Paul LaPointe, University of Alberta

Research

Atpase Chaperones Enzymology Genetics Heat Shock Protein 90 Post-Translational Modifications Protein Folding Proteostasis

Latest papers

Sarcolipin is a Conformation-Dependent Regulator of the Sarcoplasmic Reticulum Calcium Pump SERCA.
The Journal of membrane biology · 2026
Dedifferentiation in endometrial cancer is associated with HLA-I silencing that may be restored by IFN-γ.
The Journal of pathology · 2026
Structural Basis for Mechanical Coupling in Hsp90: Hinge Flexibility Coordinates ATP Gate Closure and β-Strap Release.
Biochemistry · 2026

All 34 publications

Latest funding

A novel role for lipid droplets in proteostasis: Implications for misfolded protein diseases of the nervous system
CIHR · 2022 · Co-investigator
$975,375
Investigating the regulation of the Hsp90 functional cycle by ATP, co-chaperones, and post-translational modifications
CIHR · 2021 · Nominated PI
$1,048,050
Genetic and biochemical analysis of the Hsp90 system in Saccharomyces cerevisiae
NSERC · 2019 · Principal investigator
$216,000

All 6 grants and awards

34 publications.

01

Sarcolipin is a Conformation-Dependent Regulator of the Sarcoplasmic Reticulum Calcium Pump SERCA.

Primeau JO, Lemieux MJ, LaPointe P, Young HS

The Journal of membrane biology2026

DOI: 10.1007/s00232-026-00402-6 PMID: 42745089

02

Dedifferentiation in endometrial cancer is associated with HLA-I silencing that may be restored by IFN-γ.

De Leo A, Wickenberg M, Grillini M, Coadǎ CA, Praveen Kumar P, Tong A, Key J, Kim H, Kommoss F, Carey M, Fu Y, Ceccarelli C, Tallini G, LaPointe P, Köbel M, Lee CH

The Journal of pathology2026

DOI: 10.1002/path.70102 PMID: 42535334

03

Structural Basis for Mechanical Coupling in Hsp90: Hinge Flexibility Coordinates ATP Gate Closure and β-Strap Release.

Magnan B, LaPointe P, Spyracopoulos L

Biochemistry2026

DOI: 10.1021/acs.biochem.6c00292 PMID: 42234987

04

Nucleotide-dependent domain interactions of Aha1-type co-chaperones with Hsp90 reveal evolutionarily conserved binding determinants.

Amoah DP, Bhat R, Trad M, Hussein SK, Overduin M, LaPointe P

Cell stress & chaperones2026Senior author

DOI: 10.1016/j.cstres.2026.100179 PMID: 42025871

05

Novel Hsp90 inhibitors as leads for the development of radiotheragnostics for Meitner-Auger electron therapy.

Kennedy AK, Herrera-Rueda MA, Wilby R, Wuest F, LaPointe P

Bioorganic chemistry2026Senior author

DOI: 10.1016/j.bioorg.2026.109522 PMID: 41576901

06

Collaboration between two conserved sequence motifs drives ATPase stimulation of Hsp90 by Aha1.

Amoah DP, Mercier R, Alyousef G, Johnson JL, LaPointe P

Protein science : a publication of the Protein Society2025Senior author

DOI: 10.1002/pro.70359 PMID: 41123251

07

Collaboration between two conserved sequence motifs drives ATPase stimulation of Hsp90 by Aha1.

Amoah DP, Mercier R, Alyousef G, Johnson JL, LaPointe P

bioRxiv : the preprint server for biology2025Senior author

DOI: 10.1101/2025.06.10.658861 PMID: 40667101

08

Symmetric stimulation of Hsp90 catalyzed ATP hydrolysis through enhanced active site gate dynamics.

Magnan B, Dumont T, Rashid S, LaPointe P, Spyracopoulos L

The Journal of biological chemistry2025

DOI: 10.1016/j.jbc.2025.110262 PMID: 40409552

09

Ordered ATP hydrolysis in the Hsp90 chaperone is regulated by Aha1 and a conserved post-translational modification.

Amoah DP, Hussein SK, Johnson JL, LaPointe P

Protein science : a publication of the Protein Society2025Senior author

DOI: 10.1002/pro.5255 PMID: 39665290

10

Asymmetric Dynamics Drive Catalytic Activation of the Hsp90 Chaperone.

Magnan B, Chen XH, Rashid S, Minard A, Chau W, Uyesugi T, Edwards RA, Panigrahi R, Glover JNM, LaPointe P, Spyracopoulos L

The journal of physical chemistry. B2024

DOI: 10.1021/acs.jpcb.4c03363 PMID: 39186634

A novel role for lipid droplets in proteostasis: Implications for misfolded protein diseases of the nervous system

Co-investigatorCIHR2022Project Grant

Principal investigators: Sipione, Simonetta

Keywords: Heat Shock Response; Huntington'S Disease; Lipid Droplets; Misfolded Proteins; Neurodegeneration; Proteostasis Network

$975,375

Investigating the regulation of the Hsp90 functional cycle by ATP, co-chaperones, and post-translational modifications

Nominated PICIHR2021Project Grant

Principal investigators: LaPointe, Paul G

Keywords: Atpase; Chaperones; Enzymology; Genetics; Heat Shock Protein 90; Post-Translational Modifications; Protein Folding; Proteostasis; Yeast

$1,048,050

Genetic and biochemical analysis of the Hsp90 system in Saccharomyces cerevisiae

Principal investigatorNSERC2019Discovery Grants Program - Individual

Principal investigators: Lapointe, Paul

$216,000

High-resolution quantitative fluorescence detection systems

Co-investigatorNSERC2016Research Tools and Instruments

Principal investigators: Eitzen, Gary

$84,452

The role of the Hsp90 system in promoting and maintaining genetic complexity

Principal investigatorNSERC2011Discovery Grants Program - Individual

Principal investigators: LaPointe, Paul

$150,000

The Role of Aha1p in the Hsp90 Chaperone Cycle

Nominated PICIHR2009Operating Grant

Principal investigators: LaPointe, Paul G

Keywords: Hsp90; Molecular Chaperones; Protein Folding

$523,932

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Oncology
Cell Biology
Medicine
Obstetrics and Gynecology
Biochemistry
Department of Biochemistry

Co-authors at University of Alberta, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Sue-Ann Mok

Biochemistry

1 shared papers, latest 2013

Walid Houry

Department of Biochemistry

1 shared papers, latest 2023

Mark Carey

Obstetrics and Gynecology

1 shared papers, latest 2026

Kristi Baker

Oncology

1 shared papers, latest 2024

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2021

Subject: Prospective PhD student: Atpase Dear Professor LaPointe, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Sarcolipin is a Conformation-Dependent Regulator of the Sarcoplasmic Reticulum Calcium Pump SERCA." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Investigating the regulation of the Hsp90 functional cycle by ATP, co-chaperones, and post-translational modifications" (2021), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

Paul LaPointe

Research

Latest papers

Latest funding

Sarcolipin is a Conformation-Dependent Regulator of the Sarcoplasmic Reticulum Calcium Pump SERCA.

Dedifferentiation in endometrial cancer is associated with HLA-I silencing that may be restored by IFN-γ.

Structural Basis for Mechanical Coupling in Hsp90: Hinge Flexibility Coordinates ATP Gate Closure and β-Strap Release.

Nucleotide-dependent domain interactions of Aha1-type co-chaperones with Hsp90 reveal evolutionarily conserved binding determinants.

Novel Hsp90 inhibitors as leads for the development of radiotheragnostics for Meitner-Auger electron therapy.

Collaboration between two conserved sequence motifs drives ATPase stimulation of Hsp90 by Aha1.

Collaboration between two conserved sequence motifs drives ATPase stimulation of Hsp90 by Aha1.

Symmetric stimulation of Hsp90 catalyzed ATP hydrolysis through enhanced active site gate dynamics.

Ordered ATP hydrolysis in the Hsp90 chaperone is regulated by Aha1 and a conserved post-translational modification.

Asymmetric Dynamics Drive Catalytic Activation of the Hsp90 Chaperone.

A novel role for lipid droplets in proteostasis: Implications for misfolded protein diseases of the nervous system

Investigating the regulation of the Hsp90 functional cycle by ATP, co-chaperones, and post-translational modifications

Genetic and biochemical analysis of the Hsp90 system in Saccharomyces cerevisiae

High-resolution quantitative fluorescence detection systems

The role of the Hsp90 system in promoting and maintaining genetic complexity

The Role of Aha1p in the Hsp90 Chaperone Cycle

Frequent collaborators

Heather Armstrong

Frank Wuest

Sue-Ann Mok

Walid Houry

Mark Carey

Kristi Baker

Paul LaPointe

Research

Latest papers

Latest funding

Sarcolipin is a Conformation-Dependent Regulator of the Sarcoplasmic Reticulum Calcium Pump SERCA.

Dedifferentiation in endometrial cancer is associated with HLA-I silencing that may be restored by IFN-&#x3b3;.

Structural Basis for Mechanical Coupling in Hsp90: Hinge Flexibility Coordinates ATP Gate Closure and &#x3b2;-Strap Release.

Nucleotide-dependent domain interactions of Aha1-type co-chaperones with Hsp90 reveal evolutionarily conserved binding determinants.

Novel Hsp90 inhibitors as leads for the development of radiotheragnostics for Meitner-Auger electron therapy.

Collaboration between two conserved sequence motifs drives ATPase stimulation of Hsp90 by Aha1.

Collaboration between two conserved sequence motifs drives ATPase stimulation of Hsp90 by Aha1.

Symmetric stimulation of Hsp90 catalyzed ATP hydrolysis through enhanced active site gate dynamics.

Ordered ATP hydrolysis in the Hsp90 chaperone is regulated by Aha1 and a conserved post-translational modification.

Asymmetric Dynamics Drive Catalytic Activation of the Hsp90 Chaperone.

A novel role for lipid droplets in proteostasis: Implications for misfolded protein diseases of the nervous system

Investigating the regulation of the Hsp90 functional cycle by ATP, co-chaperones, and post-translational modifications

Genetic and biochemical analysis of the Hsp90 system in Saccharomyces cerevisiae

High-resolution quantitative fluorescence detection systems

The role of the Hsp90 system in promoting and maintaining genetic complexity

The Role of Aha1p in the Hsp90 Chaperone Cycle

Frequent collaborators

Heather Armstrong

Frank Wuest

Sue-Ann Mok

Walid Houry

Mark Carey

Kristi Baker

Dedifferentiation in endometrial cancer is associated with HLA-I silencing that may be restored by IFN-γ.

Structural Basis for Mechanical Coupling in Hsp90: Hinge Flexibility Coordinates ATP Gate Closure and β-Strap Release.