Arthur Brown, Western University

Research

Read how they describe their research on their Western University profile.

Spinal Cord Injury Neuroplasticity Behaviour Chondroitin Sulfate Proteoglcans Anti-Inflammatory Behavioral Outcomes Immunotherapy Monoclonal Antibody

Latest papers

MRI investigation of orientation-dependent changes in microstructure and function in a mouse model of mild traumatic brain injury.
Acta neuropathologica communications · 2025 · senior author
Microstructural maturation of the adult mouse brain.
Communications biology · 2025
A Clinically Relevant Mouse Model of Concussion Incorporating High Rotational Forces.
Neurotrauma reports · 2025 · senior author

All 47 publications

Latest funding

Microstructural brain aging across the lifespan of mice
CIHR · 2025 · Co-investigator
$998,326
Developing Novel Brain Imaging and Blood Testing Against a Major Early Disease Driver for Timely Diagnosis and Effective Treatment of Age-Dependent Tauopathies
CIHR · 2024 · Co-investigator
$1,075,000
Evaluating inhibitors of CSPG synthesis in models of spinal cord injury
CIHR · 2019 · Nominated PI
$986,850

All 8 grants and awards

47 publications.

01

MRI investigation of orientation-dependent changes in microstructure and function in a mouse model of mild traumatic brain injury.

Eed A, Hamilton J, Xu X, Geremia N, Prado VF, Prado MAM, Baron CA, Menon RS, Brown A

Acta neuropathologica communications2025Senior author

DOI: 10.1186/s40478-025-02183-w PMID: 41327381

02

Microstructural maturation of the adult mouse brain.

Rahman N, Hamilton J, Xu K, Brown A, Baron CA

Communications biology2025

DOI: 10.1038/s42003-025-08981-1 PMID: 41258159

03

A Clinically Relevant Mouse Model of Concussion Incorporating High Rotational Forces.

Teasell EM, Potts E, Geremia N, Lu L, Xu X, Mao H, Brown A

Neurotrauma reports2025Senior author

DOI: 10.1089/neur.2024.0165 PMID: 40129895

04

Humanized anti-CD11d monoclonal antibodies suitable for basic research and therapeutic applications.

Blythe EN, Barreira C, Fink C, Brown A, Weaver LC, Dekaban GA

Antibody therapeutics2025

DOI: 10.1093/abt/tbae031 PMID: 39839909

05

Robust frequency-dependent diffusional kurtosis computation using an efficient direction scheme, axisymmetric modelling, and spatial regularization.

Hamilton J, Xu K, Geremia N, Prado VF, Prado MAM, Brown A, Baron CA

Imaging neuroscience (Cambridge, Mass.)2024

DOI: 10.1162/imag_a_00055 PMID: 40800517

06

A longitudinal microstructural MRI dataset in healthy C57Bl/6 mice at 9.4 Tesla.

Rahman N, Xu K, Budde MD, Brown A, Baron CA

Scientific data2023

DOI: 10.1038/s41597-023-01942-5 PMID: 36788251

07

Test-Retest Reproducibility of In Vivo Magnetization Transfer Ratio and Saturation Index in Mice at 9.4 Tesla.

Rahman N, Ramnarine J, Xu K, Brown A, Baron CA

Journal of magnetic resonance imaging : JMRI2022

DOI: 10.1002/jmri.28106 PMID: 35156740

08

The Effect of Three-Dimensional Whole, Major, and Small Vasculature on Mouse Brain Strain Under Both Diffuse and Focal Brain Injury Loading.

Lu L, Liu X, Bian K, Sled JG, Monson K, Brown A, Mao H

Journal of biomechanical engineering2022

DOI: 10.1115/1.4053664 PMID: 35079765

09

β2 Integrin CD11d/CD18: From Expression to an Emerging Role in Staged Leukocyte Migration.

Blythe EN, Weaver LC, Brown A, Dekaban GA

Frontiers in immunology2021

DOI: 10.3389/fimmu.2021.775447 PMID: 34858434

10

Test-retest reproducibility of in vivo oscillating gradient and microscopic anisotropy diffusion MRI in mice at 9.4 Tesla.

Rahman N, Xu K, Omer M, Budde MD, Brown A, Baron CA

PloS one2021

DOI: 10.1371/journal.pone.0255711 PMID: 34739479

Microstructural brain aging across the lifespan of mice

Co-investigatorCIHR2025Project Grant

Principal investigators: Baron, Corey A; Khan, Ali R

Keywords: Aging; Brain; Diffusion Mri; Lifespan; Light Sheet; Microscopy; Microstructure; Mouse; Mri; Neurodegeneration

$998,326

Developing Novel Brain Imaging and Blood Testing Against a Major Early Disease Driver for Timely Diagnosis and Effective Treatment of Age-Dependent Tauopathies

Co-investigatorCIHR2024Team Grant: CCNA Phase III - Biomarkers

Principal investigators: Lu, Kun Ping; Bartha, Robert; Lee, Ting-Yim; Paré, Guillaume; Pasternak, Stephen H; Zhou, Xiao Zhen

Keywords: Alzheimer'S Disease; Blood Biomarker; Dementia; Diagnostics; Pet Imaging; Phosphorylated Tau; Pin1; Protein Conformation; Tauopathies; Traumatic Brain Injury

$1,075,000

Evaluating inhibitors of CSPG synthesis in models of spinal cord injury

Nominated PICIHR2019Project Grant

Principal investigators: Brown, Arthur

Keywords: Behaviour; Chondroitin Sulfate Proteoglcans; Neuroplasticity; Spinal Cord Injury

$986,850

Anti-CD11d immunotherapy for CNS trauma

Principal investigatorCIHR2016Project Grant

Principal investigators: Dekaban, Gregory A; Brown, Arthur

Keywords: Anti-Inflammatory; Behavioral Outcomes; Immunotherapy; Monoclonal Antibody; Neuroprotection; Spinal Cord Injury; Systemic Inflammatory Response Syndrome; Traumatic Brain Injury

$802,725

Treadmill training and SOX9 ablation: a combination therapy to improve locomotor recovery of spinal cord-injured mice

SupervisorCIHR2013Undergraduate: Mobility, musculoskeletal health and arthritis - ICS

Principal investigators: Au, Victoria

Keywords: Chondroitin Sulfate Proteoglycans; Incomplete Spinal Cord Injury; Locomotor Recovery; Neural Plasticity; Sox9 Ablation; Tissue Repair; Treadmill Training

$4,950

Investigating the role of SOX9 in recovery from spinal cord injury

Nominated PICIHR2013Operating Grant

Principal investigators: Brown, Arthur

Keywords: Neuro Stem Cells; Neuroplasticity; Sox 9; Spinal Cord Injury; Tract Tracing

$655,672

Cafe Scientifique on Pediatric Traumatic Brain Injury

Co-investigatorCIHR2012CIHR Café Scientifique Program

Principal investigators: Fraser, Douglas D

Keywords: Children; Traumatic Brain Injury

$3,000

Developing a molecular screen to identify SOX9 inhibitors for locomotor rehabilitation

SupervisorCIHR2012Undergraduate: Mobility, musculoskeletal health and arthritis - ICS

Principal investigators: Scheinbach, Lior

Keywords: Drug Screening; High Throughput Screen; Locomotor; Rehabilitation; Sox9; Tissue Culture

$4,950

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

John P. Robarts Research Institute
Biochemistry
Department of Physiology and Pharmacology
Department of Medical Biophysics
Centre for Research in Neurosciences
Zoology
Other

Co-authors at Western University, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Robert Bartha

Biochemistry

7 shared papers, latest 2021

Lynne Weaver

Department of Physiology and Pharmacology

2 shared papers, latest 2012

Wei-Yang Lu

Department of Physiology and Pharmacology

1 shared papers, latest 2012

Ravi Menon

Department of Medical Biophysics

1 shared papers, latest 2021

Douglas Fraser

Biochemistry

1 shared papers, latest 2020

Vania Prado

John P. Robarts Research Institute

1 shared papers, latest 2021

Samuel David

Centre for Research in Neurosciences

1 shared papers, latest 2015

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2019

Subject: Prospective PhD student: Spinal Cord Injury Dear Professor Brown, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "MRI investigation of orientation-dependent changes in microstructure and function in a mouse model of mild traumatic brain injury." (2025), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Evaluating inhibitors of CSPG synthesis in models of spinal cord injury" (2019), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

Arthur Brown

Research

Latest papers

Latest funding

MRI investigation of orientation-dependent changes in microstructure and function in a mouse model of mild traumatic brain injury.

Microstructural maturation of the adult mouse brain.

A Clinically Relevant Mouse Model of Concussion Incorporating High Rotational Forces.

Humanized anti-CD11d monoclonal antibodies suitable for basic research and therapeutic applications.

Robust frequency-dependent diffusional kurtosis computation using an efficient direction scheme, axisymmetric modelling, and spatial regularization.

A longitudinal microstructural MRI dataset in healthy C57Bl/6 mice at 9.4 Tesla.

Test-Retest Reproducibility of In Vivo Magnetization Transfer Ratio and Saturation Index in Mice at 9.4 Tesla.

The Effect of Three-Dimensional Whole, Major, and Small Vasculature on Mouse Brain Strain Under Both Diffuse and Focal Brain Injury Loading.

β2 Integrin CD11d/CD18: From Expression to an Emerging Role in Staged Leukocyte Migration.

Test-retest reproducibility of in vivo oscillating gradient and microscopic anisotropy diffusion MRI in mice at 9.4 Tesla.

Microstructural brain aging across the lifespan of mice

Developing Novel Brain Imaging and Blood Testing Against a Major Early Disease Driver for Timely Diagnosis and Effective Treatment of Age-Dependent Tauopathies

Evaluating inhibitors of CSPG synthesis in models of spinal cord injury

Anti-CD11d immunotherapy for CNS trauma

Treadmill training and SOX9 ablation: a combination therapy to improve locomotor recovery of spinal cord-injured mice

Investigating the role of SOX9 in recovery from spinal cord injury

Cafe Scientifique on Pediatric Traumatic Brain Injury

Developing a molecular screen to identify SOX9 inhibitors for locomotor rehabilitation

Frequent collaborators

Robert Bartha

Lynne Weaver

Wei-Yang Lu

Ravi Menon

Lisa Saksida

Wolfram Tetzlaff

Douglas Fraser

Vania Prado

Samuel David

Arthur Brown

Research

Latest papers

Latest funding

MRI investigation of orientation-dependent changes in microstructure and function in a mouse model of mild traumatic brain injury.

Microstructural maturation of the adult mouse brain.

A Clinically Relevant Mouse Model of Concussion Incorporating High Rotational Forces.

Humanized anti-CD11d monoclonal antibodies suitable for basic research and therapeutic applications.

Robust frequency-dependent diffusional kurtosis computation using an efficient direction scheme, axisymmetric modelling, and spatial regularization.

A longitudinal microstructural MRI dataset in healthy C57Bl/6 mice at 9.4 Tesla.

Test-Retest Reproducibility of In Vivo Magnetization Transfer Ratio and Saturation Index in Mice at 9.4 Tesla.

The Effect of Three-Dimensional Whole, Major, and Small Vasculature on Mouse Brain Strain Under Both Diffuse and Focal Brain Injury Loading.

&#x3b2;2 Integrin CD11d/CD18: From Expression to an Emerging Role in Staged Leukocyte Migration.

Test-retest reproducibility of in vivo oscillating gradient and microscopic anisotropy diffusion MRI in mice at 9.4 Tesla.

Frequent collaborators

Robert Bartha

Lynne Weaver

Wei-Yang Lu

Ravi Menon

Lisa Saksida

Wolfram Tetzlaff

Douglas Fraser

Vania Prado

Samuel David

β2 Integrin CD11d/CD18: From Expression to an Emerging Role in Staged Leukocyte Migration.