This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a McGill University directory, so their courses may be missing. Find their university profile.
Research
Latest papers
The Recycling Endosomal (Na+, K+)/H+ Exchanger NHE6/SLC9A6 Facilitates Signal Transduction by Shuttling Cyclin-Dependent Kinase 5 to the Plasma Membrane.
Acta physiologica (Oxford, England) · 2026 · senior author
Pain experience of children with Christianson syndrome.
Pain · 2025
Impaired hippocampal plasticity associated with loss of recycling endosomal SLC9A6/NHE6 is ameliorated by the TrkB agonist 7,8-dihydroxyflavone.
Biochimica et biophysica acta. Molecular basis of disease · 2025
Latest funding
- $1,021,276
Mechanisms of Sensory Dysfunction in Christianson Syndrome
CIHR · 2019 · Nominated PI
- $918,000
Roles of Alkali Cation/Proton Exchangers in Organellar Function and Neurodevelopmental Disorders
CIHR · 2017 · Nominated PI
- $7,500
Support for 2nd International Basic Science and Clinical Conference on Christianson Syndrome
CIHR · 2017 · Nominated PI
29 publications.
The Recycling Endosomal (Na+, K+)/H+ Exchanger NHE6/SLC9A6 Facilitates Signal Transduction by Shuttling Cyclin-Dependent Kinase 5 to the Plasma Membrane.
Flessner R, Ilie A, Han L, Boucher A, McKinney RA, Sharif-Naeini R, Orlowski J
Pain experience of children with Christianson syndrome.
Premachandran S, Ocay DD, Beaulieu C, Balduzzi J, Ye DL, Davidova A, Bokhari R, Ouellet JA, Orlowski J, Gendron L, Sharif-Naeini R, Ferland CE
Impaired hippocampal plasticity associated with loss of recycling endosomal SLC9A6/NHE6 is ameliorated by the TrkB agonist 7,8-dihydroxyflavone.
Gao AYL, Inglebert Y, Shi R, Ilie A, Popic J, Mustian J, Sonenberg N, Orlowski J, McKinney RA
Nuclear SMAD5 dances to a different tune in regulating insulin secretion.
Orlowski J
Determinants, maintenance, and function of organellar pH.
Freeman SA, Grinstein S, Orlowski J
Structural basis of autoinhibition of the human NHE3-CHP1 complex.
Dong Y, Li H, Ilie A, Gao Y, Boucher A, Zhang XC, Orlowski J, Zhao Y
Roles of Endomembrane Alkali Cation/Proton Exchangers in Synaptic Function and Neurodevelopmental Disorders.
Gao AYL, Lourdin-De Filippis E, Orlowski J, McKinney RA
Sleep and daytime behavior in individuals with Christianson Syndrome.
Gruber R, Scholes S, Bertone A, McKinney RA, Orlowski J, Wise MS
Structure and mechanism of the human NHE1-CHP1 complex.
Dong Y, Gao Y, Ilie A, Kim D, Boucher A, Li B, Zhang XC, Orlowski J, Zhao Y
Loss of SLC9A6/NHE6 impairs nociception in a mouse model of Christianson syndrome.
Petitjean H, Fatima T, Mouchbahani-Constance S, Davidova A, Ferland CE, Orlowski J, Sharif-Naeini R
Mechanisms of Sensory Dysfunction in Christianson Syndrome
Principal investigators: Orlowski, John
Keywords: Alkali Cation/Proton Exchangers; Christianson Syndrome; Electrophysiology; Intracellular Ph Regulation; Pain; Protein Trafficking; Proteomics; Recycling Endosomes; Transgenic Mice; Viral Vectors
Roles of Alkali Cation/Proton Exchangers in Organellar Function and Neurodevelopmental Disorders
Principal investigators: Orlowski, John
Keywords: Alkali Cation/Proton Exchangers; Christianson Syndrome; Fluorescence Microscopy; Gene Cloning And Mutagenesis; Intracellular Ph Regulation; Neuronal Development And Function; Protein Trafficking; Proteomics; Recycling Endosomes; Yeast Two-Hybrid Gene Screening
Support for 2nd International Basic Science and Clinical Conference on Christianson Syndrome
Principal investigators: Orlowski, John
Keywords: Alkali Cation/Proton Exchangers; Christianson Syndrome; Epilepsy; Genetic Mutations; Neurodegeneration; Neurodevelopment; Recycling Endosomes; Slc9a6; X-Linked Intellectual Disability
Roles of Organellar pH-regulating Transporters in Cellular Homeostasis and Disease
Principal investigators: Orlowski, John
Keywords: Alkali Cation/Proton Exchangers; Dna Transfections; Fluorescence Microscopy; Gene Cloning; Mammalian Cell Culture; Mutagenesis; Organellar Ion Homeostasis; Protein Processing & Membrane Trafficking
CIHR Strategic Training Program in Chemical Biology
Principal investigators: Thomas, David Y
Keywords: Asthma; Biochemistry; Bioinformatics; Biopharmaceutical; Chemical; Chemical Biology; Chemistry; Cystic Fibrosis; Genetics; Infectious Diseases; Pharmacology; Structural Biology
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
Frequent collaborators
- Alvin Shrier and John Orlowski: 4 shared papers
- Reza Sharif-Naeini and John Orlowski: 3 shared papers
- Nahum Sonenberg and John Orlowski: 2 shared papers
- Reut Gruber and Armando Bertone: 2 shared papers
- Louis Gendron and Reza Sharif-Naeini: 1 shared paper
- Louis Gendron and John Orlowski: 1 shared paper
- Nahum Sonenberg and Reza Sharif-Naeini: 1 shared paper
- Nahum Sonenberg and Franck Duong: 1 shared paper
- Nahum Sonenberg and Michel Roberge: 1 shared paper
- Sergio Grinstein and John Orlowski: 1 shared paper
- Reut Gruber and John Orlowski: 1 shared paper
- Franck Duong and Michel Roberge: 1 shared paper
- Franck Duong and John Orlowski: 1 shared paper
- Michel Roberge and John Orlowski: 1 shared paper
- Armando Bertone and John Orlowski: 1 shared paper
- Physiology
- Biochemistry and Molecular Biology
- Biochemistry
- Médecine
- Psychiatry
- Cell Biology
- Other
Co-authors at McGill University, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.
Alvin Shrier
Physiology
4 shared papers, latest 2016
Reza Sharif-Naeini
Physiology
3 shared papers, latest 2026
Nahum Sonenberg
Biochemistry
2 shared papers, latest 2025
Franck Duong
Biochemistry and Molecular Biology
1 shared papers, latest 2012
Michel Roberge
Biochemistry and Molecular Biology
1 shared papers, latest 2012
Louis Gendron
Médecine
1 shared papers, latest 2025
Armando Bertone
Faculty
1 shared papers, latest 2022
Sergio Grinstein
Cell Biology
1 shared papers, latest 2023
Reut Gruber
Psychiatry
1 shared papers, latest 2022
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