Elias Georges, McGill University

Latest papers

Epitope specific antibodies to N- and C cytoplasmic domains of the Plasmodium falciparum chloroquine resistance transporter (PfCRT) differentiate native and post-translationally modified variant.
Biochemical and biophysical research communications · 2023 · senior author
The anti-estrogen receptor drug, tamoxifen, is selectively Lethal to P-glycoprotein-expressing Multidrug resistant tumor cells.
BMC cancer · 2023 · senior author
Down-regulation of ABCB1 by collateral sensitivity drugs reverses multidrug resistance and up-regulates enolase I.
Journal of biochemistry · 2022 · senior author

All 27 publications

Latest funding

Functional Mapping of ABC Transporters Protein Interaction Networks
NSERC · 2017 · Principal investigator
$156,000
Regulation of ABC proteins functions through protein interactions: role of linker domains of ABCB1/C1 in modulating protein functions
NSERC · 2010 · Principal investigator
$135,000
The multidrug resistance proteins (MRPs): molecular mechanisms of drug binding and transport
NSERC · 2005 · Principal investigator
$197,000

All 13 grants and awards

27 publications.

01

Epitope specific antibodies to N- and C cytoplasmic domains of the Plasmodium falciparum chloroquine resistance transporter (PfCRT) differentiate native and post-translationally modified variant.

Baakdah F, Georges E

Biochemical and biophysical research communications2023Senior author

DOI: 10.1016/j.bbrc.2023.05.096 PMID: 37267860

02

The anti-estrogen receptor drug, tamoxifen, is selectively Lethal to P-glycoprotein-expressing Multidrug resistant tumor cells.

Bakadlag R, Limniatis G, Georges G, Georges E

BMC cancer2023Senior author

DOI: 10.1186/s12885-022-10474-x PMID: 36609245

03

Down-regulation of ABCB1 by collateral sensitivity drugs reverses multidrug resistance and up-regulates enolase I.

Limniatis G, Georges E

Journal of biochemistry2022Senior author

DOI: 10.1093/jb/mvac032 PMID: 35471238

04

Knockout of P-glycoprotein abolish the collateral sensitivity of CHORC5 multidrug resistant cells.

Limniatis G, Georges E

Biochemical and biophysical research communications2022Senior author

DOI: 10.1016/j.bbrc.2022.03.148 PMID: 35381425

05

Direct and specific binding of cholesterol to the mitochondrial translocator protein (TSPO) using PhotoClick cholesterol analogue.

Georges E, Sottas C, Li Y, Papadopoulos V

Journal of biochemistry2021First author

DOI: 10.1093/jb/mvab031 PMID: 33846725

06

The phenothiazine, trifluoperazine, is selectively lethal to ABCB1-expressing multidrug resistant cells.

Limniatis G, Georges E

Biochemical and biophysical research communications2021Senior author

DOI: 10.1016/j.bbrc.2021.07.031 PMID: 34284140

07

Epitope-specific IgG pools identify PfCRT monomer and homodimer polypeptides that are differentially phosphorylated at Ser411 in Plasmodium falciparum.

Baakdah F, Georges E

Biochemical and biophysical research communications2021Senior author

DOI: 10.1016/j.bbrc.2021.04.034 PMID: 33894412

08

Inorganic ions on hemozoin surface provide a glimpse into Plasmodium biology.

Guerra ED, Baakdah F, Gourgas O, Tam M, Stevenson MM, Georges E, Bohle DS, Cerruti M

Journal of inorganic biochemistry2019

DOI: 10.1016/j.jinorgbio.2019.110808 PMID: 31487576

09

What is pure hemozoin? A close look at the surface of the malaria pigment.

Guerra ED, Baakdah F, Georges E, Bohle DS, Cerruti M

Journal of inorganic biochemistry2019

DOI: 10.1016/j.jinorgbio.2019.01.021 PMID: 30877896

10

Malaria Detection by Third-Harmonic Generation Image Scanning Cytometry.

Kazarine A, Baakdah F, Gopal AA, Oyibo W, Georges E, Wiseman PW

Analytical chemistry2019

DOI: 10.1021/acs.analchem.8b04791 PMID: 30601655

Functional Mapping of ABC Transporters Protein Interaction Networks

Principal investigatorNSERC2017Discovery Grants Program - Individual

Principal investigators: Georges, Elias

$156,000

Regulation of ABC proteins functions through protein interactions: role of linker domains of ABCB1/C1 in modulating protein functions

Principal investigatorNSERC2010Discovery Grants Program - Individual

Principal investigators: Georges, Elias

$135,000

The multidrug resistance proteins (MRPs): molecular mechanisms of drug binding and transport

Principal investigatorNSERC2005Discovery Grants Program - Individual

Principal investigators: Georges, Elias

$197,000

Request for a microplate fluorometer/luminometer

Co-investigatorNSERC2001Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Ribeiro, Paula

$63,782

Gel documentation system

Co-investigatorNSERC2001Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Beech, Robin

$21,244

High performance centrifuge

Co-investigatorNSERC2001Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Chadee, Khrisendath

$39,055

Multidrug resistance in Malaria

Principal investigatorNSERC2000Discovery Grants Program - Individual

Principal investigators: Georges, Elias

$180,000

Scintillation counter

Co-investigatorNSERC1997Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Faubert, Gaétan

$38,102

Drug resistance in Malaria

Principal investigatorNSERC1996Discovery Grants Program - Individual

Principal investigators: Georges, Elias

$85,100

Mechanism of action of moxidectin in parasitic nematodes

Co-investigatorNSERC1995Collaborative Research and Development Grants

Principal investigators: Prichard, Roger

$188,900

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Institute of Parasitology
Mining and Materials Engineering
Microbiology and Immunology
Biochemistry
Physique

Co-authors at McGill University, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Marta Cerruti

Mining and Materials Engineering

2 shared papers, latest 2019

Petra Rohrbach

Institute of Parasitology

1 shared papers, latest 2014

Martin Olivier

Microbiology and Immunology

1 shared papers, latest 2009

Philippe Gros

Biochemistry

1 shared papers, latest 2005

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mention

Subject: Prospective PhD student Dear Professor Georges, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Epitope specific antibodies to N- and C cytoplasmic domains of the Plasmodium falciparum chloroquine resistance transporter (PfCRT) differentiate native and post-translationally modified variant." (2023), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

Elias Georges

Latest papers

Latest funding

Epitope specific antibodies to N- and C cytoplasmic domains of the Plasmodium falciparum chloroquine resistance transporter (PfCRT) differentiate native and post-translationally modified variant.

The anti-estrogen receptor drug, tamoxifen, is selectively Lethal to P-glycoprotein-expressing Multidrug resistant tumor cells.

Down-regulation of ABCB1 by collateral sensitivity drugs reverses multidrug resistance and up-regulates enolase I.

Knockout of P-glycoprotein abolish the collateral sensitivity of CHORC5 multidrug resistant cells.

Direct and specific binding of cholesterol to the mitochondrial translocator protein (TSPO) using PhotoClick cholesterol analogue.

The phenothiazine, trifluoperazine, is selectively lethal to ABCB1-expressing multidrug resistant cells.

Epitope-specific IgG pools identify PfCRT monomer and homodimer polypeptides that are differentially phosphorylated at Ser411 in Plasmodium falciparum.

Inorganic ions on hemozoin surface provide a glimpse into Plasmodium biology.

What is pure hemozoin? A close look at the surface of the malaria pigment.

Malaria Detection by Third-Harmonic Generation Image Scanning Cytometry.

Functional Mapping of ABC Transporters Protein Interaction Networks

Regulation of ABC proteins functions through protein interactions: role of linker domains of ABCB1/C1 in modulating protein functions

The multidrug resistance proteins (MRPs): molecular mechanisms of drug binding and transport

Request for a microplate fluorometer/luminometer

Gel documentation system

High performance centrifuge

Multidrug resistance in Malaria

Scintillation counter

Drug resistance in Malaria

Mechanism of action of moxidectin in parasitic nematodes

Frequent collaborators

Marta Cerruti

Petra Rohrbach

Richard Leonelli

Martin Olivier

Philippe Gros