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Silvia Penuela

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Associate ProfessorDepartment of Anatomy & Cell BiologyWestern University

Silvia Penuela

Associate Professor

Department of Anatomy & Cell Biology

Schulich School of Medicine & Dentistry

Western University

London, Ontario, Canada

Supervision signals

Professors usually supervise graduate students in their department's programs.
18 publications in the last five years, latest in 2026.
Senior (last) author on 12 recent papers, a sign of leading a research group.
Principal investigator on 6 research grants (4 CIHR, 2 NSERC), most recently in 2025.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

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Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

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Signals and details

Research

Read how they describe their research on their Western University profile.

Pannexin Cell Communication Channels Melanoma Panx1 Skin Skin Cancer Tumour

Latest papers

From channels to communication networks: a perspective on connexins, pannexins and innexins.
Cell and tissue research · 2026 · senior author
Pannexin 1 phosphorylation sites differentially modulate channel activity and physiological outcomes.
bioRxiv : the preprint server for biology · 2026
Human pannexin mutations and their implications in erosive osteoarthritis.
Proceedings of the National Academy of Sciences of the United States of America · 2026 · senior author

All 56 publications

Latest funding

Proteoforms of PANX1 as novel regulators in melanoma
CIHR · 2025 · Nominated PI
$994,500
Targeting Pannexin-1 Channels in Glioblastoma Multiforme
CIHR · 2022 · Nominated PI
$971,550
Pannexin-2 Channel Regulation and Signalling
NSERC · 2022 · Principal investigator
$120,000

All 8 grants and awards

56 publications.

From channels to communication networks: a perspective on connexins, pannexins and innexins.

Aasen T, Smyth JW, Penuela S

Cell and tissue research2026Senior author

DOI: 10.1007/s00441-026-04095-0 PMID: 42749928

Pannexin 1 phosphorylation sites differentially modulate channel activity and physiological outcomes.

O'Donnell BL, Dunaway LS, Zhang X, Loeb SA, Juśkiewicz ZJ, Schug WJ, Leonhardt SA, Wolpe AG, Luse MA, Bielefeld SC, Boyce AKJ, Williams MD, Billaud M, Best AK, Johnstone SR, Penuela S, Columbus L, Thévenin AF, Thompson RJ, Bayliss DA, Koval M, Isakson BE

bioRxiv : the preprint server for biology2026

DOI: 10.64898/2026.07.12.738047 PMID: 42523382

Human pannexin mutations and their implications in erosive osteoarthritis.

Tang J, Lu J, Johnston D, Hoshijima K, Wakefield B, Bai D, Stathopulos PB, Thompson RJ, Lohman AW, Jurynec MJ, Beier F, Penuela S

Proceedings of the National Academy of Sciences of the United States of America2026Senior author

DOI: 10.1073/pnas.2535302123 PMID: 42127103

Panx3 deficiency in mice impairs bone fracture healing and causes transient hypoglycemia in neonatal animals.

Jiang S, Baranowsky A, Luther J, O'Donnell BL, Wakefield B, Bassen C, Neven M, Eis-Janzyk G, Amling M, Penuela S, Schinke T, Keller J

Molecular medicine (Cambridge, Mass.)2026

DOI: 10.1186/s10020-026-01458-9 PMID: 41857514

Connexin-Pannexin duality in glioblastoma.

Kanji R, Penuela S, Mesnil M

Cell and tissue research2026

DOI: 10.1007/s00441-025-04031-8 PMID: 41543596

Pannexin 1 and pannexin 3 differentially regulate the cancer cell properties of cutaneous squamous cell carcinoma.

O'Donnell BL, Johnston D, Bhatt A, Kardan Z, Stefan D, Bysice A, Sayedyahossein S, Dagnino L, Cecchini M, Loganathan SK, Roth K, Penuela S

The Journal of physiology2025Senior author

DOI: 10.1113/jp286172 PMID: 39560179

Severe osteoarthritis in aged PANX3 knockout mice: implications for a novel primary osteoarthritis model.

Wakefield B, Tang J, Balanta-Melo J, Hutchinson JL, Kanji R, Herold G, O'Donnell BL, Brooks C, Kiser P, Grol MW, Séguin CA, Plotkin LI, Beier F, Penuela S

JBMR plus2025Senior author

DOI: 10.1093/jbmrpl/ziaf057 PMID: 40386290

Pannexin 1 crosstalk with the Hippo pathway in malignant melanoma.

Sayedyahossein S, Huang K, Zhang C, Karimi M, Bahmani M, O'Donnell BL, Wakefield B, Li Z, Johnston D, Leighton SE, Huver MS, Dagnino L, Sacks DB, Penuela S

The FEBS journal2025Senior author

DOI: 10.1111/febs.17396 PMID: 39786847

Pannexin 1 crosstalk with the Hippo pathway in malignant melanoma.

Sayedyahossein S, Huang K, Zhang C, Karimi M, Bahmani M, O'Donnell BL, Wakefield B, Li Z, Johnston D, Leighton SE, Huver MS, Dagnino L, Sacks DB, Penuela S

bioRxiv : the preprint server for biology2024Senior author

DOI: 10.1101/2024.09.03.611059 PMID: 39372769

Pannexin 3 deletion in mice results in knee osteoarthritis and intervertebral disc degeneration after forced treadmill running.

Wakefield B, Tang J, Hutchinson JL, Kanji R, Brooks C, Grol MW, Séguin CA, Penuela S, Beier F

Journal of orthopaedic research : official publication of the Orthopaedic Research Society2024

DOI: 10.1002/jor.25830 PMID: 38499500

Profile data last refreshed on November 9, 2025 from the university directory, publication records and CIHR, NSERC and SSHRC funding.

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Silvia Penuela

Research

Latest papers

Latest funding

From channels to communication networks: a perspective on connexins, pannexins and innexins.

Pannexin 1 phosphorylation sites differentially modulate channel activity and physiological outcomes.

Human pannexin mutations and their implications in erosive osteoarthritis.

Panx3 deficiency in mice impairs bone fracture healing and causes transient hypoglycemia in neonatal animals.

Connexin-Pannexin duality in glioblastoma.

Pannexin 1 and pannexin 3 differentially regulate the cancer cell properties of cutaneous squamous cell carcinoma.

Severe osteoarthritis in aged PANX3 knockout mice: implications for a novel primary osteoarthritis model.

Pannexin 1 crosstalk with the Hippo pathway in malignant melanoma.

Pannexin 1 crosstalk with the Hippo pathway in malignant melanoma.

Pannexin 3 deletion in mice results in knee osteoarthritis and intervertebral disc degeneration after forced treadmill running.

Proteoforms of PANX1 as novel regulators in melanoma

Targeting Pannexin-1 Channels in Glioblastoma Multiforme

Pannexin-2 Channel Regulation and Signalling

The role of Pannexin 3 in aging-associated osteoarthritis

Robotic Instrumentation to Establish Workflows for Systematic Cell-Based Analyses.

Pannexin 1 channels as novel regulators of malignant melanoma

Regulation of Pannexin2 Channels by Post-translational Modifications

The cellular life and function of pannexins

Frequent collaborators

Lina Dagnino

Frank Beier

Donglin Bai

Amira Klip

Robert Gros

Steven Latosinsky

Matthew Cecchini

Patti Kiser

Kathryn Roth

Aymeric Ravel-Chapuis

Lauren Flynn

Steven Kerfoot