Ran Kafri, University of Toronto

Research

Cell Cycle Cell Signaling Cell Size Systems Biology Anabolic Activity Cancer Computational Biology

Latest papers

Inferring feedback regulation from static snapshots of a single signal.
Biochemistry and biophysics reports · 2026 · senior author
TP53 variant clusters stratify phenotypic diversity in germline carriers and reveal an osteosarcoma-prone subgroup.
Nature communications · 2025
CDK-4 regulates nucleolar size and metabolism at the cost of late-life fitness in C. elegans.
Heredity · 2025

All 16 publications

Latest funding

Developing diagnostics of patient-specific cancer risk and early-stage tumorigenesis
CIHR · 2023 · Co-investigator
$906,526
Identifying mechanisms of cell size sensing with implications in normal and malignant populations
CIHR · 2021 · Nominated PI
$921,826
Quantitative Cell Biology
NSERC · 2021 · Principal investigator
$350,000

All 8 grants and awards

16 publications.

01

Inferring feedback regulation from static snapshots of a single signal.

Ginzberg M, Tan C, Patel N, Kafri R

Biochemistry and biophysics reports2026Senior author

DOI: 10.1016/j.bbrep.2026.102747 PMID: 42643853

02

TP53 variant clusters stratify phenotypic diversity in germline carriers and reveal an osteosarcoma-prone subgroup.

Fischer NW, Ong N, Laverty B, Psarianos P, Giovino C, Alon N, Montellier E, Hainaut P, Maxwell KN, Kratz CP, Kafri R, Malkin D

Nature communications2025

DOI: 10.1038/s41467-025-63528-6 PMID: 41022739

03

CDK-4 regulates nucleolar size and metabolism at the cost of late-life fitness in C. elegans.

Webster R, Quintana M, Yu B, Fluke S, Kafri R, Derry WB

Heredity2025

DOI: 10.1038/s41437-025-00769-7 PMID: 40383750

04

Oversized cells activate global proteasome-mediated protein degradation to maintain cell size homeostasis.

Liu S, Tan C, Melo-Gavin C, Ginzberg MB, Blutrich R, Patel N, Rape M, Mark KG, Kafri R

eLife2025Senior author

DOI: 10.7554/elife.75393 PMID: 39791360

05

What programs the size of animal cells?

Liu S, Tan C, Tyers M, Zetterberg A, Kafri R

Frontiers in cell and developmental biology2022Senior author

DOI: 10.3389/fcell.2022.949382 PMID: 36393871

06

Virtual screening for small-molecule pathway regulators by image-profile matching.

Rohban MH, Fuller AM, Tan C, Goldstein JT, Syangtan D, Gutnick A, DeVine A, Nijsure MP, Rigby M, Sacher JR, Corsello SM, Peppler GB, Bogaczynska M, Boghossian A, Ciotti GE, Hands AT, Mekareeya A, Doan M, Gale JP, Derynck R, Turbyville T, Boerckel JD, Singh S, Kiessling LL, Schwarz TL, Varelas X, Wagner FF, Kafri R, Eisinger-Mathason TSK, Carpenter AE

Cell systems2022

DOI: 10.1016/j.cels.2022.08.003 PMID: 36057257

07

Proteomic Characterization of a Candidate Polygenic Driver of Metabolism in Non-small Cell Lung Cancer.

Badr H, Blutrich R, Chan K, Tong J, Taylor P, Zhang W, Kafri R, Röst HL, Tsao MS, Moran MF

Journal of molecular biology2022

DOI: 10.1016/j.jmb.2022.167636 PMID: 35595168

08

Visual barcodes for clonal-multiplexing of live microscopy-based assays.

Kaufman T, Nitzan E, Firestein N, Ginzberg MB, Iyengar S, Patel N, Ben-Hamo R, Porat Z, Hunter J, Hilfinger A, Rotter V, Kafri R, Straussman R

Nature communications2022

DOI: 10.1038/s41467-022-30008-0 PMID: 35585055

09

p38-mediated cell growth and survival drive rapid embryonic wound repair.

Scepanovic G, Hunter MV, Kafri R, Fernandez-Gonzalez R

Cell reports2021

DOI: 10.1016/j.celrep.2021.109874 PMID: 34686334

10

Cell size homeostasis is maintained by CDK4-dependent activation of p38 MAPK.

Tan C, Ginzberg MB, Webster R, Iyengar S, Liu S, Papadopoli D, Concannon J, Wang Y, Auld DS, Jenkins JL, Rost H, Topisirovic I, Hilfinger A, Derry WB, Patel N, Kafri R

Developmental cell2021Senior author

DOI: 10.1016/j.devcel.2021.04.030 PMID: 34022133

Developing diagnostics of patient-specific cancer risk and early-stage tumorigenesis

Co-investigatorCIHR2023Project Grant

Principal investigators: Malkin, David D

Keywords: Cancer Predisposition; Early Tumor Detection; Epigenetics; Horvath Clock; Li-Fraumeni Syndrome; Metabolics; P53; Pharmacologic Prevention

$906,526