Marc Fabian, McGill University

Research

Mrna Stability Mrna Translation Gene Expression Post-Transcriptional Control Ccr4-Not Complex Cancer Predisposition Syndrome Microrna Processing Sarcoma

Latest papers

High-Density Proximity Mapping Reveals the Subcellular Organization of mRNA-Associated Granules and Bodies.
Molecular cell · 2018
The Paradoxical Signals of Two TrkC Receptor Isoforms Supports a Rationale for Novel Therapeutic Strategies in ALS.
PloS one · 2016

All 2 publications

Latest funding

Investigating and targeting pathogenic variants in DICER1-related tumour predisposition
CIHR · 2026 · Principal investigator
$1,338,908
Uncovering the CCR4-NOT Recruitment Code Across Cellular States
CIHR · 2026 · Nominated PI
$1,093,950
Investigating and targeting pathogenic variants in DICER1 tumour predisposition syndrome
CIHR · 2024 · Principal investigator
$100,000

All 14 grants and awards

2 publications.

01

High-Density Proximity Mapping Reveals the Subcellular Organization of mRNA-Associated Granules and Bodies.

Youn JY, Dunham WH, Hong SJ, Knight JDR, Bashkurov M, Chen GI, Bagci H, Rathod B, MacLeod G, Eng SWM, Angers S, Morris Q, Fabian M, Côté JF, Gingras AC

Molecular cell2018

DOI: 10.1016/j.molcel.2017.12.020 PMID: 29395067

02

The Paradoxical Signals of Two TrkC Receptor Isoforms Supports a Rationale for Novel Therapeutic Strategies in ALS.

Brahimi F, Maira M, Barcelona PF, Galan A, Aboulkassim T, Teske K, Rogers ML, Bertram L, Wang J, Yousefi M, Rush R, Fabian M, Cashman N, Saragovi HU

PloS one2016

DOI: 10.1371/journal.pone.0162307 PMID: 27695040

Investigating and targeting pathogenic variants in DICER1-related tumour predisposition

Principal investigatorCIHR2026Project Grant

Principal investigators: Foulkes, William D; Fabian, Marc R; Huang, Sidong

Keywords: Cancer Predisposition Syndrome; Dicer1-Related Tumour Predisposition; Microrna Processing; Sarcoma

$1,338,908

Uncovering the CCR4-NOT Recruitment Code Across Cellular States

Nominated PICIHR2026Project Grant

Principal investigators: Fabian, Marc R

Keywords: Cancer; Ccr4-Not Complex; Cellular Stress; Microrna-Mediated Gene Silencing; Mrna Decay; Rna-Protein Interactions

$1,093,950

Investigating and targeting pathogenic variants in DICER1 tumour predisposition syndrome

Principal investigatorCIHR2024Operating Grant - PA: Genetics (Bridge Funding: Research Priorities)

Principal investigators: Foulkes, William D; Fabian, Marc R; Huang, Sidong

Keywords: Cancer Predisposition Syndrome; Dicer1 Tumour Predisposition Syndrome; Microrna Processing; Sarcoma

$100,000

Action of PABP in selectively regulating the mammalian transcriptome

Nominated PICIHR2023Project Grant

Principal investigators: Fabian, Marc R

Keywords: Mrna Stability; Mrna Translation; Mtor Signaling; Rna Binding Proteins

$749,700

24th RiboClub Annual Meeting

Nominated PICIHR2023Planning and Dissemination Grant - Institute Community Support

Principal investigators: Fabian, Marc R

Keywords: Deregulation In Disease; Gene Expression Regulation; Regulatory Rna; Rna Biology; Rna Complexes; Rna Delivery; Rna In Biotechnology; Rna Interactions; Rna Structure; Transcriptomics

$10,000

Action of PABP in selectively regulating the mammalian transcriptome

Nominated PICIHR2022Project Grant

Principal investigators: Fabian, Marc R

Keywords: Mrna Stability; Mrna Translation; Mtor Signaling; Rna Binding Proteins

$100,000

Investigating how mRNA decapping factors regulate gene silencing programs

Principal investigatorNSERC2022Discovery Grants Program - Individual

Principal investigators: Fabian, Marc

$102,000

Investigating nPABP, a putative neural translational repressor

Nominated PICIHR2017Project Grant

Principal investigators: Fabian, Marc R

Keywords: Gene Expression; Mrna Stability; Mrna Translation; Poly(A) Binding Protein; Post-Transcriptional Control; Rna Binding Protein

$784,125

Exploring the influence of DICER1 mutations on the mTOR signalling pathway

Principal investigatorCIHR2016Project Grant

Principal investigators: Foulkes, William D; Fabian, Marc R

Keywords: Dicer1; Gene Expression; Gene Silencing; Metabolism; Microrna; Mtor; Neoplasm

$955,625

Investigating the mechanics of mRNA decapping in gene silencing

Principal investigatorNSERC2015Discovery Grants Program - Individual

Principal investigators: Fabian, Marc

$301,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Oncology
Department of Molecular Genetics
Molecular Medicine
UBC James Hogg Research Centre
Donnelly Centre

Co-authors at McGill University, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Ji-Young Youn

Molecular Medicine

1 shared papers, latest 2018

Anne-Claude Gingras

Department of Molecular Genetics

1 shared papers, latest 2018

Neil Cashman

UBC James Hogg Research Centre

1 shared papers, latest 2016

Quaid Morris

Donnelly Centre

1 shared papers, latest 2018

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2026

Subject: Prospective PhD student: Mrna Stability Dear Professor Fabian, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "High-Density Proximity Mapping Reveals the Subcellular Organization of mRNA-Associated Granules and Bodies." (2018), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Investigating and targeting pathogenic variants in DICER1-related tumour predisposition" (2026), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]