Anthony Mittermaier

Research

Antiviral Covalent Inhibitors Sars-Cov-2 3cl Protease 14-3-3 Protein Fusiccocin A Gcn1 Protein/Protein Interaction Virtual Screening

Latest papers

Protocol for detecting in vitro riboswitch conformational switching using a fluorescence anisotropy single-stranded RNA-targeting approach.
STAR protocols · 2026 · senior author
Collision-induced transfer enhances ligand-binding kinetics in guanine quadruplex DNA.
Nucleic acids research · 2026 · senior author
Effects of flanking regions on DNA i-motif folding and stability.
Nucleic acids research · 2025 · senior author

All 34 publications

Latest funding

Advancing POP inhibitors as potential Parkinson's disease therapeutics
CIHR · 2024 · Co-investigator
$1,067,176
Multi-mode Microplate Reader
NSERC · 2023 · Co-investigator
$149,316
DNA dynamics in biology and technology
NSERC · 2022 · Principal investigator
$186,000

All 15 grants and awards

34 publications.

01

Protocol for detecting in vitro riboswitch conformational switching using a fluorescence anisotropy single-stranded RNA-targeting approach.

Clairoux A, Rivera M, McKeague M, Mittermaier A

STAR protocols2026Senior author

DOI: 10.1016/j.xpro.2026.104439 PMID: 41860872

02

Collision-induced transfer enhances ligand-binding kinetics in guanine quadruplex DNA.

Nizal H, Mittermaier A

Nucleic acids research2026Senior author

DOI: 10.1093/nar/gkag450 PMID: 42109246

03

Effects of flanking regions on DNA i-motif folding and stability.

Zhang C, Nizal H, Hennecker C, Mittermaier A

Nucleic acids research2025Senior author

DOI: 10.1093/nar/gkaf815 PMID: 40867052

04

Mechanistic Characterization of Covalent Enzyme Inhibition by Isothermal Titration Calorimetry Kinetic Competition (ITC-KC).

Hennecker C, Venegas F, Wang G, Stille J, Milaczewska A, Moitessier N, Mittermaier A

Analytical chemistry2025Senior author

DOI: 10.1021/acs.analchem.4c04003 PMID: 40106584

05

A sensitive and scalable fluorescence anisotropy single stranded RNA targeting approach for monitoring riboswitch conformational states.

Rivera M, Ayon OS, Diaconescu-Grabari S, Pottel J, Moitessier N, Mittermaier A, McKeague M

Nucleic acids research2024

DOI: 10.1093/nar/gkae118 PMID: 38375901

06

Structural Polymorphism of Guanine Quadruplex-Containing Regions in Human Promoters.

Hennecker C, Yamout L, Zhang C, Zhao C, Hiraki D, Moitessier N, Mittermaier A

International journal of molecular sciences2022Senior author

DOI: 10.3390/ijms232416020 PMID: 36555662

07

Modulating the selectivity of inhibitors for prolyl oligopeptidase inhibitors and fibroblast activation protein-α for different indications.

Plescia J, Hédou D, Pousse ME, Labarre A, Dufresne C, Mittermaier A, Moitessier N

European journal of medicinal chemistry2022

DOI: 10.1016/j.ejmech.2022.114543 PMID: 35797897

08

Using transient equilibria (TREQ) to measure the thermodynamics of slowly assembling supramolecular systems.

Hennecker CD, Lachance-Brais C, Sleiman H, Mittermaier A

Science advances2022Senior author

DOI: 10.1126/sciadv.abm8455 PMID: 35385301

09

Binding interactions in a kinase active site modulate background ATP hydrolysis.

Wang Y, Hanrahan G, Azar FA, Mittermaier A

Biochimica et biophysica acta. Proteins and proteomics2022Senior author

DOI: 10.1016/j.bbapap.2021.140720 PMID: 34597835

10

Frustrated folding of guanine quadruplexes in telomeric DNA.

Carrino S, Hennecker CD, Murrieta AC, Mittermaier A

Nucleic acids research2021Senior author

DOI: 10.1093/nar/gkab140 PMID: 33693924

Advancing POP inhibitors as potential Parkinson's disease therapeutics

Co-investigatorCIHR2024Project Grant

Principal investigators: Moitessier, Nicolas R

Keywords: Alpha-Synuclein Aggregation; Disease Modifying Therapy; Parkinson'S Disease; Therapeutics

$1,067,176

Multi-mode Microplate Reader

Co-investigatorNSERC2023Research Tools and Instruments

Principal investigators: Cosa, Gonzalo

$149,316

DNA dynamics in biology and technology

Principal investigatorNSERC2022Discovery Grants Program - Individual

Principal investigators: Mittermaier, Anthony

$186,000

COVID-19 Variant Supplement - Development of COVID-2019 main protease inhibitors as potential antivirals against the 2019 coronavirus.

Principal investigatorCIHR2021Operating Grant: SARS-CoV-2 variants supplement stream 1

Principal investigators: Moitessier, Nicolas R; Mittermaier, Anthony

Keywords: Antiviral; Covalent Inhibitors; Sars-Cov-2 3cl Protease

$50,000

Development of COVID-2019 main protease inhibitors as potential antivirals against the 2019 coronavirus.

Principal investigatorCIHR2020Operating Grant: COVID-19 - Therapeutics

Principal investigators: Moitessier, Nicolas R; Mittermaier, Anthony

Keywords: Antiviral; Covalent Inhibitors; Sars-Cov-2 3cl Protease

$203,000

Development of 14-3-3 protein/protein interaction agonists as potential therapies for spinal cord injury and stroke

Principal investigatorCIHR2019Project Grant

Principal investigators: Gleason, James L; Fournier, Alyson Elise; Mittermaier, Anthony; Moitessier, Nicolas R

Keywords: 14-3-3 Protein; Fusiccocin A; Gcn1; Protein/Protein Interaction; Virtual Screening

$286,875

From Rational Design To in vivo Evaluation of Dual Covalent Prolyl Oligopeptidase / Fibroblast Activation Protein Inhibitors as Potential Cancer Therapeutics.

Co-investigatorCIHR2014Operating Grant

Principal investigators: Moitessier, Nicolas R

Keywords: Animal Models; Cancer Therapeutics; Computer-Aided Drug Design; Fibroblast Activation Protein; In Vivo Testing; Medicinal Chemistry; Nmr Spectroscopy; Organic Synthesis; Prolyl Oligopeptidase

$371,344

Binding Mechanisms and Conformational Equilibria in Biomacromolecular Interactions

Principal investigatorNSERC2014Discovery Grants Program - Individual

Principal investigators: Mittermaier, Anthony

$432,000

Overcoming Aminoglycoside Resistance

Co-investigatorCIHR2011Operating Grant

Principal investigators: Auclair, Karine

Keywords: Acetyltransferase; Aminoglycoside; Inhibition; Medicinal Chemistry; Resistance

$711,620

Quantifying the dynamics of protein function at the atomic level using NMR and calorimetry

Principal investigatorNSERC2009Discovery Grants Program - Individual

Principal investigators: Mittermaier, Anthony

$250,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Chemistry
Pharmacology and Therapeutics
Biochemistry
Anatomy and Cell Biology
Oncology
Biology

Co-authors at McGill University, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Nicolas Moitessier

Chemistry

8 shared papers, latest 2025

Karine Auclair

Chemistry

3 shared papers, latest 2016

Maureen McKeague

Pharmacology and Therapeutics

2 shared papers, latest 2026

Hanadi Sleiman

Oncology

1 shared papers, latest 2022

Chantal Autexier

Anatomy and Cell Biology

1 shared papers, latest 2012

Jackie Vogel

Biology

1 shared papers, latest 2018

Albert Berghuis

Biochemistry

1 shared papers, latest 2014

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their NSERC grant from 2022

Subject: Prospective PhD student: Antiviral Dear Professor Mittermaier, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Protocol for detecting in vitro riboswitch conformational switching using a fluorescence anisotropy single-stranded RNA-targeting approach." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your NSERC-funded project "DNA dynamics in biology and technology" (2022), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

Anthony Mittermaier

Research

Latest papers

Latest funding

Protocol for detecting in vitro riboswitch conformational switching using a fluorescence anisotropy single-stranded RNA-targeting approach.

Collision-induced transfer enhances ligand-binding kinetics in guanine quadruplex DNA.

Effects of flanking regions on DNA i-motif folding and stability.

Mechanistic Characterization of Covalent Enzyme Inhibition by Isothermal Titration Calorimetry Kinetic Competition (ITC-KC).

A sensitive and scalable fluorescence anisotropy single stranded RNA targeting approach for monitoring riboswitch conformational states.

Structural Polymorphism of Guanine Quadruplex-Containing Regions in Human Promoters.

Modulating the selectivity of inhibitors for prolyl oligopeptidase inhibitors and fibroblast activation protein-&#x3b1; for different indications.

Using transient equilibria (TREQ) to measure the thermodynamics of slowly assembling supramolecular systems.

Binding interactions in a kinase active site modulate background ATP hydrolysis.

Frustrated folding of guanine quadruplexes in telomeric DNA.

Advancing POP inhibitors as potential Parkinson's disease therapeutics

Multi-mode Microplate Reader

DNA dynamics in biology and technology

COVID-19 Variant Supplement - Development of COVID-2019 main protease inhibitors as potential antivirals against the 2019 coronavirus.

Development of COVID-2019 main protease inhibitors as potential antivirals against the 2019 coronavirus.

Development of 14-3-3 protein/protein interaction agonists as potential therapies for spinal cord injury and stroke

From Rational Design To in vivo Evaluation of Dual Covalent Prolyl Oligopeptidase / Fibroblast Activation Protein Inhibitors as Potential Cancer Therapeutics.

Binding Mechanisms and Conformational Equilibria in Biomacromolecular Interactions

Overcoming Aminoglycoside Resistance

Quantifying the dynamics of protein function at the atomic level using NMR and calorimetry

Frequent collaborators

Nicolas Moitessier

Karine Auclair

Maureen McKeague

Hanadi Sleiman

Chantal Autexier

Jackie Vogel

Albert Berghuis

Modulating the selectivity of inhibitors for prolyl oligopeptidase inhibitors and fibroblast activation protein-α for different indications.