Faculty profile
Nawwaf Kharma
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Research
Latest papers
Robustness and evolvability: Revisited, redefined and applied.
Bio Systems · 2024 · first author
BioCloneBot: A versatile, low-cost, and open-source automated liquid handler.
HardwareX · 2024
Computational design and experimental verification of pseudoknotted ribozymes.
RNA (New York, N.Y.) · 2023
Latest funding
- $1,067,176
Rationally designed ribozymes switched-on by nucleotide repeat extensions as potential tools of genetic therapy for repeat expansion disorders.
CIHR · 2023 · Principal investigator
- $100,000
Rationally designed ribozymes switched-on by nucleotide repeat extensions as potential tools of genetic therapy for repeat expansion disorders.
CIHR · 2022 · Principal investigator
- $100,000
Rationally designed ribozymes switched-on by nucleotide repeat extensions as potential tools of genetic therapy for repeat expansion disorders.
CIHR · 2022 · Principal investigator
10 publications.
Robustness and evolvability: Revisited, redefined and applied.
Kharma N, Bédard-Couture R
BioCloneBot: A versatile, low-cost, and open-source automated liquid handler.
Wells KC, Kharma N, Jaunky BB, Nie K, Aguiar-Tawil G, Berry D
Computational design and experimental verification of pseudoknotted ribozymes.
Najeh S, Zandi K, Kharma N, Perreault J
Toehold-mediated strand displacement to measure released product from self-cleaving ribozymes.
Kapadia JB, Kharma N, Davis AN, Kamel N, Perreault J
Digital Microfluidics Chips for the Execution and Real-Time Monitoring of Multiple Ribozymatic Cleavage Reactions.
Davis AN, Samlali K, Kapadia JB, Perreault J, Shih SCC, Kharma N
Computer-Aided Design of Active Pseudoknotted Hammerhead Ribozymes.
Najeh S, Zandi K, Djerroud S, Kharma N, Perreault J
RNA-Based Therapy Utilizing Oculopharyngeal Muscular Dystrophy Transcript Knockdown and Replacement.
Abu-Baker A, Kharma N, Perreault J, Grant A, Shekarabi M, Maios C, Dona M, Neri C, Dion PA, Parker A, Varin L, Rouleau GA
An Adaptive Defect Weighted Sampling Algorithm to Design Pseudoknotted RNA Secondary Structures.
Zandi K, Butler G, Kharma N
Automated design of hammerhead ribozymes and validation by targeting the PABPN1 gene transcript.
Kharma N, Varin L, Abu-Baker A, Ouellet J, Najeh S, Ehdaeivand MR, Belmonte G, Ambri A, Rouleau G, Perreault J
Computational simulation of a gene regulatory network implementing an extendable synchronous single-input delay flip-flop.
Hoteit I, Kharma N, Varin L
Rationally designed ribozymes switched-on by nucleotide repeat extensions as potential tools of genetic therapy for repeat expansion disorders.
Principal investigators: Rouleau, Guy A; Kharma, Nawwaf; Perreault, Jonathan
Keywords: Amyotrophic Lateral Sclerosis; Gene Silencing; Huntington Disease; Machado-Joseph Disease; Neurogenerative Disease; Oculopharyngeal Muscular Dystrophy; Pseudoknot; Repeat Expansion; Ribozyme; Trinucleotide Repeats
Rationally designed ribozymes switched-on by nucleotide repeat extensions as potential tools of genetic therapy for repeat expansion disorders.
Principal investigators: Rouleau, Guy A; Kharma, Nawwaf; Perreault, Jonathan
Keywords: Amyotrophic Lateral Sclerosis; Gene Silencing; Huntington Disease; Machado-Joseph Disease; Neurogenerative Disease; Oculopharyngeal Muscular Dystrophy; Pseudoknot; Repeat Expansion; Ribozyme; Trinucleotide Repeats
Rationally designed ribozymes switched-on by nucleotide repeat extensions as potential tools of genetic therapy for repeat expansion disorders.
Principal investigators: Rouleau, Guy A; Kharma, Nawwaf; Perreault, Jonathan
Keywords: Amyotrophic Lateral Sclerosis; Gene Silencing; Huntington Disease; Machado-Joseph Disease; Neurogenerative Disease; Oculopharyngeal Muscular Dystrophy; Pseudoknot; Repeat Expansion; Ribozyme; Trinucleotide Repeats
Novel DNA/RNA-regulated hammerhead ribozymes for biosensor applications
Principal investigators: Kharma, Nawwaf N
Computational Design and Experimental Validation of Switchable Ribozymes
Principal investigators: Kharma, Nawwaf
Keywords: switching ribozymes; selective gene silencing; repeat expansion disorders; evolutionary algorithms; computational design & optimization
Training Program in Synthetic Biology Applications (SynBioApps)
Principal investigators: Whiteway, Malcolm MS
Keywords: biological engineering; cellular modeling; genetic engineering; industrial biotechnology; metabolic engineering; microbiology; molecular biology; sustainability; synthetic biology
Development of Web-services for Automated Design of Catalytic RNA Molecules
Principal investigators: Kharma, Nawwaf
An Improved Sparse Distributed Memory for Anomaly Detection Applications
Principal investigators: Kharma, Nawwaf
Evolutionary Computing Application to Biomedical Image Segmentation
Principal investigators: Kharma, Nawwaf
Ellipzoid 1.0: a multiple population genetic algorithm for detection of multiple elliptic objects in noisy microscopic image
Principal investigators: Kharma, Nawwaf
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
Frequent collaborators
- Guy Rouleau and Alex Parker: 1 shared paper
- Guy Rouleau and Nawwaf Kharma: 1 shared paper
- Alex Parker and Nawwaf Kharma: 1 shared paper
- Gregory Butler and Nawwaf Kharma: 1 shared paper
- Electrical & Computer Engineering
- Neurosciences
- Computer Science and Software Engineering
- Neurology and Neurosurgery
Co-authors at Concordia University, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.
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