Faculty profile

Philippe Gros

ResearcherBiochemistryMcGill University

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a McGill University directory, so their courses may be missing. Find their university profile.

Philippe Gros

Researcher

Biochemistry

Health Sciences

McGill University

Montreal, Quebec, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
12 publications in the last five years, latest in 2026.
Senior (last) author on 2 recent papers, a sign of leading a research group.
Principal investigator on 7 research grants (7 CIHR), most recently in 2025.
Supervisor on 3 trainee awards (3 CIHR), most recently in 2010.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

117

Publications

283

Citations

Collaborators

Grants

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

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Signals and details

Research

Inflammation Tuberculosis Crohn'S Disease Ulcerative Colitis Gene Mutation Macrophage Mouse Genetics Mycobacterial Infections

Latest papers

Type I interferon-dependent and -independent signaling underlie autoantibody production in a murine lupus model.
Journal of translational autoimmunity · 2026
Human LY9 governs CD4+ T cell IFN-γ immunity to Mycobacterium tuberculosis.
Science immunology · 2025
In vivo CRISPR screens reveal SCAF1 and USP15 as drivers of pancreatic cancer.
Nature communications · 2024

All 117 publications

Latest funding

RARRES3 Deficiency, Macrophage Function and Susceptibility to Mycobacterial Infections
CIHR · 2025 · Nominated PI
$765,000
Genetic analysis of susceptibility to infections and to inflammation
CIHR · 2015 · Nominated PI
$2,170,632
A Canada-Japan integrative meta-omics approach to define diet-microbiome derived metabolites that promote IBD in genetically susceptible individuals
CIHR · 2015 · Principal investigator

All 16 grants and awards

117 publications.

Type I interferon-dependent and -independent signaling underlie autoantibody production in a murine lupus model.

Levine JS, Pilon C, Subang R, Salem D, Lonina E, Qureshi ST, Fonseca GJ, Gros P, Rauch J

Journal of translational autoimmunity2026

DOI: 10.1016/j.jtauto.2026.100351 PMID: 41704663

Human LY9 governs CD4+ T cell IFN-γ immunity to Mycobacterium tuberculosis.

Ogishi M, Puchan J, Yang R, Arias AA, Han JE, Nguyen T, Gutiérrez-Cózar R, Conil C, Seeleuthner Y, Rinchai D, Zhang P, Ponsin K, Chaldebas M, Feng Y, Neehus AL, Delmonte OM, Khan T, Landegren N, Eriksson D, Bohlen J, Peel JN, Fagniez I, Pelham SJ, Lei WT, Chrabieh M, Laine C, Ouair H, Benhsaien I, Abid A, Abderrhamani Ghorfi I, Souhi H, Ouazzani H, Aniss R, Riminton DS, Kämpe O, Turvey SE, Marr N, Notarangelo LD, Hatipoglu N, Bousfiha A, Ozcelik T, El Baghdadi J, Cobat A, Ma CS, Abel L, Puel A, Bustamante J, Engel P, Gros P, Tangye SG, Sallusto F, Boisson-Dupuis S, Casanova JL

Science immunology2025

DOI: 10.1126/sciimmunol.ads7377 PMID: 40446017

In vivo CRISPR screens reveal SCAF1 and USP15 as drivers of pancreatic cancer.

Martinez S, Wu S, Geuenich M, Malik A, Weber R, Woo T, Zhang A, Jang GH, Dervovic D, Al-Zahrani KN, Tsai R, Fodil N, Gros P, Gallinger S, Neely GG, Notta F, Sendoel A, Campbell K, Elling U, Schramek D

Nature communications2024

DOI: 10.1038/s41467-024-49450-3 PMID: 38902237

The potential importance of the built-environment microbiome and its impact on human health.

Bosch TCG, Wigley M, Colomina B, Bohannan B, Meggers F, Amato KR, Azad MB, Blaser MJ, Brown K, Dominguez-Bello MG, Ehrlich SD, Elinav E, Finlay BB, Geddie K, Geva-Zatorsky N, Giles-Vernick T, Gros P, Guillemin K, Haraoui LP, Johnson E, Keck F, Lorimer J, McFall-Ngai MJ, Nichter M, Pettersson S, Poinar H, Rees T, Tropini C, Undurraga EA, Zhao L, Melby MK

Proceedings of the National Academy of Sciences of the United States of America2024

DOI: 10.1073/pnas.2313971121 PMID: 38662573

Human inherited CCR2 deficiency underlies progressive polycystic lung disease.

Neehus AL, Carey B, Landekic M, Panikulam P, Deutsch G, Ogishi M, Arango-Franco CA, Philippot Q, Modaresi M, Mohammadzadeh I, Corcini Berndt M, Rinchai D, Le Voyer T, Rosain J, Momenilandi M, Martin-Fernandez M, Khan T, Bohlen J, Han JE, Deslys A, Bernard M, Gajardo-Carrasco T, Soudée C, Le Floc'h C, Migaud M, Seeleuthner Y, Jang MS, Nikolouli E, Seyedpour S, Begueret H, Emile JF, Le Guen P, Tavazzi G, Colombo CNJ, Marzani FC, Angelini M, Trespidi F, Ghirardello S, Alipour N, Molitor A, Carapito R, Mazloomrezaei M, Rokni-Zadeh H, Changi-Ashtiani M, Brouzes C, Vargas P, Borghesi A, Lachmann N, Bahram S, Crestani B, Fayon M, Galode F, Pahari S, Schlesinger LS, Marr N, Bogunovic D, Boisson-Dupuis S, Béziat V, Abel L, Borie R, Young LR, Deterding R, Shahrooei M, Rezaei N, Parvaneh N, Craven D, Gros P, Malo D, Sepulveda FE, Nogee LM, Aladjidi N, Trapnell BC, Casanova JL, Bustamante J

Cell2024

DOI: 10.1016/j.cell.2023.11.036 PMID: 38157855

Impaired development of memory B cells and antibody responses in humans and mice deficient in PD-1 signaling.

Ogishi M, Kitaoka K, Good-Jacobson KL, Rinchai D, Zhang B, Wang J, Gies V, Rao G, Nguyen T, Avery DT, Khan T, Smithmyer ME, Mackie J, Yang R, Arias AA, Asano T, Ponsin K, Chaldebas M, Zhang P, Peel JN, Bohlen J, Lévy R, Pelham SJ, Lei WT, Han JE, Fagniez I, Chrabieh M, Laine C, Langlais D, Gruber C, Al Ali F, Rahman M, Aytekin C, Benson B, Dufort MJ, Domingo-Vila C, Moriya K, Shlomchik M, Uzel G, Gray PE, Suan D, Preece K, Chua I, Okada S, Chikuma S, Kiyonari H, Tree TI, Bogunovic D, Gros P, Marr N, Speake C, Oram RA, Béziat V, Bustamante J, Abel L, Boisson B, Korganow AS, Ma CS, Johnson MB, Chamoto K, Boisson-Dupuis S, Honjo T, Casanova JL, Tangye SG

Immunity2024

DOI: 10.1016/j.immuni.2024.10.014 PMID: 39603236

CCDC88B interacts with RASAL3 and ARHGEF2 and regulates dendritic cell function in neuroinflammation and colitis.

Olivier JF, Langlais D, Jeyakumar T, Polyak MJ, Galarneau L, Cayrol R, Jiang H, Molloy KR, Xu G, Suzuki H, LaCava J, Gros P, Fodil N

Communications biology2024

DOI: 10.1038/s42003-023-05751-9 PMID: 38200184

Gene: environment interactions in immune and inflammatory responses to severe acute respiratory syndrome coronavirus 2 infection.

Yang Y, Azzuolo A, Fodil N, Gros P

Current opinion in immunology2024Senior author

DOI: 10.1016/j.coi.2024.102459 PMID: 39243725

Reconciling Mouse and Human Immunology at the Altar of Genetics.

Gros P, Casanova JL

Annual review of immunology2023First author

DOI: 10.1146/annurev-immunol-101721-065201 PMID: 36525691

Biphosphoglycerate Mutase: A Novel Therapeutic Target for Malaria?

Azzuolo A, Yang Y, Berghuis A, Fodil N, Gros P

Transfusion medicine reviews2023Senior author

DOI: 10.1016/j.tmrv.2023.150748 PMID: 37827586

RARRES3 Deficiency, Macrophage Function and Susceptibility to Mycobacterial Infections

Nominated PICIHR2025Project Grant

Principal investigators: Gros, Philippe

Keywords: Gene Mutation; Inflammation; Macrophage; Mouse Genetics; Mycobacterial Infections; Phospholipase; Rarres; Tuberculosis

$765,000

Genetic analysis of susceptibility to infections and to inflammation

Nominated PICIHR2015Foundation Grant

Principal investigators: Gros, Philippe

Keywords: Genetic Analysis; Infections; Inflammation; Inflammatory Diseases; Interferon Response Factor; Malaria; Myeloid Cells; Primary Immunodeficiencies; Tuberculosis

$2,170,632

A Canada-Japan integrative meta-omics approach to define diet-microbiome derived metabolites that promote IBD in genetically susceptible individuals

Principal investigatorCIHR2015Environments, Genes and Chronic Disease - LOI

Principal investigators: Saleh, Maya; Bernstein, Charles N; Bitton, Alain; Bourque, Guillaume; Des Rosiers, Christine; Gros, Philippe; Lathrop, Mark; Matsuda, Fumihiko; Shatenstein, Bryna; Surette, Michael G; Tsutomu, CHIBA

Keywords: Chronic Inflammation; Crohn'S Disease; Diet (Environment); Genetics; Gnotobiotic Mice (Germ-Free); Humanized Mice; Inflammatory Bowel Diseases; Metabolome; Microbiome; Ulcerative Colitis

Immunopathogenesis of inflammatory diseases: genetic, cellular and molecular pathways regulating acute and chronic inflammation

Co-investigatorCIHR2013Operating Grant

Principal investigators: Vidal, Silvia M

Keywords: Biochemistry; Cerebral Malaria; Dna Sequence Analysis; Enu-Mutations; Herpes Encephalitis; Immunophenotyping; Inflammation; Inflammatory Bowel Disease; Mouse Genetic Models; Multiple Sclerosis

$841,655

ImmunoSeq: novel immunogenetic discovery tool and its translation to personalized medicine in Finnish and Canadian partnership

Co-investigatorCIHR2012Team Grant: Health Challenges in Chronic Inflammation Initiative (LOI)

Principal investigators: Pastinen, Tomi; Lathrop, Mark

Keywords: Autoimmune Disease; Genetic Risk; Immune System; Inflammatory Disease; Personalized Medicine

$20,000

Validation and characterization of causative genetic determinants common to important inflammatory diseases

Nominated PICIHR2012Team Grant: Health Challenges in Chronic Inflammation Initiative (LOI)

Principal investigators: Gros, Philippe

Keywords: Crohn'S Disease; Exome Sequencing; Gwas; Ibd; Lentiviral Delivery System; Mouse Models; Multiple Sclerosis; Transgenics; Ulcerative Colitis

$20,000

Genetic studies of blood stage malaria: from mouse models to human disease

Nominated PICIHR2011Operating Grant

Principal investigators: Gros, Philippe

Keywords: Artemisinin; Cysteamine; Erythrocyte; Genetics; Infectious Diseases; Malaria; Mouse Models; Positional Cloning; Pyruvate Kinase

$707,360

Role of Vangl proteins in normal development and in neural tube defects

Nominated PICIHR2011Operating Grant

Principal investigators: Gros, Philippe

Keywords: Development; Genetics; Membrane Protein; Molecular Biology; Nephrologie; Neural Tube Defects; Retinal Degeneration

$730,740

Positional cloning of the Char10 malaria susceptibility locus

SupervisorCIHR2010Doctoral Award - Frederick Banting and Charles Best Canada Graduate Scholarships

Principal investigators: Laroque, Aurélie

Keywords: Biochemistry; Expression Analysis (Micro-Array; Facs; Genetics; Malaria; Mouse Model; Plasmodium Chabaudi; Positional Cloning; Qtl Analysis; Rt-Pcr...); Sequencing

$105,000

Genetic Determinants of Susceptibility to Mycobacterial Infections

Nominated PICIHR2010Operating Grant

Principal investigators: Gros, Philippe

Keywords: Genetics; Irf8; Mouse; Mycobacterial Infections; Positional Cloning; Tuberculosis

$812,214

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Philippe Gros

Research

Latest papers

Latest funding

Type I interferon-dependent and -independent signaling underlie autoantibody production in a murine lupus model.

Human LY9 governs CD4+ T cell IFN-&#x3b3; immunity to Mycobacterium tuberculosis.

In vivo CRISPR screens reveal SCAF1 and USP15 as drivers of pancreatic cancer.

The potential importance of the built-environment microbiome and its impact on human health.

Human inherited CCR2 deficiency underlies progressive polycystic lung disease.

Impaired development of memory B cells and antibody responses in humans and mice deficient in PD-1 signaling.

CCDC88B interacts with RASAL3 and ARHGEF2 and regulates dendritic cell function in neuroinflammation and colitis.

Gene: environment interactions in immune and inflammatory responses to severe acute respiratory syndrome coronavirus 2 infection.

Reconciling Mouse and Human Immunology at the Altar of Genetics.

Biphosphoglycerate Mutase: A Novel Therapeutic Target for Malaria?

Frequent collaborators

David Langlais

Nicole Beauchemin

Danielle Malo

Elena Torban

Mark Lathrop

Zoha Kibar

Maya Saleh

Jacek Majewski

Albert Berghuis

Mathieu Blanchette

Anastasia Nijnik

Pierre Drapeau

Erwin Schurr

Jerry Pelletier

Carolina Tropini

Guillaume Bourque

Hendrik Poinar

Subburaj Ilangumaran

Anne-Marie Mes-Masson

Daniel Schramek

Michel Cayouette

David Goltzman

Meghan Azad

Luke McCaffrey

Mariela Segura

Marcel Behr

Alexandre Prat

Karen Mossman

Frank Sicheri

Robert Sladek

Human LY9 governs CD4+ T cell IFN-γ immunity to Mycobacterium tuberculosis.