Faculty profile

Matthieu Schapira

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ProfessorStructural Genomics ConsortiumUniversity of Toronto

Matthieu Schapira

Professor

Structural Genomics Consortium

Temerty Faculty of Medicine

University of Toronto

Toronto, Ontario, Canada

Scholar ORCID

Supervision signals

Professors usually supervise graduate students in their department's programs.
37 publications in the last five years, latest in 2026.
Senior (last) author on 16 recent papers, a sign of leading a research group.
Principal investigator on 4 research grants (3 NSERC, 1 CIHR), most recently in 2023.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

123

Publications

Citations

Collaborators

Grants

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

Education

PhD
M.Sc

Profiles and links

University Profile Personal Website Google Scholar iDORCID

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Signals and details

Research

Read how they describe their research on their University of Toronto profile.

Artificial Intelligence Biophysical Assays Chemical Library Chemical Reaction Chemical Synthesis Cheminformatics Drug Discovery Virtual Screening

Latest papers

Targeting the RNA-Binding Site of SARS-CoV-2 NSP13 by FRASE-bot in CACHE Challenge #2.
Journal of chemical information and modeling · 2026
Development of a Dual Chemical Probe for the USP16 and HDAC6 Zinc-Finger Ubiquitin-Binding Domain.
Journal of medicinal chemistry · 2026
CACHE Challenge #3: Targeting the Nsp3 Macrodomain of SARS-CoV-2.
Journal of chemical information and modeling · 2026 · senior author

All 123 publications

Latest funding

Chemical technologies for controlling T cell glycosylation in health and disease
CIHR · 2024 · Co-investigator
$956,250
A pan-Canadian chemical library to explore uncharted chemistry space for drug discovery
CIHR · 2023 · Nominated PI
$1,189,575
Development and Characterization of Novel CB1 Allosteric Modulators
CIHR · 2020 · Co-investigator
$765,000

All 7 grants and awards

123 publications.

Targeting the RNA-Binding Site of SARS-CoV-2 NSP13 by FRASE-bot in CACHE Challenge #2.

Wang X, Mettu A, Herasymenko O, Silva M, Houliston S, Chau I, Ghiabi P, Gibson E, Perveen S, Seitova A, Schapira M, Kireev D

Journal of chemical information and modeling2026

DOI: 10.1021/acs.jcim.6c00560 PMID: 42670858

Development of a Dual Chemical Probe for the USP16 and HDAC6 Zinc-Finger Ubiquitin-Binding Domain.

Silva M, Mann M, Mirabi B, Szewczyk MM, Loup J, Dupeux A, Chandrasekaran R, Bajohr J, Arrowsmith C, Schapira M, Lautens M, Barsyte-Lovejoy D, Harding RJ, Santhakumar V

Journal of medicinal chemistry2026

DOI: 10.1021/acs.jmedchem.5c02976 PMID: 41718545

CACHE Challenge #3: Targeting the Nsp3 Macrodomain of SARS-CoV-2.

Herasymenko O, Silva M, Correy GJ, Abu-Saleh AAA, Ackloo S, Arrowsmith C, Ashworth A, Ban F, Beck H, Bishop KP, Bohórquez HJ, Bolotokova A, Breznik M, Chau I, Chen Y, Cherkasov A, Dehaen W, Della Corte D, Denzinger K, Doering NP, Edfeldt K, Edwards A, Fayne D, Gentile F, Gibson E, Gokdemir O, Gunnarsson A, Günther J, Irwin JJ, Jensen JH, Harding RJ, Hillisch A, Hoffer L, Hogner A, Hutchinson A, Kandwal S, Karlova A, Koirala K, Kotelnikov S, Kozakov D, Lee J, Lee S, Lessel U, Liu S, Liu X, Loppnau P, Meiler J, Moretti R, Moroz YS, Muvva C, Oprea TI, Paige B, Pandit A, Park K, Poda G, Protopopov MV, Pütter V, Ravichandran R, Rognan D, Rosta E, Sabnis Y, Scott T, Seitova A, Sharma P, Sindt F, Song M, Steinmann C, Stevens R, Talagayev V, Tararina VV, Tarkhanova O, Tingey D, Trant JF, Treleaven D, Tropsha A, Walters P, Wells J, Westermaier Y, Wolber G, Wortmann L, Zheng S, Fraser JS, Schapira M

Journal of chemical information and modeling2026Senior author

DOI: 10.1021/acs.jcim.5c02441 PMID: 41565251

Enantioselective protein affinity selection mass spectrometry (E-ASMS).

Wang X, Sun J, Ahmad S, Yang D, Li F, Chan UH, Zeng H, Simoben CV, Green SR, Silva M, Houliston S, Dong A, Bolotokova A, Gibson E, Kutera M, Ghiabi P, Kondratov I, Matviyuk T, Chuprina A, Mavridi D, Lenz C, Joerger AC, Brown BD, Heath RB, Yue WW, Robbie LK, Beyett TS, Müller S, Knapp S, Owen DR, Harding R, Schapira M, Brown PJ, Santhakumar V, Ackloo S, Arrowsmith CH, Edwards AM, Peng H, Halabelian L

Nature communications2025

DOI: 10.1038/s41467-025-67403-2 PMID: 41407727

Structure-based discovery of inhibitors of Mac1 domain of nonstructural protein-3 of SARS-CoV-2 by machine learning-augmented screening of chemical space.

Ban F, Ravichandran R, Correy GJ, Herasymenko O, Silva M, Ackloo S, Bolotokova A, Chau I, Gibson E, Harding R, Hutchinson A, Loppnau P, Fraser JS, Schapira M, Cherkasov A, Gentile F

bioRxiv : the preprint server for biology2025

DOI: 10.1101/2025.09.05.674529 PMID: 40964377

k-Nearest Neighbor Adaptive Sampling, a Simple Tool to Efficiently Explore Conformational Space.

Rovers E, Thudi A, Hénin J, Maddison CJ, Schapira M

Journal of chemical theory and computation2025Senior author

DOI: 10.1021/acs.jctc.5c00462 PMID: 40839780

CACHE Challenge #2: Targeting the RNA Site of the SARS-CoV-2 Helicase Nsp13.

Herasymenko O, Silva M, Abu-Saleh AAA, Ahmad A, Alvarado-Huayhuaz J, Arce OEA, Armstrong RJ, Arrowsmith C, Bachta KE, Beck H, Berta D, Bieniek MK, Blay V, Bolotokova A, Bourne PE, Breznik M, Brown PJ, Campbell ADG, Carosati E, Chau I, Cole DJ, Cree B, Dehaen W, Denzinger K, Dos Santos Machado K, Dunn I, Durai P, Edfeldt K, Edwards A, Fayne D, Felfoldi D, Friston K, Ghiabi P, Gibson E, Günther J, Gunnarsson A, Hillisch A, Houston DR, Jensen JH, Harding RJ, Harris KS, Hoffer L, Hogner A, Horton JT, Houliston S, Hultquist JF, Hutchinson A, Irwin JJ, Jukič M, Kandwal S, Karlova A, Katis VL, Kich RP, Kireev D, Koes D, Inniss NL, Lessel U, Liu S, Loppnau P, Lu W, Martino S, McGibbon M, Meiler J, Mettu A, Money-Kyrle S, Moretti R, Moroz YS, Muvva C, Newman JA, Obendorf L, Paige B, Pandit A, Park K, Perveen S, Pirie R, Poda G, Protopopov M, Pütter V, Ricci F, Roper NJ, Rosta E, Rzhetskaya M, Sabnis Y, Satchell KJF, Schmitt Kremer F, Scott T, Seitova A, Steinmann C, Talagayev V, Tarkhanova OO, Tatum NJ, Treleaven D, Velasque Werhli A, Walters WP, Wang X, Wells J, Wells G, Westermaier Y, Wolber G, Wortmann L, Zhang J, Zhao Z, Zheng S, Schapira M

Journal of chemical information and modeling2025Senior author

DOI: 10.1021/acs.jcim.5c00535 PMID: 40539604

Active Learning-Guided Hit Optimization for the Leucine-Rich Repeat Kinase 2 WDR Domain Based on In Silico Ligand-Binding Affinities.

Gusev F, Gutkin E, Gentile F, Ban F, Koby SB, Li F, Chau I, Ackloo S, Arrowsmith CH, Bolotokova A, Ghiabi P, Gibson E, Halabelian L, Houliston S, Harding RJ, Hutchinson A, Loppnau P, Perveen S, Seitova A, Zeng H, Schapira M, Cherkasov A, Isayev O, Kurnikova MG

Journal of chemical information and modeling2025

DOI: 10.1021/acs.jcim.5c00588 PMID: 40415386

Enantioselective Protein Affinity Selection Mass Spectrometry (E-ASMS).

Wang X, Sun J, Ahmad S, Yang D, Li F, Chan UH, Zeng H, Simoben CV, Green SR, Silva M, Houliston S, Dong A, Bolotokova A, Gibson E, Kutera M, Ghiabi P, Kondratov I, Matviyuk T, Chuprina A, Mavridi D, Lenz C, Joerger AC, Brown BD, Heath RB, Yue WW, Robbie LK, Beyett TS, Müller S, Knapp S, Harding R, Schapira M, Brown PJ, Santhakumar V, Ackloo S, Arrowsmith CH, Edwards AM, Peng H, Halabelian L

bioRxiv : the preprint server for biology2025

DOI: 10.1101/2025.01.17.633682 PMID: 39896675

The Need for Continuing Blinded Pose- and Activity Prediction Benchmarks.

Kramer C, Chodera J, Damm-Ganamet KL, Gilson MK, Günther J, Lessel U, Lewis RA, Mobley D, Nittinger E, Pecina A, Schapira M, Walters WP

Journal of chemical information and modeling2025

DOI: 10.1021/acs.jcim.4c02296 PMID: 39951479

Chemical technologies for controlling T cell glycosylation in health and disease

Co-investigatorCIHR2024Project Grant

Principal investigators: Edgar, Landon J

Keywords: Autoimmunity; Cancer; Dendritic Cells; Glycocalyx; Glycosylation; Glycosyltransferases; Immunostimulant; Nucleotide Sugars; Sialic Acid; T Cells

$956,250

A pan-Canadian chemical library to explore uncharted chemistry space for drug discovery

Nominated PICIHR2023Project Grant

Principal investigators: Schapira, Matthieu

Keywords: Artificial Intelligence; Biophysical Assays; Chemical Library; Chemical Reaction; Chemical Synthesis; Cheminformatics; Drug Discovery; Virtual Screening

$1,189,575

Development and Characterization of Novel CB1 Allosteric Modulators

Co-investigatorCIHR2020Project Grant

Principal investigators: Ross, Ruth A

Keywords: Cannabinoid; Drug Discovery; Mental Health

$765,000

Integrating druggability and genetic variability of coronavirus genomes to inform drug discovery against COVID-19 and future pandemic threats_x000d_ _x000d_ _x000d_ _x000d_

Principal investigatorNSERC2020Alliance Grants

Principal investigators: Schapira, Matthieu

$50,000

Developing an integrative bioinformatic approach for the selection of therapeutic targets

Principal investigatorNSERC2019Discovery Grants Program - Individual

Principal investigators: Schapira, Matthieu

Keywords: Bioinformatics; Chemical biology; Structural biology

$252,000

Developing an integrative bioinformatic approach for the selection of therapeutic targets

Principal investigatorNSERC2018Discovery Grants Program - Individual

Principal investigators: Schapira, Matthieu

$23,000

Molecular and cellular mechanisms of dopamine transporter pharmacological chaperones.

Co-investigatorCIHR2018Project Grant

Principal investigators: Salahpour, Ali

Keywords: Bupropion; Dopamine Transporter Deficiency Syndrome; Dopamine Transporter,; Ibogaine; Pharmacological Chaperones; Protein Trafficking

$791,775

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Profile data last refreshed on September 26, 2026 from the university directory, publication records and CIHR, NSERC and SSHRC funding.

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Matthieu Schapira

Research

Latest papers

Latest funding

Targeting the RNA-Binding Site of SARS-CoV-2 NSP13 by FRASE-bot in CACHE Challenge #2.

Development of a Dual Chemical Probe for the USP16 and HDAC6 Zinc-Finger Ubiquitin-Binding Domain.

CACHE Challenge #3: Targeting the Nsp3 Macrodomain of SARS-CoV-2.

Enantioselective protein affinity selection mass spectrometry (E-ASMS).

Structure-based discovery of inhibitors of Mac1 domain of nonstructural protein-3 of SARS-CoV-2 by machine learning-augmented screening of chemical space.

k-Nearest Neighbor Adaptive Sampling, a Simple Tool to Efficiently Explore Conformational Space.

CACHE Challenge #2: Targeting the RNA Site of the SARS-CoV-2 Helicase Nsp13.

Active Learning-Guided Hit Optimization for the Leucine-Rich Repeat Kinase 2 WDR Domain Based on In Silico Ligand-Binding Affinities.

Enantioselective Protein Affinity Selection Mass Spectrometry (E-ASMS).

The Need for Continuing Blinded Pose- and Activity Prediction Benchmarks.

Chemical technologies for controlling T cell glycosylation in health and disease

A pan-Canadian chemical library to explore uncharted chemistry space for drug discovery

Development and Characterization of Novel CB1 Allosteric Modulators

Integrating druggability and genetic variability of coronavirus genomes to inform drug discovery against COVID-19 and future pandemic threats_x000d_ _x000d_ _x000d_ _x000d_

Developing an integrative bioinformatic approach for the selection of therapeutic targets

Developing an integrative bioinformatic approach for the selection of therapeutic targets

Molecular and cellular mechanisms of dopamine transporter pharmacological chaperones.

Frequent collaborators

Dalia Barsyte-Lovejoy

Jinrong Min

Cheryl Arrowsmith

Francesco Gentile

Ahmed Aman

Artem Cherkasov

Rachel Harding

Aled Edwards

Anne-Claude Gingras

Vijay Shahani

Hui Peng

Brian Wilson

Yoshua Bengio

Rongmin Zhao

Colby Zaph

Ruth Ross

Mathieu Lupien

Ray Truant

Ali Salahpour

Benjamin Haibe-Kains

Yufeng Tong