Philippe Séguéla, McGill University

Research

Chronic Pain Sensory Neurons Dopamine Prefrontal Cortex Pyramidal Cells Calcium Chemogenetics Drg

Latest papers

Targeting C1q prevents microglia-mediated synaptic removal in neuropathic pain.
Nature communications · 2025

All 1 publications

Latest funding

Sommet Francophone de la Recherche sur la Douleur
CIHR · 2022 · Co-investigator
$10,000
Dopaminergic Modulation of the ACC in Chronic Pain
CIHR · 2022 · Nominated PI
$841,500
Genetic engineering of mammalian somatosensory circuits
NSERC · 2020 · Principal investigator
$240,000

All 12 grants and awards

1 publications.

01

Targeting C1q prevents microglia-mediated synaptic removal in neuropathic pain.

Yousefpour N, Tansley SN, Locke S, Sharif B, Parisien M, Bourojeni FB, Deamond H, Mathur V, Arana NR, Austin JS, Bourassa V, Wang C, Cabana VC, Wong C, Lister KC, Rodrigues R, St-Louis M, Paquet ME, Carroll MC, Andrews-Zwilling Y, Seguela P, Kania A, Yednock T, Mogil JS, De Koninck Y, Diatchenko L, Khoutorsky A, Ribeiro-da-Silva A

Nature communications2025

DOI: 10.1038/s41467-025-59849-1 PMID: 40382320

Sommet Francophone de la Recherche sur la Douleur

Co-investigatorCIHR2022Planning and Dissemination Grant - Institute Community Support

Principal investigators: Sharif-Naeini, Reza

Keywords: Collaboration Scientifique; Douleur; Reseautage; Sciences Cliniques; Sciences Fondamentales

$10,000

Dopaminergic Modulation of the ACC in Chronic Pain

Nominated PICIHR2022Project Grant

Principal investigators: Séguéla, Philippe A

Keywords: Chronic Pain; Dopamine; Prefrontal Cortex; Pyramidal Cells

$841,500

Genetic engineering of mammalian somatosensory circuits

Principal investigatorNSERC2020Discovery Grants Program - Individual

Principal investigators: Séguéla, Philippe

$240,000

Individual Differences in Pain Sensitivity: Genetic and Environmental Factors in Mice and Humans

Co-investigatorCIHR2016Foundation Grant

Principal investigators: Mogil, Jeffrey S

Keywords: Algesiometry; Genetics; Pain; Sex Differences; Social Modulation; Translation

$1,346,653

Analgesic mechanisms of melatonin MT2 receptor ligands.

Co-investigatorCIHR2016Project Grant

Principal investigators: Gobbi, Gabriella

Keywords: Electrophysiology; Gpcr; Melatonin; Molecular Biology; Mt2 Receptor; Neuropathic Pain; Pain

$459,000

In vivo interrogation and control of genetically-identified somatosensory neurons in neuropathic pain pathways

Nominated PICIHR2016Project Grant

Principal investigators: Séguéla, Philippe A

Keywords: Calcium; Chemogenetics; Chronic Pain; Drg; Mechanoreceptors; Neuropathy; Nociception; Optogenetics; Sensory Neurons; Touch

$757,350

Genetic Engineering of Mammalian Sensory Circuits

Principal investigatorNSERC2015Discovery Grants Program - Individual

Principal investigators: Séguéla, Philippe

$165,000

Molecular Physiology of P2X ATP Receptor Channels in Pain Pathways

Nominated PICIHR2013Operating Grant

Principal investigators: Séguéla, Philippe A

Keywords: Analgesia; Atp Receptor Channels; Chronic Pain; Microglia; Receptor Antagonist; Sensory Neurons

$592,636

Physiologie moléculaire des canaux ioniques ASIC

Principal investigatorNSERC2010Discovery Grants Program - Individual

Principal investigators: Seguela, Philippe

$200,000

Intracellular regulation of P2X4 receptors by phosphoinositides via P2Y activation

SupervisorCIHR2009Canada Graduate Scholarships - Michael Smith Foreign Study Supplements

Principal investigators: Bernier, Louis-Philippe

$6,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Neurology and Neurosurgery
Pharmacology and Therapeutics
Anesthesia
Biochimie et microbiologie
Other

Co-authors at McGill University, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Yves De Koninck

Faculty

1 shared papers, latest 2025

Alfredo Ribeiro-Da-Silva

Pharmacology and Therapeutics

1 shared papers, latest 2025

Luda Diatchenko

Faculty

1 shared papers, latest 2025

Arkady Khoutorsky

Anesthesia

1 shared papers, latest 2025

Marie-Eve Paquet

Biochimie et microbiologie

1 shared papers, latest 2025

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Mention their CIHR grant from 2022

Subject: Prospective PhD student: Chronic Pain Dear Professor Séguéla, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Targeting C1q prevents microglia-mediated synaptic removal in neuropathic pain." (2025), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Dopaminergic Modulation of the ACC in Chronic Pain" (2022), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]