Faculty profile

Lawrence Kazak

ResearcherBiochemistryMcGill University

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a McGill University directory, so their courses may be missing. Find their university profile.

Lawrence Kazak

Researcher

Biochemistry

Health Sciences

McGill University

Montreal, Quebec, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
18 publications in the last five years, latest in 2026.
Senior (last) author on 13 recent papers, a sign of leading a research group.
Principal investigator on 12 research grants (10 CIHR, 2 NSERC), most recently in 2026.
Supervised 3 trainees who won CIHR awards, most recently in 2025.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

Citations

h-index

Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

Profiles and links

Search on Google Scholar

Find them onX · LinkedIn · Bluesky · YouTube

Signals and details

Research

Energy Expenditure Adipose Tissue Thermogenesis Obesity Food Intake Cardiometabolic Disease Cell Development Metabolism

Latest papers

Protocol for targeted gene manipulation and thermogenic evaluation in mouse brown adipocytes.
STAR protocols · 2026 · senior author
Cold exposure induces the constitutively active thermogenic receptor, GPR3, via ERRα and ERRγ.
Molecular metabolism · 2026
Glycerol-driven TNAP activation in thermogenesis and mineralization.
Nature · 2026 · senior author

All 35 publications

Latest funding

Coordinated GPCR signaling in adipose tissue regulates energy expenditure and feeding behavior
CIHR · 2026 · Nominated PI
$1,048,050
Defining mechanisms of obesity-accelerated breast cancer progression
CIHR · 2025 · Nominated PI
$67,500
Adipose Biology Conference: Advancing Health Through Scientific Unity
CIHR · 2025 · Nominated PI
$15,000

All 16 grants and awards

35 publications.

Protocol for targeted gene manipulation and thermogenic evaluation in mouse brown adipocytes.

Bunk J, Soni D, Calderon M, Samborska B, Kazak L

STAR protocols2026Senior author

DOI: 10.1016/j.xpro.2025.104317 PMID: 41474618

Cold exposure induces the constitutively active thermogenic receptor, GPR3, via ERRα and ERRγ.

Sveidahl Johansen O, McIntyre RL, Rahbani JF, Zhang Q, Scholtes C, Lagarde DM, Billon C, Côté I, Delgado-Martin M, Tandio D, Basse AL, Eury E, Kralli A, Burris TP, Giguère V, Kazak L, Gerhart-Hines Z

Molecular metabolism2026

DOI: 10.1016/j.molmet.2025.102277 PMID: 41173363

Glycerol-driven TNAP activation in thermogenesis and mineralization.

Hussain MF, Krishnan SS, Carroll BL, Samborska B, Mousa A, Williamson A, Delgado-Martin M, Srinivasu BY, Bunk J, Rahbani JF, Oppong A, Roesler A, Kaiser Z, Ersin M, Zhang Q, Guerra Martinez M, Shaw A, Cheng J, Klemets H, Illes KK, DeMambro VE, Rosen CJ, Millán JL, Wales TE, Langenberg C, McKee MD, Guarné A, Kazak L

Nature2026Senior author

DOI: 10.1038/s41586-026-10396-9 PMID: 42020733

The Futile Creatine Cycle powers UCP1-independent thermogenesis in classical BAT.

Bunk J, Hussain MF, Delgado-Martin M, Samborska B, Ersin M, Shaw A, Rahbani JF, Kazak L

Nature communications2025Senior author

DOI: 10.1038/s41467-025-58294-4 PMID: 40185737

Creatine kinase B promotes non-small cell lung cancer survival and metastasis.

Tlili M, Samborska B, Girondel C, Abu-Thuraia A, Zhang Q, Bunk J, Hussain MF, Siegel PM, Kazak L

The Journal of biological chemistry2025Senior author

DOI: 10.1016/j.jbc.2025.110805 PMID: 41072771

Creatine kinase B mediates UCP1-independent beige fat thermogenesis via the futile creatine cycle in mice.

Bunk J, Ersin M, Hussain MF, Samborska B, Guerra-Martinez M, Soni D, Kazak L

Molecular metabolism2025Senior author

DOI: 10.1016/j.molmet.2025.102193 PMID: 40562311

Emerging debates and resolutions in brown adipose tissue research.

Cypess AM, Cannon B, Nedergaard J, Kazak L, Chang DC, Krakoff J, Tseng YH, Schéele C, Boucher J, Petrovic N, Blondin DP, Carpentier AC, Virtanen KA, Kooijman S, Rensen PCN, Cero C, Kajimura S

Cell metabolism2025

DOI: 10.1016/j.cmet.2024.11.002 PMID: 39644896

A consensus guide to preclinical indirect calorimetry experiments

Banks AS, Allison DB, Alquier T, Ansarullah, Austad SN, Auwerx J, Ayala JE, Baur JA, Carobbio S, Churchill GA

Nature Metabolism202539 citations

DOI: 10.1038/s42255-025-01360-4

BAT-tling oxidative stress through BCAA catabolism.

Delgado-Martin M, Zhang Q, Kazak L

Life metabolism2024Senior author

DOI: 10.1093/lifemeta/loae028 PMID: 39872145

Non-invasive mapping of brown adipose tissue activity with magnetic resonance imaging.

Cai Z, Zhong Q, Feng Y, Wang Q, Zhang Z, Wei C, Yin Z, Liang C, Liew CW, Kazak L, Cypess AM, Liu Z, Cai K

Nature metabolism2024

DOI: 10.1038/s42255-024-01082-z PMID: 39054361

Coordinated GPCR signaling in adipose tissue regulates energy expenditure and feeding behavior

Nominated PICIHR2026Project Grant

Principal investigators: Kazak, Lawrence

Keywords: Adipose Tissue; Energy Expenditure; Food Intake; Thermogenesis

$1,048,050

Defining mechanisms of obesity-accelerated breast cancer progression

Nominated PICIHR2025CIHR - ICR / Cancer Research Society Partnership - Res. Grants - Breast Cancer

Principal investigators: Kazak, Lawrence

Keywords: Cancer

$67,500

Adipose Biology Conference: Advancing Health Through Scientific Unity

Nominated PICIHR2025Planning and Dissemination Grants - Institute/Initiative Community Support

Principal investigators: Kazak, Lawrence

Keywords: Adipose Tissue; Cardiometabolic Disease; Cell Development; Energy Expenditure; Food Intake; Metabolism; Obesity; Tissue Crosstalk

$15,000

Allosteric TNAP activation for bone and fat cell health: from basic mechanism to therapeutic development.

SupervisorCIHR2025DRA : Canada Graduate Research Scholarship - Doctoral Program (CGRS D)

Principal investigators: Oppong, Abel

Keywords: Adipose Tissue; Bone Mineralization; Diabetes; Hypophosphatasia; Obesity; Thermogenesis

$120,000

Defining Glycerol-Mediated TNAP Activation in Bone Mineralization and Thermogenesis: Implications for Treating Hypophosphatasia and Metabolic Disorders

SupervisorCIHR2024CIHR Fellowship

Principal investigators: Raka, Fitore

Keywords: Bone Mineralization; Brown Adipose Tissue; Energy Homeostasis; Hypophosphatasia; Obesity; Thermogenesis; Type Ii Diabetes

$210,000

Allosteric activation of the alkaline phosphatase TNAP: from basic biology to therapeutic potential

Nominated PICIHR2024Project Grant

Principal investigators: Kazak, Lawrence

Keywords: Bioenergetics; Bone Mineralization; Creatine; Enzyme Kinetics; Glycerol; Phosphocreatine; Protein Purification; Protein Structure; Thermogenesis; Tissue Nonspecific Alkaline Phosphatase

$1,048,050

A histology platform to visualize cells, tissues and organs across living systems

Co-investigatorNSERC2024Research Tools and Instruments

Principal investigators: Cockburn, Katherine

Keywords: Animal models; Biomedical engineering; Cell biology; Cell morphology; Gene expression; Histology; Materials science; Tissue architecture; Tissue sectioning

$97,880

Exploring Advances in Adipose Biology: Uniting Global Scholars to Illuminate and Shape the Future of Health and Wellness

Nominated PICIHR2024Planning and Dissemination Grant - Institute Community Support

Principal investigators: Kazak, Lawrence

Keywords: Adipose Tissue; Cardiometabolic Disease; Cell Development; Energy Expenditure; Food Intake; Metabolism; Obesity; Tissue Crosstalk

$15,000

Parallel Control of Adipocyte Thermogenesis by UCP1 and CKB

Nominated PICIHR2023Project Grant

Principal investigators: Kazak, Lawrence

Keywords: Brown Adipose Tissue; Creatine Kinase B; Energy Expenditure; Mouse Physiology; Uncoupling Protein 1 (Ucp1)

$925,650

Canada Research Chair - Tier 2

Nominated PICIHR2022Canada Research Chairs - CIHR Funded - Tier 2

Principal investigators: Kazak, Lawrence

Keywords: Crc

$500,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Something wrong or missing on this profile? Suggest a correction

Lawrence Kazak

Research

Latest papers

Latest funding

Protocol for targeted gene manipulation and thermogenic evaluation in mouse brown adipocytes.

Cold exposure induces the constitutively active thermogenic receptor, GPR3, via ERRα and ERRγ.

Glycerol-driven TNAP activation in thermogenesis and mineralization.

The Futile Creatine Cycle powers UCP1-independent thermogenesis in classical BAT.

Creatine kinase B promotes non-small cell lung cancer survival and metastasis.

Creatine kinase B mediates UCP1-independent beige fat thermogenesis via the futile creatine cycle in mice.

Emerging debates and resolutions in brown adipose tissue research.

A consensus guide to preclinical indirect calorimetry experiments

BAT-tling oxidative stress through BCAA catabolism.

Non-invasive mapping of brown adipose tissue activity with magnetic resonance imaging.

Coordinated GPCR signaling in adipose tissue regulates energy expenditure and feeding behavior

Defining mechanisms of obesity-accelerated breast cancer progression

Adipose Biology Conference: Advancing Health Through Scientific Unity

Allosteric TNAP activation for bone and fat cell health: from basic mechanism to therapeutic development.

Defining Glycerol-Mediated TNAP Activation in Bone Mineralization and Thermogenesis: Implications for Treating Hypophosphatasia and Metabolic Disorders

Allosteric activation of the alkaline phosphatase TNAP: from basic biology to therapeutic potential

A histology platform to visualize cells, tissues and organs across living systems

Exploring Advances in Adipose Biology: Uniting Global Scholars to Illuminate and Shape the Future of Health and Wellness

Parallel Control of Adipocyte Thermogenesis by UCP1 and CKB

Canada Research Chair - Tier 2

Frequent collaborators

Gregory Steinberg

Ivan Topisirovic

Thierry Alquier

Michael Pollak

Lawrence Kazak

Research

Latest papers

Latest funding

Protocol for targeted gene manipulation and thermogenic evaluation in mouse brown adipocytes.

Cold exposure induces the constitutively active thermogenic receptor, GPR3, via ERR&#x3b1; and ERR&#x3b3;.

Glycerol-driven TNAP activation in thermogenesis and mineralization.

The Futile Creatine Cycle powers UCP1-independent thermogenesis in classical BAT.

Creatine kinase B promotes non-small cell lung cancer survival and metastasis.

Creatine kinase B mediates UCP1-independent beige fat thermogenesis via the futile creatine cycle in mice.

Emerging debates and resolutions in brown adipose tissue research.

A consensus guide to preclinical indirect calorimetry experiments

BAT-tling oxidative stress through BCAA catabolism.

Non-invasive mapping of brown adipose tissue activity with magnetic resonance imaging.

A histology platform to visualize cells, tissues and organs across living systems

Frequent collaborators

Gregory Steinberg

Ivan Topisirovic

Thierry Alquier

Michael Pollak

Cold exposure induces the constitutively active thermogenic receptor, GPR3, via ERRα and ERRγ.