · 2026
Latest funding
- $930,874
Intervening across the first 2000 Days of Life to Transform a Lifetime
CIHR · 2026 · Principal investigator
- $20,000
Elucidation of the Individualized Response to an 8-year Lifestyle Intervention aimed at Reducing Cardiometabolic Risk in Young Women before, during and after Pregnancy
CIHR · 2024 · Principal investigator
- $20,000
A pragmatic, individualized, e-health lifestyle intervention to optimize cardiometabolic health in pregnancy planning women and their partners: setting the stage for improved intergenerational health across diverse Canadian communities.
CIHR · 2024 · Co-investigator
72 publications.
Independent effects of depression and elevated body mass index on maternal CRP levels in pregnancy.
Levitan RD, Korczak D, Wade M, McGowan P, Zhang CXW, Knight JA, Hung RJ, Bertoni K, Wong J, Murphy K, Lye S, Matthews SG
Somatostatin and its type 2 receptor expression in the pregnant and labouring myometrium.
Shynlova O, Boros-Rausch A, Baishnob A, Dorogin A, Aguiar-Cabeza E, Nadeem L, Lye S
Seasonal moderators of maternal CRP levels during pregnancy.
Zhang CXW, Levinsky J, Korczak D, McGowan P, Wade M, Knight JA, Hung R, Bertoni K, Murphy K, Lye S, Matthews SG, Levitan RD
Preconception mental health (Healthy Life Trajectories Initiative): Identifying factors associated with probable anxiety and depression among young women living in urban-poor South Africa.
Norris SA, Hart C, Nyati LH, Taljaard W, Hung RJ, Retnakaran R, Lye S, Draper CE, Craig A
Prevalence and correlates of depressive and anxiety symptoms among pregnant women from an urban informal settlement in Nairobi, Kenya: a community-based cross-sectional study.
Mulupi S, Abubakar A, Nyongesa MK, Angwenyi V, Kabue M, Mwangi PM, Odhiambo R, Marangu J, Njoroge E, Mokaya MM, Obulemire EK, Ombech E, Ssewanyana D, Moran G, Martin MC, Proulx K, Marfo K, Lye S
Retention in the Bukhali trial in Soweto, South Africa: a qualitative analysis using self-determination theory.
Draper CE, Tshetu N, Nkosi N, Lye S, Norris SA
Prospective harmonisation of four international randomised controlled trials in Canada, China, India and South Africa: the Healthy Life Trajectories Initiative
Bergeron J, Nechba A, Tiali SEB, Atkinson S, Birken C, Draper C, Krishnaveni GV, Fraser W, Dennis CL, Abdelouahab N
A qualitative exploration of the reasons and influencing factors for pregnancy termination among young women in Soweto, South Africa: a Socio-ecological perspective.
Mabetha K, Soepnel LM, SSewanyana D, Draper CE, Lye S, Norris SA
Caregiving experiences and practices: qualitative formative research towards development of integrated early childhood development interventions targeting Kenyans and refugees in Nairobi's informal settlements.
Angwenyi V, Abubakar A, Kabue M, Njoroge E, Nasambu C, Ssewanyana D, Mulupi S, Marangu J, Ombech E, Mokaya MM, Obulemire EK, Zhang L, Moran G, Proulx K, Malti T, Martin MC, Lye S, Marfo K
A qualitative analysis of community health worker perspectives on the implementation of the preconception and pregnancy phases of the Bukhali randomised controlled trial.
Soepnel LM, Norris SA, Mabetha K, Motlhatlhedi M, Nkosi N, Lye S, Draper CE
Intervening across the first 2000 Days of Life to Transform a Lifetime
Principal investigators: Retnakaran, Ravi R; Beukes, Johanna M; Hung, Rayjean; Lye, Stephen J; Norris, Shane A
Keywords: Cardiometabolic Risk; Childhood; Dohad; Early Life; Human Capital Outcomes; Intervention; Life Course; School Age; Trajectories
Elucidation of the Individualized Response to an 8-year Lifestyle Intervention aimed at Reducing Cardiometabolic Risk in Young Women before, during and after Pregnancy
Principal investigators: Retnakaran, Ravi R; Hung, Rayjean; Lye, Stephen J; Norris, Shane A; Ware, Lisa J
Keywords: Cardiometabolic Risk; Diabetes; Genomics; Insulin Resistance; Lifestyle Intervention; Lipidomics; Postpartum; Pre-Diabetes; Preconception; Pregnancy
A pragmatic, individualized, e-health lifestyle intervention to optimize cardiometabolic health in pregnancy planning women and their partners: setting the stage for improved intergenerational health across diverse Canadian communities.
Principal investigators: Comelli, Elena M; Marini, Flavia; Birken, Catherine S; Dennis, Cindy-Lee E; Miliku, Kozeta
Keywords: Cardiovascular Disease; Diabetes; Individualized Lifestyle Intervention; Nutrition; Preconception; Prevention; Randomized Controlled Trial
Elucidation of the Individualized Response to an 8-year Lifestyle Intervention aimed at Reducing Cardiometabolic Risk in Young Women before, during and after Pregnancy
Principal investigators: Retnakaran, Ravi R; Hung, Rayjean; Lye, Stephen J; Norris, Shane A; Ware, Lisa J
Keywords: Cardiometabolic Risk; Diabetes; Insulin Resistance; Lifestyle Intervention; Lipidomics; Metabolomics; Postpartum; Pre-Diabetes; Preconception; Pregnancy
Mechanisms Underlying Preeclampsia: Cellular Interactions at the Fetal-Maternal Interface
Principal investigators: Lye, Stephen J
Keywords: Decidua; Placenta; Preeclampsia; Pregnancy; Trophoblast; Trophoblast Stem Cells
Preconception Lifestyle Intervention by Community Health Workers for the Prevention of Gestational Diabetes Mellitus: A Randomized Clinical Trial
Principal investigators: Retnakaran, Ravi R
Keywords: Adiponectin; Beta-Cell Function; Community Health Workers; Gestational Diabetes; Insulin Resistance; Lifestyle Intervention; Preconception; Weight Reduction; Women'S Health
Early Interventions to Support Trajectories for Healthy Life in India (EINSTEIN)
Principal investigators: Matthews, Stephen G; Sellen, Daniel W; CHANDAK, GIRIRAJ R; Comelli, Elena M; Krishnaveni, Ghattu V; Kumaran, Kalyanaraman; Shah, Prakeshkumar; Suryanarayana, Kumar G; Wade, Mark
Keywords: Cardiometabolic Outcome; Child; Cohort Studies; Dohad; India; Intervention; Lifecourse; Mental Health Outcome; Preconception; Pregnancy
Preconception Lifestyle Intervention by Community Health Workers for the Prevention of Gestational Diabetes Mellitus: A Randomized Clinical Trial
Principal investigators: Retnakaran, Ravi R
Keywords: Adiponectin; Beta-Cell Function; Community Healthcare Workers; Gestational Diabetes; Insulin Resistance; Lifestyle Intervention; Preconception; Weight Reduction; Women'S Health
Association of socioeconomic and environmental factors with neonatal and childhood outcomes of preterm neonates <29 weeks' gestation in Canada
Principal investigators: Shah, Prakeshkumar; Brook, Jeffrey R; Luu, Thuy Mai
Keywords: Developmental Origins Of Health And Disease (Dohad); Developmental Outcomes; Environmental Factors; Maternal Environmental Exposures; Neonatal Outcomes; Outcomes Research; Preterm Neonates; Retrospective Cohort Study; Socioeconomic Factors
Control of Myometrial Contractility: Identifying New Targets for Preterm Birth Prevention
Principal investigators: Lye, Stephen J
Keywords: Chemokine/Cytokines; Immune Cells; Labour; Myometrium; Preterm Birth
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
Frequent collaborators
- Nutritional Sciences
- Medicine
- Endocrinology and Metabolism
- Department of Obstetrics and Gynaecology
- Psychology
- Pediatrics
- Obstetrics & Gynecology
- Other
Co-authors at University of Toronto, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.
Oksana Shynlova
Faculty
26 shared papers, latest 2026
Cindy-Lee Dennis
Nutritional Sciences
6 shared papers, latest 2023
Kellie Murphy
Department of Obstetrics and Gynaecology
5 shared papers, latest 2026
Laurent Briollais
Biostatistics Division
5 shared papers, latest 2023
Tina Malti
Psychology
4 shared papers, latest 2024
Xuesen Dong
Urologic Sciences
4 shared papers, latest 2018
Catherine Birken
Nutritional Sciences
3 shared papers, latest 2025
Chun Peng
Biology
3 shared papers, latest 2013
Rayjean Hung
Endocrinology and Metabolism
3 shared papers, latest 2026
Patrick McGowan
Faculty
3 shared papers, latest 2026
Stephanie Atkinson
Pediatrics
3 shared papers, latest 2025
Hala Kufaishi
Medicine
3 shared papers, latest 2016
Daphne Korczak
Faculty
2 shared papers, latest 2026
Donna Slater
Physiology and Pharmacology
2 shared papers, latest 2018
Jean-Patrice Baillargeon
Medicine
2 shared papers, latest 2025
Flavia Marini
Nutritional Sciences
2 shared papers, latest 2025
Rohan D'Souza
Medicine
2 shared papers, latest 2019
Mark Wade
Lunenfeld-Tanenbaum Research Institute
2 shared papers, latest 2026
Mark Wade
Psychology
2 shared papers, latest 2026
Stephen Scherer
Department of Molecular Genetics
2 shared papers, latest 2022
Rohan D'Souza
Obstetrics & Gynecology
2 shared papers, latest 2019
John Kingdom
Department of Obstetrics and Gynaecology
2 shared papers, latest 2023
Prabhat Jha
Centre for Global Health Research
1 shared papers, latest 2021
Anick Bérard
Medicine
1 shared papers, latest 2021
Zulfiqar Bhutta
Department of Paediatrics
1 shared papers, latest 2022
Suzanne Tough
Psychology
1 shared papers, latest 2022
Joel Ray
Medicine
1 shared papers, latest 2021
Zdenka Pausova
Faculty
1 shared papers, latest 2023
Astrid Guttmann
Department of Paediatrics
1 shared papers, latest 2021
Nicole Letourneau
Faculty
1 shared papers, latest 2021
Robyn Stremler
Faculty
1 shared papers, latest 2021
Jennifer Jenkins
Faculty
1 shared papers, latest 2022
Deborah Da Costa
School of Nursing
1 shared papers, latest 2021
Andrea Feller
Pediatrics
1 shared papers, latest 2021
Patricia Li
Pediatrics
1 shared papers, latest 2021
Peter Szatmari
Health Research Methods, Evidence, and Impact
1 shared papers, latest 2021
Magdalena Janus
Psychiatry & Behavioural Neurosciences
1 shared papers, latest 2021
Deborah Sloboda
Biochemistry & Biomedical Sciences
1 shared papers, latest 2022
Alison Holloway
Obstetrics & Gynecology
1 shared papers, latest 2010
Ravi Retnakaran
Endocrinology and Metabolism
1 shared papers, latest 2026
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