William Trimble, University of Toronto

Research

Septins Cytoskeleton Myosin Actin Endoplasmic Reticulum Mitochondria Cell Migration Cytokinesis

Latest papers

Lysosomal integral membrane protein-2 (LIMP-2/SCARB2) is involved in lysosomal cholesterol export.
Nature communications · 2019
Size uniformity of animal cells is actively maintained by a p38 MAPK-dependent regulation of G1-length.
eLife · 2018
OxLDL receptor chromatography from live human U937 cells identifies SYK(L) that regulates phagocytosis of oxLDL.
Analytical biochemistry · 2016

All 5 publications

Latest funding

Regulation of septin polymerization in vitro
NSERC · 2020 · Principal investigator
$210,000
Role of septins in mitochondrial fission
CIHR · 2018 · Nominated PI
$1,036,575
The Role of Scaffold Proteins in Cytokinesis and Ciliogenesis in Human Cells
CIHR · 2017 · Supervisor
$90,000

All 19 grants and awards

5 publications.

01

Lysosomal integral membrane protein-2 (LIMP-2/SCARB2) is involved in lysosomal cholesterol export.

Heybrock S, Kanerva K, Meng Y, Ing C, Liang A, Xiong ZJ, Weng X, Ah Kim Y, Collins R, Trimble W, Pomès R, Privé GG, Annaert W, Schwake M, Heeren J, Lüllmann-Rauch R, Grinstein S, Ikonen E, Saftig P, Neculai D

Nature communications2019

DOI: 10.1038/s41467-019-11425-0 PMID: 31387993

02

Size uniformity of animal cells is actively maintained by a p38 MAPK-dependent regulation of G1-length.

Liu S, Ginzberg MB, Patel N, Hild M, Leung B, Li Z, Chen YC, Chang N, Wang Y, Tan C, Diena S, Trimble W, Wasserman L, Jenkins JL, Kirschner MW, Kafri R

eLife2018

DOI: 10.7554/elife.26947 PMID: 29595474

03

OxLDL receptor chromatography from live human U937 cells identifies SYK(L) that regulates phagocytosis of oxLDL.

Howard JC, Florentinus-Mefailoski A, Bowden P, Trimble W, Grinstein S, Marshall JG

Analytical biochemistry2016

DOI: 10.1016/j.ab.2016.07.021 PMID: 27510553

04

A phagocytosis assay for oxidized low-density lipoprotein versus immunoglobulin G-coated microbeads in human U937 macrophages.

Vance DT, Dufresne J, Florentinus-Mefailoski A, Tucholska M, Trimble W, Grinstein S, Marshall JG

Analytical biochemistry2016

DOI: 10.1016/j.ab.2016.01.007 PMID: 26800863

05

Septins at a glance.

Beise N, Trimble W

Journal of cell science2011Senior author

DOI: 10.1242/jcs.087007 PMID: 22247190

Regulation of septin polymerization in vitro

Principal investigatorNSERC2020Discovery Grants Program - Individual

Principal investigators: Trimble, William

$210,000

Role of septins in mitochondrial fission

Nominated PICIHR2018Project Grant

Principal investigators: Trimble, William S

Keywords: Actin; Cytoskeleton; Endoplasmic Reticulum; Mitochondria; Myosin; Septins

$1,036,575

The Role of Scaffold Proteins in Cytokinesis and Ciliogenesis in Human Cells

SupervisorCIHR2017CIHR Fellowship

Principal investigators: Safavian, Darya

Keywords: Adaptor Proteins; Cancer; Cell Division; Cell Signalling; Cilia; Gene Silencing; Immunofluorescence; Immunoprecipitation; Protein Complex; Septins

$90,000

NSF-mediated disssembly of SNARE complexes

Principal investigatorNSERC2015Discovery Grants Program - Individual

Principal investigators: Trimble, William

$225,000

Septins as a signaling platform in cancer and metastasis.

Nominated PICIHR2013Operating Grant

Principal investigators: Trimble, William S

Keywords: Cell Migration; Cytokinesis; Myosin; Pin1; Rho; Rock; Septins; Signal Transduction; Transgenic

$807,584

Molecular characterization of lipid transport by the scavenger receptor SCARB1

Nominated PICIHR2012Operating Grant

Principal investigators: Trimble, William S; Grinstein, Sergio

Keywords: Atherosclerosis; Cholesterol; Endocytosis; Hdl; Hypercholesterolemia; Scarb1; Scavenger Receptor; Stroke

$585,799

The role of septins in ciliogenesis and primary cilia function

Nominated PICIHR2012Operating Grant

Principal investigators: Trimble, William S

Keywords: Adenomatous Polyposis Coli; Ciliopathy; Cytoskeleton; Hedgehog Signaling; Membrane Mobility; Microtubule; Polycystic Kidney Disease; Primary Cilium; Septins

$763,784

CANADA RESEARCH CHAIRHOLDER / TITULAIRE DE CHAIRE DE RECHERCHE DU CANADA

Nominated PICIHR2011Canada Research Chairs - CIHR Funded - Tier 1

Principal investigators: Trimble, William S

Keywords: Crc

$1,400,000

The role of septins in ciliogenesis and primary cilia function

Nominated PICIHR2011Operating Grant - PA: Institute of Genetics (Bridge Funding)

Principal investigators: Trimble, William S

Keywords: Adenomatous Polyposis Coli; Ciliopathy; Cytoskeleton; Hedgehog Signaling; Membrane Mobility; Microtubule; Primary Cilium; Septins

$100,000

Regulation of membrane fusion

Principal investigatorNSERC2010Discovery Grants Program - Individual

Principal investigators: Trimble, William

$135,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Cell Biology

Co-authors at University of Toronto, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Sergio Grinstein

Cell Biology

3 shared papers, latest 2019

Ran Kafri

Cell Biology

1 shared papers, latest 2018

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their NSERC grant from 2020

Subject: Prospective PhD student: Septins Dear Professor Trimble, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Lysosomal integral membrane protein-2 (LIMP-2/SCARB2) is involved in lysosomal cholesterol export." (2019), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your NSERC-funded project "Regulation of septin polymerization in vitro" (2020), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]