Faculty profile
Lina Dagnino
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Read how they describe their research on their Western University profile.
Latest papers
Essential Role of Integrin-Linked Kinase in Keratinocyte Responses to Mechanical Strain.
International journal of molecular sciences · 2026 · senior author
Role of Kindlin-2 in Cutaneous Squamous Carcinoma Cell Migration and Proliferation: Implications for Tumour Progression.
International journal of molecular sciences · 2025 · senior author
Pannexin 1 and pannexin 3 differentially regulate the cancer cell properties of cutaneous squamous cell carcinoma.
The Journal of physiology · 2025
Latest funding
- $2,000,000
Skin Investigation Network of Canada (SkIN Canada): Advancing interdisciplinary, patient-relevant research to improve skin health
CIHR · 2023 · Co-investigator
- $59,761
Roles of microenvironment hyaluronan in preventing skin cancer initiation
CIHR · 2022 · Co-investigator
- $150,000
Microscale thermophoresis for assessing diverse molecular interactions.
NSERC · 2020 · Co-investigator
56 publications.
Essential Role of Integrin-Linked Kinase in Keratinocyte Responses to Mechanical Strain.
Rudkouskaya A, Ivanova IA, Sayedyahossein S, Dagnino L
Role of Kindlin-2 in Cutaneous Squamous Carcinoma Cell Migration and Proliferation: Implications for Tumour Progression.
Dutta A, Calder M, Dagnino L
Pannexin 1 and pannexin 3 differentially regulate the cancer cell properties of cutaneous squamous cell carcinoma.
O'Donnell BL, Johnston D, Bhatt A, Kardan Z, Stefan D, Bysice A, Sayedyahossein S, Dagnino L, Cecchini M, Loganathan SK, Roth K, Penuela S
Pannexin 1 crosstalk with the Hippo pathway in malignant melanoma.
Sayedyahossein S, Huang K, Zhang C, Karimi M, Bahmani M, O'Donnell BL, Wakefield B, Li Z, Johnston D, Leighton SE, Huver MS, Dagnino L, Sacks DB, Penuela S
RNA Interference Approaches to Study Epidermal Cell Adhesion.
Dutta A, Calder M, Dagnino L
β-arrestin 1 and integrin-linked kinase interact in epidermal keratinocytes and regulate cell motility.
Murphy-Marshman H, Ivanova IA, Bhattacharya M, Dagnino L
Pannexin 1 crosstalk with the Hippo pathway in malignant melanoma.
Sayedyahossein S, Huang K, Zhang C, Karimi M, Bahmani M, O'Donnell BL, Wakefield B, Li Z, Johnston D, Leighton SE, Huver MS, Dagnino L, Sacks DB, Penuela S
Ubiquitylated histone H2A: a molecular Jekyll and Hyde in the epidermis.
Dagnino L
Global pannexin 1 deletion increases tumor-infiltrating lymphocytes in the BRAF/Pten mouse melanoma model.
Sanchez-Pupo RE, Finch GA, Johnston DE, Craig H, Abdo R, Barr K, Kerfoot S, Dagnino L, Penuela S
Analysis of Proliferation, Apoptosis, and Motility in Mouse Embryonic Melanocytic Precursor Cells.
Crawford M, Barr K, Dagnino L
Skin Investigation Network of Canada (SkIN Canada): Advancing interdisciplinary, patient-relevant research to improve skin health
Principal investigators: Chan, An-Wen; Manion, Rachael; Drucker, Aaron M; Dutz, Jan P; Fradette, Julie; Germain, Lucie; Gniadecki, Robert; Grimshaw, Jeremy M; Litvinov, Ivan V; Logsetty, Sarvesh; Mydlarski, Paule R; Philip, Anie; Piguet, Vincent; Zhou, Youwen
Keywords: Clinical Trials; Observational Studies; Research Network; Skin Health; Skin Research; Translational Research
Roles of microenvironment hyaluronan in preventing skin cancer initiation
Principal investigators: Turley, Eva A
Keywords: Apoptosis ; Oncogenes And Tumour Suppressors ; Targets And Biomarkers
Microscale thermophoresis for assessing diverse molecular interactions.
Principal investigators: Stathopulos, Peter
Epidermal progenitor cell self-renewal and wound healing
Principal investigators: Dagnino, Lina
Keywords: Epidermal Regeneration; Epidermal Stem Cells; Epidermis; Integrins; Mechanotransduction; Non-Healing Wounds; Proliferation And Differentiation; Wound Healing
Signalling in melanocyte development and melanogenesis
Principal investigators: Dagnino, Lina
Signaling during melanocyte development
Principal investigators: Dagnino, Lina
Pannexin 1 channels as novel regulators of malignant melanoma
Principal investigators: Penuela, Silvia
Keywords: Cell Communication; Channels; Melanoma; Pannexin; Panx1; Skin; Skin Cancer; Trasgenic Mice; Tumour; Xenograft
Modulation of TGF-beta receptor signalling
Principal investigators: Dagnino, Lina
Modulation of TGF-beta signalling
Principal investigators: Dagnino, Lina
Regulation of TGF-beta signaling by focal adhesion proteins
Principal investigators: Dagnino, Lina
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
Frequent collaborators
- Microbiology and Immunology
- Department of Physiology and Pharmacology
- Department of Anatomy & Cell Biology
- Department of Otolaryngology - Head and Neck Surgery
- PATHOLOGY & LABORATORY MEDICINE, Western University
- Physiology and Pharmacology
- Department of Surgery
Co-authors at Western University, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.
Silvia Penuela
Department of Anatomy & Cell Biology
8 shared papers, latest 2025
Kathryn Roth
Department of Otolaryngology - Head and Neck Surgery
1 shared papers, latest 2025
Steven Latosinsky
Department of Surgery
1 shared papers, latest 2019
Matthew Cecchini
PATHOLOGY & LABORATORY MEDICINE, Western University
1 shared papers, latest 2025
Bryan Heit
Microbiology and Immunology
1 shared papers, latest 2020
Steven Kerfoot
Microbiology and Immunology
1 shared papers, latest 2024
Moshmi Bhattacharya
Physiology and Pharmacology
1 shared papers, latest 2025
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Profile data last refreshed on November 9, 2025 from the university directory, publication records and CIHR, NSERC and SSHRC funding.