Hong Ling, Western University

Research

Read how they describe their research on their Western University profile.

Biochemical

Latest papers

The trimeric Shu complex in C. elegans is an ATPase that remodels RAD51 filaments in the homologous recombination-associated DNA damage response.
The FEBS journal · 2026 · senior author
The role of human Shu complex in ATP-dependent regulation of RAD51 filaments during homologous recombination-associated DNA damage response.
The Journal of biological chemistry · 2025 · senior author
The Shu complex is an ATPase that regulates Rad51 filaments during homologous recombination in the DNA damage response.
DNA repair · 2025 · senior author

All 23 publications

Latest funding

Preparative Ultracentrifuge and Rotors for Western BioCORE Facility
NSERC · 2023 · Co-investigator
$128,886
Bio--Layer interferometry system for biomolecular interaction analysis
NSERC · 2021 · Co-investigator
$150,000
A nano-LC system to enable functional proteomics research
NSERC · 2020 · Co-investigator
$137,302

All 9 grants and awards

23 publications.

01

The trimeric Shu complex in C. elegans is an ATPase that remodels RAD51 filaments in the homologous recombination-associated DNA damage response.

Chu SSH, Xing G, Paik K, Gartner A, Ling H

The FEBS journal2026Senior author

DOI: 10.1111/febs.70671 PMID: 42545832

02

The role of human Shu complex in ATP-dependent regulation of RAD51 filaments during homologous recombination-associated DNA damage response.

Chu SSH, Xing G, Ling H

The Journal of biological chemistry2025Senior author

DOI: 10.1016/j.jbc.2025.110212 PMID: 40345587

03

The Shu complex is an ATPase that regulates Rad51 filaments during homologous recombination in the DNA damage response.

Chu SSH, Xing G, Jha VK, Ling H

DNA repair2025Senior author

DOI: 10.1016/j.dnarep.2024.103792 PMID: 39647428

04

Annexin A5 Inhibits Endothelial Inflammation Induced by Lipopolysaccharide-Activated Platelets and Microvesicles via Phosphatidylserine Binding.

Tschirhart BJ, Lu X, Gomes J, Chandrabalan A, Bell G, Hess DA, Xing G, Ling H, Burger D, Feng Q

Pharmaceuticals (Basel, Switzerland)2023

DOI: 10.3390/ph16060837 PMID: 37375784

05

2.0 Å resolution crystal structure of human polκ reveals a new catalytic function of N-clasp in DNA replication.

Jha V, Ling H

Scientific reports2018Senior author

DOI: 10.1038/s41598-018-33371-5 PMID: 30310122

06

Structural Basis for Human DNA Polymerase Kappa to Bypass Cisplatin Intrastrand Cross-Link (Pt-GG) Lesion as an Efficient and Accurate Extender.

Jha V, Ling H

Journal of molecular biology2018Senior author

DOI: 10.1016/j.jmb.2018.04.023 PMID: 29715472

07

Mechanism of Error-Free DNA Replication Past Lucidin-Derived DNA Damage by Human DNA Polymerase κ.

Yockey OP, Jha V, Ghodke PP, Xu T, Xu W, Ling H, Pradeepkumar PI, Zhao L

Chemical research in toxicology2017

DOI: 10.1021/acs.chemrestox.7b00227 PMID: 28972744

08

Structural basis of accurate replication beyond a bulky major benzo[a]pyrene adduct by human DNA polymerase kappa.

Jha V, Ling H

DNA repair2017Senior author

DOI: 10.1016/j.dnarep.2016.11.001 PMID: 27894903

09

Structure and mechanism of error-free replication past the major benzo[a]pyrene adduct by human DNA polymerase κ.

Jha V, Bian C, Xing G, Ling H

Nucleic acids research2016Senior author

DOI: 10.1093/nar/gkw204 PMID: 27034468

10

Attenuating Ischemia-Reperfusion Injury in Kidney Transplantation by Perfusing Donor Organs With siRNA Cocktail Solution.

Zheng X, Zang G, Jiang J, He W, Johnston NJ, Ling H, Chen R, Zhang X, Liu Y, Haig A, Luke P, Jevnikar AM, Min WP

Transplantation2016

DOI: 10.1097/tp.0000000000000960 PMID: 26998850

Preparative Ultracentrifuge and Rotors for Western BioCORE Facility

Co-investigatorNSERC2023Research Tools and Instruments

Principal investigators: Shilton, Brian

$128,886

Bio--Layer interferometry system for biomolecular interaction analysis

Co-investigatorNSERC2021Research Tools and Instruments

Principal investigators: Choy, Wing-Yiu

$150,000

A nano-LC system to enable functional proteomics research

Co-investigatorNSERC2020Research Tools and Instruments

Principal investigators: Li, Shawn

$137,302

Molecular Mechanism of Error-free DNA Damage Response

Principal investigatorNSERC2019Discovery Grants Program - Individual

Principal investigators: Ling, Hong

$192,000

High-throughput Crystallization Imaging System

Co-investigatorNSERC2019Research Tools and Instruments

Principal investigators: Shaw, Gary

$149,165

Operations and Maintenance Support for a Regional Protein Characterization Facility

Co-investigatorNSERC2017Research Tools and Instruments

Principal investigators: Junop, Murray

$144,600

Molecular Mechanism of Error-free DNA Damage Tolerance

Principal investigatorNSERC2014Discovery Grants Program - Individual

Principal investigators: Ling, Hong

$235,000

Translesion DNA Replication and its Regulation

Nominated PICIHR2013Operating Grant

Principal investigators: Ling, Hong

Keywords: Biochemical

$906,525

Y-family polymerases and co-factors in translesion DNA replication and mutagenesis

Nominated PICIHR2008Operating Grant

Principal investigators: Ling, Hong

Keywords: Cancer; Carcinogenesis; Chromotography; Dna Damage; Dna Replication; X-Ray Crystallography

$633,680

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

PATHOLOGY & LABORATORY MEDICINE, Western University
Physiology and Pharmacology
Department of Surgery
Biochemistry
Surgery
Cellular and Molecular Medicine
Other

Co-authors at Western University, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Qingping Feng

Physiology and Pharmacology

1 shared papers, latest 2023

Dylan Burger

Cellular and Molecular Medicine

1 shared papers, latest 2023

Patrick Luke

Department of Surgery

1 shared papers, latest 2016

Bertha Garcia

PATHOLOGY & LABORATORY MEDICINE, Western University

1 shared papers, latest 2010

Aaron Haig

PATHOLOGY & LABORATORY MEDICINE, Western University

1 shared papers, latest 2016

Weiping Min

Department of Surgery

1 shared papers, latest 2013

Bradley Urquhart

Physiology and Pharmacology

1 shared papers, latest 2013

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their NSERC grant from 2019

Subject: Prospective PhD student: Biochemical Dear Professor Ling, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "The trimeric Shu complex in C. elegans is an ATPase that remodels RAD51 filaments in the homologous recombination-associated DNA damage response." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your NSERC-funded project "Molecular Mechanism of Error-free DNA Damage Response" (2019), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

Hong Ling

Research

Latest papers

Latest funding

The trimeric Shu complex in C. elegans is an ATPase that remodels RAD51 filaments in the homologous recombination-associated DNA damage response.

The role of human Shu complex in ATP-dependent regulation of RAD51 filaments during homologous recombination-associated DNA damage response.

The Shu complex is an ATPase that regulates Rad51 filaments during homologous recombination in the DNA damage response.

Annexin A5 Inhibits Endothelial Inflammation Induced by Lipopolysaccharide-Activated Platelets and Microvesicles via Phosphatidylserine Binding.

2.0 Å resolution crystal structure of human polκ reveals a new catalytic function of N-clasp in DNA replication.

Structural Basis for Human DNA Polymerase Kappa to Bypass Cisplatin Intrastrand Cross-Link (Pt-GG) Lesion as an Efficient and Accurate Extender.

Mechanism of Error-Free DNA Replication Past Lucidin-Derived DNA Damage by Human DNA Polymerase κ.

Structural basis of accurate replication beyond a bulky major benzo[a]pyrene adduct by human DNA polymerase kappa.

Structure and mechanism of error-free replication past the major benzo[a]pyrene adduct by human DNA polymerase κ.

Attenuating Ischemia-Reperfusion Injury in Kidney Transplantation by Perfusing Donor Organs With siRNA Cocktail Solution.

Preparative Ultracentrifuge and Rotors for Western BioCORE Facility

Bio--Layer interferometry system for biomolecular interaction analysis

A nano-LC system to enable functional proteomics research

Molecular Mechanism of Error-free DNA Damage Response

High-throughput Crystallization Imaging System

Operations and Maintenance Support for a Regional Protein Characterization Facility

Molecular Mechanism of Error-free DNA Damage Tolerance

Translesion DNA Replication and its Regulation

Y-family polymerases and co-factors in translesion DNA replication and mutagenesis

Frequent collaborators

Xiufen Zheng

Qingping Feng

Dylan Burger

Patrick Luke

Bertha Garcia

Aaron Haig

James Koropatnick

Weiping Min

Bradley Urquhart

Hong Ling

Research

Latest papers

Latest funding

The trimeric Shu complex in C. elegans is an ATPase that remodels RAD51 filaments in the homologous recombination-associated DNA damage response.

The role of human Shu complex in ATP-dependent regulation of RAD51 filaments during homologous recombination-associated DNA damage response.

The Shu complex is an ATPase that regulates Rad51 filaments during homologous recombination in the DNA damage response.

Annexin A5 Inhibits Endothelial Inflammation Induced by Lipopolysaccharide-Activated Platelets and Microvesicles via Phosphatidylserine Binding.

2.0&#x2009;&#xc5; resolution crystal structure of human pol&#x3ba; reveals a new catalytic function of N-clasp in DNA replication.

Structural Basis for Human DNA Polymerase Kappa to Bypass Cisplatin Intrastrand Cross-Link (Pt-GG) Lesion as an Efficient and Accurate Extender.

Mechanism of Error-Free DNA Replication Past Lucidin-Derived DNA Damage by Human DNA Polymerase &#x3ba;.

Structural basis of accurate replication beyond a bulky major benzo[a]pyrene adduct by human DNA polymerase kappa.

Structure and mechanism of error-free replication past the major benzo[a]pyrene adduct by human DNA polymerase &#x3ba;.

Attenuating Ischemia-Reperfusion Injury in Kidney Transplantation by Perfusing Donor Organs With siRNA Cocktail Solution.

Preparative Ultracentrifuge and Rotors for Western BioCORE Facility

Bio--Layer interferometry system for biomolecular interaction analysis

A nano-LC system to enable functional proteomics research

Molecular Mechanism of Error-free DNA Damage Response

High-throughput Crystallization Imaging System

Operations and Maintenance Support for a Regional Protein Characterization Facility

Molecular Mechanism of Error-free DNA Damage Tolerance

Translesion DNA Replication and its Regulation

Y-family polymerases and co-factors in translesion DNA replication and mutagenesis

Frequent collaborators

Xiufen Zheng

Qingping Feng

Dylan Burger

Patrick Luke

Bertha Garcia

Aaron Haig

James Koropatnick

Weiping Min

Bradley Urquhart

2.0 Å resolution crystal structure of human polκ reveals a new catalytic function of N-clasp in DNA replication.

Mechanism of Error-Free DNA Replication Past Lucidin-Derived DNA Damage by Human DNA Polymerase κ.

Structure and mechanism of error-free replication past the major benzo[a]pyrene adduct by human DNA polymerase κ.