Faculty profile

Chantal Autexier

ResearcherAnatomy and Cell BiologyMcGill University

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a McGill University directory, so their courses may be missing. Find their university profile.

Chantal Autexier

Researcher

Anatomy and Cell Biology

Health Sciences

McGill University

Montreal, Quebec, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
7 publications in the last five years, latest in 2026.
Senior (last) author on 4 recent papers, a sign of leading a research group.
Principal investigator on 7 research grants (4 CIHR, 3 NSERC), most recently in 2025.
Supervisor on 4 trainee awards (4 CIHR), most recently in 2025.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

Citations

Collaborators

Grants

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

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Signals and details

Research

Dyskerin Telomerase Telomere Premature Aging Syndrome Sumoylation Cancer Telomere Biology Disorder Telomere Maintenance Syndrome

Latest papers

Disease mutations in the N-terminal extension and α2'-helix of dyskerin do not abolish dimerization but disrupt binding to the telomerase RNA.
RNA (New York, N.Y.) · 2026 · senior author
Foundations and Strategic Vision of the Canadian Translational Geroscience Network
The journals of gerontology. Series A, Biological sciences and medical sciences · 2025
R-2-hydroxyglutarate-mediated inhibition of KDM4A compromises telomere integrity.
Nucleic acids research · 2025

All 41 publications

Latest funding

Telomerase retention at telomeres through its unique IFD and motif 3 domains: Implications for Cancer Therapeutics
CIHR · 2025 · Supervisor
$1,500
Mechanisms regulating telomerase biogenesis and function at telomeres
CIHR · 2025 · Nominated PI
$971,550
Regulation of telomere length homeostasis by a unique telomerase domain
CIHR · 2024 · Supervisor
$120,000

All 14 grants and awards

41 publications.

Disease mutations in the N-terminal extension and α2'-helix of dyskerin do not abolish dimerization but disrupt binding to the telomerase RNA.

Qin J, Lambert-Lanteigne P, Garus A, Autexier C

RNA (New York, N.Y.)2026Senior author

DOI: 10.1261/rna.081234.126 PMID: 42538130

Foundations and Strategic Vision of the Canadian Translational Geroscience Network

Hajj-Boutros G, Faust A, Muscedere J, Kim P, Gouspillou G, Harrington L, Kirkland JL, Kuchel GA, Van Raamsdonk J, Rylett RJ

The journals of gerontology. Series A, Biological sciences and medical sciences2025

DOI: 10.1093/gerona/glaf111

R-2-hydroxyglutarate-mediated inhibition of KDM4A compromises telomere integrity.

Couteau F, Gagné LM, Boulay K, Rousseau P, Carbonneau M, McQuaid M, Sharma J, Sawchyn C, Fernandez E, Glatz D, Rizk R, Lalonde ME, Mehrjoo Y, Chu TW, Moquin-Beaudry G, Beauséjour C, Sergeev M, Costantino S, Avizonis D, Topisirovic I, Jabado N, Wurtele H, Autexier C, Mallette FA

Nucleic acids research2025

DOI: 10.1093/nar/gkaf512 PMID: 40498073

The C-terminal extension of dyskerin is a dyskeratosis congenita mutational hotspot that modulates interaction with telomerase RNA and subcellular localization.

Qin J, Garus A, Autexier C

Human molecular genetics2024Senior author

DOI: 10.1093/hmg/ddad180 PMID: 37879098

Orchestrating nucleic acid-protein interactions at chromosome ends: telomerase mechanisms come into focus.

Lue NF, Autexier C

Nature structural & molecular biology2023Senior author

DOI: 10.1038/s41594-023-01022-7 PMID: 37400652

Complex interaction network revealed by mutation of human telomerase 'insertion in fingers' and essential N-terminal domains and the telomere protein TPP1.

Lambert-Lanteigne P, Young A, Autexier C

The Journal of biological chemistry2023Senior author

DOI: 10.1016/j.jbc.2023.102916 PMID: 36649908

Long-term male-specific chronic pain via telomere- and p53‑mediated spinal cord cellular senescence.

Muralidharan A, Sotocinal SG, Yousefpour N, Akkurt N, Lima LV, Tansley S, Parisien M, Wang C, Austin JS, Ham B, Dutra GM, Rousseau P, Maldonado-Bouchard S, Clark T, Rosen SF, Majeed MR, Silva O, Nejade R, Li X, Donayre Pimentel S, Nielsen CS, Neely GG, Autexier C, Diatchenko L, Ribeiro-da-Silva A, Mogil JS

The Journal of clinical investigation2022

DOI: 10.1172/jci151817 PMID: 35426375

Dyskerin: an essential pseudouridine synthase with multifaceted roles in ribosome biogenesis, splicing, and telomere maintenance.

Garus A, Autexier C

RNA (New York, N.Y.)2021Senior author

DOI: 10.1261/rna.078953.121 PMID: 34556550

Homologous recombination-mediated irreversible genome damage underlies telomere-induced senescence.

Ghadaouia S, Olivier MA, Martinez A, Kientega T, Qin J, Lambert-Lanteigne P, Cardin GB, Autexier C, Malaquin N, Rodier F

Nucleic acids research2021

DOI: 10.1093/nar/gkab965 PMID: 34725692

PCNA, a focus on replication stress and the alternative lengthening of telomeres pathway.

Shen M, Young A, Autexier C

DNA repair2021Senior author

DOI: 10.1016/j.dnarep.2021.103055 PMID: 33581499

Telomerase retention at telomeres through its unique IFD and motif 3 domains: Implications for Cancer Therapeutics

SupervisorCIHR2025Travel Awards - Institute Community Support

Principal investigators: Young, Adrian L

Keywords: Cancer Biology; Enzyme Structure And Function; Mutational Analysis; Shelterin Complex; Telomerase; Telomerase Recruitment; Telomere Maintenance; Therapeutic Targets

$1,500

Mechanisms regulating telomerase biogenesis and function at telomeres

Nominated PICIHR2025Project Grant

Principal investigators: Autexier, Chantal

Keywords: Cancer; Dyskerin; Premature Aging Syndrome; Telomerase; Telomere; Telomere Biology Disorder

$971,550

Regulation of telomere length homeostasis by a unique telomerase domain

SupervisorCIHR2024Doctoral Research Award: Canada Graduate Scholarships

Principal investigators: Pallotto, Linda M

Keywords: Aging; Cancer; Cell Biology; Molecular Biology; Telomerase; Telomeres

$120,000

Surface plasmon resonance system for molecular interaction studies

Co-investigatorNSERC2024Research Tools and Instruments

Principal investigators: Reinhardt, Dieter

Keywords: Bioengineering; Biosensors; Chromosomes; Elastic nanofibers; Extracellular matrix; Genome stability; Macromolecular assembly; Nanocomposites; Protein-protein interactions; Telomeres

$144,329

Role of PCNA and replication stress in telomere maintenance

Principal investigatorNSERC2023Discovery Grants Program - Individual

Principal investigators: Autexier, Chantal

Keywords: ALT-associated PML bodies; alternative lengthening of telomere; DNA damage; G-quadruplex; proliferating cell nuclear antigen; replication protein A; replication stress; R-loops; sumoylation; Telomere

$80,000

Mechanisms regulating telomerase and telomeres

Nominated PICIHR2019Project Grant

Principal investigators: Autexier, Chantal

Keywords: Dyskerin; Premature Aging Syndrome; Sumoylation; Telomerase; Telomere; Telomere Maintenance Syndrome

$826,200

Regulation of chromosome end maintenance by recombination

Principal investigatorNSERC2017Discovery Grants Program - Individual

Principal investigators: Autexier, Chantal

$168,000

X-Ray Irradiation Platform for cells and small animal studies

Co-investigatorNSERC2017Research Tools and Instruments

Principal investigators: Orthwein, Alexandre

$149,671

Telomerase Regulation through Post-translational Modification of Dyskerin

SupervisorCIHR2016Doctoral Award - Frederick Banting and Charles Best Canada Graduate Scholarships

Principal investigators: MacNeil, Deanna

Keywords: Bone Marrow Failure; Cancer; Dyskerin; Genomic Stability; H/Aca Rna; Post-Translational Modifications; Premature Aging; Telomerase; Telomere; Telomeropathy

$105,000

Regulation of chromosome end maintenance by recombination

Principal investigatorNSERC2015Discovery Grants Program - Individual

Principal investigators: Autexier, Chantal

$30,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Chantal Autexier

Research

Latest papers

Latest funding

Disease mutations in the N-terminal extension and &#x3b1;2'-helix of dyskerin do not abolish dimerization but disrupt binding to the telomerase RNA.

Foundations and Strategic Vision of the Canadian Translational Geroscience Network

R-2-hydroxyglutarate-mediated inhibition of KDM4A compromises telomere integrity.

The C-terminal extension of dyskerin is a dyskeratosis congenita mutational hotspot that modulates interaction with telomerase RNA and subcellular localization.

Orchestrating nucleic acid-protein interactions at chromosome ends: telomerase mechanisms come into focus.

Complex interaction network revealed by mutation of human telomerase 'insertion in fingers' and essential N-terminal domains and the telomere protein TPP1.

Long-term male-specific chronic pain via telomere- and p53&#x2011;mediated spinal cord cellular senescence.

Dyskerin: an essential pseudouridine synthase with multifaceted roles in ribosome biogenesis, splicing, and telomere maintenance.

Homologous recombination-mediated irreversible genome damage underlies telomere-induced senescence.

PCNA, a focus on replication stress and the alternative lengthening of telomeres pathway.

Telomerase retention at telomeres through its unique IFD and motif 3 domains: Implications for Cancer Therapeutics

Mechanisms regulating telomerase biogenesis and function at telomeres

Regulation of telomere length homeostasis by a unique telomerase domain

Surface plasmon resonance system for molecular interaction studies

Role of PCNA and replication stress in telomere maintenance

Mechanisms regulating telomerase and telomeres

Regulation of chromosome end maintenance by recombination

X-Ray Irradiation Platform for cells and small animal studies

Telomerase Regulation through Post-translational Modification of Dyskerin

Regulation of chromosome end maintenance by recombination

Frequent collaborators

Ivan Topisirovic

Nicolas Moitessier

Nancy Mayo

Mohammad Auais

Jeremy Van Raamsdonk

Ivan Topisirovic

Anthony Mittermaier

Francis Rodier

Daniel Sinnett

Genevieve Deblois

John Muscedere

Gustavo Duque

Michael Kobor

Alexandra Papaioannou

Silvia Bacchetti

Sabine Mai

Michael Witcher

Jonathan Afilalo

Howard Bergman

Nada Jabado

Kenneth Rockwood

Disease mutations in the N-terminal extension and α2'-helix of dyskerin do not abolish dimerization but disrupt binding to the telomerase RNA.

Long-term male-specific chronic pain via telomere- and p53‑mediated spinal cord cellular senescence.