Oksana Shynlova, University of Toronto

Research

Cervical Length Shortening Cervical Ripening Lps-Induced Preterm Labor Magnetic Resonance Imaging (Mri)Maternal Peripheral Blood Mouse Models Of Preterm Labor Peripheral Blood Activation Markers Preterm Birth

Latest papers

The Pathophysiology of Spontaneous Preterm Birth: Emerging Mechanisms Reviewed by the Preterm Birth International Collaborative.
Reproductive sciences (Thousand Oaks, Calif.) · 2026
Somatostatin and its type 2 receptor expression in the pregnant and labouring myometrium.
American journal of physiology. Cell physiology · 2026 · first author
VHL Gene Restoration Supports RCC Reprogramming to iPSCs but Does Not Ensure Line Stability.
Cancers · 2025

All 71 publications

Latest funding

Control of Myometrial Contractility: Identifying New Targets for Preterm Birth Prevention
CIHR · 2021 · Co-investigator
$1,426,725
Discovering the transcription regulatory networks that control uterine contractions
CIHR · 2020 · Co-investigator
$895,050
Magnetic Resonance Imaging of cervical morphology and maternal serum blood markers predict spontaneous human preterm birth
CIHR · 2016 · Nominated PI
$199,650

All 8 grants and awards

71 publications.

01

The Pathophysiology of Spontaneous Preterm Birth: Emerging Mechanisms Reviewed by the Preterm Birth International Collaborative.

Mikkelsen E, Amabebe E, Olmos-Ortiz A, Hamburg-Shields E, Prewit EB, Shynlova O, Gibbons DL, Mesiano S, Taggart MJ

Reproductive sciences (Thousand Oaks, Calif.)2026

DOI: 10.1007/s43032-026-02108-5 PMID: 42090122

02

Somatostatin and its type 2 receptor expression in the pregnant and labouring myometrium.

Shynlova O, Boros-Rausch A, Baishnob A, Dorogin A, Aguiar-Cabeza E, Nadeem L, Lye S

American journal of physiology. Cell physiology2026First author

DOI: 10.1152/ajpcell.00050.2026 PMID: 42747790

03

VHL Gene Restoration Supports RCC Reprogramming to iPSCs but Does Not Ensure Line Stability.

Lichner Z, Shamshirgaran Y, Pieczonka K, Jonebring A, Kibschull M, Shynlova O, Meens J, Kim RH, Ailles L, Bilican B, Hicks R, Rogers IM

Cancers2025

DOI: 10.3390/cancers17223693 PMID: 41301058

04

M1 Macrophages Are a Source of IL-1α: A Driver of Progesterone Metabolism and Myometrial Contraction.

Nadeem L, Librach M, Boros-Rausch A, Matthews B, Aguiar-Cabeza E, Shynlova O, Lye SJ

Cells2025

DOI: 10.3390/cells14211692 PMID: 41227337

05

JUND plays a genome-wide role in the quiescent to contractile switch in the pregnant human myometrium.

Khader N, Dorogin A, Shynlova O, Mitchell JA

PLoS genetics2025

DOI: 10.1371/journal.pgen.1011261 PMID: 40455848

06

A Broad-Spectrum Chemokine Inhibitor Drives M2 Macrophage Polarization Through Modulation of the Myometrial Secretome.

Boros-Rausch A, Dorogin A, Nadeem L, Shynlova O, Lye SJ

Cells2025

DOI: 10.3390/cells14070514 PMID: 40214468

07

Promegestone Prevents Lipopolysaccharide-Induced Cervical Remodeling in Pregnant Mice.

Nadeem A, Nadeem L, Lye SJ, Shynlova O

Cells2025Senior author

DOI: 10.3390/cells14040242 PMID: 39996716

08

SOX4 exerts contrasting regulatory effects on labor-associated gene promoters in myometrial cells.

Khader N, Shchuka VM, Dorogin A, Shynlova O, Mitchell JA

PloS one2024

DOI: 10.1371/journal.pone.0297847 PMID: 38635533

09

The Future of Basic Science: Development of the Next Generation of Mechanistic Researchers in Female Pelvic Medicine.

Alperin M, Alarab M, Botros-Brey S, Drutz H, King J, Shynlova O

International urogynecology journal2024Senior author

DOI: 10.1007/s00192-024-05766-8 PMID: 38523162

10

Progesterone control of myometrial contractility.

Shynlova O, Nadeem L, Lye S

The Journal of steroid biochemistry and molecular biology2023First author

DOI: 10.1016/j.jsbmb.2023.106397 PMID: 37683774

Control of Myometrial Contractility: Identifying New Targets for Preterm Birth Prevention

Co-investigatorCIHR2021Project Grant

Principal investigators: Lye, Stephen J

Keywords: Chemokine/Cytokines; Immune Cells; Labour; Myometrium; Preterm Birth

$1,426,725

Discovering the transcription regulatory networks that control uterine contractions

Co-investigatorCIHR2020Project Grant

Principal investigators: Mitchell, Jennifer A

Keywords: Chromatin; Gene Expression; Gene Regulation; Hormone Receptors; Transcription Factor

$895,050

Magnetic Resonance Imaging of cervical morphology and maternal serum blood markers predict spontaneous human preterm birth

Nominated PICIHR2016Catalyst Grant: Catalyzing Innovation in Preterm Birth Research

Principal investigators: Shynlova, Oksana

Keywords: Cervical Length Shortening; Cervical Ripening; Lps-Induced Preterm Labor; Magnetic Resonance Imaging (Mri); Maternal Peripheral Blood; Mouse Models Of Preterm Labor; Peripheral Blood Activation Markers; Preterm Birth; Ru486-Induced Preterm Labor; Trans-Vaginal Ultrasound

$199,650

Discovering the transcription regulatory networks that control uterine contractions

Co-investigatorCIHR2016Project Grant

Principal investigators: Mitchell, Jennifer A

Keywords: Chromatin; Gene Regulation; Transcription Factor

$387,855

Pregnancy Complications and Developmental Health: Mechanisms, Diagnostics and Therapeutics.

Co-investigatorCIHR2014Foundation Grant

Principal investigators: Lye, Stephen J

Keywords: Fetal/Child Development; Human Development; Labour; Maternal/Child Health; Myometrium; Placenta; Preeclampsia; Pregnancy; Preterm Birth; Progesterone

$5,575,713

HIV antiretrovirals and their impact on sex steroids during pregnancy; a potential mechanism for the increased adverse pregnancy outcomes in women with HIV.

Co-investigatorCIHR2013Operating Grant

Principal investigators: Serghides, Lena

Keywords: Biomarkers; Drug Safety; Hiv Antiretrovirals; Human Pregnancy; Low Birth Weight; Mouse Model; Placenta; Sex Steroids

$639,764

Interdisciplinary HIV Pregnancy Research Group: Care and Research to Optimize HIV-positive Women's Health during Preconception, Pregnancy and Motherhood.

Co-investigatorCIHR2011Emerging Team Grant - Maternal Health: From Pre-conception to the Empty Nest

Principal investigators: Loutfy, Mona R; Serghides, Lena; Yudin, Mark H

Keywords: Health Systems; Hiv; Maternal Health; Motherhood; Policy Development; Postpartum; Preconception; Pregnancy; Team Building; Translational Research

$900,000

Control of Myometrial Contractile Activity During Pregnancy

Co-investigatorCIHR2010Operating Grant

Principal investigators: Lye, Stephen J

Keywords: Cytokines; Inflammation; Labour; Leukocytes; Myometrium; Pregnancy; Preterm Birth

$912,320

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Medicine
Endocrinology and Metabolism
Obstetrics & Gynecology
Urologic Sciences
Biology
Obstetrics and Gynecology
Physiology and Pharmacology
Other

Co-authors at University of Toronto, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Stephen Lye

Endocrinology and Metabolism

26 shared papers, latest 2026

Hala Kufaishi

Medicine

4 shared papers, latest 2016

Rohan D'Souza

Medicine

2 shared papers, latest 2019

Rohan D'Souza

Obstetrics & Gynecology

2 shared papers, latest 2019

Xuesen Dong

Urologic Sciences

2 shared papers, latest 2016

Donna Slater

Physiology and Pharmacology

1 shared papers, latest 2015

David Olson

Obstetrics and Gynecology

1 shared papers, latest 2021

Laurie Ailles

Department of Medical Biophysics

1 shared papers, latest 2025

Chun Peng

Biology

1 shared papers, latest 2018

Isabella Caniggia

Lunenfeld-Tanenbaum Research Institute

1 shared papers, latest 2019

Heyu Ni

Laboratory Medicine & Pathobiology

1 shared papers, latest 2018

Laurent Briollais

Biostatistics Division

1 shared papers, latest 2017

Write to this professor

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Applying for

Paper to mention

Subject: Prospective PhD student: Cervical Length Shortening Dear Professor Shynlova, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "The Pathophysiology of Spontaneous Preterm Birth: Emerging Mechanisms Reviewed by the Preterm Birth International Collaborative." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

Oksana Shynlova

Research

Latest papers

Latest funding

The Pathophysiology of Spontaneous Preterm Birth: Emerging Mechanisms Reviewed by the Preterm Birth International Collaborative.

Somatostatin and its type 2 receptor expression in the pregnant and labouring myometrium.

VHL Gene Restoration Supports RCC Reprogramming to iPSCs but Does Not Ensure Line Stability.

M1 Macrophages Are a Source of IL-1&#x3b1;: A Driver of Progesterone Metabolism and Myometrial Contraction.

JUND plays a genome-wide role in the quiescent to contractile switch in the pregnant human myometrium.

A Broad-Spectrum Chemokine Inhibitor Drives M2 Macrophage Polarization Through Modulation of the Myometrial Secretome.

Promegestone Prevents Lipopolysaccharide-Induced Cervical Remodeling in Pregnant Mice.

SOX4 exerts contrasting regulatory effects on labor-associated gene promoters in myometrial cells.

The Future of Basic Science: Development of the Next Generation of Mechanistic Researchers in Female Pelvic Medicine.

Progesterone control of myometrial contractility.

Frequent collaborators

Stephen Lye

Hala Kufaishi

Rohan D'Souza

Rohan D'Souza

Xuesen Dong

Donna Slater

David Olson

Laurie Ailles

Chun Peng

Isabella Caniggia

Heyu Ni

Laurent Briollais

M1 Macrophages Are a Source of IL-1α: A Driver of Progesterone Metabolism and Myometrial Contraction.