Faculty profile

Ji-Young Youn

ResearcherMolecular MedicineUniversity of Toronto

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Ji-Young Youn

Researcher

Molecular Medicine

University of Toronto

Toronto, Ontario, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
10 publications in the last five years, latest in 2026.
Senior (last) author on 3 recent papers, a sign of leading a research group.
Principal investigator on 2 research grants (2 CIHR), most recently in 2022.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

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Publications

Collaborators

Grants

Publications by year

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Signals and details

Research

Amyotrophic Lateral Sclerosis Biomolecular Condensates Immunofluorescence Microscopy Live-Cell Imaging Proximity-Dependent Biotinylation (Bioid)Rna Regulation Stress Granules Subcellular Localization

Latest papers

A functional map of the human intrinsically disordered proteome.
Proceedings of the National Academy of Sciences of the United States of America · 2026
Stress Granule Sequestration of CCR4-NOT Promotes Poly(A) Lengthening of Stress-Survival Transcripts.
bioRxiv : the preprint server for biology · 2026 · senior author
Molecular cartography of the human down syndrome and trisomic mouse brain.
Nature communications · 2025

All 27 publications

Latest funding

Molecular fundamentals of TDP-43 dysregulation in amyotrophic lateral sclerosis.
CIHR · 2022 · Nominated PI
$830,026
Systematic interrogation of host:parasite interactions that allow Toxoplasma gondii to infect and persist
CIHR · 2021 · Co-investigator
$952,425
Canada Research Chair - Tier 2
CIHR · 2020 · Nominated PI
$600,000

All 3 grants and awards

27 publications.

A functional map of the human intrinsically disordered proteome.

Pritišanac I, Alderson TR, Kolarić Đ, Zarin T, Xie S, Lu A, Alam A, Maqsood A, Youn JY, Forman-Kay JD, Moses AM

Proceedings of the National Academy of Sciences of the United States of America2026

DOI: 10.1073/pnas.2604562123 PMID: 42150060

Stress Granule Sequestration of CCR4-NOT Promotes Poly(A) Lengthening of Stress-Survival Transcripts.

Tsai YC, Uechi H, Millar SR, Kadijk E, Minkovich A, Ouyang JPT, Schreiber KJ, Huang JQ, Lyons CA, Kasmaeifar V, Zhang Z, Barsacchi R, Möbius C, Janosch A, Savage JC, Rissland OS, Röst H, Hyman AA, Youn JY

bioRxiv : the preprint server for biology2026Senior author

DOI: 10.1101/2025.02.04.636058 PMID: 42094516

Molecular cartography of the human down syndrome and trisomic mouse brain.

Feng MY, Cao W, Tahmasian N, Kukreja B, Li G, Rusu B, Youn JY, Kalish BT

Nature communications2025

DOI: 10.1038/s41467-025-63752-0 PMID: 41027953

Mapping C. difficile TcdB interactions with host cell-surface and intracellular factors using proximity-dependent biotinylation labeling.

Ward JS, Schreiber KJ, Tam J, Youn J-Y, Melnyk RA

mBio2025

DOI: 10.1128/mbio.03336-24 PMID: 39818874

The TSC22D, WNK, and NRBP gene families exhibit functional buffering and evolved with Metazoa for cell volume regulation.

Xiao YX, Lee SY, Aguilera-Uribe M, Samson R, Au A, Khanna Y, Liu Z, Cheng R, Aulakh K, Wei J, Farias AG, Reilly T, Birkadze S, Habsid A, Brown KR, Chan K, Mero P, Huang JQ, Billmann M, Rahman M, Myers C, Andrews BJ, Youn JY, Yip CM, Rotin D, Derry WB, Forman-Kay JD, Moses AM, Pritišanac I, Gingras AC, Moffat J

Cell reports2024

DOI: 10.1016/j.celrep.2024.114417 PMID: 38980795

High-resolution electron cryomicroscopy of V-ATPase in native synaptic vesicles.

Coupland CE, Karimi R, Bueler SA, Liang Y, Courbon GM, Di Trani JM, Wong CJ, Saghian R, Youn JY, Wang LY, Rubinstein JL

Science (New York, N.Y.)2024

DOI: 10.1126/science.adp5577 PMID: 38900912

Exploring Options for Proximity-Dependent Biotinylation Experiments: Comparative Analysis of Labeling Enzymes and Affinity Purification Resins.

Schreiber KJ, Kadijk E, Youn JY

Journal of proteome research2024Senior author

DOI: 10.1021/acs.jproteome.3c00908 PMID: 38507741

A New Phase of Networking: The Molecular Composition and Regulatory Dynamics of Mammalian Stress Granules.

Millar SR, Huang JQ, Schreiber KJ, Tsai YC, Won J, Zhang J, Moses AM, Youn JY

Chemical reviews2023Senior author

DOI: 10.1021/acs.chemrev.2c00608 PMID: 36662637

Mapping Protein-Protein Interactions Using Data-Dependent Acquisition without Dynamic Exclusion.

Zhang S, Larsen B, Colwill K, Wong CJ, Youn JY, Gingras AC

Analytical chemistry2022

DOI: 10.1021/acs.analchem.2c00755 PMID: 35848333

Author Correction: A proximity-dependent biotinylation map of a human cell.

Go CD, Knight JDR, Rajasekharan A, Rathod B, Hesketh GG, Abe KT, Youn JY, Samavarchi-Tehrani P, Zhang H, Zhu LY, Popiel E, Lambert JP, Coyaud É, Cheung SWT, Rajendran D, Wong CJ, Antonicka H, Pelletier L, Palazzo AF, Shoubridge EA, Raught B, Gingras AC

Nature2022

DOI: 10.1038/s41586-021-04308-2 PMID: 35017685

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Ji-Young Youn

Research

Latest papers

Latest funding

A functional map of the human intrinsically disordered proteome.

Stress Granule Sequestration of CCR4-NOT Promotes Poly(A) Lengthening of Stress-Survival Transcripts.

Molecular cartography of the human down syndrome and trisomic mouse brain.

Mapping C. difficile TcdB interactions with host cell-surface and intracellular factors using proximity-dependent biotinylation labeling.

The TSC22D, WNK, and NRBP gene families exhibit functional buffering and evolved with Metazoa for cell volume regulation.

High-resolution electron cryomicroscopy of V-ATPase in native synaptic vesicles.

Exploring Options for Proximity-Dependent Biotinylation Experiments: Comparative Analysis of Labeling Enzymes and Affinity Purification Resins.

A New Phase of Networking: The Molecular Composition and Regulatory Dynamics of Mammalian Stress Granules.

Mapping Protein-Protein Interactions Using Data-Dependent Acquisition without Dynamic Exclusion.

Author Correction: A proximity-dependent biotinylation map of a human cell.

Molecular fundamentals of TDP-43 dysregulation in amyotrophic lateral sclerosis.

Systematic interrogation of host:parasite interactions that allow Toxoplasma gondii to infect and persist

Canada Research Chair - Tier 2

Frequent collaborators

Anne-Claude Gingras

Darrell Desveaux

Charles Boone

Brian Raught

Brenda Andrews

Rajagopal Subramaniam

Laurence Pelletier

Jean-Philippe Lambert

Shelley Lumba

Mojca Mattiazzi Usaj

Alan Moses

Nicholas Provart

Daniela Rotin

Quaid Morris

Marc Fabian

Frank Sicheri

Lu-Yang Wang

Jason Moffat