Steven Kerfoot, Western University

Research

B Cells Multiple Sclerosis T Cells Inflammation Animal Models Facs Immunofluorescence Microscopy

Latest papers

Turncoat antibodies unmasked in a model of autoimmune demyelination: from biology to therapy.
bioRxiv : the preprint server for biology · 2024
Global pannexin 1 deletion increases tumor-infiltrating lymphocytes in the BRAF/Pten mouse melanoma model.
Molecular oncology · 2024
Opposing Roles for the Related ETS-Family Transcription Factors Spi-B and Spi-C in Regulating B Cell Differentiation and Function.
Frontiers in immunology · 2020

All 4 publications

Latest funding

Guardians of Immunity: Investigating the Reciprocal Influence of Apoptotic Cells and Pathogens on MHC II Regulation and Vesicular Trafficking.
CIHR · 2024 · Co-investigator
$1,055,700
Development of an HIV-1 vaccine with enhanced CD4 engagement and inducing broadly neutralizing antibodies
CIHR · 2024 · Co-investigator
$1,162,800
Multimodal Microplate Reader for Research in Microbiology and Immunology
NSERC · 2022 · Co-investigator
$149,160

All 7 grants and awards

4 publications.

01

Turncoat antibodies unmasked in a model of autoimmune demyelination: from biology to therapy.

Taghipour-Mirakmahaleh R, Morin F, Zhang Y, Bourhoven L, Béland LC, Zhou Q, Jaworski J, Park A, Dominguez JM, Corbeil J, Flanagan EP, Marignier R, Larochelle C, Kerfoot S, Vallières L

bioRxiv : the preprint server for biology2024

DOI: 10.1101/2024.12.03.623846 PMID: 39677612

02

Global pannexin 1 deletion increases tumor-infiltrating lymphocytes in the BRAF/Pten mouse melanoma model.

Sanchez-Pupo RE, Finch GA, Johnston DE, Craig H, Abdo R, Barr K, Kerfoot S, Dagnino L, Penuela S

Molecular oncology2024

DOI: 10.1002/1878-0261.13596 PMID: 38327091

03

Opposing Roles for the Related ETS-Family Transcription Factors Spi-B and Spi-C in Regulating B Cell Differentiation and Function.

Laramée AS, Raczkowski H, Shao P, Batista C, Shukla D, Xu L, Haeryfar SMM, Tesfagiorgis Y, Kerfoot S, DeKoter R

Frontiers in immunology2020

DOI: 10.3389/fimmu.2020.00841 PMID: 32457757

04

ICAM1+ neutrophils promote chronic inflammation via ASPRV1 in B cell-dependent autoimmune encephalomyelitis.

Whittaker Hawkins RF, Patenaude A, Dumas A, Jain R, Tesfagiorgis Y, Kerfoot S, Matsui T, Gunzer M, Poubelle PE, Larochelle C, Pelletier M, Vallières L

JCI insight2017

DOI: 10.1172/jci.insight.96882 PMID: 29212956

Guardians of Immunity: Investigating the Reciprocal Influence of Apoptotic Cells and Pathogens on MHC II Regulation and Vesicular Trafficking.

Co-investigatorCIHR2024Project Grant

Principal investigators: Heit, Bryan J

Keywords: Antigen Presentation; Apoptosis; Autoimmunity; Dendritic Cells; Inflammation; Major Histocompatibility Molecule Type Ii; Pathogens; Rab Gtpases; T Cell Activation; Vesicular Trafficking

$1,055,700

Development of an HIV-1 vaccine with enhanced CD4 engagement and inducing broadly neutralizing antibodies

Co-investigatorCIHR2024Project Grant

Principal investigators: Arts, Eric J

Keywords: Antibody; B Cells; Hiv; Vaccine

$1,162,800

Multimodal Microplate Reader for Research in Microbiology and Immunology

Co-investigatorNSERC2022Research Tools and Instruments

Principal investigators: McCormick, John

$149,160

Defining novel, non-classical roles for tissue-infiltrating B cells in chronic CNS autoimmunity

Nominated PICIHR2020Project Grant

Principal investigators: Kerfoot, Steven

Keywords: B Cells; Inflammation; Multiple Sclerosis; T Cells

$856,800

Upgrades to an advanced multiphoton microscope with unique equipment to improve tissue access for intravital imaging and improved image stability

Principal investigatorNSERC2020Research Tools and Instruments

Principal investigators: Kerfoot, Steven

$105,961

Identifying mechanisms and determinants of T cell control over B cell fate choice in the germinal centre response.

Principal investigatorNSERC2019Discovery Grants Program - Individual

Principal investigators: Kerfoot, Steven

$192,000

Initiating and maintaining central nervous system autoimmunity through interactions between myelin-reactive T and B cells.

Nominated PICIHR2015Operating Grant

Principal investigators: Kerfoot, Steven

Keywords: Animal Models; B Cells; Facs; Immunofluorescence; Microscopy; Multiple Sclerosis; T Cells

$726,200

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Microbiology and Immunology
Neurosciences
Molecular Medicine
Department of Physiology and Pharmacology
Department of Anatomy & Cell Biology

Co-authors at Western University, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Catherine Larochelle

Neurosciences

2 shared papers, latest 2024

Jacques Corbeil

Molecular Medicine

1 shared papers, latest 2024

Silvia Penuela

Department of Anatomy & Cell Biology

1 shared papers, latest 2024

Lina Dagnino

Department of Physiology and Pharmacology

1 shared papers, latest 2024

Martin Pelletier

Microbiology and Immunology

1 shared papers, latest 2017

Rodney DeKoter

Microbiology and Immunology

1 shared papers, latest 2020

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2020

Subject: Prospective PhD student: B Cells Dear Professor Kerfoot, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Turncoat antibodies unmasked in a model of autoimmune demyelination: from biology to therapy." (2024), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Defining novel, non-classical roles for tissue-infiltrating B cells in chronic CNS autoimmunity" (2020), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]