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Research
Latest papers
The "Community Effect" of spermatogonial stem cells (SSCs) and their descendants on the induction of the SSC niche: Perspectives and hypotheses.
Current topics in developmental biology · 2026 · first author
Postnatal development of mouse spermatogonial stem cells as determined by immunophenotype, regenerative capacity, and long-term culture-initiating ability: a model for practical applications.
Scientific reports · 2024 · senior author
Dissecting the spermatogonial stem cell niche using spatial transcriptomics.
Cell reports · 2023
Latest funding
- $918,000
Isolation and in vitro amplification of human spermatogonial stem cells for fertility restoration for prepubertal boys whose fertility is at risk.
CIHR · 2025 · Nominated PI
- $1,044,226
Transient disruption of the blood-testis barrier using synthetic anti-claudin compounds in human and pig models: towards improving the efficiency of spermatogonial stem cell transplantation for fertility restoration in pediatric cancer survivors
CIHR · 2024 · Nominated PI
- $654,076
Identity and in vitro expansion of human spermatogonial stem cells
CIHR · 2017 · Nominated PI
11 publications.
The "Community Effect" of spermatogonial stem cells (SSCs) and their descendants on the induction of the SSC niche: Perspectives and hypotheses.
Nagano M
Postnatal development of mouse spermatogonial stem cells as determined by immunophenotype, regenerative capacity, and long-term culture-initiating ability: a model for practical applications.
Song Y, Zhang X, Desmarais JA, Nagano M
Dissecting the spermatogonial stem cell niche using spatial transcriptomics.
Rajachandran S, Zhang X, Cao Q, Caldeira-Brant AL, Zhang X, Song Y, Evans M, Bukulmez O, Grow EJ, Nagano M, Orwig KE, Chen H
Spermatogonial Transplantation.
Nagano M, Zhang X
Screening of Potential Plasticizer Alternatives for Their Toxic Effects on Male Germline Stem Cells.
Zhang X, Nagano M
Huwe1 Regulates the Establishment and Maintenance of Spermatogonia by Suppressing DNA Damage Response.
Fok KL, Bose R, Sheng K, Chang CW, Katz-Egorov M, Culty M, Su S, Yang M, Ruan YC, Chan HC, Iavarone A, Lasorella A, Cencic R, Pelletier J, Nagano M, Xu W, Wing SS
Erasure of DNA methylation, genomic imprints, and epimutations in a primordial germ-cell model derived from mouse pluripotent stem cells.
Miyoshi N, Stel JM, Shioda K, Qu N, Odajima J, Mitsunaga S, Zhang X, Nagano M, Hochedlinger K, Isselbacher KJ, Shioda T
Preterm birth among the Hmong, other Asian subgroups and non-Hispanic whites in California.
Vang ZM, Elo IT, Nagano M
Aging results in molecular changes in an enriched population of undifferentiated rat spermatogonia.
Paul C, Nagano M, Robaire B
CD9 is expressed on human male germ cells that have a long-term repopulation potential after transplantation into mouse testes.
Zohni K, Zhang X, Tan SL, Chan P, Nagano M
Isolation and in vitro amplification of human spermatogonial stem cells for fertility restoration for prepubertal boys whose fertility is at risk.
Principal investigators: Nagano, Makoto
Keywords: Cell Biology; Cell Culture; Cell Sorting; Male Fertility; Male Germline Stem Cells; Transplantation; Xenotransplantation
Transient disruption of the blood-testis barrier using synthetic anti-claudin compounds in human and pig models: towards improving the efficiency of spermatogonial stem cell transplantation for fertility restoration in pediatric cancer survivors
Principal investigators: Nagano, Makoto
Keywords: Animal Model; Cell Delivery; Claudin; Human Organ Culture; Male Fertility Restoration; Pediatric Cancer Survivors; Spermatogenesis; Tight Junction
Identity and in vitro expansion of human spermatogonial stem cells
Principal investigators: Nagano, Makoto
Keywords: Fertility Preservation; Fluorescent-Activated Cell Sorting; Male Fertility; Spermatogenesis; Tissue Culture; Transplantation
Transient disruption of blood-testis barrier for efficient delivery of spermatogonial stem cells to their niches: Toward a novel fertility restoration strategy for boys with cancer
Principal investigators: Nagano, Makoto; Ryan, Aimée K
Keywords: Cell Adhesion; Cell Culture; Cell Transplantation; Claudin; Male Fertility Preservation; Spermatogenesis
The regulatory mechanism of spermatogonial stem cell proliferation and differentiation
Principal investigators: Nagano, Makoto
Keywords: Basic Research; Cancer Survivors; Cell Culture; Fate Decision Control; Genetic Modification; Male Fertility Preservation & Restoration; Male Reproduction; Mouse; Stem Cells; Transplantation
Sex-specific susceptibility windows for fetal origins of adult disease and transgenerational effects
Principal investigators: Trasler, Jacquetta M
Keywords: Dna Methylation; Epigenetic; Fetus; Folate; Germ Cells; Sex-Specific; Transgenerational
Facilitating engraftment of male germ line stem cells: Toward developing a novel fertility restoration strategy for boys with cancer
Principal investigators: Nagano, Makoto
Keywords: Blood Testis Barrier; Cancer; Fertility Restoration - Male; Sertoli Cells; Stem Cells; Tight Juction; Transplantation
Stem Cell Network/Réseau de cellules souches
Principal investigators: Rudnicki, Michael
Towards fertility restoration and mitigation of adverse reproductive outcomes in male childhood cancer survivors
Principal investigators: Chan, Peter T; Hales, Barbara F; Jabado, Nada; Nagano, Makoto; Robaire, Bernard
Keywords: Childhood Cancers; Male Fertility Preservation And Restoration; Randomized Controlled Trial; Sperm Chromatin Integrity; Spermatogonial Stem Cells
CIHR Team in Impact of exposure to phthalates, their metabolites and "green" plasticizers on male reproductive health
Principal investigators: Robaire, Bernard
Keywords: Leydig Cells; Male Reproductive Health; Phthalate; Plasticizer; Testic Cancer; Testis Function
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
Frequent collaborators
- Obstetrics and Gynecology
- Pharmacology and Therapeutics
- Biochemistry
- Medicine
Co-authors at McGill University, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.
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