Faculty profile

Sergio Grinstein

ResearcherCell BiologyUniversity of Toronto

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Toronto directory, so their courses and email address may be missing. Find their university profile.

Sergio Grinstein

Researcher

Cell Biology

Health Sciences

University of Toronto

Toronto, Ontario, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
24 publications in the last five years, latest in 2026.
Senior (last) author on 2 recent papers, a sign of leading a research group.
Principal investigator on 6 research grants (6 CIHR), most recently in 2014.
Supervised 2 trainees who won CIHR awards, most recently in 2017.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

205

Publications

144

Citations

h-index

Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

Profiles and links

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Signals and details

Research

Ph Regulation Cytoskeleton Macrophages Phagocytosis Phospholipids Receptors Membrane Traffic Na/H Exchange

Latest papers

Is the Parkinson's-associated protein TMEM175 a proton channel: Yay or nay?
The Journal of cell biology · 2026 · senior author
Ion transport as a determinant of membrane fusion and fission.
Nature structural & molecular biology · 2026
Lipid scrambling via TMEM16F mediates the formation and release of extracellular vesicles.
Molecular biology of the cell · 2026

All 205 publications

Latest funding

Defining the role of ArpC1b and the actin cytoskeleton in macrophage migration, phagocytosis, and immunoregulation
CIHR · 2017 · Supervisor
$105,000
Innate immunity and its disruption by microbial and genetic factors
CIHR · 2016 · Co-investigator
$4,492,432
Innate immune regulation of intestinal homeostasis: insight into Crohn's disease pathogenesis.
CIHR · 2014 · Co-investigator
$2,404,680

All 12 grants and awards

From the 150 most recent of 205 publications.

Is the Parkinson's-associated protein TMEM175 a proton channel: Yay or nay?

Freeman SA, Grinstein S

The Journal of cell biology2026Senior author

DOI: 10.1083/jcb.202511084 PMID: 41295951

Ion transport as a determinant of membrane fusion and fission.

Levin-Konigsberg R, Grinstein S, Freeman SA

Nature structural & molecular biology2026

DOI: 10.1038/s41594-026-01860-1 PMID: 42618799

Lipid scrambling via TMEM16F mediates the formation and release of extracellular vesicles.

Le T, Collado MEP, Li YM, Saric A, Holthuis JCM, Grinstein S, Freeman SA

Molecular biology of the cell2026

DOI: 10.1091/mbc.e25-05-0245 PMID: 41604453

Beyond transport: Lysosomal solute carriers as orchestrators of immune signaling.

Netting DJ, Grinstein S, Mantegazza AR

Molecular biology of the cell2026

DOI: 10.1091/mbc.e26-04-0158 PMID: 42234593

Author Correction: Ion transport as a determinant of membrane fusion and fission.

Levin-Konigsberg R, Grinstein S, Freeman SA

Nature structural & molecular biology2026

DOI: 10.1038/s41594-026-01900-w PMID: 42760325

Salmonella exploits LRRK2-dependent plasma membrane dynamics to invade host cells.

Zhu H, Sydor AM, Yan BR, Li R, Boniecki MT, Lyons C, Cygler M, Muise AM, Maxson ME, Grinstein S, Raught B, Brumell JH

Nature communications2025

DOI: 10.1038/s41467-025-57453-x PMID: 40057496

Sorting nexin 10 regulates lysosomal ionic homeostasis via ClC-7 by controlling PI(3,5)P2.

Wu JZ, Pemberton JG, Morioka S, Sasaki J, Bablani P, Sasaki T, Balla T, Grinstein S, Freeman SA

The Journal of cell biology2025

DOI: 10.1083/jcb.202408174 PMID: 40138451

Redistribution of the glycocalyx exposes phagocytic determinants on apoptotic cells.

Le T, Ferling I, Qiu L, Nabaile C, Assunção L, Roskelley CD, Grinstein S, Freeman SA

Developmental cell2024

DOI: 10.1016/j.devcel.2024.01.020 PMID: 38359833

Salmonella exploits membrane reservoirs for invasion of host cells.

Zhu H, Sydor AM, Boddy KC, Coyaud E, Laurent EMN, Au A, Tan JMJ, Yan BR, Moffat J, Muise AM, Yip CM, Grinstein S, Raught B, Brumell JH

Nature communications2024

DOI: 10.1038/s41467-024-47183-x PMID: 38600106

Target lysis by cholesterol extraction is a rate limiting step in the resolution of phagolysosomes.

Barreda D, Grinstein S, Freeman SA

European journal of cell biology2024

DOI: 10.1016/j.ejcb.2023.151382 PMID: 38171214

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Sergio Grinstein

Research

Latest papers

Latest funding

Is the Parkinson's-associated protein TMEM175 a proton channel: Yay or nay?

Ion transport as a determinant of membrane fusion and fission.

Lipid scrambling via TMEM16F mediates the formation and release of extracellular vesicles.

Beyond transport: Lysosomal solute carriers as orchestrators of immune signaling.

Author Correction: Ion transport as a determinant of membrane fusion and fission.

Salmonella exploits LRRK2-dependent plasma membrane dynamics to invade host cells.

Sorting nexin 10 regulates lysosomal ionic homeostasis via ClC-7 by controlling PI(3,5)P2.

Redistribution of the glycocalyx exposes phagocytic determinants on apoptotic cells.

Salmonella exploits membrane reservoirs for invasion of host cells.

Target lysis by cholesterol extraction is a rate limiting step in the resolution of phagolysosomes.

Frequent collaborators

Michael Glogauer

Michal Bohdanowicz

Brian Raught

Andras Kapus

William Trimble

Jim Hu

Chung-Wai Chow

Nades Palaniyar

Spencer Freeman

Amra Saric

Daniel Coombs

Katalin Szaszi

Jason Moffat

Ramzi Fattouh

John Marshall

James Shaw

Christoph Licht

John Orlowski

Pauline Johnson

Michelle Maxson

Gregory Fairn

Robert Inman

Laura Erdman

Bryan Heit

Jun Liu

Laurence Pelletier

Anne-Claude Gingras

Christopher Yip

Lori Burrows

Boris Hinz

Nathan Magarvey