This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a McGill University directory, so their courses and email address may be missing. Find their university profile.
Research
Latest papers
Robustness and evolvability: Revisited, redefined and applied.
Bio Systems · 2024 · first author
Computational design and experimental verification of pseudoknotted ribozymes.
RNA (New York, N.Y.) · 2023
Toehold-mediated strand displacement to measure released product from self-cleaving ribozymes.
RNA (New York, N.Y.) · 2022
Latest funding
- $1,067,176
Rationally designed ribozymes switched-on by nucleotide repeat extensions as potential tools of genetic therapy for repeat expansion disorders.
CIHR · 2023 · Principal investigator
- $100,000
Rationally designed ribozymes switched-on by nucleotide repeat extensions as potential tools of genetic therapy for repeat expansion disorders.
CIHR · 2022 · Principal investigator
- $100,000
Rationally designed ribozymes switched-on by nucleotide repeat extensions as potential tools of genetic therapy for repeat expansion disorders.
CIHR · 2022 · Principal investigator
9 publications.
Robustness and evolvability: Revisited, redefined and applied.
Kharma N, Bédard-Couture R
Computational design and experimental verification of pseudoknotted ribozymes.
Najeh S, Zandi K, Kharma N, Perreault J
Toehold-mediated strand displacement to measure released product from self-cleaving ribozymes.
Kapadia JB, Kharma N, Davis AN, Kamel N, Perreault J
Digital Microfluidics Chips for the Execution and Real-Time Monitoring of Multiple Ribozymatic Cleavage Reactions.
Davis AN, Samlali K, Kapadia JB, Perreault J, Shih SCC, Kharma N
Computer-Aided Design of Active Pseudoknotted Hammerhead Ribozymes.
Najeh S, Zandi K, Djerroud S, Kharma N, Perreault J
RNA-Based Therapy Utilizing Oculopharyngeal Muscular Dystrophy Transcript Knockdown and Replacement.
Abu-Baker A, Kharma N, Perreault J, Grant A, Shekarabi M, Maios C, Dona M, Neri C, Dion PA, Parker A, Varin L, Rouleau GA
An Adaptive Defect Weighted Sampling Algorithm to Design Pseudoknotted RNA Secondary Structures.
Zandi K, Butler G, Kharma N
Automated design of hammerhead ribozymes and validation by targeting the PABPN1 gene transcript.
Kharma N, Varin L, Abu-Baker A, Ouellet J, Najeh S, Ehdaeivand MR, Belmonte G, Ambri A, Rouleau G, Perreault J
Computational simulation of a gene regulatory network implementing an extendable synchronous single-input delay flip-flop.
Hoteit I, Kharma N, Varin L
Rationally designed ribozymes switched-on by nucleotide repeat extensions as potential tools of genetic therapy for repeat expansion disorders.
Principal investigators: Rouleau, Guy A; Kharma, Nawwaf; Perreault, Jonathan
Keywords: Amyotrophic Lateral Sclerosis; Gene Silencing; Huntington Disease; Machado-Joseph Disease; Neurogenerative Disease; Oculopharyngeal Muscular Dystrophy; Pseudoknot; Repeat Expansion; Ribozyme; Trinucleotide Repeats
Rationally designed ribozymes switched-on by nucleotide repeat extensions as potential tools of genetic therapy for repeat expansion disorders.
Principal investigators: Rouleau, Guy A; Kharma, Nawwaf; Perreault, Jonathan
Keywords: Amyotrophic Lateral Sclerosis; Gene Silencing; Huntington Disease; Machado-Joseph Disease; Neurogenerative Disease; Oculopharyngeal Muscular Dystrophy; Pseudoknot; Repeat Expansion; Ribozyme; Trinucleotide Repeats
Rationally designed ribozymes switched-on by nucleotide repeat extensions as potential tools of genetic therapy for repeat expansion disorders.
Principal investigators: Rouleau, Guy A; Kharma, Nawwaf; Perreault, Jonathan
Keywords: Amyotrophic Lateral Sclerosis; Gene Silencing; Huntington Disease; Machado-Joseph Disease; Neurogenerative Disease; Oculopharyngeal Muscular Dystrophy; Pseudoknot; Repeat Expansion; Ribozyme; Trinucleotide Repeats
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
Frequent collaborators
- Neurology and Neurosurgery
- Neurosciences
Co-authors at McGill University, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.
A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.