Faculty profile

Ivan Topisirovic

ResearcherLady Davis Institute for Medical ResearchMcGill University

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a McGill University directory, so their courses may be missing. Find their university profile.

Ivan Topisirovic

Researcher

Lady Davis Institute for Medical Research

Health Sciences

McGill University

Montreal, Quebec, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
29 publications in the last five years, latest in 2026.
Senior (last) author on 4 recent papers, a sign of leading a research group.
Principal investigator on 8 research grants (8 CIHR), most recently in 2026.
Supervisor on 2 trainee awards (2 CIHR), most recently in 2019.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

116

Publications

5,052

Citations

Collaborators

Grants

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

Profiles and links

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Signals and details

Research

Mrna Translation Signal Transduction Cancer Ck2 Breast Cancer Metastasis Mrna Translation,Protein Synthesis,

Latest papers

LARP1 at the nexus of oncogenic MYC and mTOR signaling.
Proceedings of the National Academy of Sciences of the United States of America · 2026 · senior author
The Emerging Role of mTOR in Shaping the Cancer Cell Secretome and Plasticity.
Molecular and cellular biology · 2026
Elongationless start-stop elements are stress-resilient translation gates that are more repressive than uTranslons.
Nucleic acids research · 2026

All 116 publications

Latest funding

Translational rheostat promotes breast cancer metastasis
CIHR · 2026 · Nominated PI
$1,124,550
Exploiting Dysregulated mRNA Translation to Unveil Novel Therapeutic Vulnerabilities in Metastatic Breast Cancers
CIHR · 2024 · Co-investigator
$1,143,676
Canada Research Chair - Tier 1
CIHR · 2023 · Nominated PI
$1,400,000

All 17 grants and awards

116 publications.

LARP1 at the nexus of oncogenic MYC and mTOR signaling.

Curdy N, Topisirovic I

Proceedings of the National Academy of Sciences of the United States of America2026Senior author

DOI: 10.1073/pnas.2619021123 PMID: 42475587

The Emerging Role of mTOR in Shaping the Cancer Cell Secretome and Plasticity.

Cooper TT, Topisirovic I, Postovit LM

Molecular and cellular biology2026

DOI: 10.1080/10985549.2026.2699146 PMID: 42446400

Elongationless start-stop elements are stress-resilient translation gates that are more repressive than uTranslons.

Rendleman J, Haizel SA, Wu S, Young LL, Liu J, Ge X, Zou H, Mohammad MP, Pressler M, Maity S, Hronová V, Gao Z, Herrmannová A, Smirnova A, Lei A, Allgoewer K, Sultanov D, Hinckley WE, Cheng Z, Shelby L, Dey T, Szkop KJ, Topisirovic I, Larsson O, Hatzoglou M, Valášek LS, Vogel C

Nucleic acids research2026

DOI: 10.1093/nar/gkag627 PMID: 42411409

Mitochondrial ETF insufficiency drives neoplastic growth by selectively optimizing cancer bioenergetics.

Papadopoli D, Palia R, Jovanovic P, Tabariès S, Ciccolini E, Sabourin V, Igelmann S, McLaughlan S, Zhan L, Kim H, Chekkal N, Szkop KJ, Bertomeu T, Zeng J, Vassalakis J, Afzali F, Mzoughi S, Guccione E, Tyers M, Avizonis D, Larsson O, Postovit LM, Djuranovic S, Ursini-Siegel J, Siegel PM, Pollak M, Topisirovic I

eLife2026Senior author

DOI: 10.7554/elife.106587 PMID: 42085321

Corrigendum to 'The Role of eIF4E in Response and Acquired Resistance to Vemurafenib in Melanoma': [Journal of Investigative Dermatology, Volume 135, Issue 5, May 2015, Pages 1368-1376].

Zhan Y, Dahabieh MS, Rajakumar A, Dobocan MC, M'Boutchou MN, Goncalves C, Lucy SL, Pettersson F, Topisirovic I, van Kempen L, Del Rincón SV, Miller WH

The Journal of investigative dermatology2026

DOI: 10.1016/j.jid.2025.10.594 PMID: 41823940

A Chemical-Genetic Interaction Matrix Reveals Drug Mechanism and Genetic Architecture.

Coulombe-Huntington J, Bertomeu T, Huard C, Chatr-Aryamontri A, St-Cyr DJ, Sánchez-Osuna M, Papadopoli D, Normandin K, Paydar M, McLaughlan S, St-Denis C, Zhang L, Say H, Palou R, Stark C, Breitkreutz BJ, van der Sloot AM, Manohar S, Lavoie H, Borden KLB, Raught B, D'Amours D, Sicheri F, Verreault A, Mader S, Meloche S, Therrien M, Thibault P, Wilhelm B, Dirks PB, Aitchison JD, Patton E, King RW, Roux PP, Sauvageau G, Hoang T, Marinier A, Harrington L, Kwok B, Archambault V, Topisirovic I, Tyers M

bioRxiv : the preprint server for biology2026

DOI: 10.64898/2026.01.28.701823 PMID: 41659671

Epigenetic alterations facilitate transcriptional and translational programs in hypoxia.

Watt K, Dauber B, Szkop KJ, Lee L, Jovanovic P, Chen S, Palia R, Vassalakis JA, Cooper TT, Papadopoli D, Masvidal L, Jewer M, Tandoc K, Plummer H, Lajoie GA, Topisirovic I, Larsson O, Postovit LM

Nature cell biology2025

DOI: 10.1038/s41556-025-01786-8 PMID: 41102449

Translon: a single term for translated regions.

Świrski MI, Tierney JAS, Albà MM, Andreev DE, Aspden JL, Atkins JF, Bassani-Sternberg M, Berry MJ, Biffo S, Boris-Lawrie K, Borodovsky M, Brierley I, Brook M, Brunet MA, Bujnicki JM, Caliskan N, Calviello L, Carvunis AR, Cate JHD, Cenik C, Chang KY, Chen Y, Chothani S, Choudhary JS, Clark PL, Clauwaert J, Cooley L, Dassi E, Dean K, Diaz JJ, Dieterich C, Dikstein R, Dinman JD, Dmitriev SE, Dontsova OA, Dunham CM, Eswarappa SM, Farabaugh PJ, Faridi P, Fierro-Monti I, Firth AE, Gatfield D, Gebauer F, Gelfand MS, Gray NK, Green R, Hill CH, Hou YM, Hübner N, Ignatova Z, Ivanov P, Iwasaki S, Johnson R, Jomaa A, Jovanovic M, Jungreis I, Kellis M, Kieft JS, Kochetov AV, Koonin EV, Korostelev AA, Kufel J, Kulakovskiy IV, Kurian L, Lafontaine DLJ, Larsson O, Loughran G, Lukeš J, Mariotti M, Martens-Uzunova ES, Martinez TF, Matsumoto A, McManus J, Medenbach J, Melnikov SV, Menschaert G, Merchante C, Mikl M, Miller WA, Mühlemann O, Namy O, Nedialkova DD, Nosek J, Orchard S, Ozretić P, Pertea M, Pervouchine DD, Romão L, Ron D, Roucou X, Rubtsova MP, Ruiz-Orera J, Saghatelian A, Salzberg SL, Seale LA, Seoighe C, Sergiev PV, Shah P, Shirokikh N, Slavoff SA, Sonenberg N, Stasevich TJ, Szczesny RJ, Tamm T, Tchórzewski M, Topisirovic I, Tremblay ML, Tuller T, Ulitsky I, Valášek LS, Van Damme P, Viero G, Vizcaino JA, Vogel C, Wallace EWJ, Weissman JS, Westhof E, Whiffin N, Wilson DN, Xie Z, Yewdell JW, Yordanova MM, Yu CH, Yurchenko V, Zagrovic B, TRANSLACORE, Valen E, Baranov PV

Nature methods2025

DOI: 10.1038/s41592-025-02810-3 PMID: 40890551

R-2-hydroxyglutarate-mediated inhibition of KDM4A compromises telomere integrity.

Couteau F, Gagné LM, Boulay K, Rousseau P, Carbonneau M, McQuaid M, Sharma J, Sawchyn C, Fernandez E, Glatz D, Rizk R, Lalonde ME, Mehrjoo Y, Chu TW, Moquin-Beaudry G, Beauséjour C, Sergeev M, Costantino S, Avizonis D, Topisirovic I, Jabado N, Wurtele H, Autexier C, Mallette FA

Nucleic acids research2025

DOI: 10.1093/nar/gkaf512 PMID: 40498073

Plasticity of the mammalian integrated stress response.

Chen CW, Papadopoli D, Szkop KJ, Guan BJ, Alzahrani M, Wu J, Jobava R, Asraf MM, Krokowski D, Vourekas A, Merrick WC, Komar AA, Koromilas AE, Gorospe M, Payea MJ, Wang F, Clayton BLL, Tesar PJ, Schaffer A, Miron A, Bederman I, Jankowsky E, Vogel C, Valášek LS, Dinman JD, Zhang Y, Tirosh B, Larsson O, Topisirovic I, Hatzoglou M

Nature2025

DOI: 10.1038/s41586-025-08794-6 PMID: 40140574

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Ivan Topisirovic

Research

Latest papers

Latest funding

LARP1 at the nexus of oncogenic MYC and mTOR signaling.

The Emerging Role of mTOR in Shaping the Cancer Cell Secretome and Plasticity.

Elongationless start-stop elements are stress-resilient translation gates that are more repressive than uTranslons.

Mitochondrial ETF insufficiency drives neoplastic growth by selectively optimizing cancer bioenergetics.

Corrigendum to 'The Role of eIF4E in Response and Acquired Resistance to Vemurafenib in Melanoma': [Journal of Investigative Dermatology, Volume 135, Issue 5, May 2015, Pages 1368-1376].

A Chemical-Genetic Interaction Matrix Reveals Drug Mechanism and Genetic Architecture.

Epigenetic alterations facilitate transcriptional and translational programs in hypoxia.

Translon: a single term for translated regions.

R-2-hydroxyglutarate-mediated inhibition of KDM4A compromises telomere integrity.

Plasticity of the mammalian integrated stress response.

Frequent collaborators

Ivan Topisirovic

Nahum Sonenberg

Laura Hulea

Michael Pollak

Julie St-Pierre

Simon-Pierre Gravel

Julie St-Pierre

Lynne-Marie Postovit

Jerry Pelletier

Lynne-Marie Postovit

Sylvain Meloche

Michael Witcher

Arnim Pause

Kevin Petrecca

Pierre Thibault

Martin Olivier

Shawn McGuirk

Mark Basik

Chantal Autexier

Kevin Petrecca

Antonis Koromilas

Sidong Huang

Stephane Angers

Morag Park

Martin Olivier

Morag Park

Gerardo Ferbeyre

Urban Emmenegger

Sonia Del Rincon

Peter Metrakos

Honglin Luo

Nada Jabado

Sylvie Mader

Vincent Archambault

William Muller

Rongtuan Lin

Michael Ohh

Mitsuhiko Ikura

Celia Greenwood

Gerardo Ferbeyre