Faculty profile

Fackson Mwale

ResearcherExperimental SurgeryMcGill University

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a McGill University directory, so their courses may be missing. Find their university profile.

Fackson Mwale

Researcher

Experimental Surgery

Health Sciences

McGill University

Montreal, Quebec, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
13 publications in the last five years, latest in 2026.
Senior (last) author on 5 recent papers, a sign of leading a research group.
Principal investigator on 5 research grants (5 CIHR), most recently in 2025.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

Citations

Collaborators

Grants

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

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Signals and details

Research

Tissue Engineering Link N Cartilage Repair Disease-Modifying Osteoarthritis Drug Disc Degeneration Osteoarthritis Vgef Receptor Inhibitor Disease-Modifying Drug

Latest papers

CRISPR screen uncovers SLC26A2 as a modulator of tungsten toxicity in endochondral ossification.
Environmental research · 2026
A Decade of Leadership and Impact: Celebrating 10 Years of the ORS Spine Section.
JOR spine · 2026
Unraveling Osteoarthritis: Mechanistic Insights and Emerging Therapies Targeting Pain and Inflammation.
Biomolecules · 2025 · senior author

All 68 publications

Latest funding

Integrative Strategies for Osteoarthritis Therapy: Combining Nanoparticle-based VEGF Receptor Inhibition with Link N Peptide Applications
CIHR · 2025 · Nominated PI
$944,775
Small molecule inhibitor of IL-1b signaling in degenerative disc disease
CIHR · 2022 · Nominated PI
$734,400
Role of Link N in Osteoarthritis
CIHR · 2021 · Principal investigator
$699,975

All 10 grants and awards

68 publications.

CRISPR screen uncovers SLC26A2 as a modulator of tungsten toxicity in endochondral ossification.

Bakadlag R, Li S, Guilbert C, Huard C, Bertomeu T, Coulombe-Huntington J, Jackson BP, Grant MP, Iskandarani L, Paganini C, Rossi A, Mwale F, Tyers M, Hales BF, Mann KK

Environmental research2026

DOI: 10.1016/j.envres.2026.124634 PMID: 42119765

A Decade of Leadership and Impact: Celebrating 10 Years of the ORS Spine Section.

Bhadouria N, Gawri R, Graziani G, Anderson DE, Chee AV, Dahia CL, Diwan A, Giers MB, Illien-Junger S, Kirilusha A, Nuckley DJ, Rosenzweig DH, Séguin C, Sheyn D, Teixeira GQ, Alini M, Ito K, Mauck RL, Sakai D, Bailey J, Fields AJ, Grad S, Gullbrand SE, Holguin N, Kandel R, Li Z, Li J, Martin JT, Mwale F, O'Connell GD, Purmessur D, Vo N, Zehra U, Chahine NO, Haglund L, Hoyland JA, Le Maitre CL, Lotz JC, Risbud MV, Smith LJ, Tang S, Iatridis JC, Wuertz-Kozak K, Samartzis D

JOR spine2026

DOI: 10.1002/jsp2.70180 PMID: 41982788

Unraveling Osteoarthritis: Mechanistic Insights and Emerging Therapies Targeting Pain and Inflammation.

Alad M, Yousef F, Epure LM, Lui A, Grant MP, Merle G, Eliopoulos N, Barralet J, Antoniou J, Mwale F

Biomolecules2025Senior author

DOI: 10.3390/biom15060874 PMID: 40563514

Link N Directly Targets IL-1β to Suppress Inflammation and Regulate Sensory Pain in Intervertebral Disc Degeneration.

Grant MP, Alad M, Yousef F, Epure LM, Antoniou J, Mwale F

Biomolecules2025Senior author

DOI: 10.3390/biom15040603 PMID: 40305345

Enhancing Bone Healing Through Localized Cold Therapy in a Murine Femoral Fracture Model.

Zakaria M, Allard J, Garcia J, Matta J, Honjol Y, Schupbach D, Grant M, Mwale F, Harvey E, Merle G

Tissue engineering. Part A2025

DOI: 10.1089/ten.tea.2024.0069 PMID: 39041619

Advances in the Regulation of Periostin for Osteoarthritic Cartilage Repair Applications.

Shih SY, Grant MP, Epure LM, Alad M, Lerouge S, Huk OL, Bergeron SG, Zukor DJ, Merle G, Im HJ, Antoniou J, Mwale F

Biomolecules2024Senior author

DOI: 10.3390/biom14111469 PMID: 39595645

Short Link N Modulates Inflammasome Activity in Intervertebral Discs Through Interaction with CD14.

Alad M, Grant MP, Epure LM, Shih SY, Merle G, Im HJ, Antoniou J, Mwale F

Biomolecules2024Senior author

DOI: 10.3390/biom14101312 PMID: 39456246

Cobalt ions induce a cellular senescence secretory phenotype in human synovial fibroblast-like cells that may be an early event in the development of adverse local tissue reactions to hip implants.

Grant MP, Alatassi R, Diab MO, Abushal M, Epure LM, Huk OL, Bergeron SG, Im Sampen HJ, Antoniou J, Mwale F

Osteoarthritis and cartilage open2024Senior author

DOI: 10.1016/j.ocarto.2024.100490 PMID: 38828014

Nanoparticle-based inhibition of vascular endothelial growth factor receptors alleviates osteoarthritis pain and cartilage damage.

Ma K, Pham T, Wang J, O-Sullivan I, DiCamillo A, Du S, Mwale F, Farooqui Z, Votta-Velis G, Bruce B, van Wijnen AJ, Liu Y, Im HJ

Science advances2024

DOI: 10.1126/sciadv.adi5501 PMID: 38354243

Loss of PKCδ/Prkcd prevents cartilage degeneration in joints but exacerbates hyperalgesia in an experimental osteoarthritis mouse model.

Singh G, O-Sullivan I, Natarajan Anbazhagan A, Ranjan K C, Farooqui Z, Ma K, Wang J, Mwale F, Votta-Velis G, Bruce B, Ronald Kahn C, van Wijnen AJ, Im HJ

Gene2024

DOI: 10.1016/j.gene.2023.147920 PMID: 37890601

Integrative Strategies for Osteoarthritis Therapy: Combining Nanoparticle-based VEGF Receptor Inhibition with Link N Peptide Applications

Nominated PICIHR2025Project Grant

Principal investigators: Mwale, Fackson; Antoniou, John

Keywords: Cartilage Repair; Disease-Modifying Osteoarthritis Drug; Link N; Osteoarthritis; Tissue Engineering; Vgef Receptor Inhibitor

$944,775

Small molecule inhibitor of IL-1b signaling in degenerative disc disease

Nominated PICIHR2022Project Grant

Principal investigators: Mwale, Fackson; Antoniou, John

Keywords: Disc Degeneration; Disease-Modifying Drug; Link N; Low Back Pain; Tissue Engineering

$734,400

Role of Link N in Osteoarthritis

Principal investigatorCIHR2021Project Grant

Principal investigators: Antoniou, John; Mwale, Fackson

Keywords: Cartilage Repair; Disease-Modifying Osteoarthritis Drug; Link N; Osteoarthritis,; Tissue Engineering

$699,975

Injectable bioactive hydrogel for the regeneration of intervertebral disc

Co-investigatorNSERC2017Collaborative Health Research Projects

Principal investigators: Lerouge, Sophie

$298,386

Short Link N as a therapeutic agent for intervertebral disc degeneration.

Principal investigatorCIHR2016Project Grant

Principal investigators: Antoniou, John; Mwale, Fackson

Keywords: Disc Degeneration; Intervertebral Disc; Mesenchymal Stem Cells; Proteoglycans; Tissue Engineering

$749,211

Bone as a Target for Tungsten-induced Toxicities

Co-investigatorCIHR2015Operating Grant

Principal investigators: Mann, Koren K

Keywords: Bone; Toxicology; Tungsten

$700,891

Bone as a Target for Tungsten-induced Toxicities

Co-investigatorCIHR2014Operating Grant

Principal investigators: Mann, Koren K

Keywords: Bone; Toxicology; Tungsten

$100,000

The efficacy of Link N as a mediator of repair in Intervertebral Disc Degeneration

Nominated PICIHR2011Operating Grant

Principal investigators: Mwale, Fackson

Keywords: Degenerative Disc Disease; Intervertebral Disc; Link N; Mesenchymal Stem Cells; Nucleus Pulposus

$454,098

Tissue Engineering of Intervertebral Discs

Co-investigatorCIHR2010Operating Grant

Principal investigators: Antoniou, John

Keywords: Collagens; Disc Degeneration; Intervertebral Disc; Link N Peptide; Mesenchymal Stem Cells; Proteoglycans; Tissue Engineering

$328,001

Novel plasma polymerised coatings for vascular implants

Co-investigatorNSERC2008Collaborative Health Research Projects

Principal investigators: Lerouge, Sophie

$276,538

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Fackson Mwale

Research

Latest papers

Latest funding

CRISPR screen uncovers SLC26A2 as a modulator of tungsten toxicity in endochondral ossification.

A Decade of Leadership and Impact: Celebrating 10&#x2009;Years of the ORS Spine Section.

Unraveling Osteoarthritis: Mechanistic Insights and Emerging Therapies Targeting Pain and Inflammation.

Link N Directly Targets IL-1&#x3b2; to Suppress Inflammation and Regulate Sensory Pain in Intervertebral Disc Degeneration.

Enhancing Bone Healing Through Localized Cold Therapy in a Murine Femoral Fracture Model.

Advances in the Regulation of Periostin for Osteoarthritic Cartilage Repair Applications.

Short Link N Modulates Inflammasome Activity in Intervertebral Discs Through Interaction with CD14.

Cobalt ions induce a cellular senescence secretory phenotype in human synovial fibroblast-like cells that may be an early event in the development of adverse local tissue reactions to hip implants.

Nanoparticle-based inhibition of vascular endothelial growth factor receptors alleviates osteoarthritis pain and cartilage damage.

Loss of PKC&#x3b4;/Prkcd prevents cartilage degeneration in joints but exacerbates hyperalgesia in an experimental osteoarthritis mouse model.

Injectable bioactive hydrogel for the regeneration of intervertebral disc

Novel plasma polymerised coatings for vascular implants

Frequent collaborators

Fackson Mwale

John Antoniou

John Antoniou

Peter Roughley

Rahul Gawri

Lisbet Haglund

Sophie Lerouge

Jean Ouellet

Sophie Lerouge

Maryam Tabrizian

Jake Barralet

Mario Lamontagne

Mihaela Iordanova

Caroline Hoemann

Edward Harvey

Gilles Soulez

Albert Yee

Gilles Soulez

Rita Kandel

Gilles Soulez

A Decade of Leadership and Impact: Celebrating 10 Years of the ORS Spine Section.

Link N Directly Targets IL-1β to Suppress Inflammation and Regulate Sensory Pain in Intervertebral Disc Degeneration.

Loss of PKCδ/Prkcd prevents cartilage degeneration in joints but exacerbates hyperalgesia in an experimental osteoarthritis mouse model.