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Wataru Inoue

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Associate ProfessorDepartment of Physiology and PharmacologyWestern University

Wataru Inoue

Associate Professor

Department of Physiology and Pharmacology

Schulich School of Medicine & Dentistry

Western University

London, Ontario, Canada

Supervision signals

Professors usually supervise graduate students in their department's programs.
15 publications in the last five years, latest in 2026.
Senior (last) author on 2 recent papers, a sign of leading a research group.
Principal investigator on 6 research grants (5 CIHR, 1 NSERC), most recently in 2025.
Supervised 1 trainee who won CIHR awards, most recently in 2019.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

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Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

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Research

Read how they describe their research on their Western University profile.

Stress Neuroendocrine Electrophysiology Major Depression Patch Clamp Electrophysiology Synaptic Plasticity Hypothalamus Intrinsic Excitability

Latest papers

Diversity of Layer 3 Pyramidal Neuron Properties Across Areas of the Primate Neocortex.
Biological psychiatry · 2026
Hypothalamic recurrent inhibition regulates functional states of stress effector neurons.
Cell reports · 2026 · senior author
Prefrontal parvalbumin neurons mediate working memory in a task demand-dependent manner.
Nature communications · 2026

All 26 publications

Latest funding

Elucidating neuron-network interactions regulating stress sensitivity
CIHR · 2025 · Nominated PI
$1,201,050
Elucidating the roles of the prefrontal cortex in behavioral selection under stress.
CIHR · 2024 · Nominated PI
$1,128,375
High resolution microelectrode arrays for mapping and manipulation of brain microcircuits
NSERC · 2023 · Co-investigator
$150,000

All 9 grants and awards

26 publications.

Diversity of Layer 3 Pyramidal Neuron Properties Across Areas of the Primate Neocortex.

Gonzalez-Burgos G, Benavides-Piccione R, Neef A, Inoue W, Muller L, Jimenez-Sosa MS, Staiger JF, Medalla M, Luebke JI

Biological psychiatry2026

DOI: 10.1016/j.biopsych.2026.08.015 PMID: 42660219

Hypothalamic recurrent inhibition regulates functional states of stress effector neurons.

Ichiyama A, Mestern S, Füzesi T, Allman BL, Nicola W, Bains JS, Muller L, Inoue W

Cell reports2026Senior author

DOI: 10.1016/j.celrep.2026.117741 PMID: 42536483

Prefrontal parvalbumin neurons mediate working memory in a task demand-dependent manner.

Dexter TD, Machado MMF, Hamidullah S, Palmer D, Hashad AM, Doyle M, Attard M, Allman BL, Inoue W, Saksida LM, Bussey TJ

Nature communications2026

DOI: 10.1038/s41467-026-73818-2 PMID: 42265093

A dual role of hippocampal perineuronal nets in plasticity and protection is revealed by improvement and impairment of diet-induced memory dysfunction.

Reichelt AC, Hashad AM, Ghosh-Swaby OR, Skirzewski M, Scott GA, Machado M, Kramar CP, Princz-Lebel O, Inoue W, Bussey TJ, Saksida LM

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2026

DOI: 10.1038/s41386-026-02343-z PMID: 41571987

Astrocytic Chromatin Remodeler ATRX Gates Hippocampal Memory Consolidation Through Metabolic and Synaptic Regulation.

Pena-Ortiz MA, Sunstrum JK, Ghahramani A, McConkey H, Dumeaux V, Inoue W, Bérubé NG

Glia2026

DOI: 10.1002/glia.70098 PMID: 41239822

Microglial deficiency in the ATRX chromatin remodeler elicits a viral mimicry immune response that impacts neuronal function and behavior.

Shafiq S, Ghahramani A, Mansour K, Pena-Ortiz M, Sunstrum JK, Pavlovic M, Jiang Y, Rowland ME, Inoue W, Bérubé NG

PLoS biology2025

DOI: 10.1371/journal.pbio.3002659 PMID: 40938932

In Search of Transcriptomic Correlates of Neuronal Firing-Rate Adaptation across Subtypes, Regions and Species: A Patch-seq Analysis.

Meng JH, Kang Y, Lai A, Feyerabend M, Inoue W, Martinez-Trujillo J, Rudy B, Wang XJ

bioRxiv : the preprint server for biology2025

DOI: 10.1101/2024.12.05.627057 PMID: 39713292

Higher dopamine D1 receptor expression in prefrontal parvalbumin neurons underlies higher distractibility in marmosets versus macaques.

Joyce MKP, Ivanov TG, Krienen FM, Mitchell JF, Ma S, Inoue W, Nandy AS, Datta D, Duque A, Arellano JI, Gupta R, Gonzalez-Burgos G, Lewis DA, Sestan N, McCarroll SA, Martinez-Trujillo J, Froudist-Walsh S, Arnsten AFT

Communications biology2025

DOI: 10.1038/s42003-025-08297-0 PMID: 40594842

Investigating microstructural changes between in vivo and perfused ex vivo marmoset brains using oscillating gradient and b-tensor encoded diffusion MRI at 9.4 T.

Santini T, Shim A, Liou JJ, Rahman N, Varela-Mattatall G, Budde MD, Inoue W, Everling S, Baron CA

Magnetic resonance in medicine2025

DOI: 10.1002/mrm.30298 PMID: 39323069

Spike frequency adaptation in primate lateral prefrontal cortex neurons results from interplay between intrinsic properties and circuit dynamics.

Koch NA, Corrigan BW, Feyerabend M, Gulli RA, Jimenez-Sosa MS, Abbass M, Sunstrum JK, Matovic S, Roussy M, Luna R, Mestern SA, Mahmoudian B, Vijayraghavan S, Igarashi H, Pradeepan KS, Assis WJ, Pruszynski JA, Tripathy S, Staiger JF, Gonzalez-Burgos G, Neef A, Treue S, Everling S, Inoue W, Khadra A, Martinez-Trujillo JC

Cell reports2025

DOI: 10.1016/j.celrep.2024.115159 PMID: 39772396

Elucidating neuron-network interactions regulating stress sensitivity

Nominated PICIHR2025Project Grant

Principal investigators: Inoue, Wataru

Keywords: Corticotropin Releasing Hormone; Hypothalamus; In Vivo Electrophysiology; Intrinsic Excitability; Major Depression; Neural Circuit Model; Neuroendocrine; Patch Clamp Electrophysiology; Stress; Synaptic Plasticity

$1,201,050

Elucidating the roles of the prefrontal cortex in behavioral selection under stress.

Nominated PICIHR2024Project Grant

Principal investigators: Inoue, Wataru

Keywords: Animal Behaviour; Cognition; Corticotropin Releasing Hormone; Electrophysiology; Fiber Photometry; Neuromodulator; Prefrontal Cortex; Stress; Touch Screen; Working Memory

$1,128,375

High resolution microelectrode arrays for mapping and manipulation of brain microcircuits

Co-investigatorNSERC2023Research Tools and Instruments

Principal investigators: Martinez-Trujillo, Julio

$150,000

Elucidating the cellular and network mechanisms for stress sensitivity control in the hypothalamus

Nominated PICIHR2021Project Grant

Principal investigators: Inoue, Wataru

Keywords: Electrophysiology; Hypothalamus; Intrinsic Excitability; Neuroendocrine; Plasticity; Stress; Synaptic Transmission

$929,476

Investigating the role of the astrocytic ATRX chromatin factor in memory processes

Co-investigatorCIHR2021Project Grant

Principal investigators: Bérubé, Nathalie G

Keywords: Astrocytes; Behaviour; Cell Biology; Chromatin Remodelling; Epigenetics; Learning And Memory; Transcriptomics

$940,950

NEURONEX: The fabric of the primate neocortex and the origin of mental representations. From transcriptomics to single neurons and neuronal networks.

Nominated PICIHR2019Team Grant: Next Generation Networks for Neuroscience (NeuroNex)

Principal investigators: Inoue, Wataru

Keywords: Circuits; Electrophysiology; Mental Representations; Neocortex; Neurons; Neurotransmitters; Nmdar; Prefrontal Cortex; Primate; Working Memory

$625,000

Investigating brain mechanisms for social interaction and stress

SupervisorCIHR2019Doctoral Research Award: Canada Graduate Scholarships

Principal investigators: Sunstrum, Julia K

Keywords: Cortisol; Electrophysiology; Hpa Axis; Hypothalamus; Marmoset; Oxytocin; Social Interaction; Stress

$105,000

Chronic stress, synaptic remodelling and neuroendocrine adaptation

Nominated PICIHR2016Project Grant

Principal investigators: Inoue, Wataru

Keywords: Glucocorticoids; Glutamate Synapse; Homeostasis; Major Depression; Neuroendocrine; Patch Clamp Electrophysiology; Stress; Stress Disorders; Synaptic Plasticity; The Hpa Axis

$611,600

Biphasic contribution of prostaglandin E2 to the hypothalamic-pituitary-adrenal axis

Principal investigatorNSERC2015Discovery Grants Program - Individual

Principal investigators: Inoue, Wataru

$266,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Profile data last refreshed on November 9, 2025 from the university directory, publication records and CIHR, NSERC and SSHRC funding.

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Wataru Inoue

Research

Latest papers

Latest funding

Diversity of Layer 3 Pyramidal Neuron Properties Across Areas of the Primate Neocortex.

Hypothalamic recurrent inhibition regulates functional states of stress effector neurons.

Prefrontal parvalbumin neurons mediate working memory in a task demand-dependent manner.

A dual role of hippocampal perineuronal nets in plasticity and protection is revealed by improvement and impairment of diet-induced memory dysfunction.

Astrocytic Chromatin Remodeler ATRX Gates Hippocampal Memory Consolidation Through Metabolic and Synaptic Regulation.

Microglial deficiency in the ATRX chromatin remodeler elicits a viral mimicry immune response that impacts neuronal function and behavior.

In Search of Transcriptomic Correlates of Neuronal Firing-Rate Adaptation across Subtypes, Regions and Species: A Patch-seq Analysis.

Higher dopamine D1 receptor expression in prefrontal parvalbumin neurons underlies higher distractibility in marmosets versus macaques.

Investigating microstructural changes between in vivo and perfused ex vivo marmoset brains using oscillating gradient and b-tensor encoded diffusion MRI at 9.4 T.

Spike frequency adaptation in primate lateral prefrontal cortex neurons results from interplay between intrinsic properties and circuit dynamics.

Elucidating neuron-network interactions regulating stress sensitivity

Elucidating the roles of the prefrontal cortex in behavioral selection under stress.

High resolution microelectrode arrays for mapping and manipulation of brain microcircuits

Elucidating the cellular and network mechanisms for stress sensitivity control in the hypothalamus

Investigating the role of the astrocytic ATRX chromatin factor in memory processes

NEURONEX: The fabric of the primate neocortex and the origin of mental representations. From transcriptomics to single neurons and neuronal networks.

Investigating brain mechanisms for social interaction and stress

Chronic stress, synaptic remodelling and neuroendocrine adaptation

Biphasic contribution of prostaglandin E2 to the hypothalamic-pituitary-adrenal axis

Frequent collaborators

Lyle Muller

Julio Martinez-Trujillo

Stefan Everling

Wei-Yang Lu

Shreejoy Tripathy

Argel Aguilar Valles

Wilten Nicola

Vanessa Dumeaux

Daniel Felsky

Melanie Woodin

Junchul Kim

Qingping Feng

Robert Gros

Wataru Inoue

Research

Latest papers

Latest funding

Diversity of Layer 3 Pyramidal Neuron Properties Across Areas of the Primate Neocortex.

Hypothalamic recurrent inhibition regulates functional states of stress effector neurons.

Prefrontal parvalbumin neurons mediate working memory in a task demand-dependent manner.

A dual role of hippocampal perineuronal nets in plasticity and protection is revealed by improvement and impairment of diet-induced memory dysfunction.

Astrocytic Chromatin Remodeler ATRX Gates Hippocampal Memory Consolidation Through Metabolic and Synaptic Regulation.

Microglial deficiency in the ATRX chromatin remodeler elicits a viral mimicry immune response that impacts neuronal function and behavior.

In Search of Transcriptomic Correlates of Neuronal Firing-Rate Adaptation across Subtypes, Regions and Species: A Patch-seq Analysis.

Higher dopamine D1 receptor expression in prefrontal parvalbumin neurons underlies higher distractibility in marmosets versus macaques.

Investigating microstructural changes between in vivo and perfused ex vivo marmoset brains using oscillating gradient and b-tensor encoded diffusion MRI at 9.4&#x2009;T.

Spike frequency adaptation in primate lateral prefrontal cortex neurons results from interplay between intrinsic properties and circuit dynamics.

Elucidating neuron-network interactions regulating stress sensitivity

Elucidating the roles of the prefrontal cortex in behavioral selection under stress.

High resolution microelectrode arrays for mapping and manipulation of brain microcircuits

Elucidating the cellular and network mechanisms for stress sensitivity control in the hypothalamus

Investigating the role of the astrocytic ATRX chromatin factor in memory processes

NEURONEX: The fabric of the primate neocortex and the origin of mental representations. From transcriptomics to single neurons and neuronal networks.

Investigating brain mechanisms for social interaction and stress

Chronic stress, synaptic remodelling and neuroendocrine adaptation

Biphasic contribution of prostaglandin E2 to the hypothalamic-pituitary-adrenal axis

Frequent collaborators

Lyle Muller

Julio Martinez-Trujillo

Stefan Everling

Wei-Yang Lu

Shreejoy Tripathy

Argel Aguilar Valles

Wilten Nicola

Vanessa Dumeaux

Daniel Felsky

Melanie Woodin

Junchul Kim

Qingping Feng

Robert Gros

Investigating microstructural changes between in vivo and perfused ex vivo marmoset brains using oscillating gradient and b-tensor encoded diffusion MRI at 9.4 T.