Lyle Muller, Western University

Research

Computational neuroscience Human memory Network theory Nonlinear dynamics Spiking neural networks Theoretical neuroscience Visual neuroscience Memory

Latest papers

Characterizing functional connectivity alterations in functional/ dissociative seizures using resting-state and naturalistic fMRI.
Epilepsy & behavior : E&B · 2026
Diversity of Layer 3 Pyramidal Neuron Properties Across Areas of the Primate Neocortex.
Biological psychiatry · 2026
Hypothalamic recurrent inhibition regulates functional states of stress effector neurons.
Cell reports · 2026

All 22 publications

Latest funding

Bridging Neuronal Activity and Excitability: A Multiscale Approach to Brain Cortex Investigation
NSERC · 2025 · Co-investigator
$150,000
Elucidating neuron-network interactions regulating stress sensitivity
CIHR · 2025 · Co-investigator
$1,201,050
Analyzing neural traveling waves (nTWs) in sleep spindles as a biological mechanism for human memory consolidation in sleep
CIHR · 2024 · Nominated PI
$692,325

All 7 grants and awards

22 publications.

01

Characterizing functional connectivity alterations in functional/ dissociative seizures using resting-state and naturalistic fMRI.

Moscol G, Castrilli B, Bucha Jain P, Mofrad MH, Jafari A, Aur D, Yartey E, Muller L, Khan AR, Johnsrude IS, Kasa LW, Menon RS, Mirsattari SM

Epilepsy & behavior : E&B2026

DOI: 10.1016/j.yebeh.2026.111189 PMID: 42456416

02

Diversity of Layer 3 Pyramidal Neuron Properties Across Areas of the Primate Neocortex.

Gonzalez-Burgos G, Benavides-Piccione R, Neef A, Inoue W, Muller L, Jimenez-Sosa MS, Staiger JF, Medalla M, Luebke JI

Biological psychiatry2026

DOI: 10.1016/j.biopsych.2026.08.015 PMID: 42660219

03

Hypothalamic recurrent inhibition regulates functional states of stress effector neurons.

Ichiyama A, Mestern S, Füzesi T, Allman BL, Nicola W, Bains JS, Muller L, Inoue W

Cell reports2026

DOI: 10.1016/j.celrep.2026.117741 PMID: 42536483

04

A Spatiotemporal Perspective on Dynamical Computation in Neural Information Processing Systems.

Keller TA, Muller L, Sejnowski TJ, Welling M

ArXiv2026

DOI: 10.1016/s0002-9394(41)91363-6 PMID: 41675349

05

Focal control of non-invasive deep brain stimulation using multipolar temporal interference.

Botzanowski B, Acerbo E, Lehmann S, Kearsley SL, Steiner M, Neufeld E, Missey F, Muller L, Jirsa V, Corneil BD, Williamson A

Bioelectronic medicine2025

DOI: 10.1186/s42234-025-00169-6 PMID: 40140933

06

Dynamical properties and mechanisms of metastability: A perspective in neuroscience.

Rossi KL, Budzinski RC, Medeiros ES, Boaretto BRR, Muller L, Feudel U

Physical review. E2025

DOI: 10.1103/physreve.111.021001 PMID: 40103058

07

Transformers and cortical waves: encoders for pulling in context across time.

Muller L, Churchland PS, Sejnowski TJ

Trends in neurosciences2024First author

DOI: 10.1016/j.tins.2024.08.006 PMID: 39341729

08

Horizontal cortical connections shape intrinsic traveling waves into feature-selective motifs that regulate perceptual sensitivity.

Davis ZW, Busch A, Steward C, Muller L, Reynolds J

Cell reports2024

DOI: 10.1016/j.celrep.2024.114707 PMID: 39243374

09

Neuronal activation sequences in lateral prefrontal cortex encode visuospatial working memory during virtual navigation.

Busch A, Roussy M, Luna R, Leavitt ML, Mofrad MH, Gulli RA, Corrigan B, Mináč J, Sachs AJ, Palaniyappan L, Muller L, Martinez-Trujillo JC

Nature communications2024

DOI: 10.1038/s41467-024-48664-9 PMID: 38796480

10

Primacy of vision shapes behavioral strategies and neural substrates of spatial navigation in marmoset hippocampus.

Piza DB, Corrigan BW, Gulli RA, Do Carmo S, Cuello AC, Muller L, Martinez-Trujillo J

Nature communications2024

DOI: 10.1038/s41467-024-48374-2 PMID: 38744848

Bridging Neuronal Activity and Excitability: A Multiscale Approach to Brain Cortex Investigation

Co-investigatorNSERC2025Research Tools and Instruments

Principal investigators: Pellegrino, Giovanni

Keywords: neuroscience; brain; cortex; neurons; activity; excitability; tms; eeg; fmri; imaging

$150,000

Elucidating neuron-network interactions regulating stress sensitivity

Co-investigatorCIHR2025Project Grant

Principal investigators: Inoue, Wataru

Keywords: Corticotropin Releasing Hormone; Hypothalamus; In Vivo Electrophysiology; Intrinsic Excitability; Major Depression; Neural Circuit Model; Neuroendocrine; Patch Clamp Electrophysiology; Stress; Synaptic Plasticity

$1,201,050

Analyzing neural traveling waves (nTWs) in sleep spindles as a biological mechanism for human memory consolidation in sleep

Nominated PICIHR2024Project Grant

Principal investigators: Muller, Lyle

Keywords: Computational Neuroscience; Memory; Memory Consolidation; Sleep

$692,325

High resolution microelectrode arrays for mapping and manipulation of brain microcircuits

Co-investigatorNSERC2023Research Tools and Instruments

Principal investigators: Martinez-Trujillo, Julio

$150,000

Spatiotemporal dynamics in cortex: new computational techniques and mathematical models

Principal investigatorNSERC2023Discovery Launch Supplement

Principal investigators: Muller, Lyle

$12,500

Spatiotemporal dynamics in cortex: new computational techniques and mathematical models

Principal investigatorNSERC2023Discovery Grants Program - Individual

Principal investigators: Muller, Lyle

Keywords: computational neuroscience; theoretical neuroscience; network theory; nonlinear dynamics; spiking neural networks; visual neuroscience; human memory

$98,000

NEURONEX: The fabric of the primate neocortex and the origin of mental representations. From transcriptomics to single neurons and neuronal networks.

Nominated PICIHR2019Team Grant: Next Generation Networks for Neuroscience (NeuroNex)

Principal investigators: Muller, Lyle

Keywords: Cell-Type Specific Models; Computational Neuroscience; Heterogeneous Networks; Multi-Scale Modeling; Network Dynamics; Working Memory

$625,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Physiology and Pharmacology
Mathematics
Clinical sciences
Developmental and Stem Cell Biology
Department of Psychiatry
Cell Biology and Anatomy

Co-authors at Western University, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Julio Martinez-Trujillo

Physiology and Pharmacology

3 shared papers, latest 2024

Wataru Inoue

Physiology and Pharmacology

3 shared papers, latest 2026

Ana Suller Marti

Clinical sciences

1 shared papers, latest 2022

Wilten Nicola

Cell Biology and Anatomy

1 shared papers, latest 2026

James Ellis

Developmental and Stem Cell Biology

1 shared papers, latest 2022

Lena Palaniyappan

Department of Psychiatry

1 shared papers, latest 2024

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2024

Subject: Prospective PhD student: Computational neuroscience Dear Professor Muller, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Characterizing functional connectivity alterations in functional/ dissociative seizures using resting-state and naturalistic fMRI." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Analyzing neural traveling waves (nTWs) in sleep spindles as a biological mechanism for human memory consolidation in sleep" (2024), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]