Faculty profile

Alfredo Ribeiro-Da-Silva

ResearcherPharmacology and TherapeuticsMcGill University

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a McGill University directory, so their courses may be missing. Find their university profile.

Alfredo Ribeiro-Da-Silva

Researcher

Pharmacology and Therapeutics

Health Sciences

McGill University

Montreal, Quebec, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
14 publications in the last five years, latest in 2026.
Senior (last) author on 4 recent papers, a sign of leading a research group.
Principal investigator on 6 research grants (5 CIHR, 1 NSERC), most recently in 2024.
Supervised 1 trainee who won CIHR awards, most recently in 2010.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

189

Citations

h-index

Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

Profiles and links

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Signals and details

Research

Confocal Microscopy Immunocytochemistry Neuropathic Pain Viral Vectors Arthritis Imaging Joints Pharmacology

Latest papers

A new and less invasive surgical approach to the mouse spared nerve injury model of peripheral neuropathic pain.
Journal of neuroscience methods · 2026
4E-BP1-dependent translation in microglia controls mechanical hypersensitivity in male and female mice.
The Journal of clinical investigation · 2025
Targeting C1q prevents microglia-mediated synaptic removal in neuropathic pain.
Nature communications · 2025 · senior author

All 67 publications

Latest funding

A New Role of Reactive Astrogliosis on Spinal Cord Dorsal Horn Neuronal Mitochondrial Function and Sensitization
NSERC · 2024 · Principal investigator
$46,000
Targeting inhibitory synaptic pruning for treatment of Neuropathic Pain
CIHR · 2023 · Nominated PI
$952,425
A neuropathic-like component in arthritis pain: characterization and therapeutic possibilities
CIHR · 2020 · Nominated PI
$879,750

All 8 grants and awards

67 publications.

A new and less invasive surgical approach to the mouse spared nerve injury model of peripheral neuropathic pain.

Rought R, Rodrigues R, Sharif-Naeini R, Stone LS, Coderre TJ, Ribeiro-da-Silva A, Millecamps M

Journal of neuroscience methods2026

DOI: 10.1016/j.jneumeth.2026.110751 PMID: 41905537

4E-BP1-dependent translation in microglia controls mechanical hypersensitivity in male and female mice.

Lister KC, Wong C, Cai W, Uttam S, Stecum P, Rodrigues R, Hooshmandi M, Brown N, Fan J, Francois-Saint-Cyr N, Tansley S, Hovhannisyan V, Tavares-Ferreira D, Inturi NN, Mazhar K, Pacis A, Yang J, Ribeiro-da-Silva A, Gkogkas CG, Price TJ, Mogil JS, Khoutorsky A

The Journal of clinical investigation2025

DOI: 10.1172/jci180190 PMID: 40454470

Targeting C1q prevents microglia-mediated synaptic removal in neuropathic pain.

Yousefpour N, Tansley SN, Locke S, Sharif B, Parisien M, Bourojeni FB, Deamond H, Mathur V, Arana NR, Austin JS, Bourassa V, Wang C, Cabana VC, Wong C, Lister KC, Rodrigues R, St-Louis M, Paquet ME, Carroll MC, Andrews-Zwilling Y, Seguela P, Kania A, Yednock T, Mogil JS, De Koninck Y, Diatchenko L, Khoutorsky A, Ribeiro-da-Silva A

Nature communications2025Senior author

DOI: 10.1038/s41467-025-59849-1 PMID: 40382320

Targeting spinal mechanistic target of rapamycin complex 2 alleviates inflammatory and neuropathic pain.

Wong C, Rodriguez-Hernandez LD, Lister KC, Gu N, Cai W, Hooshmandi M, Fan J, Brown N, Nguyen V, Ribeiro-da-Silva A, Bonin RP, Khoutorsky A

Brain : a journal of neurology2025

DOI: 10.1093/brain/awae275 PMID: 39167538

Temporal changes of spinal microglia in murine models of neuropathic pain: a scoping review.

Dhir S, Derue H, Ribeiro-da-Silva A

Frontiers in immunology2024Senior author

DOI: 10.3389/fimmu.2024.1460072 PMID: 39735541

Absence of paresthesia during high-rate spinal cord stimulation reveals importance of synchrony for sensations evoked by electrical stimulation.

Sagalajev B, Zhang T, Abdollahi N, Yousefpour N, Medlock L, Al-Basha D, Ribeiro-da-Silva A, Esteller R, Ratté S, Prescott SA

Neuron2024

DOI: 10.1016/j.neuron.2023.10.021 PMID: 37972595

Distinct and sex-specific expression of mu opioid receptors in anterior cingulate and somatosensory S1 cortical areas.

Zamfir M, Sharif B, Locke S, Ehrlich AT, Ochandarena NE, Scherrer G, Ribeiro-da-Silva A, Kieffer BL, Séguéla P

Pain2023

DOI: 10.1097/j.pain.0000000000002751 PMID: 35973045

Therapeutic exercise interventions in rat models of arthritis.

Derue H, Ribeiro-da-Silva A

Neurobiology of pain (Cambridge, Mass.)2023Senior author

DOI: 10.1016/j.ynpai.2023.100130 PMID: 37179770

Time-dependent and selective microglia-mediated removal of spinal synapses in neuropathic pain.

Yousefpour N, Locke S, Deamond H, Wang C, Marques L, St-Louis M, Ouellette J, Khoutorsky A, De Koninck Y, Ribeiro-da-Silva A

Cell reports2023Senior author

DOI: 10.1016/j.celrep.2023.112010 PMID: 36656715

Modulating the activity of human nociceptors with a SCN10A promoter-specific viral vector tool.

Mouchbahani-Constance S, Lagard C, Schweizer J, Labonté I, Georgiopoulos M, Otis C, St-Louis M, Troncy E, Sarret P, Ribeiro-Da-Silva A, Ouellet JA, Séguéla P, Paquet ME, Sharif-Naeini R

Neurobiology of pain (Cambridge, Mass.)2023

DOI: 10.1016/j.ynpai.2023.100120 PMID: 36816616

A New Role of Reactive Astrogliosis on Spinal Cord Dorsal Horn Neuronal Mitochondrial Function and Sensitization

Principal investigatorNSERC2024Discovery Grants Program - Individual

Principal investigators: Ribeiro-da-Silva, Alfredo

Keywords: astrocytes; neurons; spinal cord; transgenic mice; adeno associated virus; glutathione; oxidative stress; central sensitization; super resolution microscopy

$46,000

Targeting inhibitory synaptic pruning for treatment of Neuropathic Pain

Nominated PICIHR2023Project Grant

Principal investigators: Ribeiro-Da-Silva, Alfredo

Keywords: Animal Behaviour Testing; Confocal Microscopy; Electrophysiology; Immunocytochemistry; Neuropathic Pain; Synapses; Transgenic Mice; Viral Vectors

$952,425

A neuropathic-like component in arthritis pain: characterization and therapeutic possibilities

Nominated PICIHR2020Project Grant

Principal investigators: Ribeiro-Da-Silva, Alfredo

Keywords: Arthritis; Chronic Pain; Confocal Microscopy; Imaging; Immunohistochemistry; In Situ Hybridization; Joints; Morphology; Pharmacology; Spinal Cord

$879,750

Inhibitory synaptic pruning as a substrate of neuropathic pain

Nominated PICIHR2019Project Grant

Principal investigators: Ribeiro-Da-Silva, Alfredo

Keywords: Animal Behaviour Tools; Immunocytochemistry; Inhibitory Synapses; Light And Electron Microscopy; Molecular Tools; Neuropathic Pain; Pharmacology; Spinal Cord; Two-Photon Calcium Imaging; Viral Vectors

$100,000

Individual Differences in Pain Sensitivity: Genetic and Environmental Factors in Mice and Humans

Co-investigatorCIHR2016Foundation Grant

Principal investigators: Mogil, Jeffrey S

Keywords: Algesiometry; Genetics; Pain; Sex Differences; Social Modulation; Translation

$1,346,653

Manipulation of endogenous neurotrophic factor levels as a novel treatment for arthritis

Nominated PICIHR2014Operating Grant

Principal investigators: Ribeiro-Da-Silva, Alfredo

Keywords: Arthritis; Biochemistry; Confocal Microscopy; Imaging; Immunocytochemistry; Joints; Nerve Growth Factor; Pain; Skin

$724,366

Synaptic organisation of dorsal horn modulatory circuits

Nominated PICIHR2010Operating Grant

Principal investigators: Ribeiro-Da-Silva, Alfredo

Keywords: Animal Behaviour; Confocal Microscopy; Immunocytochemistry; Nerve Lesions; Pain

$820,760

Synaptic Circuitry in the Dorsal Horn of the Spinal Cord in Normal Rats and in a Model of Neuropathic Pain

SupervisorCIHR2010Master's Award: Canada Graduate Scholarships

Principal investigators: Magnussen, Claire A

Keywords: Confocal Microscopy; Immunohistochemistry; Neuropathic Pain; Projection Neurons; Retrograde Labelling; Spinal Cord Circuitry; Spinal Cord Dorsal Horn

$17,500

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Alfredo Ribeiro-Da-Silva

Research

Latest papers

Latest funding

A new and less invasive surgical approach to the mouse spared nerve injury model of peripheral neuropathic pain.

4E-BP1-dependent translation in microglia controls mechanical hypersensitivity in male and female mice.

Targeting C1q prevents microglia-mediated synaptic removal in neuropathic pain.

Targeting spinal mechanistic target of rapamycin complex 2 alleviates inflammatory and neuropathic pain.

Temporal changes of spinal microglia in murine models of neuropathic pain: a scoping review.

Absence of paresthesia during high-rate spinal cord stimulation reveals importance of synchrony for sensations evoked by electrical stimulation.

Distinct and sex-specific expression of mu opioid receptors in anterior cingulate and somatosensory S1 cortical areas.

Therapeutic exercise interventions in rat models of arthritis.

Time-dependent and selective microglia-mediated removal of spinal synapses in neuropathic pain.

Modulating the activity of human nociceptors with a SCN10A promoter-specific viral vector tool.

A New Role of Reactive Astrogliosis on Spinal Cord Dorsal Horn Neuronal Mitochondrial Function and Sensitization

Targeting inhibitory synaptic pruning for treatment of Neuropathic Pain

A neuropathic-like component in arthritis pain: characterization and therapeutic possibilities

Inhibitory synaptic pruning as a substrate of neuropathic pain

Individual Differences in Pain Sensitivity: Genetic and Environmental Factors in Mice and Humans

Manipulation of endogenous neurotrophic factor levels as a novel treatment for arthritis

Synaptic organisation of dorsal horn modulatory circuits

Synaptic Circuitry in the Dorsal Horn of the Spinal Cord in Normal Rats and in a Model of Neuropathic Pain

Frequent collaborators

Arkady Khoutorsky

Yves De Koninck

Reza Sharif-Naeini

Yves De Koninck

Luda Diatchenko

Masha Prager-Khoutorsky

Ji Zhang

Nahum Sonenberg

Marie-Eve Paquet

Lisbet Haglund

Sylvain Chemtob

Jean Ouellet

Morley Hollenberg

Linda Wykes

Pierre Chaurand

Frank Rauch

Artur Kania

Przemyslaw Sapieha

Philippe Séguéla

Rikard Blunck

Kjetil Ask

Przemyslaw Sapieha

James Lorne Henry

Philippe Sarret

Thomas Schricker