Faculty profile

Samuel Asfaha

ResearcherMedicineWestern University

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a Western University directory, so their courses may be missing. Find their university profile.

Samuel Asfaha

Researcher

Medicine

Health Sciences

Western University

London, Ontario, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
9 publications in the last five years, latest in 2026.
Senior (last) author on 5 recent papers, a sign of leading a research group.
Principal investigator on 11 research grants (11 CIHR), most recently in 2026.
Supervised 2 trainees who won CIHR awards, most recently in 2023.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

Citations

h-index

Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

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Signals and details

Research

Read how they describe their research on their Western University profile.

Colon Cancer Stem Cells Cancer Colitis Inflammation Transgenic Mice Viral Mimicry Antibiotic Discovery

Latest papers

Viral mimicry acts as a tumor suppressor in colitis.
Nature communications · 2026 · senior author
Development of a tissue-specific bioscaffold for intestinal stem cell culture.
PloS one · 2025 · senior author
Reevaluating Stemness in the Intestinal Crypt.
Gastroenterology · 2025 · first author

All 17 publications

Latest funding

Cell-intrinsic regulation of colorectal cancer stem cells by transposable element-driven viral mimicry
CIHR · 2026 · Nominated PI
$1,074,826
Modifying histones to prevent and treat colon cancer
CIHR · 2025 · Nominated PI
$67,500
Canadian Conference in Organoid Research (CANCOR): "Organoids: Transforming Disease Modelling into Personalized Medicine"
CIHR · 2024 · Co-investigator
$23,000

All 15 grants and awards

17 publications.

Viral mimicry acts as a tumor suppressor in colitis.

Larsen F, Jeong W, Schep D, Good HJ, Shin AE, Zhang L, Derouet MF, Wang TC, Castellani CA, Shooshtari P, Asfaha S

Nature communications2026Senior author

DOI: 10.1038/s41467-026-68850-1 PMID: 41639092

Development of a tissue-specific bioscaffold for intestinal stem cell culture.

Kakar S, Derouet MF, Zhang L, Gillis CJ, Larsen F, Paul A, Flynn LE, Asfaha S

PloS one2025Senior author

DOI: 10.1371/journal.pone.0328898 PMID: 40768435

Reevaluating Stemness in the Intestinal Crypt.

Asfaha S, Jones NL

Gastroenterology2025First author

DOI: 10.1053/j.gastro.2024.09.010 PMID: 39278280

Prostaglandin E2 and Akt Promote Stemness in Apc Mutant Dclk1+ Cells to Give Rise to Colitis-associated Cancer.

Good HJ, Larsen F, Shin AE, Zhang L, Derouet M, Meriwether D, Worthley D, Reddy ST, Wang TC, Asfaha S

Cellular and molecular gastroenterology and hepatology2025Senior author

DOI: 10.1016/j.jcmgh.2025.101469 PMID: 39884575

Cannabis Use in Patients With Inflammatory Bowel Disease Following Legalization of Cannabis in Canada.

Iablokov V, Gregor J, Chande N, Ponich T, Jairath V, Khanna R, Asfaha S

Crohn's & colitis 3602024Senior author

DOI: 10.1093/crocol/otae031 PMID: 38800569

EZH2 inhibition stimulates repetitive element expression and viral mimicry in resting splenic B cells.

Kim SJ, Kiser PK, Asfaha S, DeKoter RP, Dick FA

The EMBO journal2023

DOI: 10.15252/embj.2023114462 PMID: 37934086

Tff2 defines transit-amplifying pancreatic acinar progenitors that lack regenerative potential and are protective against Kras-driven carcinogenesis.

Jiang Z, Wu F, Laise P, Takayuki T, Na F, Kim W, Kobayashi H, Chang W, Takahashi R, Valenti G, Sunagawa M, White RA, Macchini M, Renz BW, Middelhoff M, Hayakawa Y, Dubeykovskaya ZA, Tan X, Chu TH, Nagar K, Tailor Y, Belin BR, Anand A, Asfaha S, Finlayson MO, Iuga AC, Califano A, Wang TC

Cell stem cell2023

DOI: 10.1016/j.stem.2023.07.002 PMID: 37541213

F4/80+Ly6Chigh Macrophages Lead to Cell Plasticity and Cancer Initiation in Colitis.

Shin AE, Tesfagiorgis Y, Larsen F, Derouet M, Zeng PYF, Good HJ, Zhang L, Rubinstein MR, Han YW, Kerfoot SM, Nichols AC, Hayakawa Y, Howlett CJ, Wang TC, Asfaha S

Gastroenterology2023Senior author

DOI: 10.1053/j.gastro.2023.01.002 PMID: 36634827

The Origin and Contribution of Cancer-Associated Fibroblasts in Colorectal Carcinogenesis.

Kobayashi H, Gieniec KA, Lannagan TRM, Wang T, Asai N, Mizutani Y, Iida T, Ando R, Thomas EM, Sakai A, Suzuki N, Ichinose M, Wright JA, Vrbanac L, Ng JQ, Goyne J, Radford G, Lawrence MJ, Sammour T, Hayakawa Y, Klebe S, Shin AE, Asfaha S, Bettington ML, Rieder F, Arpaia N, Danino T, Butler LM, Burt AD, Leedham SJ, Rustgi AK, Mukherjee S, Takahashi M, Wang TC, Enomoto A, Woods SL, Worthley DL

Gastroenterology2022

DOI: 10.1053/j.gastro.2021.11.037 PMID: 34883119

BHLHA15-Positive Secretory Precursor Cells Can Give Rise to Tumors in Intestine and Colon in Mice.

Hayakawa Y, Tsuboi M, Asfaha S, Kinoshita H, Niikura R, Konishi M, Hata M, Oya Y, Kim W, Middelhoff M, Hikiba Y, Higashijima N, Ihara S, Ushiku T, Fukayama M, Tailor Y, Hirata Y, Guha C, Yan KS, Koike K, Wang TC

Gastroenterology2019

DOI: 10.1053/j.gastro.2018.11.024 PMID: 30448068

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Samuel Asfaha

Research

Latest papers

Latest funding

Viral mimicry acts as a tumor suppressor in colitis.

Development of a tissue-specific bioscaffold for intestinal stem cell culture.

Reevaluating Stemness in the Intestinal Crypt.

Prostaglandin E2 and Akt Promote Stemness in Apc Mutant Dclk1+ Cells to Give Rise to Colitis-associated Cancer.

Cannabis Use in Patients With Inflammatory Bowel Disease Following Legalization of Cannabis in Canada.

EZH2 inhibition stimulates repetitive element expression and viral mimicry in resting splenic B cells.

Tff2 defines transit-amplifying pancreatic acinar progenitors that lack regenerative potential and are protective against Kras-driven carcinogenesis.

F4/80+Ly6Chigh Macrophages Lead to Cell Plasticity and Cancer Initiation in Colitis.

The Origin and Contribution of Cancer-Associated Fibroblasts in Colorectal Carcinogenesis.

BHLHA15-Positive Secretory Precursor Cells Can Give Rise to Tumors in Intestine and Colon in Mice.

Cell-intrinsic regulation of colorectal cancer stem cells by transposable element-driven viral mimicry

Modifying histones to prevent and treat colon cancer

Canadian Conference in Organoid Research (CANCOR): "Organoids: Transforming Disease Modelling into Personalized Medicine"

A deep-learning approach to identify inhibitors of adherent-invasive Escherichia coli in the pathogenesis of inflammatory bowel disease

Integrating genome editing and imaging tools into human colonic organoids to study colorectal cancer in preclinical models

Formation of an islet regenerative niche using human mesenchymal stem cell secreted signals

Role of DNA methylation in stemness of tuft cells

Defining the cellular origin of colorectal cancer.

Role of inflammation in Dclk1+ tuft cell-derived colitis-associated cancer

Identification of novel intestinal stem cell targets in colitis and cancer

Frequent collaborators

Vipul Jairath

Parisa Shooshtari

Arghya Paul