Faculty profile

Jonathan Kimmelman

ResearcherBiomedical EthicsMcGill University

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a McGill University directory, so their courses may be missing. Find their university profile.

Jonathan Kimmelman

Researcher

Biomedical Ethics

Health Sciences

McGill University

Montreal, Quebec, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
42 publications in the last five years, latest in 2026.
Senior (last) author on 28 recent papers, a sign of leading a research group.
Principal investigator on 7 research grants (7 CIHR), most recently in 2020.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

156

Publications

Citations

h-index

Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

Profiles and links

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Signals and details

Research

Clinical Trials Research Ethics Drug Development Validity Risk Human Protections Risk / Benefit Evaluation Supporting Evidence

Latest papers

Alignment of registered cell therapy trial protocols with regulatory guidance on preclinical evidence: a systematic, cross-sectional, protocol-level analysis.
EBioMedicine · 2026
Adaptive versus fixed designs in confirmatory clinical trials: centering the choice on ethics.
Clinical trials (London, England) · 2026
Risk-Benefit of Phase 2 Monotherapy Trials in Adult Solid Cancers: A Systematic Review and Meta-Analysis.
International journal of cancer · 2026 · senior author

All 156 publications

Latest funding

PREGTRIAL (Inclusion of PREgnant and lactatinG people in clinical TRIALs)
CIHR · 2024 · Co-investigator
$598,561
Enabling novel cardiac therapies with pluripotent stem cells
SSHRC · 2022 · Co-investigator
$7,908,900
Navigating the Valley of Death: How Evidence is Evaluated in Phase 2 Trial Initiation
CIHR · 2020 · Nominated PI
$390,152

All 14 grants and awards

From the 150 most recent of 156 publications.

Alignment of registered cell therapy trial protocols with regulatory guidance on preclinical evidence: a systematic, cross-sectional, protocol-level analysis.

Jeffers MS, Tangamornsuksan W, Dorus B, Bedford P, Kimmelman J, McIsaac DI, Fergusson DA, Lalu MM

EBioMedicine2026

DOI: 10.1016/j.ebiom.2026.106456 PMID: 42664603

Adaptive versus fixed designs in confirmatory clinical trials: centering the choice on ethics.

Baas S, Pin L, Robertson DS, Bretz F, Cho HJ, Flight L, van der Graaf R, Graham M, Jacko P, Jaki T, Kimmelman J, Manfrin A, Milne R, Mozgunov P, Pallmann P, Parke T, Parmar MKB, Pirard V, Sahan K, Singh JA, Tom BDM, Whittaker JC, Wozniak K, Wright D, Zheng H, London AJ, Sheehan M, Villar SS

Clinical trials (London, England)2026

DOI: 10.1177/17407745261468001 PMID: 42549731

Risk-Benefit of Phase 2 Monotherapy Trials in Adult Solid Cancers: A Systematic Review and Meta-Analysis.

Ouimet C, Rosu M, Kimmelman J

International journal of cancer2026Senior author

DOI: 10.1002/ijc.70538 PMID: 42117884

Drug approvals in crowded drug classes potentially reflect efficacy overestimates and false positivity: A portfolio analysis of immune checkpoint inhibitor trials.

Carlisle BG, Gönen M, Fernandez L, Del Paggio JC, Kimmelman J

Journal of clinical epidemiology2026Senior author

DOI: 10.1016/j.jclinepi.2026.112182 PMID: 41692173

Planned time burden for patients participating in phase 2 cancer trials.

Ouimet C, Iskander R, Nipp R, Kimmelman J

The oncologist2026Senior author

DOI: 10.1093/oncolo/oyag096 PMID: 41838412

Meta-Analysis of Median Survival Times With Inverse-Variance Weighting.

McGrath S, Yang CH, Kimmelman J, Ozturk O, Steele R, Benedetti A

Statistics in medicine2026

DOI: 10.1002/sim.70533 PMID: 41998861

Early-phase trial efficacy and safety effect estimates regress upon testing in phase 3 trials.

Nelson A, Moyer H, Vigneault K, Fernandez L, Sefranek L, Mauguen A, Kimmelman J

Journal of clinical epidemiology2026Senior author

DOI: 10.1016/j.jclinepi.2026.112149 PMID: 41565164

New oncology trial designs and equipoise: Commentary on Heynemann et al.

Kimmelman J

Clinical trials (London, England)2026First author

DOI: 10.1177/17407745261471455 PMID: 42723605

Evaluating the translational value of preclinical models: Available tools and frameworks, challenges and strategies.

Pistollato F, Furtmann F, Straccia M, Avey M, Azilagbetor DM, Camp C, Delaney C, Ferreira GS, Garcia-Bermejo ML, Gastaldello A, Gurusamy K, Holden L, Kimmelman J, Lohse S, Marigliani B, Menon JML, Ritskes-Hoitinga M, Sarasija S, Tagle D, Tripodi IJ, Turner J, Wehling M, Costantino H

Alternatives to laboratory animals : ATLA2026

DOI: 10.1177/02611929251398821 PMID: 41308166

Weighing Open Science Against Research Participation Burden in Informed Consent: A Randomized Pilot Study.

Iskander R, Kane P, Sharp M, Kimmelman J

Journal of empirical research on human research ethics : JERHRE2025Senior author

DOI: 10.1177/15562646251384573 PMID: 41069046

PREGTRIAL (Inclusion of PREgnant and lactatinG people in clinical TRIALs)

Co-investigatorCIHR2024Op. Grant: NWHRI: Innovation Fund - Healthcare implementation research

Principal investigators: Dayan, Natalie; Devereaux, Philip J; Bérard, Anick

Keywords: Accelerating Clinical Trials; Equity, Diversity And Inclusion; Implementation Science; Pregnancy And Lactation

$598,561

Enabling novel cardiac therapies with pluripotent stem cells

Co-investigatorSSHRC2022New Frontiers in Research Fund - Transformation

Principal investigators: Laflamme, Michael

Keywords: Cardiac regeneration; Pluripotent stem cells; Cell manufacturing; Heart failure; Synthetic biology; Tissue engineering; Biomedical imaging; 3D bioprinting; Mathematical modeling; Health technology assessment; Bioethics

$7,908,900

Navigating the Valley of Death: How Evidence is Evaluated in Phase 2 Trial Initiation

Nominated PICIHR2020Project Grant

Principal investigators: Kimmelman, Jonathan

Keywords: Clinical Trials; Drug Development; Human Protections; Research Ethics; Risk / Benefit Evaluation; Supporting Evidence; Trial Protocols; Validity; Vignette Studies

$390,152

Regulatory, Policy and Ethical Implications of Clinical Trial Portfolios

Nominated PICIHR2019Project Grant

Principal investigators: Kimmelman, Jonathan

Keywords: Bias; Cancer; Clinical Trials; Drug Regulation; Research Ethics

$531,675

Translation of Highly Promising Basic Science Research into Clinical Applications: A Systematic Review

Co-investigatorCIHR2019Project Grant

Principal investigators: Fergusson, Dean A; Lalu, Manoj M

Keywords: Clinical Translation

$122,400

Interventions for the Opioid Crisis: A Systematic Review Examining Approaches in the Canadian Context and Vulnerable Sub-Populations

Co-investigatorCIHR2018Operating Grant: Evaluation of Interventions to Address the Opioid Crisis

Principal investigators: Eisenberg, Mark J; Johnson, Sonia

Keywords: Clinical; Interventions; Knowledge Translation; Opioid Crisis; Opioid-Related Harms; Policy; Public Health; Systematic Review; Vulnerable Populations

$99,997

Legalization of Recreational Cannabis Use in Canada: A Knowledge Synthesis

Co-investigatorCIHR2017Catalyst Grant: Pop. Health Intervention Research on Legalization of Cannabis

Principal investigators: Eisenberg, Mark J; Abramovici, Hanan

Keywords: Cannabis; Scoping Review

$99,998

Ethics, Efficiency and Patient Burden in Drug Development

Nominated PICIHR2016Project Grant

Principal investigators: Kimmelman, Jonathan

Keywords: Clinical Trials; Drug Development; Knowledge Translation; Medical Evidence; Research Ethics; Research Integrity; Risk; Systematic Review; Translational Research; Validity

$366,960

Can Researchers Predict Trial Outcomes and Feasibility? An Empirical Investigation

Nominated PICIHR2013Operating Grant - Priority Announcement: Ethics

Principal investigators: Kimmelman, Jonathan

Keywords: Behavioral Science; Calibration; Clinical Equipoise; Clinical Trials; Drug Development; Forecasting; Recruitment; Research Ethics; Risk

$280,007

The Clinical, Regulatory, and Ethical Implications of Electronic Cigarettes: A Knowledge Synthesis Grant

Co-investigatorCIHR2013Knowledge Synthesis Grant

Principal investigators: Eisenberg, Mark J; Oliver, Susan

Keywords: Electronic Cigarettes; Ethics; Regulation; Scoping Review; Smoking Cessation; Systematic Review

$100,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Jonathan Kimmelman

Research

Latest papers

Latest funding

Alignment of registered cell therapy trial protocols with regulatory guidance on preclinical evidence: a systematic, cross-sectional, protocol-level analysis.

Adaptive versus fixed designs in confirmatory clinical trials: centering the choice on ethics.

Risk-Benefit of Phase 2 Monotherapy Trials in Adult Solid Cancers: A Systematic Review and Meta-Analysis.

Drug approvals in crowded drug classes potentially reflect efficacy overestimates and false positivity: A portfolio analysis of immune checkpoint inhibitor trials.

Planned time burden for patients participating in phase 2 cancer trials.

Meta-Analysis of Median Survival Times With Inverse-Variance Weighting.

Early-phase trial efficacy and safety effect estimates regress upon testing in phase 3 trials.

New oncology trial designs and equipoise: Commentary on Heynemann et al.

Evaluating the translational value of preclinical models: Available tools and frameworks, challenges and strategies.

Weighing Open Science Against Research Participation Burden in Informed Consent: A Randomized Pilot Study.

Enabling novel cardiac therapies with pluripotent stem cells

Frequent collaborators

Dean Fergusson

Andrea Benedetti

Andrea Benedetti

Timothy Caulfield

Karine Vigneault

Natasha Kekre

Jesse Papenburg

Irina Kudrina

Jesse Papenburg

Danielle Rice

Ian Shrier

Ubaka Ogbogu

Kaveh Shojania

Madeleine Sharp

Harold Atkins

Petra Schweinhardt

Raphael Saginur

Janet Rossant

Russell Steele

Glen Hazlewood

Justin Presseau

Dean Fergusson

Marc Carrier

Jean-Simon Diallo

Jeremy Snyder

Christopher McCabe

Rebecca Auer

Marie Hudson

Judy Illes

David Moher