Paul Kubes, Queen's University

Research

Asthma Eosinophils Imaging Inflammation Lung Microbiome Neuroinflammation Neutrophils

Latest papers

Intravital Imaging as a Tool to Uncover Roles of Immune Cells in Chronic Liver Diseases.
JHEP reports : innovation in hepatology · 2026 · senior author
Neutrophil-hybrid CAR-macrophages bring double trouble to tumors.
Nature immunology · 2026 · senior author
A nerve and mast cell sentinel system releases extracellular condensates to induce macrophage repair.
The Journal of experimental medicine · 2026 · senior author

All 14 publications

Latest funding

Immunotherapeutic Targeting of the Peritoneal Cavity Microenvironment in Treatment of Peritoneal Carcinomatosis from High-Grade Serous Ovarian Cancer
CIHR · 2025 · Supervisor
$120,000
Investigating Neutrophils as Regulators of the Gut Microbiome
CIHR · 2024 · Supervisor
$210,000
Wildfire Particles Exacerbate Asthma by Increasing Inflammation Through Neural and Microbial Alterations
CIHR · 2023 · Nominated PI
$1,875,000

All 4 grants and awards

14 publications.

01

Intravital Imaging as a Tool to Uncover Roles of Immune Cells in Chronic Liver Diseases.

Rashid MU, Lee WY, Kubes P

JHEP reports : innovation in hepatology2026Senior author

DOI: 10.1016/j.jhepr.2026.102030 PMID: 42744247

02

Neutrophil-hybrid CAR-macrophages bring double trouble to tumors.

Siwicki M, Kubes P

Nature immunology2026Senior author

DOI: 10.1038/s41590-026-02650-z PMID: 42711526

03

A nerve and mast cell sentinel system releases extracellular condensates to induce macrophage repair.

Salm L, Lopez MA, Jenkins E, Shim R, Tejada O, Abou Mehrem B, Huang S, Etemadi Nezhad P, Derakhshani A, Lee WY, Nusse Y, Mewburn JB, Noskovicova N, Bayer J, Rashid MU, Li X, Baltaci Z, Young D, Carneiro MB, Fritzsche M, Jakubzick CV, Peters NC, Deniset JF, Zindel J, Dufour A, Yipp BG, Ditlev JA, Dustin ML, Canton J, Kubes P

The Journal of experimental medicine2026Senior author

DOI: 10.1084/jem.20260410 PMID: 42484560

04

Gut serotonin regulates Kupffer cell appetite for drug carriers.

Norris PAA, Zhai L, Kubes P

Cell research2026Senior author

DOI: 10.1038/s41422-026-01263-3 PMID: 42204351

05

Kupffer cells in liver homeostasis and disease: from immune sentinels to metabolic gatekeepers.

Araujo David B, Andreata F, Blériot C, Ginhoux F, Kubes P, Iannacone M

Nature reviews. Immunology2026

DOI: 10.1038/s41577-026-01288-0 PMID: 41951893

06

Peritoneal macrophages regulate distal wound healing via endocrine release of plasma fibronectin.

Salm L, Zwicky SN, Spari D, Yarahmadov T, Siwicki M, Castanheira FVES, Zbinden J, Stroka D, Zindel J, Dufour A, Kubes P, Beldi G

The Journal of clinical investigation2026

DOI: 10.1172/jci198632 PMID: 41871299

07

Kupffer cells are central to mitigating intravascular infections.

Oliveira FRMB, Kubes P

Current opinion in gastroenterology2025Senior author

DOI: 10.1097/mog.0000000000001128 PMID: 40986476

08

Liver macrophages: development, dynamics, and functions.

Nusse Y, Kubes P

Cellular & molecular immunology2025Senior author

DOI: 10.1038/s41423-025-01298-3 PMID: 40461700

09

Single-strand DNA is the link between neutrophil extracellular traps and thrombin.

Jenne C, Kubes P

Proceedings of the National Academy of Sciences of the United States of America2025Senior author

DOI: 10.1073/pnas.2515545122 PMID: 40854143

10

Innate immunity of the lungs in homeostasis and disease.

Norris PAA, Kubes P

Mucosal immunology2025Senior author

DOI: 10.1016/j.mucimm.2025.04.001 PMID: 40220792

Immunotherapeutic Targeting of the Peritoneal Cavity Microenvironment in Treatment of Peritoneal Carcinomatosis from High-Grade Serous Ovarian Cancer

SupervisorCIHR2025DRA : Canada Graduate Research Scholarship - Doctoral Program (CGRS D)

Principal investigators: Huang, Ken Q

Keywords: Car-T Cells; Flow Cytometry; Immune Checkpoint Inhibitors; Inflammation; Intravital Microscopy; Lymphatic Drainage; Macrophage; Peritoneal Biology

$120,000

Investigating Neutrophils as Regulators of the Gut Microbiome

SupervisorCIHR2024CIHR Fellowship

Principal investigators: Norris, Peter A

Keywords: Dysbiosis; Flow Cytometry; Fluorescent Mouse Models; Germ-Free Mice; Gut Microbiome; Intestine; Intravital Microscopy; Microbiome Regulation; Neutrophil Homeostasis; Neutrophils

$210,000

Wildfire Particles Exacerbate Asthma by Increasing Inflammation Through Neural and Microbial Alterations

Nominated PICIHR2023Team Grant: Lung Health - Inflammation and Lung Health

Principal investigators: Kubes, Paul; Jull, Janet E; Kaufmann, Eva; Leigh, Richard; Talbot, Sébastien; Thornton, Christina S; Zhao, Ran

Keywords: Asthma; Eosinophils; Imaging; Inflammation; Lung; Microbiome; Neuroinflammation; Neutrophils; Trained Immunity; Wildfires

$1,875,000

Canada Research Excellence Chair in Immunophysiology and Immunotherapy

Nominated PICIHR2022Canada Excellence Research Chair

Principal investigators: Kubes, Paul

Keywords: Cerc

$8,000,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Physiology and Pharmacology
Microbiology and Infectious Diseases
Medicine
Comparative Biology and Experimental Medicine
Department of Laboratory Medicine and Pathobiology
Medical Microbiology and Immunology
Other

Co-authors at Queen's University, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Paul Kubes

Physiology and Pharmacology

11 shared papers, latest 2026

Antoine Dufour

Microbiology and Infectious Diseases

2 shared papers, latest 2026

Jérôme Fortin

Faculty

1 shared papers, latest 2025

Sonya MacParland

Department of Laboratory Medicine and Pathobiology

1 shared papers, latest 2024

Wael Elhenawy

Medical Microbiology and Immunology

1 shared papers, latest 2024

Johnathan Canton

Comparative Biology and Experimental Medicine

1 shared papers, latest 2026

Kathy McCoy

Physiology and Pharmacology

1 shared papers, latest 2024

Craig Jenne

Medicine

1 shared papers, latest 2025

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2023

Subject: Prospective PhD student: Asthma Dear Professor Kubes, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Intravital Imaging as a Tool to Uncover Roles of Immune Cells in Chronic Liver Diseases." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Wildfire Particles Exacerbate Asthma by Increasing Inflammation Through Neural and Microbial Alterations" (2023), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]