Walid Houry, University of Toronto

Research

Read how they describe their research on their University of Toronto profile.

Molecular Chaperones Protein Degradation Protein Folding Protein Homeostasis Cancer Clpxp Mitochondria Cell Stress Response

Latest papers

Second Virtual International Symposium on Cellular and Organismal Stress Responses, September 8-9, 2022.
Cell stress & chaperones · 2023
Mitochondrial ClpP-Mediated Proteolysis Induces Selective Cancer Cell Lethality.
Cancer cell · 2019

All 2 publications

Latest funding

Dissecting the Function and Substrate Repertoire of the ClpXP Protease and Its Adaptor PDIP38
CIHR · 2026 · Nominated PI
$1,116,900
Multi-parameter characterization of macromolecular structure and dynamics
NSERC · 2025 · Principal investigator
$150,000
Characterizing the molecular basis of Perrault Syndrome
CIHR · 2024 · Supervisor
$120,000

All 29 grants and awards

2 publications.

01

Second Virtual International Symposium on Cellular and Organismal Stress Responses, September 8-9, 2022.

van Oosten-Hawle P, Backe SJ, Ben-Zvi A, Bourboulia D, Brancaccio M, Brodsky J, Clark M, Colombo G, Cox MB, De Los Rios P, Echtenkamp F, Edkins A, Freeman B, Goloubinoff P, Houry W, Johnson J, LaPointe P, Li W, Mezger V, Neckers L, Nillegoda NB, Prahlad V, Reitzel A, Scherz-Shouval R, Sistonen L, Tsai FTF, Woodford MR, Mollapour M, Truman AW

Cell stress & chaperones2023

DOI: 10.1007/s12192-022-01318-5 PMID: 36602710

02

Mitochondrial ClpP-Mediated Proteolysis Induces Selective Cancer Cell Lethality.

Ishizawa J, Zarabi SF, Davis RE, Halgas O, Nii T, Jitkova Y, Zhao R, St-Germain J, Heese LE, Egan G, Ruvolo VR, Barghout SH, Nishida Y, Hurren R, Ma W, Gronda M, Link T, Wong K, Mabanglo M, Kojima K, Borthakur G, MacLean N, Ma MCJ, Leber AB, Minden MD, Houry W, Kantarjian H, Stogniew M, Raught B, Pai EF, Schimmer AD, Andreeff M

Cancer cell2019

DOI: 10.1016/j.ccell.2019.03.014 PMID: 31056398

Dissecting the Function and Substrate Repertoire of the ClpXP Protease and Its Adaptor PDIP38

Nominated PICIHR2026Project Grant

Principal investigators: Houry, Walid A

Keywords: Cancer; Cellular Stress Response; Clpxp; Mitochondria; Molecular Chaperones; Protein Degradation; Protein Folding; Protein Homeostasis; Protein Structure; Protein Unfolding

$1,116,900

Multi-parameter characterization of macromolecular structure and dynamics

Principal investigatorNSERC2025Research Tools and Instruments

Principal investigators: Houry, Walid

Keywords: protein stability; protein oligomerization; protein structure; protein-protein interaction; protein-ligand interaction; nano-differential scanning fluorimetry; dynamic light scattering; static light scattering; back reflection; thermal melt

$150,000

Characterizing the molecular basis of Perrault Syndrome

SupervisorCIHR2024Doctoral Research Award: Canada Graduate Scholarships

Principal investigators: Aljghami, Mazen E

Keywords: Enzymatic Degradation Assays (Michaelis-Menten Kinetics); Immunostaining And Immunoblotting; Mitochondrial Health; Perrault Syndrome; Primary Cell Lines And Induced Pluripotent Stem Cells; Protein Homeostasis (Proteostasis); Protein Misfolding; Protein Purification; Proteomics And Transcriptomics; X-Ray Crystallography

$120,000

Automated cryo-plunger for preparation of vitrified samples for cryo-electron microscopy and cryo-electron tomography

Co-investigatorNSERC2022Research Tools and Instruments

Principal investigators: Lee, Jeffrey

$150,000

Characterizing the role of the novel PAQosome chaperone in Proteostasis: A Structural and Functional study

SupervisorCIHR2021CIHR Fellowship

Principal investigators: Razi, Aida

Keywords: Cancer; Cancer Drug; Client Proteins; Cryo Electron Microscopy; Drug Delivery; Heat Shock Protein; Kinase; Paqosome

$135,000

Detectors for Serial Nanocrystal Electron Diffraction

Co-investigatorNSERC2021Research Tools and Instruments

Principal investigators: Ernst, Oliver

$150,000

Towards single-molecule protein sequencing utilizing an enzyme-assisted solid-state nanopore system

Co-investigatorSSHRC2020New Frontiers in Research Fund - Exploration

Principal investigators: Tabard-Cossa, Vincent

$250,000

The role of the novel R2TP chaperone complex in ciliogenesis

Nominated PICIHR2020Project Grant

Principal investigators: Houry, Walid A

Keywords: Aaa+ Atpases; Assembly; Cilia; Epithilium; Function; Molecular Chaperones; Nmr; R2tp; Structure; X-Ray

$845,326

Upgrade Advanced EPR/DEER Spectroscopy Facility

Co-investigatorNSERC2020Research Tools and Instruments

Principal investigators: Ernst, Oliver

$150,000

Role of the ATP-dependent Protease ClpXP in Mitochondrial Protein Homeostasis

Nominated PICIHR2020Project Grant

Principal investigators: Houry, Walid A

Keywords: Cancer; Cell Stress Response; Clpxp; Mass Spectrometry; Mitochondria; Molecular Chaperones; Protein Degradation; Protein Folding; Protein Homeostasis; Protein Translation

$898,876

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Department of Biochemistry
Research Institute
Cell Biology

Co-authors at University of Toronto, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Brian Raught

Research Institute

1 shared papers, latest 2019

Paul LaPointe

Cell Biology

1 shared papers, latest 2023

Write to this professor

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Applying for

Paper to mentionMention their CIHR grant from 2026

Subject: Prospective PhD student: Molecular Chaperones Dear Professor Houry, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Second Virtual International Symposium on Cellular and Organismal Stress Responses, September 8-9, 2022." (2023), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Dissecting the Function and Substrate Repertoire of the ClpXP Protease and Its Adaptor PDIP38" (2026), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]