Jérôme Fortin, McGill University

Research

Brain Cancer Epigenetics Functional Genomic Screens Genetically Engineered Mouse Models

Latest papers

Cholinergic regulation of thymocyte negative selection.
Nature immunology · 2025
Mutant IDH1 cooperates with NPM1c or FLT3ITD to drive distinct myeloid diseases and molecular outcomes.
Proceedings of the National Academy of Sciences of the United States of America · 2025
B cell-derived acetylcholine promotes liver regeneration by regulating Kupffer cell and hepatic CD8+ T cell function.
Immunity · 2025

All 5 publications

Latest funding

Cell biological role of the cancer-related gene SPOCD1 in the formation of mesenchymal-like cells in Glioblastoma
CIHR · 2025 · Co-investigator
$1,185,750
Characterizing and improving new treatments for IDH-mutant diffuse gliomas
CIHR · 2024 · Nominated PI
$1,051,875
Characterizing and improving new treatments for IDH-mutant diffuse gliomas
CIHR · 2024 · Nominated PI
$25,000

All 3 grants and awards

5 publications.

01

Cholinergic regulation of thymocyte negative selection.

Liu S, Zheng C, Nechanitzky R, Luo P, Ramachandran P, Nguyen D, Elia AJ, Moghadas Jafari S, Law R, Snow BE, Wakeham AC, Berger T, Chen H, Gill KT, Mcwilliam R, Fortin J, Modares NF, Saunders ME, Murakami K, Qiu Y, You Z, Mohtashami M, Qi H, Ohashi PS, Zúñiga-Pflücker JC, Mak TW

Nature immunology2025

DOI: 10.1038/s41590-025-02152-4 PMID: 40399609

02

Mutant IDH1 cooperates with NPM1c or FLT3ITD to drive distinct myeloid diseases and molecular outcomes.

Sakamoto T, Leca J, Zhang X, Meydan C, Foox J, Ramachandran P, Hendrikse LD, Zhou W, Berger T, Fortin J, Chan SM, Chiang MF, Inoue S, Li WY, Chu MF, Duncan GS, Wakeham A, Lemonnier F, Tobin C, Mcwilliam R, Colonna I, Bontoux C, Jafari SM, Bowman RL, Nicolay B, Ronseaux S, Narayanaswamy R, Levine RL, Melnick AM, Mason CE, Minden MD, Mak TW

Proceedings of the National Academy of Sciences of the United States of America2025

DOI: 10.1073/pnas.2415779122 PMID: 40377995

03

B cell-derived acetylcholine promotes liver regeneration by regulating Kupffer cell and hepatic CD8+ T cell function.

Modares NF, Hendrikse LD, Smith LK, Paul MS, Haight J, Luo P, Liu S, Fortin J, Tong FK, Wakeham AC, Jafari SM, Zheng C, Buckland M, Flick R, Silvester J, Berger T, Ketela T, Helke S, Foffi E, Niavarani R, Mcwilliam R, Saunders ME, Colonna I, David BA, Rastogi T, Lee WY, Kubes P, Mak TW

Immunity2025

DOI: 10.1016/j.immuni.2025.04.002 PMID: 40286791

04

Oncogenic IDH1mut drives robust loss of histone acetylation and increases chromatin heterogeneity.

Furth N, Cohen N, Spitzer A, Salame TM, Dassa B, Mehlman T, Brandis A, Moussaieff A, Friedmann-Morvinski D, Castro MG, Fortin J, Suvà ML, Tirosh I, Erez A, Ron G, Shema E

Proceedings of the National Academy of Sciences of the United States of America2025

DOI: 10.1073/pnas.2403862122 PMID: 39793065

05

Mutant IDH inhibitors induce lineage differentiation in IDH-mutant oligodendroglioma.

Spitzer A, Gritsch S, Nomura M, Jucht A, Fortin J, Raviram R, Weisman HR, Gonzalez Castro LN, Druck N, Chanoch-Myers R, Lee JJY, Mylvaganam R, Lee Servis R, Fung JM, Lee CK, Nagashima H, Miller JJ, Arrillaga-Romany I, Louis DN, Wakimoto H, Pisano W, Wen PY, Mak TW, Sanson M, Touat M, Landau DA, Ligon KL, Cahill DP, Suvà ML, Tirosh I

Cancer cell2024

DOI: 10.1016/j.ccell.2024.03.008 PMID: 38579724

Cell biological role of the cancer-related gene SPOCD1 in the formation of mesenchymal-like cells in Glioblastoma

Co-investigatorCIHR2025Project Grant

Principal investigators: McPherson, Peter S

Keywords: Brain Tumors; Cell Biology; Dna Methylation; Glioblastoma; Protein Methylation; Spocd1

$1,185,750

Characterizing and improving new treatments for IDH-mutant diffuse gliomas

Nominated PICIHR2024Project Grant

Principal investigators: Fortin, Jérôme

Keywords: Brain Cancer; Epigenetics; Functional Genomic Screens; Genetically Engineered Mouse Models

$1,051,875

Characterizing and improving new treatments for IDH-mutant diffuse gliomas

Nominated PICIHR2024PRIZE - Project Grant - PA: Prize: Early Career Investigator in Cancer

Principal investigators: Fortin, Jérôme

Keywords: Brain Cancer; Epigenetics; Functional Genomic Screens; Genetically Engineered Mouse Models

$25,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Physiology and Pharmacology
Other

Co-authors at McGill University, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Paul Kubes

Physiology and Pharmacology

1 shared papers, latest 2025

Paul Kubes

Faculty

1 shared papers, latest 2025

Write to this professor

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Applying for

Paper to mentionMention their CIHR grant from 2024

Subject: Prospective PhD student: Brain Cancer Dear Professor Fortin, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Cholinergic regulation of thymocyte negative selection." (2025), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Characterizing and improving new treatments for IDH-mutant diffuse gliomas" (2024), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]