Faculty profile

Raphael Saginur

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Associate ProfessorDepartment of MedicineUniversity of Ottawa

Signals and details

Research

Read how they describe their research on their University of Ottawa profile.

Latest papers

A Crossover Trial of Hospital-Wide Lactated Ringer’s Solution versus Normal Saline
New England Journal of Medicine · 2025
Clinical and serological predictors of post COVID-19 condition-findings from a Canadian prospective cohort study.
Frontiers in public health · 2024
Results of the Stop the Spread Ottawa (SSO) cohort study: a Canadian urban-based prospective evaluation of antibody responses and neutralisation efficiency to SARS-CoV-2 infection and vaccination.
BMJ open · 2023

All 30 publications

Latest funding

Pregnant and Lactating Individuals & Newborns COVID-19 Vaccination Study
CIHR · 2021 · Co-investigator
$500,000
Coronavirus Variants Rapid Response Network: CoVaRR-Net
CIHR · 2021 · Co-investigator
$9,000,000
Coronavirus Variants Rapid Response Network: CoVaRR-Net - Extension
CIHR · 2021 · Co-investigator
$9,000,000

All 8 grants and awards

30 publications.

A Crossover Trial of Hospital-Wide Lactated Ringer’s Solution versus Normal Saline

McIntyre L, Fergusson D, McArdle T, English S, Cook DJ, Fox-Robichaud AE, Martin C, Marshall J, Pugliese M, Menon K

New England Journal of Medicine202530 citations

DOI: 10.1056/nejmoa2416761

Clinical and serological predictors of post COVID-19 condition-findings from a Canadian prospective cohort study.

Collins E, Galipeau Y, Arnold C, Bhéreur A, Booth R, Buchan AC, Cooper C, Crawley AM, McCluskie PS, McGuinty M, Pelchat M, Rocheleau L, Saginur R, Gravel C, Hawken S, Langlois MA, Little J

Frontiers in public health2024

DOI: 10.3389/fpubh.2024.1276391 PMID: 38784593

Results of the Stop the Spread Ottawa (SSO) cohort study: a Canadian urban-based prospective evaluation of antibody responses and neutralisation efficiency to SARS-CoV-2 infection and vaccination.

Keeshan A, Galipeau Y, Heiskanen A, Collins E, McCluskie PS, Arnold C, Saginur R, Booth R, Little J, McGuinty M, Buchan CA, Crawley A, Langlois MA, Cooper C

BMJ open2023

DOI: 10.1136/bmjopen-2023-077714 PMID: 37907304

What do we talk about when we talk about "equipoise"? Stakeholder interviews assessing the use of equipoise in clinical research ethics.

Dewar B, Chevrier S, De Meulemeester J, Fedyk M, Rodriguez R, Kitto S, Saginur R, Shamy M

Trials2023

DOI: 10.1186/s13063-023-07221-3 PMID: 36934250

No time for complacency: The CoVaRR-Net Biobank is an essential element of laboratory preparedness for infectious disease outbreaks.

Saginur R, Robblee JA, Vranjkovic A, Tamblyn L, Hsu A, Cooper CL, Vinh DC, Langlois MA, Crawley AM

Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada2023First author

DOI: 10.3138/jammi-2022-0009 PMID: 37008580

FLUID trial: a hospital-wide open-label cluster cross-over pragmatic comparative effectiveness randomised pilot trial comparing normal saline to Ringer’s lactate

McIntyre LA, Fergusson DA, McArdle T, Fox-Robichaud A, English SW, Martin C, Marshall J, Cook DJ, Graham ID, Hawken S

BMJ Open20237 citationsOpen Access

DOI: 10.1136/bmjopen-2022-067142 PMID: W4319078509

A Hospital-Wide Open-Label Cluster Crossover Pragmatic Comparative Effectiveness Randomized Trial Comparing Normal Saline to Ringer’s Lactate: Protocol and Statistical Analysis Plan of The FLUID Trial

Shaw JF, Ouyang Y, Fergusson DA, McArdle T, Martin C, Cook D, Graham ID, Hawken S, McCartney CJL, Menon K

JMIR Research Protocols20234 citationsOpen Access

DOI: 10.2196/51783 PMID: W4386142532

Cohort profile: Stop the Spread Ottawa (SSO)-a community-based prospective cohort study on antibody responses, antibody neutralisation efficiency and cellular immunity to SARS-CoV-2 infection and vaccination.

Collins E, Galipeau Y, Arnold C, Bosveld C, Heiskanen A, Keeshan A, Nakka K, Shir-Mohammadi K, St-Denis-Bissonnette F, Tamblyn L, Vranjkovic A, Wood LC, Booth R, Buchan CA, Crawley AM, Little J, McGuinty M, Saginur R, Langlois MA, Cooper CL

BMJ open2022

DOI: 10.1136/bmjopen-2022-062187 PMID: 36691221

How are randomized clinical trials ethically justified? A systematic scoping review and thematic analysis of reasons that ethically justify randomized clinical trials.

Fedyk M, Dewar B, Jurkovic L, Chevrier S, Kitto S, Rodriguez R, Saginur R, Dowlatshahi D, Fahed R, Shamy M

Journal of clinical epidemiology2022

DOI: 10.1016/j.jclinepi.2022.04.005 PMID: 35413418

Rheumatic heart disease in Indigenous young peoples.

Wyber R, Wade V, Anderson A, Schreiber Y, Saginur R, Brown A, Carapetis J

The Lancet. Child & adolescent health2021

DOI: 10.1016/s2352-4642(20)30308-4 PMID: 33705693

Pregnant and Lactating Individuals & Newborns COVID-19 Vaccination Study

Co-investigatorCIHR2021Operating Grant: Emerging COVID-19 Research Gaps and Priorities - Vaccines

Principal investigators: El-Chaar, Darine; Langlois, Marc-Andre; McGuinty, Michaeline

Keywords: Breastfeeding; Covid-19 Vaccines; Immunogenicity; Infant Outcomes; Maternal Newborn Health; Pregnancy

$500,000

Coronavirus Variants Rapid Response Network: CoVaRR-Net

Co-investigatorCIHR2021Operating Grant: CIHR Network for Emerging COVID-19 Variants Research

Principal investigators: Langlois, Marc-Andre; Brouwers, Melissa C; Flamand, Louis; Gingras, Anne-Claude; Gommerman, Jennifer L; Muhajarine, Nazeem; Ragoussis, Ioannis; Shapiro, Jesse

Keywords: Covarr-Net; Covid-19; Rapid-Response; Sars-Cov-2; Variants Of Concern

$9,000,000

Coronavirus Variants Rapid Response Network: CoVaRR-Net - Extension

Co-investigatorCIHR2021Op. Gr.: Coronavirus Variants Rapid Response Network (CoVaRR-Net) Extension

Principal investigators: Langlois, Marc-Andre; Abraham, Ninan; Behr, Marcel A; Brouwers, Melissa C; Crawley, Angela M; Flamand, Louis; Gingras, Anne-Claude; Gommerman, Jennifer L; Grimshaw, Jeremy M; Hsu, Amy T; Huyser, Kimberly R; Manuel, Douglas G; Muhajarine, Nazeem; Ragoussis, Ioannis; Rasmussen, Angela; Shapiro, Jesse

Keywords: Covarr-Net; Covid-19; Rapid-Response; Sars-Cov-2; Variants Of Concern

$9,000,000

Crystalloid FLUID Choices for Resuscitation of Hospitalized Patients: A Pragmatic Comparative Effectiveness Trial (FLUID)

Co-investigatorCIHR2018Project Grant

Principal investigators: McIntyre, Lauralyn A; Fergusson, Dean A; Taljaard, Monica

Keywords: Cluster Cross-Over Randomized Controlled Trial; Comparative Effectiveness Trial; Crystalloid Fluid; Fluid Therapy; Normal Saline; Resuscitation; Ringers Lactate

$374,851

Elaborating The Epistemic Conditions that Ethically Justify Randomized Clinical Trials

Co-investigatorCIHR2017Catalyst Grant: Ethics

Principal investigators: Shamy, Michel C

Keywords: Epistemology; Ethics; Randomized Clinical Trials; Regulation; Research Ethics Boards

$98,551

Crystalloid FLUID Choices for Resuscitation of Hospitalized Patients: A Pragmatic Cluster Cross Over Pilot Trial

Co-investigatorCIHR2015Operating Grant

Principal investigators: McIntyre, Lauralyn A; Taljaard, Monica

Keywords: Cluster Cross-Over Randomized Controlled Trial; Crystalloid Fluid; Fluid Therapy; Normal Saline; Pilot Trial; Resuscitation; Ringers Lactate

$99,504

International dissemination of the Ottawa Statement on the Ethical Conduct and Ethics Review of Cluster Randomized Trials

Co-investigatorCIHR2012Dissemination Events - Priority Announcement: Ethics

Principal investigators: Taljaard, Monica; Grimshaw, Jeremy M; Weijer, Charles E

Keywords: Cluster Randomized Trials; Health Services Research; Implementation Research; Informed Consent; Randomized Controlled Trials; Research Ethics; Research Ethics Committees; Research Ethics Guidelines

$25,000

Setting a research agenda for quality assessment in research ethics review

Co-investigatorCIHR2012Planning Grants - Priority Announcement: Ethics

Principal investigators: Brehaut, Jamie C; Nicholls, Stuart G

Keywords: Assessment; Discussion; Evaluation; Quality; Research; Research Ethics

$24,732

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Profile data last refreshed on September 25, 2026 from the university directory, publication records and CIHR, NSERC and SSHRC funding.

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Raphael Saginur

Research

Latest papers

Latest funding

A Crossover Trial of Hospital-Wide Lactated Ringer’s Solution versus Normal Saline

Clinical and serological predictors of post COVID-19 condition-findings from a Canadian prospective cohort study.

Results of the Stop the Spread Ottawa (SSO) cohort study: a Canadian urban-based prospective evaluation of antibody responses and neutralisation efficiency to SARS-CoV-2 infection and vaccination.

What do we talk about when we talk about "equipoise"? Stakeholder interviews assessing the use of equipoise in clinical research ethics.

No time for complacency: The CoVaRR-Net Biobank is an essential element of laboratory preparedness for infectious disease outbreaks.

FLUID trial: a hospital-wide open-label cluster cross-over pragmatic comparative effectiveness randomised pilot trial comparing normal saline to Ringer’s lactate

A Hospital-Wide Open-Label Cluster Crossover Pragmatic Comparative Effectiveness Randomized Trial Comparing Normal Saline to Ringer’s Lactate: Protocol and Statistical Analysis Plan of The FLUID Trial

Cohort profile: Stop the Spread Ottawa (SSO)-a community-based prospective cohort study on antibody responses, antibody neutralisation efficiency and cellular immunity to SARS-CoV-2 infection and vaccination.

How are randomized clinical trials ethically justified? A systematic scoping review and thematic analysis of reasons that ethically justify randomized clinical trials.

Rheumatic heart disease in Indigenous young peoples.

Frequent collaborators

Steven Hawken

Charles Weijer

Kednapa Thavorn

Dean Fergusson

Monica Taljaard

Kusum Menon

Deborah Cook

Alison Fox-Robichaud

Kednapa Thavorn

Charles Weijer

John Marshall

Claudio Martin

Ronald Booth

Michel Shamy

Julian Little

Michaeline McGuinty

Shane English

Lauralyn McIntyre

Curtis Cooper

Ian Stiell

Simon Kitto

Thien-Fah Mah

Daniel Bainbridge