Cristian O'Flaherty

Research

Redox Signaling Sperm Capacitation Fertilization Male Infertility Oxidative Stress Spermatogenesis Idiopathic Male Infertility Lipid Signaling

Latest papers

Gut Microbial Dysbiosis and Male Reproductive Health: Current Insights and Future Directions.
International journal of molecular sciences · 2026 · senior author
Levels of Protein CoAlation Regulate Redox Signaling Events of Human Sperm Capacitation.
Antioxidants (Basel, Switzerland) · 2026 · senior author
Deoxycholic Acid Impairs Human Sperm Quality and Function Through Oxidative Stress-Driven Damage.
Antioxidants (Basel, Switzerland) · 2025 · senior author

All 46 publications

Latest funding

Sperm capacitation: A brand new perspective to tackle idiopathic male infertility
CIHR · 2023 · Nominated PI
$1,078,650
Regulation of male fertility by peroxiredoxin 6
CIHR · 2019 · Nominated PI
$749,700
Redox regulation of male reproduction
CIHR · 2013 · Nominated PI
$471,685

All 4 grants and awards

46 publications.

01

Gut Microbial Dysbiosis and Male Reproductive Health: Current Insights and Future Directions.

Pan M, O'Flaherty C

International journal of molecular sciences2026Senior author

DOI: 10.3390/ijms27104482 PMID: 42196459

02

Levels of Protein CoAlation Regulate Redox Signaling Events of Human Sperm Capacitation.

Onochie C, Filonenko V, Gout I, O'Flaherty C

Antioxidants (Basel, Switzerland)2026Senior author

DOI: 10.3390/antiox15050600 PMID: 42193221

03

Deoxycholic Acid Impairs Human Sperm Quality and Function Through Oxidative Stress-Driven Damage.

Serafini S, Pranov E, Timova Bauer K, Onochie C, O'Flaherty C

Antioxidants (Basel, Switzerland)2025Senior author

DOI: 10.3390/antiox14111271 PMID: 41300429

04

Redox signaling regulation in human spermatozoa: a primary role of peroxiredoxins.

O'Flaherty C

Asian journal of andrology2025First author

DOI: 10.4103/aja2024126 PMID: 39902615

05

Novel insights into the lipid signalling in human spermatozoa.

Serafini S, O'Flaherty C

Human reproduction (Oxford, England)2025Senior author

DOI: 10.1093/humrep/deaf085 PMID: 40409756

06

Dysregulation of sphingolipid and cholesterol homeostasis imposes oxidative stress in human spermatozoa.

Serafini S, O'Flaherty C

Redox biology2025Senior author

DOI: 10.1016/j.redox.2025.103669 PMID: 40435557

07

Role of Redox-Induced Protein Modifications in Spermatozoa in Health and Disease.

Onochie C, Evi K, O'Flaherty C

Antioxidants (Basel, Switzerland)2025Senior author

DOI: 10.3390/antiox14060720 PMID: 40563353

08

Sphingolipids modulate redox signalling during human sperm capacitation.

Serafini S, O'Flaherty C

Human reproduction (Oxford, England)2025Senior author

DOI: 10.1093/humrep/deae268 PMID: 39658334

09

Essential role of germ cell glycerol-3-phosphate phosphatase for sperm health, oxidative stress control and male fertility in mice.

Oppong A, Leung YH, Ghosh A, Peyot ML, Paquet M, Morales C, Clarke HJ, Al-Mulla F, Boyer A, Madiraju SRM, Boerboom D, O'Flaherty C, Prentki M

Molecular metabolism2024

DOI: 10.1016/j.molmet.2024.102063 PMID: 39542419

10

Citrate Promotes Nitric Oxide Production during Human Sperm Capacitation.

Loggia D, O'Flaherty C

Antioxidants (Basel, Switzerland)2024Senior author

DOI: 10.3390/antiox13080885 PMID: 39199131

Sperm capacitation: A brand new perspective to tackle idiopathic male infertility

Nominated PICIHR2023Project Grant

Principal investigators: O'Flaherty, Cristian

Keywords: Idiopathic Male Infertility; Lipid Signaling; Male Fertility; Reactive Oxygen And Nitrogen Species; Reactive Oxygen Species; Redox Signaling; Sperm Capacitation; Spermatozoza

$1,078,650

Regulation of male fertility by peroxiredoxin 6

Nominated PICIHR2019Project Grant

Principal investigators: O'Flaherty, Cristian

Keywords: Antioxidants; Fertility; Fertilization; Male Infertility; Oxidative Stress; Physiology And Pathology Of Male Reproduction; Redox Signaling; Sperm Capacitation; Spermatogenesis

$749,700

Redox regulation of male reproduction

Nominated PICIHR2013Operating Grant

Principal investigators: O'Flaherty, Cristian

Keywords: Fertilization; Male Infertility; Oxidative Stress; Redox Regulation; Signaling; Sperm Function; Spermatogenesis

$471,685

Regulation of redox signaling in male reproduction

Nominated PICIHR2009Operating Grant - PA: Reproductive and Child Heath (start-up grants)

Principal investigators: O'Flaherty, Cristian

Keywords: Male Infertility

$100,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Urology
Pharmacology and Therapeutics
Medicine
Nutrition
Medical Genetics
Surgery
Other

Co-authors at McGill University, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Bernard Robaire

Pharmacology and Therapeutics

2 shared papers, latest 2023

Pierre Lachapelle

Medical Genetics

1 shared papers, latest 2019

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2023

Subject: Prospective PhD student: Redox Signaling Dear Professor O'Flaherty, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Gut Microbial Dysbiosis and Male Reproductive Health: Current Insights and Future Directions." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Sperm capacitation: A brand new perspective to tackle idiopathic male infertility" (2023), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

Cristian O'Flaherty

Research

Latest papers

Latest funding

Gut Microbial Dysbiosis and Male Reproductive Health: Current Insights and Future Directions.

Levels of Protein CoAlation Regulate Redox Signaling Events of Human Sperm Capacitation.

Deoxycholic Acid Impairs Human Sperm Quality and Function Through Oxidative Stress-Driven Damage.

Redox signaling regulation in human spermatozoa: a primary role of peroxiredoxins.

Novel insights into the lipid signalling in human spermatozoa.

Dysregulation of sphingolipid and cholesterol homeostasis imposes oxidative stress in human spermatozoa.

Role of Redox-Induced Protein Modifications in Spermatozoa in Health and Disease.

Sphingolipids modulate redox signalling during human sperm capacitation.

Essential role of germ cell glycerol-3-phosphate phosphatase for sperm health, oxidative stress control and male fertility in mice.

Citrate Promotes Nitric Oxide Production during Human Sperm Capacitation.

Sperm capacitation: A brand new perspective to tackle idiopathic male infertility

Regulation of male fertility by peroxiredoxin 6

Redox regulation of male reproduction

Regulation of redox signaling in male reproduction

Frequent collaborators

Martine Culty

Bernard Robaire

Richard Oko

Teruko Taketo

Marc Prentki

Pierre Lachapelle