This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a Université de Montréal directory, so their courses and email address may be missing. Find their university profile.
Research
Latest papers
Glycerol 3-phosphate phosphatase/PGPH-2 counters metabolic stress and promotes healthy aging via a glycogen sensing-AMPK-HLH-30-autophagy axis in C. elegans.
Nature communications · 2023
RNA-Based Therapy Utilizing Oculopharyngeal Muscular Dystrophy Transcript Knockdown and Replacement.
Molecular therapy. Nucleic acids · 2019
Valproic acid is protective in cellular and worm models of oculopharyngeal muscular dystrophy.
Neurology · 2018
Latest funding
- $952,425
Impact of lipid metabolism in neurodegeneration models
CIHR · 2025 · Nominated PI
- $1,067,176
Rationally designed ribozymes switched-on by nucleotide repeat extensions as potential tools of genetic therapy for repeat expansion disorders.
CIHR · 2023 · Co-investigator
- $703,800
Investigating neuroprotective strategies in genetic models of neurodegeneration
CIHR · 2023 · Nominated PI
3 publications.
Glycerol 3-phosphate phosphatase/PGPH-2 counters metabolic stress and promotes healthy aging via a glycogen sensing-AMPK-HLH-30-autophagy axis in C. elegans.
Possik E, Klein LL, Sanjab P, Zhu R, Côté L, Bai Y, Zhang D, Sun H, Al-Mass A, Oppong A, Ahmad R, Parker A, Madiraju SRM, Al-Mulla F, Prentki M
RNA-Based Therapy Utilizing Oculopharyngeal Muscular Dystrophy Transcript Knockdown and Replacement.
Abu-Baker A, Kharma N, Perreault J, Grant A, Shekarabi M, Maios C, Dona M, Neri C, Dion PA, Parker A, Varin L, Rouleau GA
Valproic acid is protective in cellular and worm models of oculopharyngeal muscular dystrophy.
Abu-Baker A, Parker A, Ramalingam S, Laganiere J, Brais B, Neri C, Dion P, Rouleau G
Impact of lipid metabolism in neurodegeneration models
Principal investigators: Parker, Alex J
Keywords: Aging; C. Elegans; Cell Signalling; Lipids; Microbiome; Neurodegeneration
Rationally designed ribozymes switched-on by nucleotide repeat extensions as potential tools of genetic therapy for repeat expansion disorders.
Principal investigators: Rouleau, Guy A; Kharma, Nawwaf; Perreault, Jonathan
Keywords: Amyotrophic Lateral Sclerosis; Gene Silencing; Huntington Disease; Machado-Joseph Disease; Neurogenerative Disease; Oculopharyngeal Muscular Dystrophy; Pseudoknot; Repeat Expansion; Ribozyme; Trinucleotide Repeats
Investigating neuroprotective strategies in genetic models of neurodegeneration
Principal investigators: Parker, Alex J
Keywords: Amyotrophic Lateral Sclerosis; Axon Degeneration; C. Elegans; Cellular Models; Frontotemporal Dementia; Genetic Signalling; Genetics; Neurodegeneration; Small Molecules
Investigating neuroprotective strategies in genetic models of neurodegeneration
Principal investigators: Parker, Alex J
Keywords: Age-Dependent Neurodegeneration; Axon Degeneration; C. Elegans; Cell Signalling; Genetics; Small Molecules
Rationally designed ribozymes switched-on by nucleotide repeat extensions as potential tools of genetic therapy for repeat expansion disorders.
Principal investigators: Rouleau, Guy A; Kharma, Nawwaf; Perreault, Jonathan
Keywords: Amyotrophic Lateral Sclerosis; Gene Silencing; Huntington Disease; Machado-Joseph Disease; Neurogenerative Disease; Oculopharyngeal Muscular Dystrophy; Pseudoknot; Repeat Expansion; Ribozyme; Trinucleotide Repeats
Proteotoxic regulation of neurodegeneration by TIR-1/Sarm1
Principal investigators: Parker, Alex
Novel C. elegans and zebrafish models of neuronal nicotinamide-N-methyltransferase to study dopaminergic neurodegeneration underlying Parkinson's disease
Principal investigators: Schmeisser, Kathrin
Keywords: Aging; C. Elegans; D. Rerio; Neurodegeneration; Neurotoxins; Nicotinamide-N-Methyltransferase; Parkinson'S Disease
Chemical-genetics approaches using in vivo models of age-dependent neurodegeneration
Principal investigators: Parker, Alex J
Keywords: Amyotrophic Lateral Sclerosis; C. Elegans; Chemical Screen; Genetics; Huntington'S Disease; Neurodegeneration
Investigating the Role of TDP-43 in Polyglutamine Toxicity
Principal investigators: Julien, Carl
Keywords: Amyotrophic Lateral Sclerosis; Drug Screening; Exome Sequencing; Functional Studies; Gene Identification; Genetic Testing; Hereditary Spastic Paraplegia; Huntington'S Disease; Mutation Detection; Standardisation Of Diagnosis
Emerging Team to identify and characterize novel and existing Hereditary Spastic Paraplegia (HSP) disease genes.
Principal investigators: Rouleau, Guy A
Keywords: Drug Screening; Exome Sequencing; Functional Studies; Gene Identification; Genetic Testing; Hereditary Spastic Paraplegia; Mutation Detection; Standardisation Of Diagnosis
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
Frequent collaborators
- Neurology and Neurosurgery
- Neurosciences
- Nutrition
Co-authors at Université de Montréal, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.
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