Martine Culty, McGill University

Research

Cell Differentiation Endocrine Disruptors Epigenetics Etiology Of Testicular Germ Cell Pathologies Fetal Exposure Gene And Protein Expression Infertility Short And Long Term Effects

Latest papers

Impact of Fetal Exposure to Endocrine Disrupting Chemical Mixtures on FOXA3 Gene and Protein Expression in Adult Rat Testes.
International journal of molecular sciences · 2023 · senior author
Role of the Ubiquitin Ligase RNF149 in the Development of Rat Neonatal Gonocytes.
Frontiers in endocrinology · 2022 · senior author
In utero exposure to low doses of genistein and di-(2-ethylhexyl) phthalate (DEHP) alters innate immune cells in neonatal and adult rat testes.
Andrology · 2020 · senior author

All 28 publications

Latest funding

Low dose effects of endocrine disruptors on male reproduction
CIHR · 2013 · Nominated PI
$520,600
Role of the ubiquitin system in testicular germ cell development
NSERC · 2013 · Principal investigator
$150,000
Fetal Origin of Endocrine Dysfunction: The Phthalate Model
CIHR · 2010 · Co-investigator
$779,382

All 6 grants and awards

28 publications.

01

Impact of Fetal Exposure to Endocrine Disrupting Chemical Mixtures on FOXA3 Gene and Protein Expression in Adult Rat Testes.

Walker C, Boisvert A, Malusare P, Culty M

International journal of molecular sciences2023Senior author

DOI: 10.3390/ijms24021211 PMID: 36674726

02

Role of the Ubiquitin Ligase RNF149 in the Development of Rat Neonatal Gonocytes.

Manku G, Kong CC, Culty M

Frontiers in endocrinology2022Senior author

DOI: 10.3389/fendo.2022.896507 PMID: 35634494

03

In utero exposure to low doses of genistein and di-(2-ethylhexyl) phthalate (DEHP) alters innate immune cells in neonatal and adult rat testes.

Walker C, Ghazisaeidi S, Collet B, Boisvert A, Culty M

Andrology2020Senior author

DOI: 10.1111/andr.12840 PMID: 32533902

04

Cyclooxygenase 2 (COX2) expression and prostaglandin synthesis in neonatal rat testicular germ cells: Effects of acetaminophen and ibuprofen.

Manku G, Papadopoulos P, Boisvert A, Culty M

Andrology2020Senior author

DOI: 10.1111/andr.12727 PMID: 31705786

05

Protective Role of Peroxiredoxins against Reactive Oxygen Species in Neonatal Rat Testicular Gonocytes.

O'Flaherty C, Boisvert A, Manku G, Culty M

Antioxidants (Basel, Switzerland)2019Senior author

DOI: 10.3390/antiox9010032 PMID: 31905831

06

Ubiquitin Ligase Huwe1 Modulates Spermatogenesis by Regulating Spermatogonial Differentiation and Entry into Meiosis.

Bose R, Sheng K, Moawad AR, Manku G, O'Flaherty C, Taketo T, Culty M, Fok KL, Wing SS

Scientific reports2017

DOI: 10.1038/s41598-017-17902-0 PMID: 29259204

07

Huwe1 Regulates the Establishment and Maintenance of Spermatogonia by Suppressing DNA Damage Response.

Fok KL, Bose R, Sheng K, Chang CW, Katz-Egorov M, Culty M, Su S, Yang M, Ruan YC, Chan HC, Iavarone A, Lasorella A, Cencic R, Pelletier J, Nagano M, Xu W, Wing SS

Endocrinology2017

DOI: 10.1210/en.2017-00396 PMID: 28938460

08

In Utero and Lactational Exposure Study in Rats to Identify Replacements for Di(2-ethylhexyl) Phthalate.

Nardelli TC, Albert O, Lalancette C, Culty M, Hales BF, Robaire B

Scientific reports2017

DOI: 10.1038/s41598-017-03979-0 PMID: 28634325

09

In vitro functional screening as a means to identify new plasticizers devoid of reproductive toxicity.

Boisvert A, Jones S, Issop L, Erythropel HC, Papadopoulos V, Culty M

Environmental research2016Senior author

DOI: 10.1016/j.envres.2016.06.033 PMID: 27423704

10

Regulation of Translocator Protein 18 kDa (TSPO) Expression in Rat and Human Male Germ Cells.

Manku G, Culty M

International journal of molecular sciences2016Senior author

DOI: 10.3390/ijms17091486 PMID: 27608010

Low dose effects of endocrine disruptors on male reproduction

Nominated PICIHR2013Operating Grant

Principal investigators: Culty, Martine G

Keywords: Cell Differentiation; Endocrine Disruptors; Epigenetics; Etiology Of Testicular Germ Cell Pathologies; Fetal Exposure; Gene And Protein Expression; Infertility; Short And Long Term Effects; Testicular Fibrosis; Testicular Germ Cell Development

$520,600

Role of the ubiquitin system in testicular germ cell development

Principal investigatorNSERC2013Discovery Grants Program - Individual

Principal investigators: Culty, Martine

$150,000

Fetal Origin of Endocrine Dysfunction: The Phthalate Model

Co-investigatorCIHR2010Operating Grant

Principal investigators: Papadopoulos, Vassilios

Keywords: Adrenal Function; Endocrine Disruptors; Environmental Exposures; Epigenetics; Hypogonadism; Metabolic Syndrome; Steroid Biosynthesis; Testicular Function; Transcription Regulation

$779,382

CIHR Team in Impact of exposure to phthalates, their metabolites and "green" plasticizers on male reproductive health

Co-investigatorCIHR2009Team Grant: Environment and Reproductive Health - Full application

Principal investigators: Robaire, Bernard

Keywords: Leydig Cells; Male Reproductive Health; Phthalate; Plasticizer; Testic Cancer; Testis Function

$2,492,500

Acute Hormonal Regulation of Steroidogenesis

Co-investigatorCIHR2009Operating Grant

Principal investigators: Papadopoulos, Vassilios

Keywords: Biochemistry; Cholesterol Transport; Hormones; Leydig Cells; Steroid Biosynthesis; Testis

$759,497

Impact of exposure to phthalates, their metabolites and "green" plasticizers on male reproductive health

Co-investigatorCIHR2008Team Grant: Environment and Reproductive Health (LOI)

Principal investigators: Robaire, Bernard

Keywords: Leydig Cells; Male Reproductive Health; Phthalate; Plasticizer; Testic Cancer; Testis Function

$10,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Medicine
Urology
Pharmacology and Therapeutics
Biochemistry
Obstetrics and Gynecology
Surgery
Other

Co-authors at McGill University, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Vassilios Papadopoulos

Medicine

9 shared papers, latest 2016

Steven Jones

Faculty

4 shared papers, latest 2016

Yasaman Aghazadeh

Faculty

2 shared papers, latest 2014

Cristian O'Flaherty

Urology

2 shared papers, latest 2019

Teruko Taketo

Surgery

1 shared papers, latest 2017

Bernard Robaire

Pharmacology and Therapeutics

1 shared papers, latest 2017

Jerry Pelletier

Biochemistry

1 shared papers, latest 2017

Makoto Nagano

Obstetrics and Gynecology

1 shared papers, latest 2017

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Subject: Prospective PhD student: Cell Differentiation Dear Professor Culty, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Impact of Fetal Exposure to Endocrine Disrupting Chemical Mixtures on FOXA3 Gene and Protein Expression in Adult Rat Testes." (2023), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]