Faculty profile

Carl Ernst

ResearcherNeurology and NeurosurgeryMcGill University

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a McGill University directory, so their courses may be missing. Find their university profile.

Carl Ernst

Researcher

Neurology and Neurosurgery

Health Sciences

McGill University

Montreal, Quebec, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
16 publications in the last five years, latest in 2026.
Senior (last) author on 8 recent papers, a sign of leading a research group.
Principal investigator on 9 research grants (8 CIHR, 1 NSERC), most recently in 2024.
Supervisor on 2 trainee awards (2 CIHR), most recently in 2023.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

Collaborators

Grants

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

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Signals and details

Research

Gene Therapy Neurology Neurodevelopment Genetics Genetic Engineering Marmoset Antisense Oligonucleotides Virus

Latest papers

Prevention of hydrocephalus with a small oligonucleotide.
Molecular therapy : the journal of the American Society of Gene Therapy · 2026 · senior author
Electrochemical measurements at human iPSC-derived FOXA2 dopaminergic neurons suggest a role for partial release in presynaptic plasticity.
QRB discovery · 2026
Developing a National Network for Leukodystrophy Research and Care in Canada: The CARELeuko Initiative.
Neurology. Genetics · 2025

All 63 publications

Latest funding

Resolving roadblocks to clinical trial readiness for rare brain disease gene therapy
CIHR · 2024 · Nominated PI
$1,137,500
Developing Gene Therapies for Rare Brain Disorders
CIHR · 2023 · Nominated PI
A new role for EHMT1 in repressing NF-kB and TGFb signaling in Kleefstra Syndrome
CIHR · 2023 · Supervisor
$105,000

All 16 grants and awards

63 publications.

Prevention of hydrocephalus with a small oligonucleotide.

Antonyan L, Bossini L, Zhang X, Ni A, Hagel MD, Baronchelli E, Geusa M, Peng H, Semenak A, Fleming P, Alsuwaidi S, Zhang Y, Hu B, Fontana D, Crippa V, Codazzi S, Macintosh J, Arriaga-Sierra A, Khan B, Hettige N, Jefri M, Liang Y, Klein S, du Toit A, Phan NTN, Schuppert A, Zhou Y, Piazza R, Murai K, Jacquemont S, Sessa A, Ernst C

Molecular therapy : the journal of the American Society of Gene Therapy2026Senior author

DOI: 10.1016/j.ymthe.2026.01.034 PMID: 41612697

Electrochemical measurements at human iPSC-derived FOXA2 dopaminergic neurons suggest a role for partial release in presynaptic plasticity.

Gu C, Lork A, Majdi S, Rabasco S, Peng H, Ni A, Ernst C, Ewing AG

QRB discovery2026

DOI: 10.1017/qrd.2026.10019 PMID: 42063621

Developing a National Network for Leukodystrophy Research and Care in Canada: The CARELeuko Initiative.

Chapleau A, Le A, Simo J, Venkateswaran S, Lacaze-Masmonteil T, Piscopo VEC, Gauthier S, Villa Tobón F, Alam SS, Lentini L, Brais B, Ernst C, Mitchell JJ, Vinh DC, Zhou Y, Kennedy TE, Goloff N, Riham B, Chapleau R, Smith B, Greger V, Della Rocca J, Louis LM, Dike A, McIntyre LL, McIntyre DF, Tardif J, Lapointe É, Barnett J, Loignon V, Bardai G, Contant S, Durcan TM, La Piana R, Bernard G, as RareKids-CAN, RARE.Qc, CARELeuko

Neurology. Genetics2025

DOI: 10.1212/nxg.0000000000200313 PMID: 41143125

Plasma Membrane Lipid Composition and Turnover in Human Midbrain Neurons Investigated by Time-of-Flight Mass Spectrometry.

Berlin E, Lork AA, Ernst C, Fletcher JS, Phan NTN

Biomolecules2025

DOI: 10.3390/biom15121650 PMID: 41463306

One-Carbon Metabolism and Midbrain Dopaminergic Cells in Lesch-Nyhan Disease.

Alsuwaidi S, Ernst C

Molecular syndromology2025Senior author

DOI: 10.1159/000549247 PMID: 41409305

Computer Vision-Assisted Data Analysis for Correlative Electron Microscopy and Secondary Ion Mass Spectrometry Imaging.

du Toit A, Lork AA, Ernst C, Phan NTN

Analytical chemistry2025

DOI: 10.1021/acs.analchem.5c04489 PMID: 41076583

Mechanistic insights into 16p13.3 microdeletions encompassing TBC1D24 and ATP6V0C through advanced sequencing approaches.

Mazel B, Coleman EA, Rousseau J, Kailasam S, Ajeawung NF, Jimenez Cruz DA, Ehresmann S, Chen G, Ernst C, Campeau PM

European journal of human genetics : EJHG2025

DOI: 10.1038/s41431-025-01912-y PMID: 40721525

Reciprocal and non-reciprocal effects of clinically relevant SETBP1 protein dosage changes.

Antonyan L, Zhang X, Ni A, Peng H, Alsuwaidi S, Fleming P, Zhang Y, Semenak A, Macintosh J, Wu H, Hettige NC, Jefri M, Ernst C

Human molecular genetics2025Senior author

DOI: 10.1093/hmg/ddaf003 PMID: 39825586

Lipid organization and turnover in the plasma membrane of human differentiating neural progenitor cells revealed by time-of-flight secondary ion mass spectrometry imaging.

Berlin E, Lork AA, Bornecrantz M, Ernst C, Phan NTN

Talanta2024

DOI: 10.1016/j.talanta.2024.125762 PMID: 38394748

Subcellular protein turnover in human neural progenitor cells revealed by correlative electron microscopy and nanoscale secondary ion mass spectrometry imaging.

Lork AA, Rabasco S, Ernst C, du Toit A, Rizzoli SO, Phan NTN

Chemical science2024

DOI: 10.1039/d3sc05629e PMID: 38425528

Resolving roadblocks to clinical trial readiness for rare brain disease gene therapy

Nominated PICIHR2024Operating Grant:Bringing Rare Disease Gene Therapies to Clinical Trial Readiness

Principal investigators: Ernst, Carl P; Rouleau, Guy A; Cléry, Justine C; Farhan, Sali M; Gentil, Benoit J; Karamchandani, Jason; Murai, Keith; Myers, Kenneth A; Oskoui, Maryam; Pandolfo, Massimo

Keywords: Gene Therapy; Genetic Engineering; Marmoset; Neurology

$1,137,500

Developing Gene Therapies for Rare Brain Disorders

Nominated PICIHR2023Op. Grant :Bringing Rare Disease Gene Therapies to Clinical Trial Readiness- LOI

Principal investigators: Ernst, Carl P; Cléry, Justine C; Gentil, Benoit J; Oskoui, Maryam; Pandolfo, Massimo

Keywords: Antisense Oligonucleotides; Gene Therapy; Neurodevelopment; Neurology; Virus

A new role for EHMT1 in repressing NF-kB and TGFb signaling in Kleefstra Syndrome

SupervisorCIHR2023Doctoral Research Award: Canada Graduate Scholarships

Principal investigators: Macintosh, Julia E

Keywords: Histone Methyltransferases; Induced Pluripotent Stem Cells; Kleefstra Syndrome; Neurodevelopmental Disorders; Neurogenetics; Rare Diseases

$105,000

Mechanisms of FOXG1 deficiency in brain cell proliferation and patterning

Nominated PICIHR2022Project Grant

Principal investigators: Ernst, Carl P

Keywords: Brain; Crispr/Cas; Disease Modeling; Foxg1 Syndrome; Genetics; Stem Cells

$918,000

Uncovering the molecular mechanism underlying KDM6A in Kabuki Syndrome

SupervisorCIHR2021Doctoral Research Award: Canada Graduate Scholarships

Principal investigators: Ni, Anjie

Keywords: Chip-Seq; Epigenetics; Genetic Engineering; Ipsc Modeling; Kabuki Syndrome; Multiple Congenital Anomalies; Neurogenetics; Personalized Medicine; Rare Disease Genetics; Rna-Seq

$105,000

Development and preclinical testing in human cell models and transgenic mice of a novel treatment for Schinzel-Giedion Syndrome

Nominated PICIHR2020Team Grant: E-Rare Joint Transnational Call

Principal investigators: Ernst, Carl P

Keywords: Neurodegeneration; Pp2a; Seizures; Setbp1; Vesicle

$225,000

Canada Research Chair - Tier 2

Nominated PICIHR2017Canada Research Chairs - CIHR Funded - Tier 2

Principal investigators: Ernst, Carl P

Keywords: Crc

$500,000

DNA methylation changes in human brain by chronic cocaine use

Nominated PICIHR2017Operating Grant: Impact Grant : CEEHRC Phase II

Principal investigators: Ernst, Carl P

Keywords: Cocaine; Dna Methylation; Human Brain; Human Derived Neurons; Rat Model Of Addiction; Rnaseq

$600,000

Roles of Alkali Cation/Proton Exchangers in Organellar Function and Neurodevelopmental Disorders

Co-investigatorCIHR2017Project Grant

Principal investigators: Orlowski, John

Keywords: Alkali Cation/Proton Exchangers; Christianson Syndrome; Fluorescence Microscopy; Gene Cloning And Mutagenesis; Intracellular Ph Regulation; Neuronal Development And Function; Protein Trafficking; Proteomics; Recycling Endosomes; Yeast Two-Hybrid Gene Screening

$918,000

A novel BAFopathy syndrome: Functional genetics using human stem cells and gene editing technologies

Nominated PICIHR2016Project Grant

Principal investigators: Ernst, Carl P

Keywords: Actl6b; Genetics; Neurodevelopment; Neuroscience

$925,650

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Carl Ernst

Research

Latest papers

Latest funding

Prevention of hydrocephalus with a small oligonucleotide.

Electrochemical measurements at human iPSC-derived FOXA2 dopaminergic neurons suggest a role for partial release in presynaptic plasticity.

Developing a National Network for Leukodystrophy Research and Care in Canada: The CARELeuko Initiative.

Plasma Membrane Lipid Composition and Turnover in Human Midbrain Neurons Investigated by Time-of-Flight Mass Spectrometry.

One-Carbon Metabolism and Midbrain Dopaminergic Cells in Lesch-Nyhan Disease.

Computer Vision-Assisted Data Analysis for Correlative Electron Microscopy and Secondary Ion Mass Spectrometry Imaging.

Mechanistic insights into 16p13.3 microdeletions encompassing TBC1D24 and ATP6V0C through advanced sequencing approaches.

Reciprocal and non-reciprocal effects of clinically relevant SETBP1 protein dosage changes.

Lipid organization and turnover in the plasma membrane of human differentiating neural progenitor cells revealed by time-of-flight secondary ion mass spectrometry imaging.

Subcellular protein turnover in human neural progenitor cells revealed by correlative electron microscopy and nanoscale secondary ion mass spectrometry imaging.

Frequent collaborators

Naguib Mechawar

Gustavo Turecki

Liam Crapper

Kathryn Vaillancourt

Corina Nagy

Moshe Szyf

YANG ZHOU

Sebastien Jacquemont

Sebastien Jacquemont

Arnold Hayer

Roberta La Piana

Thierry Lacaze-Masmonteil

Frank Vitaro

Martin Alda

Nada Jabado

Tomi Pastinen

Laurent Mottron

Julie Lessard

Guillaume Bourque

Bernard Brais

Keith Murai

Elsa Rossignol

Philip Barker

Jacques Drouin

Richard Tremblay

Nahum Sonenberg